Trial was made on a new way of administering drugs topically for eye conditions using a collagen corneal shield to deliver the agents. A 4mm perforating incision was made at the center of the rabbit's cornea. Thirty rabbits were used which were devided at random into 3 groups. The first group served as control, the second group was given basic fibroblastic growth factor (bFGF) as eyedrops, and the third groedup collgsu aen shields which had been soaked in bFGF. After 8 days, the maximum pressures that the corneas could stand were significantly different among the 3 groups (p

Ascorbic acid was found to inhibit the activity of collagenase in vitro significantly at the concentration of 56.7mmlo/L and completely at the concentration of 85.0mmol/L. This effect was destroyed by heat. The experiment explained further the useful action of topical ascorbic acid in the treatment of corneal alkaline burn and ulcer.

To evaluate the role and efficacy of vitrectomy in the treatment of eye injuries in children with posterior segment involvement, forty-six eyes in 45 children aged under 16 with injuries involved posterior segment treated with pars plana vitreetomy are studied retrospectively. Six eyes underwent vitreetomy only, the others combined with seleral buekling and/ or gas-fluid exchange, and rarely, silicon oil tam-ponade; Seventeen eyes with lensectomy. Thirty-four (73.91%) of the 46 eyes achieved surgical success. Of 13 (28.26%) eyes with retinal detachments, six (46.15%) achieved reatachment. The failure of surgery was mainly due to retinal detachment, which mostly characterized by anterior proliferative vitreoretinopathy (PVR). We conclude that pars plana vitrectomy is an important therapeutic operation for eye injury in children with posterior segment involvement. The key factor that influence the outcome of eye injury in children is the treatment of traumatic retinal deatchment.

Nineteen eyes of 18 patients with intraorbital angioma were studied by color Doppler ultrasonography and the results were compared to the diagnosis of CT (16 eyes), MRI (5 eyes) and pathology (5 eyes). Blood flow images in intraorbital angioma were detected in 15/19 eyes (78.95%), and blood flow spectrums were analyzed in 7/19 eyes (36.64%). It is suggested that color Doppler ultrasonography be helpful to the identification of the intraorbital angioma.

At 4Hz and 16Hz temporal frequencies and at a range of 3—37.8 cycles per degree (cpd) of spatial frequency which were divide into 12 grades, an instrument with a flickering sinusoid grate was used to measure the laser retina-visual cortex spatiotemporal visual modulation transfer function (S-TMTF) in patients with glaucoma. There were 34 cases (65 eyes) with early primary open-angle glaucoma (POAG), 18 cases (31 eyes) with moderate or late glaucoma and 19 cases (37 eyes) with suspect glaucoma (SG). In 6 months. 16 patients of SG were followed. The results showed that in patients with early POAG, abnormal S-TMTF values might occur in low frequency region, the abnormal values tended to be general in the middle frequency region, and in the high frequency region all the S-TMTF values were significantly lower than that of the control. In cases with SG, lowering of S-TMTF was seen in many frequency points above 9.5 cpd, but did not found in regions below 9.5 cpd. The S-TMTF values at 16 Hz were lower than that at 4 Hz in each corresponding spatial frequency, and with aggravation of the disease, the greatest discrepancy value appeared to be shifting from high to low frequency points. In the follow-up period, an early glaucomatous visual field change occurred in a female case with ocular hypertension. It is demonstrated that the S-TMTF value is of high sensitivity for diagnosis of POAG, but it is difficult to screen the specific diagnostic frequency point and its critical value.

Herpes simplex keratitis models were created with healthy New Zealand rabbits. During the quiescent period, one group of the rabbits were performed autograft penetrating keratoplasty and another group cross penetrating keratoplasty with noninfeeted rabbits. After removal of the sutures, epinephrine iontophoresis was done for reactivation of the virus, and all the corneal buttons were stained positive of HSV-1 antigens. Transmission electron microscopy revealed signs of viral infection and culture of corneal graft keratoeytes also demonstrated HSV-1 infection, suggesting that the cornea was a site of HSV-1 latency and source of recurrence.

92 comfirmed cases of malignant glaucoma hospitalized from 1979 to 1989 at Zhongshan Ophthalmic Center are retrospectively studied. The risk factors and new clinical discoveries in its pathogenesis are analyzed with comments. The developments in the managements of the disease during the 10 years are summerized with recommendation of principles for its diagnosis and treatment. The authors also put forth suggestions with regard to the nomenclature and classification of malignant glaucoma.

With electronystagmography (ENG), various tests were carried out in 16 patients of congenital and 10 patients of acquired nystagmus. The results indicated that the two groups manifested distinct differences in gaze nystagmus, responses of saeeade and eye tracking, and optokinetic nystagmus. It is believed that the ENG can help make objective differential diagnoses between the two kinds of nystagmus.

213 eyes (138 cases)with diabetic retinopathy (DR) were treated with laser panretinal photoeoagulation(PRP)and followed up for 3～72 months, during which time the visual acuity improved in 70 eyes (32.9％), remained unaltered in 77 eyes(36.1％), and diminished in 66 eyes (31％). The results indicated that PRP for the treatment of DR was effective and safe, with few complications. Factors affecting performance of the technique and visual prognosis were discussed.

39 cases (49 eyes) with retinal periphlebitis (Eales' disease) were treated by laser photocoagulation and followed up for 3～64 months, averaging 17 months. The visual acuity improved in 29 eyes (59.1％), remained unaltered 15 eyes (30.7％),and diminished in 5 eyes (10.2％). The results showed that laser photocoagulation was effective and safe for the treatment of Eales' disease. The importance of early diagnosis, early treatment, periodical follow-up and the use of corticosteroids were discussed.