Journal of Traditional Chinese Medicine.2001;42(2):89-91.
Sixty cases of chronic pulmonary heart disease at acute attack stage in the treatment group and 60 cases of the control group were treated with oxygen-inspiration, relieving spasm and asthma,anti-infection, and correcting respiratory failure and heart failure as basic treatment. Self-made Chinese drug Fei Xin Ning Mixture was added to the treatment group. In the two groups,15 days constituted one course.Plasma endothelin-1(ET-1) level and hemorheologic indices were determined before and after treatment. Results indicated that the markedly effective rate,effectice rate and the total effective rate in the treatment group were 73.33%,20% and 93.34% respectively,and 35%,33.34% and 68.34% in the control group,with significant difference in the total effective rate between the two groups(P<0.01).Plasma endothelin-1 level after treatment in the treatment group was significantly lower than that in the control group(P<0.01),and the hemorheologic indices in the treatment group decreased significantly as compared with those before treatment or after treatment in the control group(P<0.05 or P<0.01).It is suggested that Fei Xin Ning Mixture can obviously increase the total effective rate and decrease plasma endothelin-1 level and improve blood rheology for chronic pulmonary heart disease at acute attack stage,and it has a better therapeutic effect than that of the simple Western medicine treatment.
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