Journal Detail Information

1

Cite

Share

Spontaneous Bacterial Empyema in a Patient with Liver Cirrhosis.

Young In CHOI ; Young Il CHOI ; Sung Hyun KU ; Young Hwa CHOI ; Sun Min LEE ; Kwang Joo PARK ; Sung Chul HWANG ; Yi Hyeong LEE ; Myung Ho HAHN

Korean Journal of Infectious Diseases.1999;31(3):262-265.

Spontaneous bacterial empyema (SBEM), a relatively rare complication of liver cirrhosis, is characterized by a bacterial infection of the transudative pleural fluid without obvious infection focus within the thoracic cavity. The analysis of pleural fluid shows characteristic 'infected transudate' with occasional identification of causative organism as in spontaneous bacterial peritonitis. The outcome is relatively favorable with early identification of the disease and subsequent proper an-tibiotic therapy alone. Closed horacotomy is not nece- ssary in most cases and may be even more hazardous. We report a case of SBEM in a 37-year old male patient with hepatitis B-virus associated liver cirrhosis, who recovered with antibiotic therapy alone.
Adult ; Bacterial Infections ; Empyema* ; Hepatitis ; Humans ; Liver Cirrhosis* ; Liver* ; Male ; Peritonitis ; Pleural Effusion ; Thoracic Cavity

2

Cite

Share

A Case of B-cell Lymphoma and Early Kaposi's Sarcoma in an AIDS Patient.

Won Suk HAN ; Byung Soon PARK ; Dae Hun SUH ; Kwang Hyun CHO ; Hee Chul EUN ; Myung Whun SUNG ; Myoung Don OH ; Kang Won CHOI

Korean Journal of Infectious Diseases.1999;31(3):257-261.

B cell lymphoma and Kaposi's sarcoma are the most common tumors in AIDS patients. They show more aggressive behavior and poor prognosis in AIDS patients than in the general population. Lymphoma and Kaposi's sarcoma in AIDS patients are associated with Epstein-Barr virus and human herpesvirus 8, respectively. We reported herein a case of lymphoma and Kaposi's sarcoma in an AIDS patient. He presented with a mass on the tongue base and a red papule on the posterior wall of the oropharynx. On the basis of his- tologic findings, immunohistochemical study, and PCR, his illnesses were diagnosed as B cell lymphoma, combined with early Kaposi's sarcoma. Unfortunately, he did not receive any treatment and died of malnutrition 1 month later. To the best of our knowledge, this is the first report of coexisting lymphoma and Kaposi's sarcoma from an AIDS patient in Korea.
B-Lymphocytes* ; Herpesvirus 4, Human ; Herpesvirus 8, Human ; Humans ; Korea ; Lymphoma ; Lymphoma, B-Cell* ; Malnutrition ; Oropharynx ; Polymerase Chain Reaction ; Prognosis ; Sarcoma, Kaposi* ; Tongue

3

Cite

Share

A Case of Mediastinal Tuberculous Abscess and Lymphadenitis after Bone Marrow Transplantation.

Chang Wook KIM ; Dong Jun LIM ; Theresa JANG ; Tae Seo SOHN ; Dong Gun LEE ; Mi Young KIM ; Jung Hyun CHOI ; Wan Shik SHIN ; Chun Choo KIM

Korean Journal of Infectious Diseases.1999;31(3):247-251.

After bone marrow transplantation (BMT), recipients can be complicated by infectious or non-infectious chest lesions such as mycobacterial infections or post- transplant lymphoproliferative disorders (PTLDs). BMT recipients usually face a lot of risks of mycobacterial infection because they have severely impaired cell- mediated immunity as a result of their underlying disease, chemotherapy, radiotherapy, acute or chronic graft-versus-host diesase (GVHD) and their treatment. We report a case of mediastinal tuberculous abscess and lymphadenitis after BMT, which mimicks PTLDs. 20 months before admission, BMT was performed on a 41 year-old woman who was diagnosed as chronic myelocytic leukemia. She showed acute and chronic GVHD with several infections of bacteria or viruses after BMT. In endemic area of tuberculosis such as Korea, PTLDs should be differentiated from pulmonary tuberculosis and tuberculous lymphadenitis.
Abscess* ; Adult ; Bacteria ; Bone Marrow Transplantation* ; Bone Marrow* ; Drug Therapy ; Female ; Humans ; Korea ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Lymphadenitis* ; Lymphoproliferative Disorders ; Radiotherapy ; Thorax ; Tuberculosis ; Tuberculosis, Lymph Node ; Tuberculosis, Pulmonary

4

Cite

Share

A Case of Tsutsugamushi Disease Complicated by Meningoencephalitis.

Sen LYU ; Eui Chang HWANG ; In Ho KIM ; Sok Kyun HONG ; Hyunjoo PAI ; Geun Ho LEE

Korean Journal of Infectious Diseases.1999;31(3):243-246.

Scrub typhus can invade central nervous system. The most common findings of CNS involvement are those of low grade meningitis, however, meningoencephalitis with coma and generalized seizure are also reported to occur in scrub typhus but only rarely. A 47-year old male was admitted to our hospital because of consciousness disturbance. The patient had a fever and rash for seven days before admission. He had been treated for diabetes mellitus for three years. Generalized seizure occurred six times after admission. CSF revealed increase of leukocytes (648/mm3) and protein level, and diffuse slow wave was found on electroencephaolography. The magnetic resonance image of the brain showed dural thickening. We diagnosed his illness as tsutsugamushi disease complicated by meningoencephalitis. After treatment with clarithromycin and an anticonvulsant, he recovered without neurological sequelae. O. tsutsugamushi should be considered as one of the causes of meningoencephalitis in endemic areas.
Brain ; Central Nervous System ; Clarithromycin ; Coma ; Consciousness ; Diabetes Mellitus ; Exanthema ; Fever ; Humans ; Leukocytes ; Male ; Meningitis ; Meningoencephalitis* ; Middle Aged ; Scrub Typhus* ; Seizures

5

Cite

Share

A Case of Mumps Virus Infection Associated with Severe Myositis.

Suk Bae KIM ; Jae Hyoung HEO ; Sok Kyun HONG ; Jung Woo SHIN ; In Ho KIM ; Hyun Joo PAI ; Jeung Hee CHO ; Joo Yeun LEE ; Jong Won PARK

Korean Journal of Infectious Diseases.1999;31(3):239-242.

Myositis caused by mumps virus is very rare. Mumps virus has been suggested as a causative agent of inclusion body myositis, but there has been no definite evidence. We experienced a case of severe myositis associated with mumps virus infection. A 21-year old man was admitted because of myalgia, headache, fever, and chill for 2 months. The cerebrospinal fluid analysis performed at a local clinic showed findings compatible with viral meningitis. His blood chemistry results revealed elevated levels of serum creatine kinase, lactate dehydrogenase, and serum myoglobin. On the 5th day of admission, the patient showed pain and swelling of parotid gland and scrotum. Electromyography was compatible with inflammatory myopathy. Muscle biopsy of his calf muscle revealed necrotizing (leukocytoclastic) vasculitis and multifocal myolysis with multinucleation. We suspected mumps virus infection because of his symptoms of meningitis, epididymo-orchitis and parotitis. Mumps virus was isolated in throat culture. The past medical history of the patient's mumps virus vaccination was unclear. After 2 weeks of supportive treatment, the patient's condition was improved.
Biopsy ; Cerebrospinal Fluid ; Chemistry ; Creatine Kinase ; Electromyography ; Fever ; Headache ; Humans ; L-Lactate Dehydrogenase ; Meningitis ; Meningitis, Viral ; Mumps virus* ; Mumps* ; Myalgia ; Myoglobin ; Myositis* ; Myositis, Inclusion Body ; Parotid Gland ; Parotitis ; Pharynx ; Scrotum ; Vaccination ; Vasculitis ; Young Adult

6

Cite

Share

Survey on Infestaton Rates of Head Lice in Two Primary Schools in Dangjin-gun, Chungchongnam-do.

Kyu Jae LEE ; Han il LEE

Korean Journal of Infectious Diseases.1999;31(3):237-238.

We examined infestation state of head lice in 2 primary schools in 1998. Among the 382 subjects, 92 (24.1%) children were confirmed as having head lice infestation. Infestation rate of each school was 13.6% and 32.9%, respectively. Infestation rate of girls (42.2%) was higher than that of boys (5.8%) and the 5th grade had more infested children (35.7%) than any other.
Child ; Chungcheongnam-do* ; Female ; Head* ; Humans ; Pediculus*

7

Cite

Share

National Surveillance of Vibrio vulnificus Infections in 1998.

Young Hack SHIN ; Jeom Kyu LEE ; Kyung Soo OH ; Jung Sik YOO ; Sang Won LEE ; Gun Young LEE ; Dong Joon CHUNG ; Ki Sang KIM

Korean Journal of Infectious Diseases.1999;31(3):232-236.

Surveillance for Vibrio vulnificus infections was performed by Korea National Institute of Health to investigate the epidemiological characteristics of recent occurence and to provide basic information for V. vulificus infection control. In 1998, a total of 44 cases of V. vulnificus infections were confirmed bacteriologically. The age groups of the patients ranged from thirties to seventies and 13 (29.5%) patients were in their fifties. Thirty-six (81.8%) patients had chronic liver diseases. Twenty-five (56.8%) had drinking habits. Eating uncooked seafood (fish, shrimp, and small octopus) produced in tideland was the main suspected source of infections and 32 (72.8%) cases were associated with raw seafood consumption. Two cases were associated with contaminated chopping board and 5 were infected through the wound. The incubation period ranged from less than 1 day to 7 days (median 2 days). The case fatality rate was 48%. In conclusion, V. vulnificus infection, a highly fatal disease, is not rare in Korea. Therefore, attention should be given to prevent V. vulnificus infections.
Drinking ; Eating ; Humans ; Infection Control ; Korea ; Liver Diseases ; Mortality ; Seafood ; Vibrio vulnificus* ; Vibrio* ; Wounds and Injuries

8

Cite

Share

Incidence and Risk Factors of Tuberculosis in Human Immunodeficiency Virus-Infected Patients in Korea.

Hyoung Shik SHIN ; Ui Seok KIM ; Nam Joong KIM ; Myoung Don OH ; Kangwon CHOE

Korean Journal of Infectious Diseases.1999;31(3):225-231.

BACKGROUND: Tuberculosis is the most frequent opportunistic infection in HIV-infected patients in Korea. We examined the incidence and risk factors for tuberculosis in HIV-infected patients. METHODS: We reviewed the medical records of 143 HIV-infected patients between January 1988 and June 1997 at the Seoul National University Hospita The incidence of tuberculosis was determined by the number of new tuberculosis per 100 patients divided by a total duration of follow-up (cases/100 person- years). The incidence of tuberculosis was analyzed with respect to CD4+ lymphocyte count, status of tuberculin skin reaction, and status of delayed hypersensitivity skin reaction. RESULTS: The total duration of follow-up was 229.6 person-years. During follow-up, 22 patients developed tuberculosis [9.6 cases per 100 person-years (95% CI, 6.0 to 14.5)]. The incidence of tuberculosis according to sex and transmission route showed no significant difference. Tuberculosis occurred more frequently in patients with minimum CD4+ T lympho-cyte counts of less than 200 cells/mm3 (14.2 cases/100 person-years) than in those with higher T lymphocyte counts (3.9 cases/100 person-years) [relative risk, 4.02 (95% CI 1.32 to 12.5), P=0.009]. The incidence of tuberculosis was higher among tuberculin- positive patients [17.0 cases/100 person-years (95% CI, 9.0 to 29.0)] than among tuberculin-negative [8.0 cases/100 person-years (95% CI, 3.2 to 16.6)], but the difference was not statistically significant [relative risk, 2.35 (95% CI, 0.88 to 6.26, P=0.078)]. The rate of tuberculosis in patients with negative delayed hypersensitivity test was not significantly different from that in patients with positive results (P=0.510). CONCLUSION: The incidence of tuberculosis was 9.6 cases per 100 person-years. CD4+ lymphocyte count (<200 cells/mm3) was the most useful predictor for the development of tuberculosis in HIV patients in Korea.
Follow-Up Studies ; HIV ; Humans* ; Hypersensitivity, Delayed ; Incidence* ; Korea* ; Lymphocyte Count ; Medical Records ; Opportunistic Infections ; Risk Factors* ; Seoul ; Skin ; Tuberculin ; Tuberculosis*

9

Cite

Share

Infectious Features In Patients with Acute Leukemia.

Jung Hyun CHOI ; You Joung KIM ; Dong Gun LEE ; Wan Shik SHIN ; Sun Woo KIM ; Sang Soo BAE ; Se Hee KIM ; Jin Hong YOO ; Kyung Mi KIM ; Kyung Ja HAN ; Jong Wook LEE ; Woo Sung MIN ; Chun Choo KIM

Korean Journal of Infectious Diseases.1999;31(3):217-224.

PURPOSE: Despite the advancement in chemotherapy and supportive care, a persisting problem in patients with leukemia is infectious complications, which are the leading cause of death. We evaluated infectious complications in acute leukemic patients to understand the current features and also evaluated risk factors for death in acute leukemia. METHODS: The medical records of 186 cases of acute leukemia who underwent chemotherapy in St. Mary's Hospital between January 1995 and December 1997 were reviewed. And we compared these data to our previous data published in 1994. RESULTS: One hundred (95%) cases among 126 leu- kemic patients who received induction chemotherapy and 42 (70%) of 60 cases who received consolidation chemotherapy experienced at least one febrile episodes during treatment. Microbiologically defined infection (MDI), clinically defined infection (CDI), and unexplained fever (UF) were evenly distributed. In MDI, the isolation rate of gram positive organism was markedly increased but that of fungus was decreased. The common clinical manifestations were bacteremia, pneumonia, neutropenic enterocolitis, and catheter infection, in the order of decreasing frequency. The overall mortality rates reduced from 50% (early of the 1980s) to 12.9%, but the infection-related mortality increased up to 80% in spite of improvement in supportive care, antimicrobials and administration of hematopoietic growth factors. Refractory or relapsed acute myelogenous leukemia (AML) had 5 times higher risk of death than primarily diagnosed AML and MDI had 10.9 times higher risk of death than UF. And one more febrile day increased the risk of death by 1.4 times. CONCLUSION: Infection is still the most important cause of morbidity and mortality in acute leukemia patients. Dominant infecting organisms are changing from gram-negative bacilli to gram-positive cocci. New preventive, diagnostic, and treatment strategies should be developed and prophylactic use of antimicrobials should be restricted as much as possible to prevent emergence of resistant microorganisms.
Bacteremia ; Catheters ; Cause of Death ; Consolidation Chemotherapy ; Drug Therapy ; Enterocolitis, Neutropenic ; Fever ; Fungi ; Gram-Positive Cocci ; Humans ; Induction Chemotherapy ; Intercellular Signaling Peptides and Proteins ; Leukemia* ; Leukemia, Myeloid, Acute ; Medical Records ; Mortality ; Neutropenia ; Pneumonia ; Risk Factors

10

Cite

Share

Epidemiology of Influenza Virus over 8 Years (1990~1998) in Seoul, Korea.

Song Yi NAH ; Su Eun PARK ; Jin Young PARK ; Hoan Jong LEE

Korean Journal of Infectious Diseases.1999;31(3):210-216.

BACKGROUND: Influenza virus is well known to cause recurrent epidemics almost every winter. However, information regarding the epidemiologic pattern of influenza virus in Korea is limited. In this study, the period of influenza virus isolation each year (1990 ~1998), influenza virus types and subtypes, and clinical features in children with influenza virus infection were evaluated. METHODS: Epidemiology of influenza virus was studied in children with lower respiratory tract infections admitted to the Seoul National University Children's Hospital during the period from 1990 through 1998. Influenza viral infection was diagnosed by viral culture in LLC-MK2 and MDCK cells and/or indirect immunofluorescent staining method of nasal aspirates. Isolated influenza A viruses were subtyped by indirect immunofluorescent staining method using monoclonal antibodies, which react specifically to H1 or H3 antigen. RESULTS: Influenza A virus was identified in 76 cases and influenza B virus in 25 cases. Of 62 strains of subtyped influenza A virus, 7 were H1 subtypes and 54 strains were H3. The occurrence of influenza viral lower respiratory tract infection peaked in infants and children between 6 months and 5 years of age (65%). Pneumonia was the most common manifestation (73.3%) and others were bronchiolitis (14.4%), croup (8.2%), and tracheobronchitis (4.1%). Influenza A virus was isolated every winter season. H1 subtype was detected only during 90~91 and 91~92 seasons, while H3 subtype was detected every season. Influenza B virus was isolated every 2 years, i.e., during 90~91, 92~93, 94~95, and 96~97 seasons. The period of influenza virus isolation and its peak time varied each season. The first recognized influenza activities were 4 times each in November and December, respectively, among the 8 seasons. CONCLUSION: The data show that influenza activity in Seoul, Korea, begins early in winter months and lasts for a long duration. These data may have implications in vaccination policy.
Antibodies, Monoclonal ; Bronchiolitis ; Child ; Croup ; Epidemiology* ; Humans ; Infant ; Influenza A virus ; Influenza B virus ; Influenza, Human* ; Korea* ; Madin Darby Canine Kidney Cells ; Orthomyxoviridae* ; Pneumonia ; Respiratory Tract Infections ; Seasons ; Seoul* ; Vaccination

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share