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The choice of different kinds of fluid for acute hypervolemic hemodilution in patients undergoing gastrointestinal operation during induction of general anesthesia

Xianling CHENG

Chinese Journal of Current Advances in General Surgery.2004;0(06):-.

B,Hb and Hct significantly increased in group B at t_2.3.PH increased in group B at t_1,furthermore exceeded the normal value,but gradually returned to the baseline at t_2;BE slightly increased at t_1 within the normal value;HCO~ - _3 unchanged before and after AHH.Lactic acid increased both in group A and group B at t_2.4.CaO_2、CcvO_2 decreased at t_1,but returned to the baseline at t_2 in group B;ERO_2 unchanged in group A,but slightly increased in group B after AHH.5.Na~+、K~+、BUN unchanged in both groups;Cl~ - decreased in group B at t_1,but returned to the baseline at t_2;Glu increased in both groups at t_2.Conclusion:The effect of rapid plasma Volume expansion with crystalloid or colloid on prevention of hypotension during induction of general anesthesia is similar.Vouven and Plasmalyte A were both safe and effective during induction of general anesthesia .Plasmalyte A was superior to stabilize physiological internal environment,while the effect of volume expansion and the time of maintainance of Voluven was superior to Plasmalyte A.

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Hemorrhage in laparoscopic cholecystectomy:the cause and management

Hua LI ; Tao YAN ; Jianping GONG ; Changan LIU ; Zuojin LIU

Chinese Journal of Current Advances in General Surgery.2004;0(06):-.

Objective:To explore the cause and treatment of hemorrhage in laparoscopic cholecystectomy(LC).Methods:The clinical data of 112 cases of LC were analyzed to summarize the causes and treatment of hemorrhage.Results:The causes of hemorrhage in LC included subjective and objective elements.All of them were successfully hemostatic in different ways including reclamping,coagulation,suturing,packing hemostasis and suspension of falciform ligament of liver.Conclusion:Hemorrhage is the serious and most common complication in LC,but it can be avoided through an immediate and effective process.

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Relationship between IL-1 gene polymorphisns and gastric adenocarcinoma

Peixiang XING ; Qingdong ZENG ; Wei GAO

Chinese Journal of Current Advances in General Surgery.2004;0(06):-.

Objective:To investigate relationships between the single nucleotide polymorphisms(SNPs) of interleukin-1B(IL-1B) and variable number of tandem repeat (VNTR)of interleukin-1RN(IL-1RN) promoter genes and susceptibility of the patients with gastric adenocarcinoma or the patients with gastric adenocarcinoma to helicobacter pylori (Hp) infection.Methods:The SNPs of the IL-1B(-31C/T and -511C/T) were determined by gene chip and The VNTR of IL-1RN were determined by agrose gel electrophoresis with a total of 130 cases of gastric adenocarcinoma and 142 healthy controls.The sera concentrations of IgG,IgM and IgA of Hp antibodies were measured by ELISA in all cases and controls.Results:H.pylori infection was detected in 69.2% of 130 patients and 46.5% of 142 controls (P=0.007,odds ratio [OR]=2.53).Frequencies of IL-1B-31TT genotype in patients with gastric adenocarcinoma or in patients with pooly-differentiated gastric adenocarcinoma were significantly higher than those in healthy controls or in well-differentiated groups,(P

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Analysis of changes of the platelet count after splenectomy in patients with cirrhosis and portal hypertension

Hongliang ZU ; Weihui ZHANG ; Bing LIU ; Dongbo XUE ; Xiaochun WANG

Chinese Journal of Current Advances in General Surgery.2004;0(06):-.

Objective:To investigate the clinical significance of changes of platelet count after splenectomy in patients with cirrhosis and portal hypertension.Methods:In this study,from January 2002 to January 2006,the platelet count and liver function in 153 splenomegaly and hypersplenism due to cirrhosis patients who had been carried out splenectomy were selected.The change tendency of platelet count was observed,the relationship of changes of platelet count and liver function was analysed,and compared with patients of spleen trauma.Results:Postoperative platelet count was higher than preoperatively in most patients with cirrhosis,the portion did not elevate,even decreased.The change tendency of platelet count was correlated with the liver function.The change in cirrhosis patients is not more than patients of spleen trauma.Conclusions:The reason of thrombocytopenia in patients with cirrhosis may be correlated with the change of liver function besides the splenomegaly.

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The diagnostic value of plasma D-dimer as an early marker in acute mesenteric Ischemia

Xiangmin DING ; Linhai ZHU ; Xicheng ZHANG

Chinese Journal of Current Advances in General Surgery.2004;0(06):-.

Objective:In this study we evaluated the diagnostic value of plasma D-dimer level as an early indicator in acute mesenteric ischemia in rats.Methods:Forty-eight mature male Wistar rats were divided equally into experimental group (EG) and control group (CG),The superior mesenteric artery was ligated In EG,and while a simple laparotomy was performed in CG.Blood samples were taken for laboratory test in both groups at 1h、6h、12h respectively.Results:The longer the duration of mesenteric ischemia,the higher were the serum D-dimer levels in the study groups,and statistical significance was obtained between these two groups (P=0.0375).Otherwise,significant difference was not found in other laboratory parameters between them.Conclusions:Serum D-dimer dynamic measurements may be a important valuable screening parameter in the early diagnosis of mesenteric ischemia.

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The relationship between immunoregulatory cytokines and intrahepatic metastasis and recurrence in primary hepatocellular carcinoma

Mujian TENG ; Minghai WANG

Chinese Journal of Current Advances in General Surgery.2004;0(06):-.

Objective:To observe the expression of immunoregulatory cytokines including interleukin-4(IL-4,Th2)、 interferon-?(IFN-?,Th1)、interleukin-betal (IL-1?) in the tissues of hepatocellular carcinoma(HCC),and to investigate the relationship between the changes of immunoregulatory cytokines in patients with hepatocellular carcinoma and intrahepatic metastasis and recurrence.Methods:The immunoregulatory cytokines:IFN-?(Th1)、IL-4(Th2)、IL-1? were analyzed by RT-PCR.Results:34 cases with HCC were compared with the ones with liver cirrhosis,the expression rates and density of IFN-?(Th1) in the tissues of hepatocellular carcinoma were much lower than that in the liver cirrhosis,they are 0.92?0.36(18/34,53.9%) and 1.63?0.64(12/15,80.0%),respectively.There is significant difference between them (P

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Immunohistochemical study of the synaptophysin in hirschsprung’s disease

Xinhai CUI ; Yuli CHEN ; Lei ZHANG ; Tangshan ZHANG

Chinese Journal of Current Advances in General Surgery.2004;0(06):-.

Objective:To study the neuromuscular junction of the colon in patients with Hirschsprung’s disease by immunohistochemical methods.Methods:The distribution of the neuromuscular junction in the muscle layers of bowel from 10 normal controls and 20 Hirschsprung’s disease patients was studied by synaptophysin immunohistochemistry.Antimouse synaptophysin serum was used for visualization of neuromuscular junction.Results:In the colon of the control cases,synaptophysin-immunoreactivity was widely distributed in the circular muscle layer.In the dilated colon with Hirschsprung’s disease cases,synaptophysin-immunoreactivity was moderately distributed within normal ganglion cell and scarcely in constricted segment within degenerated ganglion cell.In contrast to the high degree of synaptophysin-immunoreactivity in the controls and dilated colon,the synaptophysin-immunoreactivity in the constricted segment were nil in the circular muscle layer.Conclutions:Dense synaptophysin-immunoreactivity nerve endings were prominent in the circular muscle layer in the control and there was almost no synaptophysin imm-unoreactivity activity in the circular muscle layer in the constricted segment.The circular muscle layer from the constricted segment is confirmed to be a region with poor innervation including extrinsic and intrinsic nerve. Based on the Cannon’s Law of Denervation,the muscles that are supplied by these nerves shorten and tighten,resulting in muscle spasm and stiffness.The constricted segment which was denervated,is incapable of transmitting normal propulsive peristaltic waves and therefore acts as a physiologic obstruction.

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The effect of rhGH on the apoptosis and expression of P53 in IgA plasmocytes of intestinal wall after intestinal ischemia-reperfusion injury of rats

Haibo LIU ; Shaochuan SUN ; Chunning ZHENG ; Yongsheng JIANG

Chinese Journal of Current Advances in General Surgery.2004;0(06):-.

Objective:To explore the effect of rhGH on apoptosis and the expression of P53 of IgA plasmocytes of intestinal wall after intestinal ischemia-reperfusion injury and the correlation between apoptosis and the expression of P53.Methods:60 Wistar rats were divided into two groups randomly:experiment group(1.33U/kg rhGH was given q.d) and control group.Each group was divided into 3 subgroups(2,4,6days,respectively).Apoptosis and the expression of P53 in IgA plasmocytes of ileal mucosal were observed.[WTH7X]Results:[WT5”XY](1)Apoptosis of IgA plasmocytes in experiment group was lower than that in control group on 2~ nd ,4~ th ,6~ th day and had statistical significance(P

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The correlation between expression of focal adhesion kinase and vascular endothelial growth factor in human rectal carcinoma

Jingyuan WANG ; Jianliang ZHANG

Chinese Journal of Current Advances in General Surgery.1998;0(01):-.

Objective: To detect the expression of focal adhesion kinase (FAK) and vascular endothelial growth factor (VEGF) in human rectal carcinoma, to study their correlation in invasion and metastasis. Methods: The expression of FAK and VEGF in 86 specimens resected from patients with rectal carcinoma and 30 non-rectal carcinoma specimens, was investigated by immunohistochemical SABC method respectively. Results: the positive rate of FAK, VEGF was 80 % and 59% respectively in rectal carcinoma. However, non-rectal carcinoma was 10% and 13 % respectively. The diference was significant (P

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The operative treatment of the true aneurysm in the initial splenic artery

Chunxi WANG ; Zhiquan DUAN ; Xiaoping LIU ; Qingbin SONG

Chinese Journal of Current Advances in General Surgery.1998;0(01):-.

Objetive: To investigate the operative method of the true aneurysm in the initial part of splenic artery, and to summary clinic therapeutic experiences. Methods: To summary the 7 patients who suffered from the initial splenic true aneurysm from 1996 to 2006, and which cases were identified by color ultrasound, CT scan and angiography. All splenic aneurysm were cut off including splenic artery revascularlization on 5 patients. Results: All patients were cured and discharged from hospital in the 10th-14th day, and which patients were followed-up for 1-9 years. 5 cases were healthy except one died of acute myocardiac infarction 2 years later post operation. Conclusion: To cut off the initial splenic true aneurysm and to revasculize splenic artery is a better operative method to cure this disease.

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