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Effects of Niaodukang on Lipid Metabolism in the Rat Modelwith Chronic Renal Failure

Journal of Guangzhou University of Traditional Chinese Medicine.1999;0(02):-.

Niaodukang is an effective formula used in the second affiliated hospithal of Guangzhou Universityof TCM for chronic renal failure, which is composed of Rhizoma Rhei,Radix Polygoni Multiflori,Radix Astragali seu Hedysari and Fructus Ligustri Lucidi with the actions of supplementing qi, warmingYang, strengthening spleen, tonifying kidney, promoting blood circulation and removing turbid pathogenicfactor. To explore the effect of Niaodukang on the lipid metabolism of chronic renal faiure, rat model wasset up with improved technique of 5/6 kidney mass removal. After the accomplishment of the rat model for2 weeks, the models matched with the geneal conditions and 24 hours' proteinuria were randomly allocated to five groups: the model group,two Niaodukang groups with high and low dosages respectively, CoatedAldehyde Oxystarch group and the nounal control group. Serum contents of triglyceride, cholesterol andapoprotein were tested.The results showed that the blood lipid level in the model group was higher than thenormal group,and decreased markedly after the treatment of Niaodukang. It is indicated that Niaodukang exerts a good effect on the blood-lipid metabolism in rat model with chronic renal failure.

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Effect of Kebimin Spray on Substan on Substance P Contents in Lung and Plasma of Guinea Pigs with Hhypersensitive Rhinitis

Yanfang QIAN ; Bingwen LI ; Zhengmou ZHOU ; Yanyan BAO ; Jinrang LI

Journal of Guangzhou University of Traditional Chinese Medicine.1999;0(02):-.

To study the antisensitiZation of Chinese drug, Inodel gUinea pigS with hypersensitive thinilistabbed with Kebindn Sray Served as Group l, and substance P(SP) contents in lung and plasma ofGroup I were detected and compared with normal coned group (Group 11),model control groUp(Group ill) and poSitive medicine control group(GrouP ac).The resultS showed that SP content inlung and plasma of Group ill were higher than thais of GrouP 11(P 0.05).SP is an active neuropeptide and over release of SP Inay result in hperetion of the nose.It is indicated that Kebimin SPlaycan inhibit type I alleds by decreasing SP contents in lung and plasma.

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An Experomental Study of Nasal Soray for Acute Ischemia Strole in Guimea Pigs

Chun WANG ; Honggui CHEN ; Wiiuni LEI

Journal of Guangzhou University of Traditional Chinese Medicine.1999;0(02):-.

Naoxing oral preparation has ho formed to be effective for ischemic stroke by preliminary clin-ical trial. To find a safe, efficient and convenient preparation Naoxing nasal spray was developed. Theeffect of Naoxing nasal spray on increasing hypoxic toleance of brain cells and improving blood circulationwas confirmed in this experiment. Twenty-eight guinea Pigs were randomly allocated to 4 groups: Group A(Naoxing nasal spray),Group B (ninodipine injection intraperitoneally), GrouP C (ligushazine injectionintrqperitoneally) and Group D(distilled water for nasal spray). After the medication for 4 days, acutecerebral ischemia was produced by the occlusion of bilatelal caretid arteries for 45 minutes. Serum NO lev-el,superoxide dismutase(SOD), glutathione superoxidase (GSH--Px) and lipid peroxide (LPO) levelsin cerebral tissue were detected. Ultrastructure of right hippocampus was oberved.The results showedthat NO, SOD, GSH-Px level in Group A is significantly higher and LPO level is significantly lower thanthere in Group D(P0.05).The damage of neuron, gliocyte and capillary under electron microscope was less thanGroup D,the differences being not significant as compared with Group B and C. It is concluded that theeffect of Naoxing nasal splay is as ed as ninodipine and ligustazine injection.

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Effects of Qi Reinforcing Blood-Circulation Activating Medicines on Cerebral edema and Brain Ultrastructure of Cerebral Ischemic Rat Model After Reperfusion

Zhimin YANG ; Wenbin ZHOU ; Peixin HUANC ; Maocai LIU

Journal of Guangzhou University of Traditional Chinese Medicine.1999;0(02):-.

Yiqi Huoxue Oral Liquid(YHOL) was a formula with Qi Reinforcing and bind-circulationactivating actions consisting of Radix Astragali seu Hedysari,Heada,Radix Ilicis Pubesceatis,etc,To study its Pharmacological mechanism, the effects of YHOL on cerebral edema and ultra- struture of cereblal ischemic rat model after reperfusion were observed. The results showed that YHOLdecreased the water content of ischemic barn to some extent, alleviated the neurological symptoms andreduced the damage of brain ultrastructure in the early stage of reperfusion. It is indicated that YHOLcan reduce cereblal edema by protecting the fumction of vascular endothelial cell and the integrity of basicmembranes and improving microcirculation, and exerts a protective effect on the delayed death of neuron.This will Provide an experimental evidence for the clinical application of YHOL.

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Imolantation of Quadrate Muscle Thigh with Bone Flap Combined with internal Fixation for Infracaput Fracture of Collum Femoris in the Youth

Zhaoqing LI

Journal of Guangzhou University of Traditional Chinese Medicine.1999;0(02):-.

Infracaput fracture of collum femoris in the youth is usually caused by tremendous violenceand characterized by obvious translocation and high ratio of ischemic necmeis of femoral head. Artificialfemoral head replacement or hip replacement is not suitable for the youth. Twenty-eight cases of suchfracture were treated with implantation of quadrate muscle of thigh with bone flap combined with internalfixation by screw,and a follow-up Period of 8 ~ 36 months was carried on. The results showed that allcases resulted in a bony union and ischemic necrosis of femoral head did not occur.It is suggested thatthe opelation should be Performed as early as possible to restore the blood circulation of femoral head,and proper reduction and firm internal fixation guarantee the union of fracture,Quadrate muscle of thighwith bone flap has a rich blood supply and operation can be accomplished in the same incision of internalfixation,so that the injury is iess and the successful rate is high.

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A Clinical Observation on Mixture Portulacae Co.in Decreasing the Recurrence Rate of Condyloma Acuminatum

Wenying SONG ; Yongchao QIU

Journal of Guangzhou University of Traditional Chinese Medicine.1999;0(02):-.

0.05 ),and the recurrence rate in Group Ⅲ was highest,the difference beingsiedcant as compared with Group Ⅰ(P

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Effects of Acupuncture on Event Related Potential P_3 in Children with Attention Deficit Hyperactivity Disorder

Tiequ CAI

Journal of Guangzhou University of Traditional Chinese Medicine.1999;0(02):-.

To observe the effects of acupuncture on event related potential P3(P3) in children with attention deficit hyperactivity disorder (ADHD), P3 in 40 ADHD children and 20 normal children was detected.It was founded that the occurrence rate of P3 in ADHD chilthen under the situations of active retention and passive attenhon was 68.9% and 46.6%,and 94.3% and 35.7% in normal children respefavely(P

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A Preliminary Strdy colonic Motility and X-ray Images of Chronic Colitis

Haihe DENG ; Weiqing CHEN ; Xuefen LIANG ; Zhicheng LIAN

Journal of Guangzhou University of Traditional Chinese Medicine.1999;0(02):-.

In 51 patients with gastrointestinal diseases,diseases,abdondnal X-lay Photos at lying POSition weretaken 6.5 hours after barium ined and 12 healthy volunteers served as coneal. The longitudinal axis,the transverse diameter,the number and the height of colonic bags in the colonic X-ray photes at fillingand evacuating Phases were counted.Chronic colitis was mainly manifested as loose stool, alternation ofconstipation and diarrhea,dyschesia or abdominal pain whenever desire to defecate. The colonic X-rayphotos showed that the diameter and the number of colonic bag in chronic colitis were reduced and the evacuation of barium became accelerated.These colonic X-ray images can explain the pathophysiologicmechasm of the above manifestations and may serve as a kinetic index providing evidence for the clinicaldiagnosis and treatment of the disease.

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Bacterial Endotoxin Test for Shengmai Injection

Xiaoqing PENG ; Jieme REN

Journal of Guangzhou University of Traditional Chinese Medicine.2000;0(04):-.

Preliminary screening test and interfering test were used to study the bacterial endotoxin test (BET) for Shengmai Injection (SI). The results showed that there is no interference when the SI is diluted by 10 times and limulus reagent with a sensibility of 0.25EU/mL is used for BET.

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Pharmacological Action of Shenfukang on Rat Model with Nephritis Induced by Cationized Bovine Serum Albumin

Jiuyao ZHOU ; Xuezhen LIAO ; Rui LI

Journal of Guangzhou University of Traditional Chinese Medicine.2000;0(04):-.

Shenfukang is an effective formula for glomerulonephritis applied in the first affiliated hospital of Guangzhou University of TCM. It is composed of Radix Folium seu Flos Tripterygii wilfordii, Radix Astragali seu Hedysari, Radix Notoginseng, Herba Leonuri, etc.. Glomerulonephritis rat model was induced by cationized bovine serum albumin (C-BSA) according to Border's method and was used to observe the pharmacological action of Shenfukang. The results showed that Shenfukang can eliminate urine protein, increase the levels of serum protein, albumin (A), globulin (G) and A/G ratio, and decrease the contents of serum cholesterol, creatinine and urea nitrogen. It can also counteract the increase of plasma TXB 2 and the decrease of plasma 6-keto-PGF 1? . LD 50 of Shenfukang for mice is 174.34?36.74?g/kg which is much larger than that of Tripterygium wilfordii (29.73?6.46?g/kg for female mice and 101.74?10.93?g/kg for male mice). It is indicated that Shenfukang exerts a protective effect on renal function and reduces toxicity of Tripterygium wilfordii.

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