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The use of muscle autograft denatured by microwave for repair of gap in removal of facial neuroma.

Zhi-qiang GAO ; Lian-shan ZHANG ; Ping-jiang GE ; Lin HE ; Wei LÜ ; Zhang HAN

Acta Academiae Medicinae Sinicae.2002;24(2):211-214.

OBJECTIVETo study the clinical value of muscle autograft denatured by microwave for repair of gap in removal of facial neuroma.

METHODSA case of patient with a larger facial nerve Schwann cell neuroma was reported. Based on the good results of our experimental research on rats recently, we completed the operation by transmastoid approach for removal of facial neuroma, and the gap of the nerve was repaired with muscle autograft denatured by microwave.

RESULTSThe patient was followed up for one year, and her facial function recovery on the affected side was satisfactory.

CONCLUSIONMuscle autograft denatured by microwave technique is convenient, highly efficient for repairing facial nerve gap after removal of facial neuroma.

Adult ; Facial Neoplasms ; complications ; surgery ; Facial Nerve ; physiology ; Facial Paralysis ; etiology ; surgery ; Female ; Follow-Up Studies ; Humans ; Microwaves ; Muscle, Skeletal ; transplantation ; Nerve Regeneration ; Neurilemmoma ; complications ; surgery ; Protein Denaturation ; Transplantation, Autologous

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Nano-structured scaffold materials used in tissue engineering.

Guo-xiang CHENG ; Zhi-jiang CAI

Acta Academiae Medicinae Sinicae.2002;24(2):207-210.

Micro- and nano-structured surfaces of scaffold materials have important effects on cells' adhesion and proliferation. Nano-structured surfaces can improve cells' adhesion and biocompatibility of materials. The effects of nano-biomaterials on the development of tissue engineering and the methods of preparation of nano-biomaterials such as molecular self-assemble and template technology are discussed.
Biocompatible Materials ; Humans ; Nanotechnology ; trends ; Tissue Engineering

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Nano biomedical material and its application.

Yu-bao LI ; Jie WEI

Acta Academiae Medicinae Sinicae.2002;24(2):203-206.

Nano biomedical material is a new area that shows promising prospect. In this paper, the researches and applications of nano inorganic biomaterial, nano polymer biomaterial and nano composite biomaterial are reviewed. The developmental tendency of nano biomedical material is also forecasted.
Biocompatible Materials ; Durapatite ; Humans ; Nanotechnology ; Polymers

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The application of nanotechnology in biomedicine.

Qi-qing ZHANG ; Yi LIANG

Acta Academiae Medicinae Sinicae.2002;24(2):197-202.

Nanotechnology is a new comprehensive system, which prepares substances or/material at molecular or nuclear level in nanometer scale, and nano materials can be explored to apply on broad aspects of industrial engineering sciences. This paper reviews the following contents: developing molecular engineering, biological molecular robot and nanometer information processing system, the application of nanobiomaterials in the field of tissue engineering, constructing drug carriers with nanobiomaterials, developing nanotechnology relating to diagnosis and monitoring. Developmental trend of nanotechnology in biomedical science is discussed prospectively.
Biomedical Technology ; Humans ; Nanotechnology ; trends

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The relationship between intracellular chloride concentration and ischemia reperfusion-induced arrhythmias in myocardial cells.

Zhong-fang LAI

Acta Academiae Medicinae Sinicae.2002;24(2):190-196.

We investigated the effects of simulated ischemia on intracellular Cl- concentration ([Cl-]i) in guinea pig ventricular myocardial cells and possible role of the [Cl-]i on the ischemia/reperfusion-induced arrhythmias in perfused rat hearts. Our results provided direct evidence that the [Cl-]i in ventricular muscle was increased under ischemic conditions, which suggested that activation of the Cl-(-)HCO3- exchanger by ischemia would partially contribute to the elevation of [Cl-]i. Application of stilbene derivatives or lowering Cl- concentration in perfusion solution delayed the onset of ischemia-induced deterioration in action potentials, pHi, [Cl-]i, and suppressed the incidence of ischemia/reperfusion-induced arrhythmias. The conclusion was made to emphasize the important role of intracellular Cl- homeostasis in cardiac physiology and pathogenesis of myocardial ischemia/reperfusion injury.
Action Potentials ; Animals ; Arrhythmias, Cardiac ; etiology ; metabolism ; Chlorides ; metabolism ; Guinea Pigs ; Hydrogen-Ion Concentration ; Microelectrodes ; Myocardial Reperfusion Injury ; complications ; metabolism ; Myocytes, Cardiac ; metabolism ; Papillary Muscles ; cytology

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Telomerase expression in various lesions of adrenal cortex.

Quan-zong MAO ; Shi RONG ; Jin-hai FAN ; Zhi-gang JI ; Han-zhong LI ; Mei-fu ZANG

Acta Academiae Medicinae Sinicae.2002;24(2):188-189.

OBJECTIVETo investigate the expression of telomerase in various lesions of adrenal cortex.

METHODSBy autoradiography-based telomeric repeat amplification protocol, telomerase expression was detected in 36 samples of adrenocortical lesions, including 29 cases adrenocortical adenoma (8 Cushing's syndrome, 17 aldosteronism and 4 nonfunctional adenomas), 5 cases of hyperplasia of adrenal cortex (presented with Chushing' syndrome), 2 cases adrenocortical carcinoma, and 4 samples of normal adrenal cortex.

RESULTSOf the 40 samples, 2 cases of adrenocortical carcinomas had telomerase expression, and the others had no telomerase expression detected.

CONCLUSIONSNo significant telomerase expression was found among different endocrine functional benign adrenocortical lesions. Telomerase expression may be used as an important marker of malignant adrenocortical tumor.

Adrenal Cortex ; enzymology ; Adrenal Cortex Neoplasms ; enzymology ; Adrenocortical Adenoma ; enzymology ; Biomarkers, Tumor ; analysis ; Cushing Syndrome ; enzymology ; Humans ; Telomerase ; analysis ; biosynthesis ; genetics

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Assay of carnitine in plasma and urine of healthy adults.

Yu-jian NIU ; Zhu-ming JIANG ; Hong SHU ; Chun-feng LI ; Wei LIU ; Guo-xiang YAO ; Ji JIANG ; Jing-quan LI ; A LONGO

Acta Academiae Medicinae Sinicae.2002;24(2):185-187.

OBJECTIVETo determine the levels of carnitine in plasma and daily excretion of carnitine in urine of healthy adults so as to provide the reference standard for studying the changes of carnitine in patients.

METHODSCarnitine in plasma and urine was assayed with high performance liquid chromatography (HPLC). The levels of total carnitine (TC), free carnitine (FC) and acetyl-carnitine (AC) in fasting plasma and the daily excretion of TC, FC and AC in urine were assayed in 40 healthy adults (20 men and 20 women) with standard diet.

RESULTSGood linearity (r 2 > or = 0.999) was observed in assaying TC, FC and AC. The relative standard deviation (RSD) was lower than 9.1% and bias lower than 5.6%. It was showed that the plasmatic levels of TC, FC and AC in healthy men [(53.1 +/- 8.5), (41.2 +/- 6.1), (6.2 +/- 0.6) mumol/L] were significantly higher than those in healthy women [(45.4 +/- 5.6), (35.2 +/- 4.9), (5.7 +/- 0.7) mumol/L] (P = 0.002, 0.002, 0.035). The daily urinary excretion of TC, FC and AC in healthy men [(386.1 +/- 22.9), (180.5 +/- 31.8), (33.8 +/- 3.3) mumol] were also significantly higher than those in healthy women [(240.1 +/- 35.6), (112.7 +/- 22.6), (29.3 +/- 4.3) mumol] (P < 0.0005, < 0.0005, < 0.0005) when the adults were given standard diet. Both the plasmatic levels and the daily urinary excretion of TC, FC and AC were of significantly positive correlation with lean body mass (LBM) (r = 0.501-0.856). The (TC-FC)/FC ratios in plasma were 0.29 +/- 0.05 for male and 0.29 +/- 0.04 for female.

CONCLUSIONGood precision and accuracy were observed in assaying carnitine with HPLC. After standard diet, both the level of carnitine in fasting plasma and the daily urinary carnitine excretion of healthy adults were positively correlated with LBM.

Acetylcarnitine ; blood ; urine ; Adult ; Carnitine ; blood ; urine ; Chromatography, High Pressure Liquid ; Female ; Humans ; Male ; Reference Values ; Sex Factors

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The role of nutritional status on serum immunoglobulins, body weight and postoperative infectious-related complications in patients with Crohn's disease receiving perioperative parenteral nutrition.

Guo-xiang YAO ; Xiu-rong WANG ; Zhu-ming JIANG ; Si-yuan ZHANG ; En-ling MA ; An-ping NI

Acta Academiae Medicinae Sinicae.2002;24(2):181-184.

OBJECTIVETo evaluate the role of nutritional status on serum immunoglobulins, body weight and postoperative infectious-related complications in patients with Crohn's disease receiving perioperative parenteral nutrition (PN).

METHODS32 patients with Crohn's disease receiving perioperative parenteral nutrition in our department between 1984 and 1994 were enrolled in this survey. 16 patients with loss of body weight in the range of 15%-30% were assigned to the malnutrition group, the other 16 patients with normal weight or loss of body weight less than 15% to the control group. Serum IgM, IgG and IgA levels were measured before and after PN by enzyme-linked immunosorbent assays. Liver function, body weight changes and postoperative complications were also analyzed.

RESULTSIgM levels were elevated before PN in both groups [control group: (133 +/- 16) mg/dl, malnutrition group: (139 +/- 41) mg/dl; normal value: (110 +/- 35) mg/dl; P = 0.04], decreased to normal value [(105 +/- 29) mg/dl, P = 0.02] in the malnutrition group while having no obvious changes in the control group [(129 +/- 13) mg/dl, P = 0.34]. No significant changes in concentrations of IgG and IgA were found (P in the range of 0.20-0.57). The average weight gain was 1.862 kg in malnutrition group [before PN: (45.8 +/- 8.9) kg, after PN: (48.0 +/- 8.8) kg; P = 0.005] and no significant changes in the control group [before PN: (55.6 +/- 6.1) kg, after PN: (56.3 +/- 6.0) kg; P = 0.46]. There was an increase in infectious complications in the control group (control group: 4 cases, 25%, malnourished group: 2 cases, 12.5%; P = 0.13).

CONCLUSIONSPerioperative parenteral nutrition ameliorated the humoral immunity, increased the body weight in patients with obvious malnutrition, whereas it had little value for those without or with mild malnutrition.

Adult ; Aged ; Body Weight ; Crohn Disease ; immunology ; surgery ; therapy ; Female ; Humans ; Immunoglobulins ; blood ; Male ; Malnutrition ; etiology ; Middle Aged ; Nutritional Status ; Parenteral Nutrition ; Pneumonia ; etiology ; Postoperative Complications ; etiology

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Clinical features of gastroesophageal reflux disease in geriatric patients.

Hong WANG ; Bin LIU ; Jia-li JIANG

Acta Academiae Medicinae Sinicae.2002;24(2):178-180.

OBJECTIVETo evaluate the features of gastroesophageal reflux disease (GERD) in elderly patients.

METHODS72 patients with GERD were investigated for the history of illness and the results of gastroscopy and 24 hours esophageal bile monitoring of 54 patients were simultaneously randomized to undergo ambulatory pH monitoring. The degrees of esophagitis were graded according to endoscopic findings.

RESULTSObesity was found in 48% of the elderly group (more than 65 years old) and 49% of the control group (less than 65 years old). There were longer acid and bile reflux time and higher frequency (65%) of hiatal hernia in the elderly, and more patients (35%) had complicated severe grade esophagitis. There were longer time of bile reflux and the higher incidence (76%) of both acid and bile reflux in elderly group than in control group (P < 0.05). But the acid reflux time (%) was similar in two groups (P > 0.05).

CONCLUSIONSThe GERD in elderly patients may be associated with obesity and hiatal hernia. The features of elderly GERD patients are high frequency of erosive esophagitis, and high frequency of both acid and bile reflux, as well as longer history of bile reflux time.

Age Factors ; Aged ; Bile Reflux ; complications ; Esophagitis, Peptic ; diagnosis ; Female ; Gastroesophageal Reflux ; diagnosis ; etiology ; Gastroscopy ; Hernia, Hiatal ; complications ; Humans ; Hydrogen-Ion Concentration ; Male ; Middle Aged ; Monitoring, Ambulatory ; Obesity ; complications

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Patellofemoral replacement for severe patellofemoral osteoarthritis: a 2-10 years follow-up study.

Jia ZHANG ; Qi-bin YE ; Gui-xing QIU ; Yi-peng WANG

Acta Academiae Medicinae Sinicae.2002;24(2):174-177.

OBJECTIVETo evaluate the therapeutic effects of patellofemoral replacement for severe patellofemoral osteoarthritis.

METHODSPatellofemoral replacement was performed in 30 patients (36 knee joints) with severe patellofemoral osteoarthritis, among whom were 5 males and 25 females. The patients ranged in age from 36 to 74 years old (mean +/- s, 55.8 +/- 8.5) and were followed up for 2-10 years.

RESULTSSignificant improvement was made in both the knee score and functional score after the patellofemoral replacement. The effective rate was 88.9% and 91.7% evaluated with knee score and functional score respectively.

CONCLUSIONPatellofemoral replacement is effective in treating severe patellofemoral osteoarthritis in appropriate cases.

Adult ; Aged ; Arthroplasty, Replacement, Knee ; methods ; Female ; Femur ; surgery ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Osteoarthritis, Knee ; surgery ; Patella ; surgery

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