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The long term curative effect of the nonpenetrating trabecular surgery.

Yan HUANG ; Ningli WANG ; Banwe WANG ; Lijun LI

Ophthalmology in China.1993;0(04):-.

Objective To evaluate the long term curative effectiveness and the failure cause of the nonpenetrating trabecular surgery (NPTS) for primary open angle glaucoma (POAG) . Design Randomized clinical trial. Participants 105 patients (111 eyes) with POAG. Methods 52 patients (55 eyes) and 53 patients (56 eyes) underwent NPTS and trabeculectomy respectively. The follow-up period was 30 to 48 months (mean, 40.1?8.2 months). Main Outcome Measures Visual acuity, intraocular pressure(IOP), filtering blebs, alteration of anterior chamber angle and complications. Results Visual acuity in the NPTS group was significantly superior to that in the trabeculectomy group (?2=7.7381,P0.05, respectively). But the successful rate in the NPTS group 48 months after operation was significantly lower than that in the trabecalectomy group (?2=5.26,P

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Pay attention to the study and clinical application of neuroprotection for retinal diseases

Yannian HUI

Ophthalmology in China.1993;0(04):-.

The outcome of visual functions in a number of retinal diseases after treatment still remains limited, although significant advances in techniques of surgery and laser treatments have been made for these diseases, such as retinal degeneration and retinal detachment. Under anoxic conditions, death of photoreceptor cell occurs after retinal damage. Apoptosis, survival and rescue of retinal neurons depend on various biochemical changes, mediators and neurotrophic factors, and are also influenced by responses of glial cells. It is, therefore, of critical importance to pay more attention to further understanding of the neuropathology, and study and clinical application of neuroprotective strategies in order to promote functional recovery of the retina.

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Inhibition of wound healing of lens epithelial monolayer wounds by an applied electric field

Enpu WANG ; Entong WANG

Ophthalmology in China.1993;0(04):-.

Objectives To investigate the effects of electric field on the healing of lens epithelial cell wounds. Design Experimental study. Participants The cultured bovine lens epithelial cells and monolayers. Methods Small circle wounds were made by stabbing the cultured bovine lens epithelial monolayers with a glass needle and exposed to an applied electric field at a physiological strength of 200 mV/mm for 2 hours (n=37), and the wounds with no electric field exposure were used as control (n=29). With an image analyzer (Leica), the wound areas at 0, 1 and 2 hours after wounding were measured. Wounds were stained with F-actin fluorescence antibodies to observe the arrangement of microfilament cytoskeleton. Main Outcome Measures The wound areas and the arrangement of microfilament cytoskeleton of wounds. Results Compared to control wounds, the healing of wounds exposed to electric field was reduced, the mean area of field-exposed wounds at 2 hours after wounding (19106?m2?2167?m2) was significantly more than that of control wounds (8555?m2?1911?m2) (t=2.942, P=0.0045). The arrangement of microfilament cytoskeleton in control wounds was centripetally and a purse string-like arrangement of microfilament cytoskeleton was showed in field-exposed wounds. Conclusion Applied electric field at a physiological strength inhibits the healing of lens epithelial wounds.

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The significance of photopic negative response in early diagnosis of primary optic nerve atrophy.

Changzheng CHEN ; Chengguo ZUO ; Yiqiao XING ; Llianfang YI

Ophthalmology in China.1993;0(04):-.

0.05). But the amplitudes of the PhNR were significantly reduced in group of primary optic nerve atrophy (P

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Expression and signification of transforming growth factor-?1 and its typeⅠ receptor in experimental choroidal neovascularization of BN rat

Xuehui SHI ; Shouzhi HE

Ophthalmology in China.1993;0(04):-.

Objective To investigate the expression and signification of Transforming growth factor-?1 and its typeⅠReceptor in choroidal neovascularization(CNV) induced with krypton laser on Brown Norway rat. Design Experimental study. Participants Five groups of 30 BN rats. Methods The rats were photocoagulated with krypton laser in single eye to induce CNV. 3 days, 1 week, 2 weeks, 3 weeks and 4 weeks after photocoagulation, the retina was processed respectively for immunohistochemistry of FⅧR:Ag, TGF-?1 and T?RⅠ, in situ hybridization of TGF-?1mRNA. Main Outcome Measures FⅧR:Ag, TGF-?1, TGF-?1mRNA and T?RⅠ. Results FⅧR:Ag positive staining cells formed vessels in the lesion 1 week after photocoagulation. TGF-?1mRNA expressed in the ganglion cells, RPE in normal BN retina, TGF-?1 and T?RⅠexpressed in the ganglion cells, inner nuclear layer, RPE in normal BN retina, and they all expressed in the lesions after photocoagulation. From 3 days to 4 weeks, the expression density of FⅧR:Ag in the lesions increased (P

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Application of contrast sensitivity function on patients with idiopathic epiretinal macular membrane

Jie LI ; Hong DAI ; Qun XIA ; Li LONG

Ophthalmology in China.1993;0(04):-.

Objective To investigate the progression of idiopathic epiretinal macular membrane(IEMM) and compare the correlation factors of contrast sensitivity function (CSF) such as visual acuity(VA) and central macular thickness. Design Prospective, case-controlled study. Participants 80 normal people (80 eyes) were divided into three groups: old-aged group (60-80 years old, of 26 eyes), middle-aged group (40-59 years old, of 30 eyes) and young-aged group (

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Residual subretina fluid recovery after scleral buckling surgery

Yong LIU ; Yi WANG ; Shiying LI

Ophthalmology in China.1993;0(04):-.

Objective By using optical coherence tomography (OCT) to observe the residual subretina fluid changes in fovea that may explain visual recovery after anatomically successful repair of rhegmatogenous retinal detachments (RD). Design Prospective observational case series. Participants 34 patients(35 eyes) with successful retinal reattachment after macula involving RD repair. Methods 34 patients were followed up at 3 days, 15 days, 2 months and 6 months after sclera buckling. The best corrected visual acuity(BCVA), eye fundus status were recorded. The OCT images through the center of the fovea were obtained. Main Outcome Measures The OCT images and BCVA after RD repair. Results The BCVA and OCT images were obtained 3 days to 6 months postoperatively. There were 3 eyes, 5 eyes, 9 eyes and 23 eyes respectively with residual subfovea fluid absorbed totally at 3 days, 15 days, 2 months and 6 months. In the residual subforvea fluid group, the mean visual acuity increased at 0.124?0.013. In the subfovea fluid absorbed group, the mean visual acuity increased at only 0.019?0.006. Conclusions After anatomically successful repair of RD performend with sclera buckling, the minimal residual subforvea fluid will exist for a long time and will be absorbed slowly. This may explain slow increase of postoperative visual acuity after anatomically successful repair.

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Analysis of the Heidelberg Retina Tomograph Ⅱ for the detection of macular diseases

Dan ZHOU ; Wenbin WEI ; Bei TIAN

Ophthalmology in China.1993;0(04):-.

Objective To analyse the detection of The Heidelberg Retina Tomograph Ⅱ (HRT-II ) for macular diseases. Design Retrospective observational case series. Participants 110 patients(201 eyes). Methods Fifty-two normal eyes, 74 eyes with macular edema, 23 eyes with macular hole, 31 eyes with macular premembrane and 21 eyes with choroidal neovascularization were examined with macular edema module(MEM) of HRT-Ⅱ. Main Outcome Measures Edema index (E value), signal width value (W value) and features of reflectance pictures. Results In normal eyes, E value and W value of some areas in macula were partly associated with age(r=0.207-0.359). E value and W value in macular diseases were significantly different from normal eyes (P=0.000). HRT-II could display macular edema cysts, configuration and size of macular holes, extension of macular premembrane and its relationship with retina and druen or subretinal neovascularization in age-related degeneration. Conclusion The reflectance pictures of HRT-Ⅱ have characteristic appearances in different macular diseases, and the measurements of E value and W value altered in pathologic stage of macular diseases. Especially E value of central zone can reflect changes of retinal thickness and light reflectance in macula, and it is obviously different in macular edema.

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The correlation between the features of optical coherence tomography and fundus fluorescein angiography in diabetic macular edema

Juan TAN ; Luosheng TANG

Ophthalmology in China.1993;0(04):-.

s Objective To assess the correlation between the features of optical coherence tomography (OCT) and fundus fluorescein angiography (FFA) in clinically significant diabetic macular edema. Design Prospective case series. Participants 102 patients(177 eyes) with clinically significant diabetic macular edema. Methods Optical coherence tomography and fluorescein angiography typing were done separately in a double-masked manner in each case of clinically significant macular edema. The correlation between FFA types and OCT types were analyzed, and their associations with the best visual acuity, central foveal thickness were evaluated. Main Outcome Measures The FFA features and OCT features of clinically significant diabetic macular edema, central foveal thickness, best visual acuity. Results The prevalence of focal leakage type was higher in the OCT type 1 (70.6%) than in the diffuse leakage type (27.2%) and diffuse cystoid leakage type (2.2%) of fluorescein angiography (P

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Morphological study of foveal retinoschisis and retinal detachment in highly myopic eyes

Xin HUANG ; Peiquan ZHAO ; Wenji WANG

Ophthalmology in China.1993;0(04):-.

Objective To describe the morphological characteristics of foveal retinoschisis and retinal detachment in highly myopic eyes. Design Retrospective observational case series. Participants Twenty-nine patients (38 eyes) of high myopia with foveal retinoschisis and retinal detachment. Methods All patients with foveal retinoschisis and retinal detachment were performed complete ophthalmic examinations, B-scan and studied cross-sectional images of the maculae with optical coherence tomography (OCT). 10 eyes underwent vitreous surgery. Main Outcome Measures Morphological characteristics. Results On biomicroscopy, the maculae of all 38 eyes had a microcystic appearance and shallow elevation without macular hole. B-scan showed posterior retinal edema or with 0.5 to 2mm detachment. OCT disclosed foveal retinoschisis and retinal detachment in all eyes. The neuroretina splitted into a thick inner layer and a thin outer layer or a thin inner layer and a thick outer layer or a thin inner layer, a thick inter layer and a thin outer layer. A hyperreflective preretinal structure resembling the posterior hyaloid was stretched over the retinoschisis and drew the retina. Vitreous surgery performed on 10 eyes, including posterior vitreous detachment, removal of the premacular vitreous cortex. In all eyes, foveal detachment and retinoschisis gradually decreased in height, and attained foveal attachment finally. Conclusion Foveal retinoschisis and retinal detachment in highly myopic eyes with staphyloma is better characterized with OCT than with biomicroscopy. Vitreomacular traction forms the posterior hyaloid and the staphyloma maybe the major cause of it.

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