Journal Detail Information

1

Cite

Share

Risk factor analysis for osteoporosis in aged people in Beicai Town of Shanghai

Junling MA ; Xiaodong YANG ; Haiying GUO ; Wenzhen JIANG ; Yaohua SUN ; Qinwu HOU ; Yong SHI ; Li SHI ; Yan ZHANG ; Minghua HE ; Zhengnan GU ; Shuxian HUANG

Chinese Journal of Geriatrics.2010;29(10):870-873. doi:10.3760/cma.j.issn.0254-9026.2010.10.026

Objective To investigate the risk factors for osteoporosis (OP) in aged people at Beicai Town in Shanghai, to provide proofs for preventing OP. Methods Questionnaire survey was carried out on bone density in 608 aged people (aged from 60 to 79 years) who were randomly chosen from 4 resident committees of Beicai Town in Shanghai. Everyone underwent bone mineral density (BMD) assay of lumbar spine and total hip by DEXA machine. Results The rate of OP was 23 % in male group, and 61% in female group. It was 40% in 60-64 years old group, 44% in 65-69 years old group, 53% in 70-74 years old group and 66% in 75-79 years old group. The rate of OP was 52% in manual work group, and 42 % in non-manual work group. In males, it was 54 % in current weight less than 60 kg group, 19% in 60-70 kg group, 15% in 70-80 kg group and 23% in over 80 kg group. In females, it was 76% in current weight less than 50 kg group, 67% in 50-60 kg group, 63% in 60-70kg group, 30% in over 70 kg group. It was 56% in low body weight group, 41% in normal weight group and 58% in over weight group in their 25-year-old. It was 61% in normal body weight group, 43% in overweight group. It was 41% in non-fracture history group, 67% in once fracture group,74% in fracture history more than twice group. It was 60% in mother humpback history group, and 47% in no history of mother humpback group. Logistic regression analysis showed that gender, age,history of fracture, mother's humpbacked history, disease of internal secretion and metabolism system were the risk factors for OP. Conclusions The occurrence of OP is related with many factors in aged people at Beicai Town in Shanghai, especially for the aged women, who suffer from diseases of internal secretion and metabolism, and has the history of fracture and mother's humpbacked, the attention should be payed to the prevention and treatment of OP.

2

Cite

Share

Evaluation of quality of life in patients aged 70 years and over following off-pump coronary artery bypass grafting

Tiefu ZHAO ; Shengyu WANG ; Qiwen ZHOU ; Hanying MA

Chinese Journal of Geriatrics.2010;29(10):818-820. doi:10.3760/cma.j.issn.0254-9026.2010.10.008

Objective To evaluate the quality of life status in patients aged 70 years and over following off-pump coronary artery bypass (OPCAB) grafting. Methods Seventy-eight patients with coronary heart disease [mean age (74.6 ± 5.3) years, 66 males, 12 females] were investigated retrospectively. Three questionnaires about the quality of life, including Seattle Angina Questionnaire (SAQ), Nottingham Healthy Profile (Part Ⅰ NHP) and Duke Activity Status Index (DASD, were used to investigate patients before and after OPCAB. Results Prior to OPCAB, there was lower quality of life index in males than in females [SAQ: (65.3±5.1) vs. (69.5±8.1); NHP: (89.4±17.3) vs. (125.2±19.9), P＜0.01; DASI: (4. 1±1.1) vs. (4.3± 1.3)]. At the 12th months after OPCABG, there were significant improvements in all patients. The effects were less pronounced in females than in males [SAQ: (83.1 ±5.8) vs. (88.5±4.5), P＜0.05; NHP: (84.7± 11.7) vs.(91.4±13.7), P＜0.05; DASI: (4.7±1.4) vs. (5.4±1.1)]. Conclusions Our study shows that OPCAB improves quality of life in elderly patients with coronary heart disease. The benefits of OPCAB are even more pronounced in male patients.

3

Cite

Share

Activation and its influence of nuclear factor-κB in peripheral blood mononuclear cells in elderly patients with obstructive sleep apnea-hypopnea syndrome

Shaohua LUO ; Xinglin GAO ; Dongfeng LI ; Jian WU ; Qi LIN ; Qiong OU ; Yunxiong LI ; Ruijin CEN ; Xiaoxia YANG

Chinese Journal of Geriatrics.2010;29(10):807-810. doi:10.3760/cma.j.issn.0254-9026.2010.10.005

Objective To evaluate the influence of nuclear factor (NF)-κB activation in peripheral blood mononuclear cells (PBMCs) on vascular inflammation in elderly patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods The 40 elderly subjects (≥65years old) were classed into control, mild, moderate and severe groups (n = 10, respectively)according to polysomnography (PSG). After PSG, the samples of peripheral venous blood were collected, and PBMCs were isolated. Nuclear protein was extracted and NF-κB was measured by Western blotting. ELISA was applied to measure the levels of TNF-α and IL-6 in serum. Blood samples from 10 cases (moderate 5 and severe 5) were measured again after four weeks of continuous positive airway pressure (CPAP) treatment. Results The expression of NF-κB in PBMCs and the concentration of TNF-α in serum were significantly increased in severe and moderate OSAHS patients compared with controls (P＜0. 05). The NF-κB expression was positively correlated with AHI (r=0. 617, P＜ 0. 001) and TNF-α concentration (r = 0. 498, P＜ 0. 001 ), negatively correlated with LSaO2 (r= -0. 548, P＜0. 001), and not correlated with IL-6 concentration (r=0. 365, P=0. 201).The CPAP treatment could significantly inhibit NF-κB activation in PBMCs and reduce TNF-αexcretion (P＜0.05, respectively). Conclusions PBMCs may play an important role in vascular endothelial injury through NF-κB expression and TNF-α excretion in elderly OSAHS patients, which is closely associated with the severity of the syndrome and night hypoxemia. CPAP treatment can inhibit the pathophysiologic process effectively.

4

Cite

Share

Monitoring results and correlation analysis of polysomnography in 110 cases of elderly patients with obstructive sleep apnea-hypopnea syndrome

Chuan SHAO ; Wenjing LI ; Shanqun LI ; Xiaodan WU ; Jing ZHOU ; Shenyuan LU ; Shanfu NIU ; Chunxue BAI

Chinese Journal of Geriatrics.2010;29(10):803-806. doi:10.3760/cma.j.issn.0254-9026.2010.10.004

Objective To improve the understanding of the characteristics of obstructive sleep apnea-hypopnea syndrome (OSAHS) in the elderly patients, and to improve the diagnosis and treatment level. Methods Monitoring results of polysomnography (PSG) from 110 elderly OSAHS patients were analyzed retrospectively. The general conditions, sleep architecture, apnea and hypopnea events, oxygen reduction as well as possible correlations between various indicators were analyzed using SPSS18.0 statistical software. Results The median rapid eye movement (REM) and non-REM (NREM) sleep time of elderly patients with OSAHS accounted for 2. 17% and 76.73%,respectively. The median arousal index was 45.6 times/h. The longest time of sleep apnea was (51.94±22.06) s, the median of average sleep apnea time was 22.50 s, the longest time of hypopnea was (47.06±12.52) s and the average hypopnca time was (21.50±4.63) s. The median respiratory disturbance index (RDI) of all patients was 21.50, the patients with RDI between 5 and 20 accounted for 46.40%, with RDI between 20 and 40 accounted for 31.80% and with RDI over 40 accounted for 21.8%. The average oxygen saturation accounted for (93.45% ± 2.81%), the lowest oxygen saturation accounted for (76.3%± 10. 5%) and the median oxygen desaturation index was 31.6;times/h. BMI was negatively correlated with lowest oxygen saturation (r=-0. 378, P＜0.01) and average oxygen saturation ( r = - 0. 355, P ＜ 0. 01 ), while was positively correlated with oxygen desaturation index (r=0. 338, P＜0. 01 ). The lowest oxygen saturation was negatively correlated with the longest time of obstructive apnea (r= -0. 47, P＜0. 01 ), the average time of obstructive apnea (r=-0.316, P＜0.01), the longest time of hypopnea (r=-0.293, P＜0.01) and the average time of hypopnea (r=-0. 277, P＜0.01). The median time intervals of oxygen desaturation during supine, left side and right side position were 2.36 min, 11.54 min and 12.45 min,respectively. The median time intervals of oxygen desaturation during left side and right side position were both longer than that of supine position (Z= -6.12 and -7. 10 respectively, both P＜0.01).Conclusions Elderly patients with OSAHS manifest obvious disorder of sleep structural and sleep fragmentation. According to RDI, the majority of the patients are classified as mild to moderate in severity. However, elderly patients with OSAHS are severe regarding to hypoxia relatively. The severity of hypoxia is related with BMI and the lasting time of sleep-disordered breathing events, and hypoxia are less severe when sleeping on left side or on right side.

5

Cite

Share

Prevalence and its impacting factors of non-motor symptoms in Parkinson's disease

Jin ZHENG ; Shenggang SUN ; Xian QIAO

Chinese Journal of Geriatrics.2010;29(10):796-799. doi:10.3760/cma.j.issn.0254-9026.2010.10.002

Objective To explore the incidence rate, total incidence numbers and possible impacting factors of non-motor symptoms (NMSs) in Parkinson's disease (PD). Methods The NMS questionnaire (NMS Quest) was used to investigate 131 out-patients diagnosed with PD, and the prevalence of each item, the total NMS numbers and their relationships with clinical features were assessed. Results All of the patients, who were distributed in every stage of PD, had NMSs and each case with 11 items on average. Autonomic symptoms such as nocturia and constipation were the most frequent ones. The patients over 65 versus less than 65 years old had a higher prevalence in a number of items such as olfactory disturbance, dysphagia and constipation. At the same time, the rigidity subtype patients had a higher prevalence in depression items than the tremor subtype ones.The total number of NMS was positively correlated with course of disease, age, UPDRS score and Hoehn & Yahr (H&Y) stage. Conclusions NMSs are common among PD patients. While the prevalence of each item may vary with different clinical features, the total number of NMS is increased with the severity of PD. More attention should be paid to the diagnosis and rational treatment of the NMSs.

6

Cite

Share

Correlation analysis between physical fatigue and motor function in patients with Parkinson's disease

Lei GAO ; Xia GAO ; Yuming LI

Chinese Journal of Geriatrics.2010;29(10):800-802. doi:10.3760/cma.j.issn.0254-9026.2010.10.003

Objective To observe the correlation between physical fatigue and motor function in patients with Parkinson's disease (PD). Methods The 36 patients (12 females, 22 males) with PD were elected from PD clinic in Beijing Hospital, and 18 health controls of age and gender matching were enrolled. The Parkinson Fatigue Scale (PFS), the timed get up and go test and the six-minute walk test were used to evaluate the disease progress, physical fatigue and motor function. The correlation between PFS score and motor function was analyzed. Results There were significant differences between patients with PD and healthy controls in PFS score, get up and Go performance time and the max six-minute walk distance (P＜0.05). In patients with PD, the PFS score was positively correlated with get up and go performance time (r= 0.82, P＜0. 01 ), and was negatively correlated with distance of six-minute walk (r= -0. 61, P＜0. 01). Conclusions Patients with PD show more fatigability and decreased motor function compared with healthy people of age and gender matching; The severity of physical fatigue symptom of patients with PD shows positive correlation with get up and go performance time, and negative correlation with the distance of six-minute walk.

7

Cite

Share

Epidemiological analysis of elderly cases with the 2009 influenza A (H1N1) in Beijing

Xinyu LI ; Yang LI ; Xin ZHAO ; Quanyi WANG ; Peng YANG ; Ting GAO ; Ying DENG ; Xinghuo PANG

Chinese Journal of Geriatrics.2010;29(10):866-869. doi:10.3760/cma.j.issn.0254-9026.2010.10.025

Objective To analyze epidemiological characteristics of elderly cases with influenza A (H1N1) in Beijing. Methods Descriptive epidemiological methods were used to describe epidemiological characteristics of elderly cases with 2009 influenza A (H1N1) in Beijing. Results The 321 laboratory-confirmed elderly cases with influenza A (H1N1) were reported in Beijing, and the morbidity was 13.2/100 000. The peak of infection occurred during November and December, the cases in this period accounted for 84.7% of the whole year, and 53.0% of them were reported in suburb areas, with the highest morbidity (19.2/100 000) in people beyond 85 years, and the morbidity increased with age (x2 = 7.24, P＜0.01). The mild cases accounted for 63.6 %, severe and critical cases accounted for 36.4%. No significant difference was found between severity and BMI (x2=8.14, P=0.52). Severity was associated with number of chronic diseases (x2= 123.0, P＜0. 01). Conclusions The H1N1 morbidity and proportion of severe cases are high among the elderly in Beijing, more attention should be paid to this population for influenza A (H1N1) prevention and control.

8

Cite

Share

Effects of pulmonary stromal cells supernatant on differentiation of mature dendritic cells

Huanxing LIU ; Qin ZHAO ; Wengang SONG ; Wenwen WANG

Chinese Journal of Geriatrics.2010;29(10):854-857. doi:10.3760/cma.j.issn.0254-9026.2010.10.021

Objective To observe the effects of lung stromal cells on differentiation of mature dendritic cells (mDCs) deriving from mouse bone marrow. Methods The mDCs were cultured by complete medium, half of which was from the lung stromal cell cultures. One week later, the mDCs were induced into regulatory dendritic cells (rDCs). The morphological characteristics of rDCs were observed by Giemasa-Wright stain. The content of cytokines (IL-10 and IL-12p70) in the co-culture supernatants was detected by enzyme-linked immunosorbent assay. The expression level of cellular phenotype was tested with fluorescence-activated cell sorting, compared with mDCs. The difference of rDCs and mDCs was observed. Results Compared with mDCs, rDCs secreted higher level of IL-10 (P＜0.01), and lower level of IL-12p70 (P＜0. 01). In cellular phenotype, the expression of CD11b on rDCs increased (P＜0.01), while the expression of CDllc, Ⅰa and CD86 declined (P＜0.01).Conclusions Lung stromal cells microenvironment may induce the mDCs differentiate into a kind of DC with different biological characteristics.

9

Cite

Share

Encoscopic retrograde cholangiopancreatography treatment of acute severe cholangitis in patients aged 80 years and over

Songmei LOU ; Xiaofeng ZHANG ; Xiao ZHANG

Chinese Journal of Geriatrics.2010;29(10):823-825. doi:10.3760/cma.j.issn.0254-9026.2010.10.010

Objective To explore the therapeutic effect and safety of endoscopic retrograde cholangiopancreatography (ERCP) in the management of acute severe cholangitis (ASC) in patients older than eighty. Methods The clinical data of 106 patients aged 80 years and over with ASC who underwent ERCP were reviewed. Results Among 106 cases, there were 95 patients with common bile duct (CBD) stones, and 11 patients with biliary tract neoplasms. The 11 cases with biliary tract neoplasms underwent endoscopic nasobiliary drainage (ENBD) to correct critical situation. After stabilization, surgical treatment or stent placement was performed. The 61 of 95 cases with CBD stones underwent ENBD in critical phase and endoscopic sphincterotomy (EST) plus stone removal for subsequent treatment after stabilization. The 34 of 95 cases with CBD stones underwent EST to remove stones. Procedure-related complications were found in 5 patients. At 24 and 72 hours postoperation, the values of white blood cell count, serum total bilirubin, body temperature, and occurrence rate of patients with shock and mental symptoms were decreased in the other 101 patients.Conclusions For patients aged 80 years and over with ASC, ERCP is a safe and effective procedure.

10

Cite

Share

Event-based and time-based prospective memory impairment in patients with Parkinson's disease

Jianjun MA ; Xue LI ; Yan FENG ; Lipin YUAN ; Hongqi YANG ; Jun XU

Chinese Journal of Geriatrics.2010;29(10):793-795. doi:10.3760/cma.j.issn.0254-9026.2010.10.001

Objective To explore the characteristics of event-based prospective memory (EBPM) and time-based prospective memory (TBPM) impairments in patients with Parkinson's disease (PD). Methods EBPM and TBPM were examined in 87 PD patients and 85 healthy controls. And both of them were divided into two groups: aged group (≥60 years old) and non-aged group (＜60 years old). Results (1) The scores of EBPM were significantly lower in aged PD patients and non-aged PD patients than in age-matched control groups [(2. 5±0. 4) vs. (5.8± 1.3),(3.9±2.4) vs. (6.3±1.5), both P＜0. 01]. There were no significant differences in the scores of EBPM between aged PD patients or non-aged PD patients and their age-matched control groups [(3.6±0.5) vs. (3.8±0.8), (4.8±0.9) vs. (4.9±0.9), both P＞0.05]. (2)The Hoehn-Yahr grade in PD patients was significantly correlated with scores of EBPM, but not with scores of TBPM.Conclusions The patients with PD have an impairment in EBPM, but not in TBPM. The impairment of EBPM may be related to the disease severity of PD.

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share