Journal Detail Information

1

Cite

Share

Fine needle aspiration cytology of thyroid and evaluation of its clinical application

Chinese Journal of Endocrinology and Metabolism.1985;0(02):-.

Thyroid fine needle aspiration biopsy, ultrasonographically guided thyroid fine needle puncture and the common cytologic pathological characterstics of various thyroid diseases are reviewed, and the clinical application is discussed.

2

Cite

Share

Hyperglycemia and hypokalemia with a pancreatic tumor

Yali AN ; Yao WANG

Chinese Journal of Endocrinology and Metabolism.1985;0(02):-.

A mid-aged male patient manifested hyperglycemia, severe hypokalemia, weight loss, thin skin, round face and psychoneurotic symptoms without hypertension. CT showed a pancreatic tumor and a normal pituitary image. Preliminary assessment (blood and urinary cortisol, blood ACTH and dexamethasone suppression test) supported the diagnosis of ectopic ACTH syndrome. The differential diagnosis and treatment of this disease were discussed.

3

Cite

Share

The role of insulin in Alzheimer′s disease

Qinchuan ZHANG ; Quan YUAN ; Shuimiao LIN

Chinese Journal of Endocrinology and Metabolism.1985;0(02):-.

Many investigations showed that abnormal blood insulin level is associated with the pathogenesis of Alzheimer′s disease and its clinical manifestation, suggesting that increasing blood insulin level and/or improving insulin sensitivity seem to be helpful for patients with Alzheimer′s disease.

4

Cite

Share

One case of Cushing′s syndrome due to primary pigmented nodular adrenocortical disease

Ying CHEN ; Yanyun GU ; Xinmin XU ; Yu ZHU ; Jiacheng XIAO ; Xiaolong JIN ; Renming HU ; Guang NING

Chinese Journal of Endocrinology and Metabolism.1985;0(02):-.

5

Cite

Share

Changes of glucose transporter 2 in rat livers under different status of thyroid function

Jian XU ; Hanhua LIN

Chinese Journal of Endocrinology and Metabolism.1985;0(02):-.

Models of hyperthyroidism and hypothyroidism were prepared in Wistar rats by levothyroxine and tapazole respectively. The levels of blood glucose, insulin and glucose transporter 2 (GLUT2) of hepatocytic membrane were higher in mild and severe hyperthyroid rats than those in control rats (P

6

Cite

Share

Improvement of leptin and insulin sensitivity due to early nutritional intervention in rats born with intrauterine growth retardation

Xiaoshan QIU ; Zhengyu SHEN ; Tingting HUANG ; Zhiyong KE

Chinese Journal of Endocrinology and Metabolism.1985;0(02):-.

Objective To look for an appropriate dietary pattern of early nutritional intervention, which does not only meet the need of catch-up growth but also avoids or reduces the incidence of insulin resistance (IR) in adulthood of rats born with intrauterine growth retardation (IUGR). Methods The model of IUGR in rats was established by maternal nutrition restriction. Sixty newborn female rats with IUGR were randomly divided into 5 groups: (1) IUGR control group fed with common diet. (2) IUGR high-carbohydrate diet group. (3) IUGR high-fat diet group. (4) IUGR high-protein diet group. (5) IUGR low-protein diet group. The IUGR newborn rats were breast-fed for 3 weeks, while the mother rats were fed with the above different diets with the same caloric amount. Twelve normal newborn female rats served as a normal control group and were fed with common diet. All newborn rats were fed routine diet starting from the 4th week of experiment. The body weight, perirenal fat weight and the serum leptin, blood glucose, insulin concentration were measured and the insulin sensitive index (ISI) were calculated at the 4th week and the 12th week of life. Results The IUGR rats fed with high-protein diet showed a catch-up growth without the increase of perirenal fat at the 4th week, a normal level of perirenal fat, leptin and ISI at the 12th week compared with the normal control group, and did not show IR. The groups fed with high carbohydrate diet and high fat diet also showed a catch-up growth, but did the same as the IUGR control group in other aspects, they all showed increased perirenal fat, higher levels of leptin, lower ISI and IR at adulthood. The group fed with low protein diet did not show IR, but kept a small body size with increased perirenal fats. The serum leptin level of rats was positively correlated to body weight at the 4th week of life and was positively correlated to the weight of perirenal fat and negatively correlated to ISI at the 12th week of life. Conclusion High protein diet is an appropriate early nutritional intervention for rats with IUGR. The serum leptin level at the 12th week of life seems to be an index of IR in adult rats with IUGR.

7

Cite

Share

In vitro effects of calcitonin on osteoclasts

Xiuzhen ZHANG ; Junfeng HAN ; Guofeng QIAN

Chinese Journal of Endocrinology and Metabolism.1985;0(02):-.

Objective To observe the effects of calcitonin on osteoclast activity and expressions of osteoprotegrin (OPG) and receptor activator of NF-?B ligand (RANKL) in vitro. Methods Osteoclasts and their precursors were mechanically isolated from long bones of SD rats and incubated on bone sheet in MEM with different concentration of calcitonin. Number, morphology of the osteoclasts were detected with tartrate-resistance acid phosphatase (TRAP) staining. Image-Pro Plus counted the resorption pits and areas on slices, stained by toludine blue. RT-PCR was used to examine the expressions of OPG and RANKL of osteoclast. Results Number of osteoclasts were decreased with increasing CT concentrations. After incubation for 5 days, resorption pits were decreased in a concentration-dependent manner (P

8

Cite

Share

Effect of estrogen on experimental autoimmune thyroiditis in Wistar rats

Xiaoqin GUO ; Enjiang TIAN ; Jiali ZHANG ; Shujun ZHAO ; Jinlong WANG

Chinese Journal of Endocrinology and Metabolism.1985;0(02):-.

Objective To observe the effects of estradiol-17? (E 2-17?) on the induction of experimental autoimmune thyroiditis (EAT). Methods Ten-week old female Wistar rats were ovariectomized (OVX). EAT of Wistar rats was induced by immunization with thyroglobulin (Tg) from SD rats in the presence of complete Freund′s adjuvant. Thyroiditis was pathologically evaluated by HE staining. E 2-17? and PRL levels were measured by RIA, anti-Tg antibody (TgAb) was detected by ELISA, and interferon (IFN)-?, interleukin (IL)-10 mRNA in thyroid were assayed by RT-PCR. Results The serum level of E 2-17? (17.60?1.02)pmol/L and PRL (2.45?0.15)?g/L were much lower in OVX rats than intact rats 〔(58.56?6.99)pmol/L and (3.22?0.17)?g/L, respectively〕 (both P

9

Cite

Share

Association of polymorphisms of estrogen receptor-? and vitamin D receptor genes with peak bone mass in Shanghai women

Jinwei HE ; Qiren HUANG ; Zhenlin ZHANG ; Yuejuan QIN ; Jinhui LU ; Miao LI ; Qi ZHOU ; Yunqiu HU ; Yujuan LIU ; Hao ZHANG

Chinese Journal of Endocrinology and Metabolism.1985;0(02):-.

Objective To investigate the association of estrogen receptor-? (ER-?) and vitamin D receptor (VDR) gene polymorphisms with peak bone mass in Shanghai women. Methods The ER-? PvuⅡ and XbaⅠ genotypes and VDR ApaⅠ genotypes were determined by PCR-RFLP in 515 unrelated healthy women aged 19-40 years of Han nationality in Shanghai. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. Results Frequencies of ER-? PvuⅡ genotype PP, Pp and pp were 13.2%, 49.3% and 37.5% respectively. Frequencies of ER-? XbaⅠ genotype XX, Xx and xx were 4.7%, 40.4% and 54.9% respectively. Frequencies of VDR ApaⅠ genotype AA, Aa and aa were 5.8%, 41.9% and 52.3% respectively. Hardy-Weinberg equilibrium was evident for both ER-? and VDR gene polymorphisms. No association was found between ER-? PvuⅡ and XbaⅠ genotypes and BMD of various sites in women. Only a significant association was found between VDR ApaⅠ genotype and BMD at L 1-4(P

10

Cite

Share

Changes of bone mineral density, bone metabolism indices and Vitamin D receptor content in patients with hyperthyroidism

Xiaoping LIANG ; Jinli WEN ; Wenying ZHOU ; Ziru ZHONG ; Yaying ZHOU

Chinese Journal of Endocrinology and Metabolism.1985;0(02):-.

Bone mineral density (BMD) of lumbar spines, femoral neck, Ward′s triangle and greater trochanter was lowered, serum calcium, phosphate, alkaline phosphatase and bone Gla-protein levels were raised, and vitamin D receptor (VDR) contents in lymphocyte was lowered in hyperthyroid patients. Both FT 3 and FT 4 were negatively correlated with BMD, suggesting that hyperthyroidism results in high-turnover type of bone loss which causes the abnormalities of bone metabolic indices and VDR content.

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share