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Observations on protective immunity in mice induced by recombinant Schistosoma japonicum Sj14FABP through several adjuvant formulations

Jinming LIU ; Zhiqiang FU ; Youmin CAI ; Yaojun SHI ; Hao LI ; Ke LU ; Jiaojiao LIN

Chinese Journal of Schistosomiasis Control.2007;19(1):32-37.

Objective To test the protective immunity in mice induced by recombinant Schistosoma japonicum Sj14FABP through several adjuvant formulations. Methods The recombinant Schistosoma japonicum Sj14FABP was prepared by expression in E. coli as a GST fusion protein (rSj14/GST) and used to vaccinate outbred Kunming mice by using complete Freund's adjuvant (FCA)/incomplete Freund's adjuvant (FIA), Bacillus Calmette-Guerin (BCG) and the immunostimulating complex (ISCOM) as adjuvant respectively. Results The purified recombinant protein rSj14/GST was immunogenic in mice, and 34.3% and 36.0% worm reduction rates were obtained in outbred Kunming mice immunized intradermally with BCG adjuvant and immunized subcutaneously with ISCOM adjuvant respectively, compared with non-vaccinated control group. However, intramuscularly vaccination with rSj14/GST in FCA/FIA was not protective, although the high level of IgG antibody was induced. Conclusion Both BCG and ISCOM are suitable adjuvants for rSj14/GST.

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Evaluation of therapeutic effects of spironolactone on schistosomal pulmonary arterial hypertension by echocardiography

Daoming ZONG ; Xiaogong ZHAO ; Weicheng DENG ; Sixi CHEN ; Keying SUN ; Yuesheng LI

Chinese Journal of Schistosomiasis Control.2006;18(3):207-210.

Objective To evaluate the therapeutic effect of spironolactone on schistosomal pulmonary arterial hypertension(SPAH). Methods A total of 62 patients suffered from hepatosplenic schistosomiasis with pulmonary arterial hypertension were divided into the spironolactone group(n=31) and control group (n=31). All the patients underwent serial echocardiography and the clinical effect before and after the treatment was evaluated by assessing the mean pulmonary arterial pressure (mPAP) and pulmonary arterial diameter (PAD). At the same time, the varieties of the clinical symptoms, signs and the distance of the 6-minute walking test (6-MWT) were investigated. Results In spironolactone group, mPAP(-x±s) decreased from (31.8±7.1) mmHg to (21.2±2.1) mmHg, PAD(-x±s) decreased from (28.0±5.0) mm to (20.0±3.5) mm before and after the treatment respectively(P<0.01). There were significant differences in mPAP, PAD, the distance of 6-MWT and the heart function before and after the treatment in the spironolactone group. However, the data did not show the significant difference in the control group. Conclusion The therapeutic effect of spironolactone in the treatment of SPAH is satisfactory.

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IEC material development for malaria control by working with target populations

Jianwei XU ; Min XIA ; Petlueng PRICHA ; Xianhua WU ; Hong TAO ; Yanchun ZHONG ; Hong JIANG ; Kaihong LI

Chinese Journal of Schistosomiasis Control.2006;18(1):56-59.

Objective To develop user-friendly information education-communication (IEC)materials and guidelines of malaria control for various target groups. Methods The participatory methods were used to make sure participation of target groups at each stages of IEC material development. Results A package consisted of interactive video, 2 posters for primary groups, sto ry booklet for students, manual for activities of "buddy system" for teachers, flipcharts for health staff at grass-root levels, guidelines on communication skill and how to use the first 5kinds of materials, was developed. Conclusion A set of user-friendly IEC materials and guidelines of malaria control has successfully been developed with sufficient participation of target groups.

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CHINESE RURAL PEOPLE'S PERCEPTIONS OF SCHISTOSOMIASIS AND OTHER DISEASES

Yixin HUANG ; Manderson LENORE

Chinese Journal of Schistosomiasis Control.2003;15(2):108-115.

Objective To describe rural people's perceptions of schistosomiasis and other dis eases, and to explore the relevance of these perceptions to disease control programs in rural areas of China. Methods A cross sectional study was conducted in Yingjiang Village, Anhui Province,China. Anthropological and epidemiological re search methods, including focus group discussions,in depth interviews, questionnaires and stool tests, were used. Results People identified various infectious diseases, such as schistosomiasis, hepatitis, hemorrhage fever, hookworm diseases, as cariasis and infection skin diseases. The knowledge of villagers regarding schistosomiasis and other diseases was not inconsiderable but not entirely accurate. Local illness taxonomy usually resulted from the concepts as to the causation of diseases. Local people thought there were about eight categories of factors that might cause diseases. These categories were worms, the unbalance of hot cold faetors, over work and starvation, "hot poison", dirty water and food, psychological factors, supernatural factors and pesticides. Conclusion Health education, improving sanitation and safe water supply may play much important roles in improving health of rural people.

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Sparganosis mansoni treated with praziquantel: one case report

Wei WU ; Yixin HUANG

Chinese Journal of Schistosomiasis Control.2009;21(6):472-472.

A patient with sparganosis mansoni was treated with praziquantel and cured with little side effect.

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Retrospective survey of cystic echinococcosis in Liyang City

Xiamei HUANG ; Laifu LV ; Lizhong HUANG ; Minyi WU ; Xiaolin JIN

Chinese Journal of Schistosomiasis Control.2009;21(6):572-573.

Seven cases of cystic eckinococcosis( CE) were surveyed retrospectively in 2008. The results showed that 6 of thosepatients were locally infected. It is important to investigate the course and characteristics of CE transmission in non-endemic areas.

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Progress of research on mathematical model for transmission of schistosomiasis

Yuanpei LI ; Yibiao ZHOU ; Qingwu JIANG

Chinese Journal of Schistosomiasis Control.2009;21(6):568-571.

Mathematical model has been increasingly applied in the description of the transmission of schistosomiasis, the prediction and selection of schistosomiasis prevention measures, and it has being developed constantly. This paper briefly introduces several typical mathematical models for transmission of schistosomiasis and summarizes their advancements.

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Progress of research on detection of Plasmodium sporozoites-carrying of mosquitoes

Hanwu ZHU ; Jun CAO ; Qi GAO

Chinese Journal of Schistosomiasis Control.2009;21(6):563-567.

Detection of Plasmodium sporozoites-carrying mosquitoes is an important indicator in monitoring mosquitoes, evaluating the control of malaria and forecasting the incidence of malaria. Here, we review the detection techniques in Plasmodium sporozoites-carrying mosquitoes and the progress of their applied research, and then briefly discuss the principles of the detection and the prospects for the field.

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Proteomics and its application in schistosome

Guoli QU ; Yonghui TAO ; Yousheng LIANG

Chinese Journal of Schistosomiasis Control.2009;21(6):559-562.

This paper reviews the core technology of proteomics, namely separation, identification and bioinformatics prediction of proteins, and its development and application in schistosome research.

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Therapeutic effect of azithromycin combined with IFN-γ on mouse toxoplasmosis

Junming TANG ; Guohong QIAO ; Xuecai WANG ; Ming XU

Chinese Journal of Schistosomiasis Control.2009;21(6):557-558.

In order to observe the therapeutic effect of azithromycin combined with IFN-γ on mouse toxoplasmosis and its impact on the cellular immune function of mouse, a total of 100 BALB/c mice were selected and divided into 5 groups, namely an infection control group (Group A) , azithromycin treatment group (Group B) , azithromycin combined with IFN-γ treatment group (Group C) , IFN-γ treatment group (Group D) and blank control group (Group E). The mice in Group A, B, C, D were infected by Toxoplasma tachyzoites through intraperitoneal injection and those in Group B, C, D were treated with relative drugs 24 h later for S days. The survival time of mice in each group and the levels of CD4 ~+ and CD8~+ T cells in blood were observed. The results showed that azithromycin combined with IFN-γ could improve the therapeutic effect of mouse toxoplasmosis and the cellular immune function of mice.

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