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Itraconazole against invasive fungal infection in patients of multiple organ dysfunction syndrome

Jianqiong XIONG ; Zhaoxia DENG ; Lei ZHANG ; Liang WEN ; Xianhui XIE

Journal of Third Military Medical University.2003;0(11):-.

Objective To evaluate the efficacy and safety of itraconazole injection in treatment of invasive fungal infection in the patients with multiple organ dysfunction syndrome.Methods Invasive fungal infection in 15 patients with multiple organ dysfunction syndrome was treated with 200 mg itraconazole injection,twice a day on the first two days,then once a day,for 8 to 14 days.During the treatment,the symptoms and signs,the results of chemical detection were recorded.Everyday fungus,sputum,stool smear or culture were performed.Results The recovery rate,effective rate,and fungal clearance in this trial with itraconazole injection were 80%(12/15),86.7%(13/15),and 86.7%(13/15) respectively.The side effect was not found.Conclusion Itraconazole injection is an effective and safe drug against invasive fungal infection in patients with multiple organ dysfunction syndrome.

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Association of genetic polymorphism of ?_2-bradykinin receptor gene and AGT gene with essential hypertension in Shenzhen population

Huiyi DONG

Journal of Third Military Medical University.2003;0(11):-.

Objective To investigate the association between ?_(2)-bradykinin receptor(?_(2)-BKR) gene and angiotensinogen gene polymorphism and essential hypertension.Methods The casecontrol study was conducted using MS-PCR and PCR-SSCP techniques to explore the ?_(2)-BKR gene-58T/C polymorphism and the AGT gene M235T polymorphism in 97 essential hypertensives and 87 normotensives of Shenzhen.Results The genotypes distribution of CC and the alletic frequency of C in EH cases were significantly higher than in controls(0.36 vs 0.14,P=0.000;0.60 vs 0.43,P=0.001).The genotype distributions of CC+MT and TC+MM in EH cases were significantly higher than controls(0.19 vs 0.06,P=0.009;0.18 vs 0.05,P=0.006).The odds ratio for those exposed to CC genotype was 1.913,95% confidence interval was 1.913 to 3.049,P=0.006.No significant difference was seen in the genotype distribution of angiotensinogen gene between EH cases and controls(P=0.091),but the alletic frequency of M in EH cases was significantly higher than controls(0.55 vs 0.44,P=0.037).Conclusion The ?_(2)-BKR gene-58T/C polymorphism might be associated with essential hypertension in Shenzhen population.CC genotype might be associated with the increased risk of EH and C allele might have a gene-gene synergetic effect with M235T polymorphism.

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Optimizing preparation of arsenic trioxide-loaded polylacticco-glycolic nanoparticles

Le ZHANG ; Shiwen ZHOU

Journal of Third Military Medical University.2003;0(11):-.

Objective To study the preparation of polylactic-co-glycolic acid(PLGA) nanoparticles carrying arsenic trioxide(As_(2)O_(3)).Methods Polymer PLGA was used to prepare arsenic trioxide nanoparticles with w/o/w double-emulsion evaporation technique,which was optimized by uniform design test.Results The shape of As_(2)O_(3)-loaded PLGA nanoparticle was round,the size was well-distributed,the mean diameter was 178.2 nm,the average encapsulation ratio reached 53.19%,and the average drug loading was 0.64%.Conclusion The technique to prepare nanoparticles is simple and the quality can be easily controlled.

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Establishment of 3-D finite element models of immediately loaded dental implants

Kun WANG

Journal of Third Military Medical University.2003;0(11):-.

Objective To create 3-D models of immediately loaded screw-type dental implants for finite element analysis by computer.Methods Using the commercial code of SolidWorks,3-D models of screw-type dental implants and a segment of mandibular bone were generated.By ABAQUS software,the 3-D implant-bone complex was meshed.The interfacial contact of bone and the implants was defined to be a frictional contact with the initial press-fit stress(by Interference Fit Option) to simulate the contact of immediately loaded implants and bone tissue.Results The finite element models of the immediately loaded screw-type implant were successfully created on the computer.As the interference fit got deeper,the interfacial initial press-fit stress got higher values.Conclusion The finite element models of the immediately loaded screw-type implants can be built with this method.The interfacial status of the primary press-fit stress can be simulated by the Interference Fit Options in the finite element software.

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Fast scan sequence of MRI in cervical vertebra

Bing XIE

Journal of Third Military Medical University.2003;0(11):-.

0.05).Conclusion IPAT sequence can gain super images in less time with more coils.IPAT sequence needs the distance between coil and checkpoint larger than 5 mm.MRI scan for vertebra just fit it.We think cutting scan time is a direct and effective method to decrease constructed defect.

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Correlation between high mobility group protein 1,VEGF-C/D expressions and lymph node metastasis in colon cancer

Yan LI

Journal of Third Military Medical University.2003;0(11):-.

Objective To discuss the correlation between the expressions of high mobility group protein box 1(HMGB1),VEGF-C/D and lymph node metastasis in colon cancer.Methods Forty-five colon cancer samples were stained by immunohistochemical method for VEGF-C/D,HMGB1.The correlations of VEGF-C/D,HMGB1 expressions and lymph node metastasis were analyzed statistically.Results Positive HMGB1 expression was in 33 specimens,lymph node metastasis was in 27 specimens with 23 specimens of positive HMGB1 and non-lymph node metastasis was in 18 specimens with 10 specimens of positive HMGB1.Positive VEGF-C expression was in 27 specimens with 20 in lymph node metastasis.The expression of HMGB1 was consistent with VEGF-C expression,and HMGB1 and VEGF-C expressions were closely correlated with lymph node metastasis,but not with age,sex,cellular differentiation.Conclusion HMGB1 and VEGF-C expression may become predictor to the prognosis of colon cancer patients.

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Relationship of inflammatory factors in blood serum and immune status of patients with active pulmonary tuberculosis

Zhi CHEN ; Minggui LIN ; Jianqin LIANG ; Jinhe WANG

Journal of Third Military Medical University.2003;0(11):-.

Objective To investigate the changes of inflammatory factors in the blood serum and their relationship with the immune status of patients with active pulmonary tuberculosis(TB).Methods A total of 97 cases of pulmonary tuberculosis were included from Feb 2003 to Oct 2005,57 of active TB,40 in resting period.Another 41 healthy people were used as normal control.ELISA and APAAP method were used to detect the level of TNF-?, IL-1,IL-6 and the changes of CD_(4),CD_(8)and CD_(4)/CD_(8).Results The levels of IL-1,IL-6,TNF-? were(15.3?1.3),(80.5?7.3) and(77.2?9.8) ng/ml in the normal controls,(33.7?3.6),(293.6?30.5) and(190.7?25.2) in the patients of active TB,and(18.2?2.1),(130.7?14.5),(87.5?10.2) ng/ml in the patients at resting period,which were highest in the patients of active TB.The ratio of CD_(4)and CD_(4)/CD_(8) was(32.3?2.9)% and(0.83?0.17) in the patients of active TB,lower than(48.2?4.4)% and(0.83?0.17) of normal controls.Conclusion The increase of inflammatory factors and decrease of immune activity were the clinical characteristic of patients with active pulmonary tuberculosis,which are of inverse relationship.

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Inhibitory effect of 5 chemotherapeutic agents on KBV200 cell line and reverse effect on multidrug resistance of Matrine

Hongyan CHEN

Journal of Third Military Medical University.2003;0(11):-.

Objective To observe the inhibitory effect of 5 chemotherapeutic agents including vincristine,adriamycin,pingyangmycin,cisplatin,cyclophosphamide on the KBV200 cell line and to study the reverse effect on the multidrug resistance of Matrine.Methods MTT assay was used to investigate the inhibition ability of 5 drugs on the cell line and the reverse effect on the multidrug resistance of Matrine.Results Vincristine,pingyangmycin,cyclophosphamide had less inhibitory effects than adriamycin,cisplatin on the KBV200 cell line.Matrine had the ability to reverse the multidrug resistance of the cell line to vincristine,adriamycin.Conclusion KBV200 cell line is multidrug-resistant to vincristine,pingyangmycin,cyclophosphamide.Matrine can enhance the sensitivity of KBV200 to the vincristine,adriamycin.

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High intensity focused ultrasound ablation for human malignant gliomas in vitro

Gang HUO ; Jiuzhou LI ; Luping ZHENG ; Faqi LI

Journal of Third Military Medical University.2003;0(11):-.

Objective To explore the efficiency,safety and suitable dosage of the non-invasive treatment of malignant gliomas with high intensity focused ultrasound(HIFU).Methods An extracorporeal HIFU with 9.7 MHz transducer(focal length: 4.5 mm,focal intensity: 2 500 W/cm~(2)) was used.Fifteen resected human malignant gliomas were randomly assigned to receive HIFU ablation for 10,20,30 s.After the treatment,the exposure coverage and marginal zone were collected and examined by HE staining and electron microscope.Results Exposure coverage and margin was safe in 10 s group.Typical coagulation necrosis was detected at exposure coverage with no detectable change at margin in 20 s group.Typical coagulation necrosis was seen at both exposure coverage and margin in 30 s group.Conclusion Under the parameters used in this study,20 s is a beneficial therapeutic dosage.HIFU is an accurate method for malignant gliomas ablation.

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Expression and clinical significance of inhibitor-of-apoptosis Livin in laryngeal squamous carcinoma

Hong XIAO ; Changyou JI ; Jichuan CHEN

Journal of Third Military Medical University.2003;0(11):-.

0.05),but had positive relationship with the clinical stages and lymphatic metastasis of the tumor. Conclusion Livin ? is highly expressed in the tissues and peripheral blood cell from the patients of laryngeal squamous carcinoma,which is closely related to the clinical stages and lymphatic metastasis of the tumor.

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