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The effects of long-term Mulanquan exercise on free radical metabolism and nitric oxide in middle aged and elderly women

Juan LIANG

Chinese Journal of Physical Medicine and Rehabilitation.2003;0(07):-.

Objective To observe the effects of long-term Mulanquan exercise on antioxidative capacity and vasodilation.To elucidate the mechanism by which Mulanquan regulates endothelial endocrine function.To provide scientific evidence for Mulanquan's regulating blood pressure,improving cardiovascular function and preventing cardi- ovascular disease.Methods Forty-nine women volunteers were divided into an exercise group and a control group. They were fifty to sixty years old.The exercise group included 27 subjects who had practiced mulanquan regularly for at least two years.The control group comprised 22 subjects who had no habit of exercise.Their levels of serum ma- londialdehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),catalase(CAT)and nitric ox- ide(NO)were quantitatively determined.Results①Serum MDA was lower in the exercise group than in the con- trol group,and the difference between the two groups was highly significant statistically.Serum SOD activity and GSH-Px activity in the exercise group were higher than in the control group,the differences between the two groups being highly significant statistically.There was no significant difference between the groups in serum CAT activity. The serum NO content of the exercise group was higher than that of the controls,with the inter-group difference statis- tically significant.②Serum NO content was positively correlated with SOD activity ,GSH-Px activity,and SOD/MDA, and negatively correlated with MDA content.Conclusion Long-term Mulanquan exercise can suppress lipid peroxi- dation in middle aged and aged women.It can help maintain high antioxidative capacity,increase the secretion of NO,and thus limit any decrease in endothelium-dependent vasodilatation,which will be good for regulating blood pressure and preventing cardiovascular disease.

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The value of electroneurograms and sympathetic skin response for diagnosing diabetic peripheral neuropathy

Jing CHEN

Chinese Journal of Physical Medicine and Rehabilitation.2003;0(08):-.

Objective To observe the value of electroneurograms and sympathetic skin response (SSR) in diagnosing diabetic peripheral neuropathy( DPN). Methods The electroneurophysiological data on 36 patients with DPN, including motor nerve conduction velocity (MCV) data, sensory nerve conduction velocity (SCV) data and sympathetic skin response ( SSR) data, were analyzed retrospectively. Results Two hundred and sixteen nerves of 36 patients with DPN were inspected. Among 108 nerves tested for MCV, 32 were found to have slowed down, 8 of them with the prolongation of distal delitescence. The amplitudes of compound muscle action potential (CMAP) induced by stimulation of 4 nerves were found to have decreased. The abnormality rate was 40. 7% . Among 108 nerves tested for SCV, 42 were found to have slowed down, 7 were tested with no potential elicited, and 6 were found to have decreased SCV with the prolongation of distal delitescence. The abnormality rate was 50. 9% . Seventy-two limbs of 36 patients with DPN were inspected. Four patients showed no SSR in both their upper and lower limbs. For 38 limbs of 22 patients, the SSR latency was found to be prolonged and the SSR amplitudes were found to have decreased. The abnormality rate was 63.8% . Among 10 patients without neuropathy, 3 patients' SSR was found to be abnormal, an abnormality rate of 30% . Conclusion Electroneurograms and SSR are sensitive indices for the diagnosis of DPN. Their diagnostic sensitivity can be improved if all the parameters are used together.

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Treating cervical cancer with radiotherapy combined with hyperbaric oxygen treatment

Daoyuan YU ; Wei ZHOU ; Jiajun CHEN ; June PANG

Chinese Journal of Physical Medicine and Rehabilitation.2003;0(08):-.

Objective To explore the clinical value when treating cervical cancer of supplementing radiotherapy with hyperbaric oxygen treatment. Methods Fifty-eight cervical cancer patients were randomly divided into 2 groups; the HBO group (n=28) received radiotherapy combined with hyperbaric oxygen treatment; a control group (n = 30) received only radiotherapy. Results The complete response rate (CR) of the HBO group was 75.0% , the partial response rate (PR) was 7.1% ,the effective rate(CR + PR) was 92.8% , the total 3 year survival rate was 71.4% , the local recurrence rate was 10.7% , and all of these results were significantly different from the controls (P

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Attention and number processing:a study of event related potentials

Jun LEI ; Haiyan ZHU ; Jianxin YUAN ; Yuxia HUANG ; Lianyuan ZHANG ; Yuejia LUO

Chinese Journal of Physical Medicine and Rehabilitation.2003;0(08):-.

Objective To investigate the effects of distractions on number processing using event-related potentials (ERPs). Methods ERPs were recorded in fourteen undergraduate students while they were asked to compare a heard number with the number "5" and judge whether its numerical value was larger or smaller than five. This task was carried out under a distracted attention (DA) condition and a focused attention (FA) condition. The reaction time and EEG signals were recorded during the experiment. Results There were significant differences between the reaction times in the different conditions (t26 = 3. 70,P

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Changes in neural stem cell proliferation after rat cerebral ischemia/reperfusion injury is treated with mild hypothermia

Guoxiang WU ; Chengyan LI ; Chunying LIU ; Jun XIA

Chinese Journal of Physical Medicine and Rehabilitation.2003;0(08):-.

Objective To study changes in neural stem cell proliferation in ischemic brain tissue after cerebral ischemia/reperfusion injury treated with mild hypothermia. Methods The middle cerebral arteries (MCA) of Sprague-Dawley rats were occluded for 2 hours, then reperfused for 3, 7, 11, 14, 18 and 28 days. Using immunohisto-chemical staining, the bromodeoxyur-idine ( BrdU)-positive cells in the brain tissue of the operationally intervened side were examined in a sham-operation group, a control group, and in rats treated using mild hypothermia. Results There were a few BrdU-positive cells in the sham-operated rats, but there were obviously more in the mild hypothermia group than in the control group. The peak period for proliferation of neural stem cells in the ischemic brain tissue was longer in the mild hypothermia group than that in the control group. Conclusion Mild hypothermia may promote proliferation of neural stem cells in ischemic brain tissue after cerebral ischemia/reperfusion injury.

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The efficacy of hyperbaric oxygen with patients with early stage cerebral infarction

Haiyun ZHOU

Chinese Journal of Physical Medicine and Rehabilitation.2003;0(09):-.

Objective To evaluate the therapeutic efficacy of hyperbaric oxygen for patients with early stage cerebral infarction.Methods One hundred and four patients with early stage cerebral infarction(within 6 hours) were divided randomly into experimental and control groups.Hyperbaric oxygen(HBO)therapy was administrated immediately after batroxobin had been dripped quickly into the experimental group.HBO was initiated after the same drug was used for 7 days in the control group.HBO was administered once a day,10 times in all.Neurological im- pairment was scored and cerebral infarction areas were determined through MRI in all patients after the HBO therapy had been completed.Results The neurological impairment scores(NIS)were significantly lower after therapy than before therapy in each group,and lower in the experimental group than in the control group.Cerebral infarction areas in the experimental group were smaller than those of the control group.Conclusion HBO can encourage neurocyte function recovery and limit cerebral infarction areas in the early stage of cerebral infarction.

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The characteristics and mechanisms of dysphagia in patients with dorsolateral medullary syndrome

Jing ZHANG ; Yun ZHOU ; Xingquan ZHAO ; Yongjun WANG

Chinese Journal of Physical Medicine and Rehabilitation.2003;0(11):-.

Objective To explore the characteristics and mechanisms of dysphagia in patients with dorsola-teral medullary syndrome ( DMS). Methods Twelve DMS patients were evaluated clinically and submitted to videofluoroscopic study in order to investigate clinical manifestations and the pathophysiological changes in swallowing. Swallowing function was recorded at discharge and during a three-month follow-up period. Results All patients had difficulties in swallowing and drinking, presenting coughing and throat clearing, and needed nasogastric feeding at admission. Insufficient soft palate elevation was observed in seven patients, who had no other oral phase dysfunction. The pharyngeal phase was injured in all patients. Decreased larynx elevation and invalid swallowing were observed in 10 patients. Delayed pharyngeal swallowing was seen in 8 patients. Under videofluoroscopy, 9 patients showed significantly decreased larynx elevation. Ten patients opened the cricopharyngeal muscles insufficiently, while two could not open at all. Larynx penetration was seen in all patients. Eleven patients were able to return to oral feeding, after 36 days on average (range 13 - 50 d). The patients with a disease history of 3 or more years could not return to oral feeding. Conclusion DMS patients are characterized by decreased larynx elevation and reduced compliance of the cricopharyngeal muscles. Early therapy may provide patients with a good prognosis.

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Sympathetic skin response and event-related potential P300 in depression patients

Junlin MU ; Luxian LV ; Zuoming CHEN ; Yufeng LI ; Zhaohui ZHANG ; Wei LIANG

Chinese Journal of Physical Medicine and Rehabilitation.2003;0(11):-.

Objective To explore the diagnostic value of sympathetic skin response ( SSR) and P300 event-related potentials (ERP) in depression patients. Methods The SSRs and ERPs of 46 depressed patients and 42 normal healthy people were measured. Results Abnormal rates of SSR were observed in 84. 8% of the depressed group (39/46) and 78.3% (36/46) of the controls. Compared with those in the control group, the latency and amplitude of the SSRs were significantly longer and lower in the depressed group. Abnormal ERPs were observed in 89. 1% of the depressed group(41/46) compared with 78. 3% of the controls (36/46). The latency of N2 and P3 and the amplitude of P3 in the ERPs of the depressed patients were longer and lower in comparison with those in the control group. Hence there was a significant difference between two groups. There was a high positive correlation between N2 and P3 latency in the ERPs and the SSR readings in the depressed group, and between amplitude of P3 and SSR, while there was a significant negative correlation between latency and amplitude in the two indexes of P300 and SSR in the depressed group. Conclusion SSR and ERP have remarkable clinical value as diagnostic indexes for depres-

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Pulsed CO_2 lasers for the treatment of syringoma

Chengrong XU ; Houyou YAN ; Guili FU

Chinese Journal of Physical Medicine and Rehabilitation.2003;0(11):-.

Objective To investigate the therapeutic effects of pulsed CO2 laser irradiation in the treatment of syringoma. Methods A retrospective comparison was performed between 28 syringoma patients treated with a pulsed CO2 laser and 30 patients treated with a continuous CO2 laser. The therapeutic effects and treatment complications were compared statistically. Results The treatments were rated effective for all patients in both groups. The outcome was rated " excellent" for 86. 7% of the pulse-treated group and 78. 6% for those treated with continuous las-ing. There was no significant difference between the two groups. There was a significant difference in the rate of pigmentation and atrophic scarring. The pulsed group showed lower levels of both effects than the continuous group. Conclusion The pulsed CO2 laser is a better tool for treating syringoma in terms of safety, efficiency and side effects.

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The influence of disease uncertainty on dependency of remedy, shoulder joint movement and ability in daily life in post-operative breast cancer patients

Dongmei LI

Chinese Journal of Physical Medicine and Rehabilitation.2003;0(11):-.

Objective To observe the influence of disease uncertainty ( DU) to patients' compliance with rehabilitation training ( CWRT) , shoulder joint movement (SJM) , and abilities in activities of daily living ( ADL) in post-operative breast cancer (BCPO) patients. Methods Sixty-seven BCPO patients uncertain about their health was assessed using Missals' DU protocol. They were then treated according to the breast cancer rehabilitation training plan recommended by the Japanese Cancer Association. CWRT, SJM and ADL were evaluated before and after treatment. Results The scores on dependency of recovery training, systematic remedy and the ability to change their life style were distinctly higher among patients with low DU scores than among those with high DU scores. The shoulder joint mobility in two groups was similar before the remedy, but became better after treatment. ADL category grades and ADL total scores in the two groups were similar before treatment, and had increased significantly after treatment. The item scores for defecating, diet, dressing and bathing, as well as ADL total scores, were significantly lower in the high uncertainty group. Conclusion DU is one of most important factors for BCPO patients. It can influence CWRT and therapeutic effects in rehabilitation.

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