Journal Detail Information

1

Cite

Share

Effect of propofol on pulmonary injury induced by early-stage severe acute pancreatitis in rats

Yisheng ZHANG ; Minghai WANG ; Kun TAO ; Fangzheng CHEN ; Guohai ZHAO

Chinese Journal of Clinical Pharmacology and Therapeutics.2004;0(11):-.

AIM:To investigate whether propofol can alter the pulmonary inflammation induced by severe acute pancreatitis(SAP)in rats during its early period.METHODS:Seventy-two adult male Sprague-Dawley(SD)rats were randomly divided into nine groups with 8 animals in each group:sham group,SAP 30,60,120,360 min groups and propofol treatment 30,60,120,360 min groups.The preparation of SAP were induced by retrograde injection of 5% sodium taurocholate into the pancreatic duct of rats.And the treatment groups received propofol with doses of 150 ?g?kg-1?min-1 injected continually immediately in vena caudalis after the preparation of ASP were made.Rats were sacrificed at different time points,and the level of AMY and LIP,the wet dry weight ratio(W/D)of pulmonary and pancreatic tissue,the pathological change of pulmonary and pancreatic tissue were examined.RESULTS:Water content and pathological score of pulmonary tissue were decreased significantly within 360 minutes after reproduction of SAP were received propofol(both P0.05).CONCLUSION:propofol can alleviate pulmonary inflammation induced by severe acute pancreatitis in its early period.But propofol can not alleviate the injury of pancreatitis tissue.

2

Cite

Share

Study on IL-12,IL-10 expression of infants with none or low response to recombinant hepatitis B vaccine stimulated by bacillus Calmette-Guerin

Junbo DI ; Yiping CHEN ; Zhiwei XU

Chinese Journal of Clinical Pharmacology and Therapeutics.2004;0(11):-.

AIM:To investigate the efficacy of Bacillus Calmette-Guerin(BCG)on IL-12,IL-10 expressions of infants with none or low response to recombinant hepatitis B vaccine.METHODS:The geometric mean titer(GMT)of anti-HBs was tested by radio-immunity assay after hepatitis B vaccine stimulation,selected 60 cases with non-or low-response(GMT

3

Cite

Share

Losartan inhibits renal sympathetic nerve activity in Paraventricular nucleus in chronic heart failure rat

Le GUI ; Jianhua ZHU ; Qinghui CHEN

Chinese Journal of Clinical Pharmacology and Therapeutics.2004;0(11):-.

AIM:Left coronary artery ligation(LAD)was used to induce heart failure.Losartan was microinjected into paraventricular nucleus(PVN),heart rate(HR),blood pressure(BP)and renal sympathetic nerve activity(RSNA)were measured.The mechanism of PVN in chronic heart failure was investigated.METHODS:Sprague-Dawley male rats were selected for LAD ligation for heart failure models,the variation of cardiac function was detected by echocardiography.Losartan was microinjected into PVN,the responses of HR,BP and RSNA were analyzed.RESULTS:Compared with sham group,the level of LV was increased(P

4

Cite

Share

Protective effect of Cistanchis glycosides on ethanol-induced liver damage in mice

Huiying LUO ; Yuan LIU ; Guozhu XI ; Jiande DU

Chinese Journal of Clinical Pharmacology and Therapeutics.2004;0(11):-.

AIM:To research the protection of Cistanchis glycosides on ethanol-induced liver damage in mice.METHODS:40 mice were divided into 4 groups in random,and administered by gavage for 4 weeks.Cistanchis glycosides were twice a day,ethanol were once a day.When time limit arrived,mice were weighted,the serum was afforded to detect the liver function index,liver homogenate were prepared for biochemical detections,liver remained were fixed for pathological investigation.RESULTS:When mice were damaged by ethanol,liver index,liver function index,contents of TG,TC,MDA and LPO were increased distinctly(P

5

Cite

Share

Research the expression of NF-?B and apoptosis of neutrophils induced by TNF-? treated with Lidocaine

Nan DONG ; Yan ZHANG

Chinese Journal of Clinical Pharmacology and Therapeutics.2004;0(12):-.

AIM:To observe the effect of lidocaine to the activation of NF-?B and apoptosis in human neutrophils(PMN)in vitro.METHODS:Human PMN were divided into five groups:control group(0.9% sodium chloride);TNF-?(200 ng/L);TNF-?+lidocaine(1.0 mmol/L);TNF-?+lidocaine(2.0 mmol/L),and TNF-?+ lidocaine(4.0 mmol/L).The expression of NF-?B subunit p65 mRNA in the nuclear and I-?B mRNA in the cytosol extracts were analyzed by Western blotting,after co-incubation for 3 h and the content of p65 protein were observed by RT-PCR.PMN apoptosis was detected on flow cytometry after co-incubation 12 h and 24 h.RESULTS:The expression of NF-?B mRNA was significantly decreased and the expression of I-?B mRNA was markedly increased in lidocaine groups(P

6

Cite

Share

Regimen based on platinum compound plus docetaxel for the treatment of advanced esophageal carcinoma as a first-line drug

Yi JIANG ; Xihui QIU ; Danxia LIN ; Hui LIN

Chinese Journal of Clinical Pharmacology and Therapeutics.2004;0(12):-.

AIM:To evaluate the efficacy and safety of the regimen based on platinum compound plus docetaxel in the treatment of advanced esophageal carcinoma as first-line drug,and to further explore prognostic factors of advanced esophageal carcinoma by survival analysis.METHODS:From August 2006 to October 2008,36 patients with advanced esophageal carcinoma were enrolled in the study,and non-randomly assigned to docetaxel 75 mg/m2 in the first day every 3 weeks,combined with cisplatin 25 mg/m2 in the first day to third day or in the first day to forth day(DT,n=27),or with carboplatin AUC=5 on day 1(CT,n=9).RESULTS:The curative and toxic side effects were evaluated to the 36 patients.There were 1 complete respone,17 partial respone,11 no changes and 7 progressive disease in 36 patients with total response rate of 50.00%.The response rates of DT,CT regimen were 59.26% and 22.22%(P=0.121).The major side effects were nausea-vomiting,all side effects were reversible by symptomatic treatment.After a median follow-up of 8.70 months,the overall median survival was 10.50 months(95% CI 7.36 to 13.64 months).The COX univariate regression analysis suggested there was no correlation with sex,age and the hemoglobin of before chemotherapy with existence.But there was statistical significance between the behavior state of chemotherapy and the existence(P=0.036).CONCLUSION:The regimen based on platinum compound plus docetaxel is tolerable and more effective as a first-line treatment for advanced esophageal carcinoma.Patients with good performance status before chemotherapy indicates good prognosis and it is an independent factor affecting survival for advanced esophageal carcinoma.

7

Cite

Share

Prevention on the side effects of erythromycin lactobionate via intervenous drop infusion for the gastrointestinal tract in children

Ailin LIU ; Li LI

Chinese Journal of Clinical Pharmacology and Therapeutics.2004;0(12):-.

AIM:To observe the preventive effects of aluminum phosphate gel and smectite powder on the side effects of erythromycin lactobionate via intervenous drop infusion for the gastrointestinal tract in children.METHODS:249 cases children with mycoplasmal pneumonia were randomly divided into three groups,aluminum phosphate gel group,smectite powder group and control group,83 cases in each group.The side effects of erythromycin lactobionate(abdominal pain,diarrhea,sicchasia,disgorging)for the gastrointestinal tract among three groups were observed.RESULTS:Compared with control group,the incidence rate of side effects was much lower in aluminum phosphate gel group and smectite powder group(P0.05).CONCLUSION:Aluminum phosphate gel and smectite powder significantly decrease the side effects of erythromycin lactobionate for the gastrointestinal tract in children,and especially the former,can be widely applied in pediatric clinic.

8

Cite

Share

Effects of intercostals neural blockade combining with intravenous dexamethasone on postoperative pain,nausea and vomiting and rehabilitation after laparoscopic cholecystectomy

Lingyang CHEN ; Congbing PENG ; Huiqin WANG

Chinese Journal of Clinical Pharmacology and Therapeutics.2004;0(12):-.

AIM:To investigate the effect of intercostals neural blockade(INB)combining with intravenous dexamethasone on postoperative pain,nausea and vomiting and rehabilitation after laparoscopic cholecystectomy(LC).METHODS:Seventy-two patients with ASA I-Ⅱ undergoing LC were randomly divided into three groups with twenty-four patients in each group.Group DI received intravenous dexamethasone infusion before induction combining with INB.Group I only received INB.Group C was control group.Propofol and remifentanil consumption were recorded,postoperative pain and fatigue were assessed according to a pain and fatigue severity score using a subjective analog visual scale(VAS)1,4,12,and 24 h after the surgery.The incidence of postoperative nausea and vomiting,times to first enterocinesia,flatus and hospital discharge were recorded.RESULTS:Propofol and remifentanil consumption,postoperative pain and fatigue scores 4,12,24 h after surgery,the postoperative nausea and vomiting incidences,times to first enterocinesia and flatus,times to hospital discharge were significantly lower in Group DI and I than those in Group C(P

9

Cite

Share

Patho-physiological function of activiated renal renin-angiotensin system in hypertension and kidney disease

Jinxiu CAO ; Liping ZHANG ; Chunlin GAO ; Junya JIA

Chinese Journal of Clinical Pharmacology and Therapeutics.2004;0(12):-.

There is an independent-regulated renin-angiotensin system(RAS)in kidney.Most of patients with hypertension or kidney diseases present increased renal RAS activity,which maintains body water and sodium balance,but contributes to the occurrence of hypertension and renal damage progression.The article reviewes some recent basic and clinical researches,focusing on the renal RAS activation mechanisms,consequences and clinical significance of the intervention of RAS blockers,which may help us recognize local RAS function of kidney,explore the treatment strategies to control hypertension and slow chronic kidney disease progression.

10

Cite

Share

Effects of Kanglaite injection on antitumor and expression of EGFR in Lewis lung carcinoma

Pei PAN ; Yan WU ; Rong WANG ; Yujie WANG

Chinese Journal of Clinical Pharmacology and Therapeutics.2000;0(01):-.

AIM:To research the effects of Kanglaite(KLT)injection on antitumor and expression of epidermal growth factor receptor(EGFR)in Lewis lung carcinoma(LLC).METHODS:A total of 40 C57BL/6 mice were randomly divided into four groups,including model group,KLT 6.25,12.5,25 mL/kg groups.All the mice were injected with 2?106 LLC cells at 1st day.At the next day,mice in the KLT groups were peritoneally injected with KLT for 14 days.And at the 16th day,all the mice were sacrificed and the tumors were harvested.The tumor weight was measured and the tumor growth inhibition rate was analyzed.The expression of EGFR was detected by westernblot.RESULTS:The growth of LLC was significantly inhibited by KLT,the changes of tumor appearance and histology were affected and the expression level of EGFR was decreased.CONCLUSION:KLT injection could obviously inhibit the growth of LLC,whose mechanism maybe related to the inhibition of EGFR expression.

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share