Journal Detail Information

1

Cite

Share

Relationship of Cardiac Damage with Traditional Chinese Medicine Syndromes and Clinical Indicators in Patients with Chronic Kidney Disease at Stage 3

Wei-Li PAN ; Yue SUN ; Xian-Fa LI

Journal of Guangzhou University of Traditional Chinese Medicine.2018;35(2):197-205. doi:10.13359/j.cnki.gzxbtcm.2018.02.001

Objective To explore the relationship of the cardiac damage with traditional Chinese medicine (TCM) syndromes and clinical indicators in patients with chronic kidney disease at stage 3 (CKD3). Methods A cross-sectional study was carried out in 108 CKD3 patients. We collected the clinical data of the included subjects, covering syndrome types, clinical indicators, and echocardiographic indices. And then we analyzed the correlation of syndrome types with echocardiography indices and risk factors of cardiac damage. Results(1) There were 48.1％ of the included subjects having the cardiac structure changes, 19.4％ having myocardial thickening and 82.4％ having left ventricular diastolic dysfunction. Hypertension, hypertension-history lasting time, anemia and phosphorus ion levels were risk factors of myocardial hypertrophy (P < 0.05). Age and free thyroxine levels were risk factors of valvular regurgitation (P < 0.05 or P < 0.01). (2) In the patients with healthy-Qi deficiency syndromes, the heart damage in Yin-Yang deficiency syndrome was more severe than that in spleen-kidney Yang deficiency syndrome and Qi-Yin deficiency syndrome, and the impairment of cardiac function was most severe in Yin-Yang deficiency syndrome(P<0.05). An increasing sequence of incidence of ventricular remodeling was shown in the syndromes of spleen-kidney Qi deficiency, spleen-kidney Yang deficiency , Qi-Yin deficiency , liver-kidney Yin deficiency , Yin-Yang deficiency(P < 0 . 05). (3) Left ventricular mass index (LVMI) in the patients with pathogen-excess complicated syndromes was higher than that in the patients without pathogen-excess complicated syndromes (P<0.05). Of the pathogen-excess complicated syndromes, blood-stasis syndrome had higher incidence of ventricular remodeling than damp-heat syndrome(P<0.01) , but the differences were insignificant among the other syndrome types (P > 0.05). Conclusion The decreased diastolic function and cardiac structure damage are relatively commonly-seen in CKD3 patients, and some of CKD3 patients have myocardial hypertrophy. Anemia, hypertension, hypertension-history lasting time and phosphorus ion level are risk factors of myocardial hypertrophy. Heart damage is more severe in CHD3 patients with Yin-Yang deficiency syndrome than that in spleen-kidney Yang deficiency syndrome and Qi-Yin deficiency syndrome, and the impairment of cardiac function is most severe in Yin-Yang deficiency syndrome. The complication of pathogen-excess can aggravate heart damage. Patients complicated with blood-stasis syndrome have more severe myocardial hypertrophy, and ventricular and atrial enlargement degree.

2

Cite

Share

Influence of Bushen Yisui Decoction on Homocysteine and Symptoms of Vascular Dementia Patients with Various Methylenetetrahydrofolate Reductase Genotypes

Jin-Can LIU ; Jian LIU

Journal of Guangzhou University of Traditional Chinese Medicine.2018;35(2):205-209. doi:10.13359/j.cnki.gzxbtcm.2018.02.002

Objective To investigate the influence of Bushen Yisui Decoction on homocysteine (Hcy) level and clinical symptoms of vascular dementia (VD) patients with various methylenetetrahydrofolate reductase(MTHFR) genotypes. Methods Kidney-essence deficiency VD patients were classified into TT(mutant) group, CT(hybrid) group, and CC(wild) group according to their MTHFR genotypes, 25 cases in each group. The patients in the 3 groups were given Bushen Yisui Decoction on the basis of treatment for underlying diseases, and the course of treatment covered 3 months. Before and after treatment, plasma Hcy level was detected, and the scores of clinical symptoms were evaluated with Mini-Mental State Examination (MMSE). After treatment, the therapeutic effect on traditional Chinese medicine(TCM) syndromes in the 3 groups was evaluated with the Scale for the Differentiation of Syndromes of Vascular Dementia (SDSVD). Results (1) After treatment, plasma Hcy level in the 3 groups was decreased(P<0.05 compared with that before treatment), and the effect on decreasing Hcy level in TT group was stronger than that in CT group and CC group, the inter-group difference of Hcy difference before and after treatment was significant(P<0.05).(2) After treatment, the mean MMSE scores in the 3 groups were increased (P < 0 . 05 compared with those before treatment), and the effect on increasing MMSE scores in TT group showed a trend of being stronger than that in CT group and CC group, but the difference was insignificant (P>0.05). (3)After treatment, the total effective rate on TCM syndromes in TT group, CT group, and CC group was 76.0％, 64.0％, 68.0％ respectively, and the effective rate in TT group was higher than that in CT group and CC group (P < 0.05). Conclusion Bushen Yisui Decoction is effective on decreasing plasma Hcy level and relieving clinical symptoms of VD patients with various MTHFR genotypes, and is more effective for VD patients with TT mutant genotype.

3

Cite

Share

Effect of Jianxin Decoction on Levels of Inflammatory Cytokines and Cardiac Function of Patients with Chronic Heart Failure

Jian-Yan XIE

Journal of Guangzhou University of Traditional Chinese Medicine.2018;35(2):209-215. doi:10.13359/j.cnki.gzxbtcm.2018.02.003

Objective To observe the effect of Jianxin Decoction, a recipe with the actions of tonifying Qi and warming Yang, strengthening spleen and removing edema, on the levels of inflammatory cytokines and cardiac function in patients with chronic heart failure (CHF). Methods Sixty-two CHF patients were randomly divided into observation group and control group, 31 cases in each group. The control group was treated with western medicine alone, and the observation group was given Jianxin Decoction combined with western medicine. After treatment for 4 weeks, the levels of serum interleukin -6 (IL-6), interleukin -10 (IL-10), tumor necrosis factor alpha(TNF-α) and brain natriuretic peptide(BNP) were detected by enzyme-linked immunosorbent assay (ELISA). The left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter(LVEDD), left ventricular ejection fraction(LVEF), cardiac output(CO) and ratio of mitral peak velocity of early filling to mitral late diastolic peak velocity(E/A) were determined with echocardiography. The effect on traditional Chinese medicine (TCM) syndromes, effect on cardiac function grading, and adverse reaction in the two groups were also observed. Results (1) After treatment, the effective rate on TCM syndromes and improvement of cardiac function in the observation group were superior to those in the control group, the difference being significant (P<0.05). (2) Levels of serum IL-6, IL-10, TNF-αand BNP of the two groups after treatment were decreased as compared with those before treatment(P < 0.05), and the decrease in the observation group was superior to that in the control group (P<0.05). (3)After treatment, LVSED and LVEDD of the two groups were much decreased, and LVEF, E/A and CO were markedly increased (P < 0.05 compared with those before treatment). The improvement of LVSED, LVEDD, LVEF, E/A and CO in observation group was significantly superior to that in the control group (P < 0.05). (4) During the treatment, the incidence of adverse reaction showed no significant differences between the two groups (P > 0.05). Conclusion Jianxin Decoction combined with western medicine can effectively reduce the levels of inflammatory cytokines and BNP, so as to relieve the clinical symptoms and improve cardiac function grading in patients with CHF. The combination has better effect and is safer than western medicine alone for CHF.

4

Cite

Share

Clinical Study on Middle-late Non-small Cell Lung Cancer Treated with Therapy of Strengthening Qi, Resolving Phlegm and Dissipating Mass

Yu-Sheng WU ; Xing-Bin DAI ; Ming-Yuan XING ; Dan-Qing LI

Journal of Guangzhou University of Traditional Chinese Medicine.2018;35(2):215-221. doi:10.13359/j.cnki.gzxbtcm.2018.02.004

Objective To observe the clinical effect of therapy of strengthening Qi, resolving phlegm and dissipating mass for middle-late non-small cell lung cancer. Methods Sixty patients with middle-late non-small cell lung cancer were randomly divided into 3 groups according to the results of intention-to-treat and genetic test. All of the 3 groups were given fundamental supportive and asymptomatic treatment, and additionally Group Ⅰ was mainly given oral use of Jinfuan Decoction with the actions of strengthening Qi, resolving phlegm and dissipating mass based on syndrome differentiation, group Ⅱ was treated with molecular targeted therapy with Gefitinib Tablets and /or Erlotinib Hydrochloride Tablets, and groupⅢ was only given the fundamental supportive and asymptomatic treatment. The 3 groups were treated for 3 cycles(84 days), and then we compared the tumor size, clinical symptoms, quality of life, distant metastasis, and the toxic and adverse effect in each group. Results (1) GroupⅠand group Ⅱhad stronger effect on relieving cough, shortness of breath and lassitude than groupⅢ(P<0.05); groupⅡand groupⅢwere more effective on relieving bloody sputum and chest pain than groupⅠ(P<0.05); groupⅠand groupⅢwere more effective on relieving fever than groupⅡ(P < 0.05). (2) In aspect of quality of life, KPS scores of groupⅠand group Ⅱwere much increased after treatment (P < 0.05), but the scores of group Ⅲ showed no obvious increase (P > 0.05). The improvement of KPS scores in groupⅠand groupⅡwas superior to that in groupⅢ(P<0.05). (3) GroupⅡhad a higher effective rate on stabilizing tumor size, the rate arrived to 65.0％, and was superior to that in groupⅠand groupⅢ(P <0.05) , and the effective rate in group Ⅰ was superior to that in group Ⅲ(P < 0.05). Group Ⅰ and group Ⅱhad a higher stabilizing rate than group Ⅲ(P < 0.05) , but the difference between group Ⅰ and group Ⅱ was insignificant (P>0.05). (4) GroupⅠhad less adverse reaction and higher safety. (5) The distant metastasis rate in groupⅠand groupⅡwas obviously lower than that in groupⅢ(P<0.05), but the difference of distant metastasis rate beetween group Ⅰ and group Ⅱ was insignificant (P > 0.05). Conclusion Therapy of strengthening Qi , resolving phlegm and dissipating mass is effective on relieving tumor-related symptoms , improving the quality of life, stabilizing the tumor, and controlling the distant metastasis in middle-late non-small cell lung cancer patients.

5

Cite

Share

Therapeutic Effects and Mechanism of Chinese Medicine Skin Dialysis for Chronic Renal Failure

Qin-Xiang TAN ; Guo-Zi CHEN ; Liu-Chang FENG ; Li-Liang WEI ; Xu-Sheng LIU

Journal of Guangzhou University of Traditional Chinese Medicine.2018;35(2):221-226. doi:10.13359/j.cnki.gzxbtcm.2018.02.005

Objective To observe the influence of Chinese medicine skin dialysis on traditional Chinese medicine (TCM) syndrome scores and microinflammation in patients with chronic renal failure(CRF). Methods A total of 180 patients with CRF were divided into groups A, B and C, 60 cases in each group. All of the 3 groups were given conventional treatment, and additionally, group A was given Chinese medicine skin dialysis, and group B was given pure water dialysis. Meanwhile, 60 healthy volunteers served as normal control group (group D), and had no any medication. The course of treatment lasted for one month. Before and after treatment, we examined the scores of TCM syndromes and the levels of 24-hour urinary protein, serum creatinine (SCr), blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), albumin (ALB), immunoglobulin A(IgA), immunoglobulin G (IgG) , immunoglobulin M(IgM), interleukin 6 (IL-6) , interleukin 1(IL-1), hyper-sensitive C reactive protein (hs-CRP), and tumor necrosis factor alpha (TNF-α). Results After treatment, the scores of TCM syndromes and the levels of 24-hour urinary protein, SCr, BUN, eGFR, IL-6, IL-1, hs-CRP, and TNF-α in the 3 groups were decreased (P < 0.05 compared with those before treatment), and were markedly lower in group A than those in group B and group C (P<0.05); serum levels of IgA, IgG, IgM and ALB in the 3 groups were increased(P < 0.05 compared with those before treatment), and the levels in group A were significantly higher than those in group B and group C (P < 0.05). However, the levels of observation indexes did not arrive to the levels of group D(P<0.05). Conclusion Chinese medicine skin dialysis is effective on relieving the symptoms of CRF patients and enhancing the therapeutic effect through decreasing inflammatory mediators, inhibiting micro-inflammation and improving nutritional status.

6

Cite

Share

Therapeutic Effect of Heat-clearing and Diuresis-promoting Herbs Combined with Febuxostat for Chronic Gout

Wei ZHAO ; Tong GUAN

Journal of Guangzhou University of Traditional Chinese Medicine.2018;35(2):227-231. doi:10.13359/j.cnki.gzxbtcm.2018.02.006

Objective To investigate the clinical efficacy of heat-clearing and diuresis-promoting herbal formula Tongfeng Recipe in treating damp-turbidity-heat accumulation type of gout with tophus. Methods Sixty qualified patients were randomized into treatment group and control group, 30 cases in each group. The control group was given oral use of Febuxostat Tablets, and the treatment group was given Tongfeng Recipe combined with Febuxostat Tablets. After treatment for 6 months, we compared the changes of serum uric acid, the maximum diameter of the tophi, attack frequency of gout, scores of traditional Chinese medicine (TCM) syndromes, and adverse reaction in the two groups. Results (1) During the trial, 2 cases from the treatment group and 3 from the control group were lost to follow-up, and the final included case number of the treatment group and control group was 28, 27 respectively. (2) After treatment, the serum uric acid level in the two groups was decreased (P<0.01 compared with that before treatment), and the decrease in the treatment group was superior to that in the control group (P<0.05). (3) After treatment, the percentage of patients with serum uric acid less than 60mg/L in the treatment group and control group was 96.43％, 77.78％ respectively, the difference being significant(P<0.05).(4) After treatment, the maximum diameter of the tophi was reduced in the two groups(P<0.05 compared with that before treatment), and the decrease in the treatment group was superior to that in the control group (P<0.05). (5) After treatment, the scores of TCM syndromes in the two groups were markedly improved (P < 0.01 compared with those before treatment) , and the improvement in the treatment group was superior to that in the control group (P < 0.05). (6) During the treatment, acute attack of gout occurred in one case of the treatment group and in 7 cases of the control group, the difference being significant (P<0.05). The treatment group had 4 cases of diarrhea and one case of hepatic function injury, and the control group had 3 cases of diarrhea and one case of hepatic function injury , the difference being insignificant between the two groups (P > 0.05). Conclusion Heat-clearing and diuresis-promoting herbal formula Tongfeng Recipe exerts certain effect in treating damp-turbidity-heat accumulation type of gout with tophus, and the recipe is effective on decreasing serum uric acid, preventing the acute attack of gout induced by anti-uric acid treatment, and improving TCM syndromes.

7

Cite

Share

Study on Therapeutic Regimen for Threatened Abortion with Low Estrogen

Yu-Lei LIU ; Xin-Yu LIU ; Jian-Hong BEI ; Yan NING ; Hui TENG ; Cui-Mei CHEN ; Pei-Lin YU

Journal of Guangzhou University of Traditional Chinese Medicine.2018;35(2):232-237. doi:10.13359/j.cnki.gzxbtcm.2018.02.007

Objective To study the relationship between estradiol (E2) and embryonic development, and to explore the optimal therapeutic regimen for threatened abortion with low estrogen. Methods One hundred and sixty threatened abortion patients 14 days after frozen embryo transfer (FET) with E2 in the range of 100-200 pg/mL were randomized into Chinese medicine group 1, Chinese medicine group 2, Chinese and western medicine group, and control group, 40 cases in each group. Chinese medicine group 1 was treated orally with Shoutai Sijun Decoction, Chinese medicine group 2 was treated orally with Shoutai Sijun Decoction combined with Placenta Hominis Granules, Chinese and western medicine group was treated orally with Shoutai Sijun Decoction combined with Femonstone white tablets, and the control group was treated orally with Femonstone white tablets. Pregnancy rate and the changes in E2 level before and after treatment in the 4 groups were compared. The sensitivity and specificity of E2 level to the prognosis of pregnancy were also investigated. Results (1) The pregnancy rate of Chinese medicine group 1, Chinese medicine group 2, Chinese and western medicine group, and control group was 70.0％, 75.0％, 95.0％, 77.5％ respectively, and Chinese and western medicine group had the highest pregnancy rate(P<0.05).(2) E2 level in the pregnant patients of 4 groups after treatment was increased, and the difference was significant compared with that on ET day 14 (P < 0.05 or P <0.01). (3) The results of prognosis of E2 for pregnancy were as follows: sensitivity was 92％, specificity was 80％, and the area of curve was 0.820 when threshold of E2 being 281 on ET day 22. Conclusion The low post-FET E2 level is correlated with disordered pregnancy, and the early monitoring of E2 and prompt intervention should be performed. Shoutai Sijun Decoction combined with Femonstone white tablets is effective on increasing E2 level rapidly and leading to a higher pregnancy rate, and the effect of Shoutai Sijun Decoction combined with Placenta Hominis Granules comes next.

8

Cite

Share

Clinical Study of Futongning Granules in Treating Functional Abdominal Pain in Children

Ying-Ying XI ; Shuo-Ping YANG

Journal of Guangzhou University of Traditional Chinese Medicine.2018;35(2):237-241. doi:10.13359/j.cnki.gzxbtcm.2018.02.008

Objective To observe the clinical effect of Futongning Granules for the treatment of functional abdominal pain in children. Methods A total of 187 children with functional abdominal pain were randomized into treatment group(N = 122)and control group(N = 65). The treatment group was treated with Futongning Granules and the control group was treated with Compound Pepsin Powder. The gastrointestinal syndrome scores of the two groups were observed, and the short-term and long-term clinical efficacy of the two groups was evaluated after treatment. Results (1)The total effective rate and the effective rate for syndromes of abdominal internal cold, spleen-stomach deficiency cold, indigestion induced by milk and food stagnation, liver-Qi stagnation, blood collateral obstruction, gastrointestinal heat stagnation in the treatment group were 92.3％, 92.9％, 95.0％, 95.2％, 90.3％, 85.7％, 90.0％, and those in the control group were 71.0％, 69.2％, 69.2％, 86.7％, 66.7％, 50.0％, 60.0％, respectively. The total effective rate and the effective rate for various syndromes in the treatment group were superior to those of the control group (P < 0.05). (2) After treatment, gastrointestinal syndrome scores of various syndromes and overall scores in the two groups were obviously decreased(P<0.05 or P<0.01 compared with those before treatment), and the decrease in the treatment group was superior to that in the control group (P < 0.05). (3) The results of 6-month follow-up showed that the clinical efficacy during the follow-up in the treatment group was better than that in the control group(P < 0.05), and the difference was statistically significant(P<0.05). Conclusion Futongning Granules exert certain effect for the treatment of functional abdominal pain in children, and are effective for significantly relieving clinical symptoms and reducing the recurrence of disease.

9

Cite

Share

Therapeutic Effect of Modified Baitouweng Decoction Enema for Ulcerative Colitis with Damp Heat in Large Intestine and Its Influence on Levels of Inflammatory Factors

Yun YANG ; Hong-Bo ZHAO ; Zhi-Ming GE ; Xiao-Jing WU ; Tong-Yi LIANG ; Bo MA

Journal of Guangzhou University of Traditional Chinese Medicine.2018;35(2):242-247. doi:10.13359/j.cnki.gzxbtcm.2018.02.009

Objective To investigate the therapeutic effect of enteral drip infusion with modified Baitouweng Decoction for the treatment of ulcerative colitis(UC) with damp heat in large intestine at active phase , and to observe its influence on serum levels of inflammatory factors. Methods Sixty patients suffering from mild to moderate UC with damp heat in the large intestine were randomly divided into treatment group and control group, 30 cases in each group. The treatment group was given enteral drip infusion with modified Baitouweng Decoction and the control group was given Mesalazine Enemas enema. The medication lasted for 8 continuous weeks. Before and after treatment, the scores of traditional Chinese medicine (TCM) syndromes and intestinal mucosal signs under enteroscopy, and serum levels of inflammatory factors were observed. Therapeutic effect on single TCM syndrome and clinical safety were also evaluated after treatment. Results After treatment, the scores of each TCM syndrome and intestinal mucosal signs under enteroscopy in the treatment group were much improved (P<0.05 compared with those in the control group); serum interleukin-8 (IL-8) and tumor necrosis factor beta (TNF-β) levels in both groups were decreased, serum IL-10 and IL-13 levels were increased (P <0.05 compared with those before treatment), and the effect in the treatment group was superior to that in the control group (P < 0.05). Except for the abdominal pain, the treatment group had better effect on relieving diarrhea, anal expansion, tenesmus, mucous stool and bloody purulent stool than the control group, the difference being statistically significant (P < 0.05). During the medication, no obvious adverse reaction was found in the treatment group, but 4 cases from the control group had anal burning sensation which had no effect on the mediciation. Conclusion Enteral drip infusion with modified Baitouweng Decoction can inhibit the release of proinflammatory cytokines, reduce the inflammatory response, and promote the healing of intestinal mucosa, which is effective for the treatment of UC with damp heat in large intestine at active phase.

10

Cite

Share

Effect of Shuangbo San on Promoting Recovery of Gastrointestinal Function of Prostatic Cancer Patients After Laparoscopic Radical Prostatectomy

Zhi-Gang WANG ; Jian-Xing XIE

Journal of Guangzhou University of Traditional Chinese Medicine.2018;35(2):247-250. doi:10.13359/j.cnki.gzxbtcm.2018.02.010

Objective To investigate the effect of Shuangbo San on promoting the recovery of gastrointestinal function of prostatic cancer patients after laparoscopic radical prostatectomy(LRP). Methods Sixty-five prostatic cancer patients after LRP were randomly divided into treatment group and control group. The treatment group (N = 33)was treated with postoperative conventional western medicine combined with acupoint application of heated Shuangbo San on Shenque(CV8), and the control group(N = 32) was treated with postoperative conventional western medicine. The treatment lasted for 7 continous days. The clinical outcomes included time for the recovery of bowel sounds, postoperative exsufflation time, postoperative defecation time, time for the relief of abdominal distension and pain, average hospitalization time and total effective rate. Results (1) Time for the recovery of bowel sounds, postoperative exsufflation time, and postoperative defecation time in the treatment group were shortened as compared with the control group, the difference being significant (P < 0.05 or P <0.01). (2) After treatment, time for the relief of abdominal distension and pain, and average hospitalization time in the treatment group were shorter, and Visual Analogue Scale (VAS) scores of abdominal distension and pain were less than those in the control group, the difference being significant(P<0.01).(3) The total effective rate of the treatment group and the control group was 93.94％, 71.88％ respectively, the difference being statistically significant (P < 0.05). Conclusion Acupoint application of heated Shuangbo San on Shenque(CV8) is effective on promoting the exsufflation and defecation of post-LRP prostatic cancer patients, relieving abdominal distension and pain, promoting the recovery of gastrointestinal function, reducing the risk of postoperative intestinal obstruction and shortening hospitalization time, and has certain advantages as compared with postoperative conventional western medicine.

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share