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Chinese Journal of Geriatrics.2003;0(09):-.

Objective To study the age-related changes of rat bone histomorphometry and its correlation to other parameters of bone metabolism. Methods Ten female SD rats at the age of 3 months old,9 months old and 15 months old were labeled with tetracycline(30 mg/kg) via abdomen on fourteen and four days before executing. Histomorphometry were performed on L4 and right tibiae. Physical density of left femur and L2 were measured. Anti-compression property of L3 was assayed. Serum levels of calcium and phosphorus and 1,25(OH)_ 2 D_ 3 were determined. Results Compared with the 3-month-old rats,the trabecular bone volume(TBV) of L4 and right tibiae decreased 43.3%( P

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Effects of inosine on the apoptosis and the expression of cytochrome C mRNA in neurons after cerebral ischemia and reperfusion in rats

Hong ZHANG ; Yue WANG ; Weiwei GONG ; Guolan SUN ; Yunliang GUO

Chinese Journal of Geriatrics.2003;0(09):-.

Objective To investigate the effects of inosine on the neuronal apoptosis and the expression of cytochrome C mRNA after focal cerebral ischemia and reperfusion in rats,and to explore the neuroprotective mechanisms of inosine. Methods SD rats model of focal ischemic reperfusion was induced by intraluminal middle cerebral artery occlusion (MCAO) with a nylon monofilament suture. Inosine (100 mg/kg) was injected intraperitoneally twice following MCAO. Apoptosis was determined by terminal deoxynucleotidy1 transferase-mediated uridine 5'-triphosphate-biotin nick end -labeling (TUNEL) staining. In situ hybridization was performed to examine the expression of cytochrome C mRNA. Results TUNEL-positive cells were observed 2 h after reperfusion and peaked at 1 d and 2 d after reperfusion in cortex and striatum respectively. Inosine reduced the number of TUNEL-positive cells at and after reperfusion 12 h. Cytochrome C mRNA expressed in cortex and striatum of ischemic hemisphere as early as at 2 h after reperfusion and reached a peak at 12 h and 1 d in cortex and striatum respectively. Inosine could diminish the expression of cytochrome C mRNA at and after reperfusion 12 h. Conclusions Inosine might play a neuroprotective role by inhibiting the neuronal apoptosis and the expression of cytochrome C mRNA which were induced by cerebral ischemia reperfusion injury.

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A study on clinical characters of implant-supported denture in elderly patients with dentition defect

Wenbin LIU ; Wanling XIAO ; Yiying ZHANG ; Yongyu DAI ; Haisong WU ; Jingyan GAO

Chinese Journal of Geriatrics.2003;0(09):-.

0.05). The bone graft rate was 13% in senile group and 9% in non-senile group( P

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The analysis and management of postmenopausal bleeding among aged women

Qiubo LU ; Guihua SHEN ; Qin WU

Chinese Journal of Geriatrics.2003;0(09):-.

20 IU/ml) as predictor was 40.0% and 75.4% respectively. Conclusions The incidence of malignant neoplasm among postmenopausal bleeding women aged 60 and over is 24.2%,ultrasonographic evaluation and CA125 value are reliable and important for diagnosis accurately. Large operation is safe and feasible in aged women.

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Clinical study on the onset of systemic lupus erythematosus in 20 postmenopausal patients

Xiangyuan LIU ; Xiaoqing YANG ; Shengguang LI ; Jian ZHU

Chinese Journal of Geriatrics.2003;0(09):-.

Objective To study the clinical characteristics of the onset of systemic lupus erythematosus(SLE) in postmenopausal patients. Methods The clinical features and prognosis of 20 SLE patients whose onset was at least one year after menopause,and 70 patients with the onset during normal menstruation and 43 male patients between 1992 and 2003 were comparatively analyzed. Results The onset of SLE was seen after menopause in 20 out of 699 (2.9%) female patients. The average age at the onset of the disease was 55 years with a peak from 50 to 59. The common clinical manifestations were arthritis,lassitude,fever,alopecia,malar rash,cardiac impairment and weight loss,while laboratory abnormalities were high ESR,decreased C3,ANA≥1∶80,hypergammaglobulinemia and positive anti-RNP antibody. As compared with normal menstruation onset group,the postmenopausal onset group was more likely to have weight loss( P

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Operative treatment for the elderly patients with pituitary adenomas

Shiqi LI ; Yongfei WANG ; Yao ZHAO ; Xuefei SHOU

Chinese Journal of Geriatrics.2003;0(09):-.

Objective To evaluate the overall effectiveness of microsurgery for elderly pituitary adenomas,and to select the optimal surgical approaches for this type of tumor. Methods Microsurgical operation was performed on 190 patients with elderly pituitary ademomas,and these patients were retrospectively analysed. The 190 cases were divided into transsphenoidal group and transcranial group with a comparison analysis of respective removal percentage,postoperative complication and follow-up. Results In the transsphenoidal group with 158 cases,total removal were performed in 112 cases (71.0%),subtotal removal in 30 cases,partial removal in 16 cases. In the transcranial group with 32 cases,total removal were performed in 8 cases (25.0%),subtotal removal in 16 cases,partial removal in 8 cases. Conclusions Transsphenoidal approach was characterized by shorter hospitalization period,less therapeutic charges and better postoperative quality of life and it should be of choice for the treatment of the elderly pituitary adenomas.

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Radiology image features of the elderly patients with spinal tuberculosis

Wei LI ; Zhuyong LI

Chinese Journal of Geriatrics.2003;0(09):-.

Objective To analyze features of radiology images for elderly spinal tuberculosis. Methods All 26 elderly patients with spinal tuberculosis were examined with X-ray plain film,9 patients were examined by CT,6 by MRI,other 11 by both CT and MRI. The image manifestations were compared with that of 30 non-elderly patients with spinal tuberculosis. Results All of elderly cases showed bone destruction and intervertebral space narrowing on plain film,16 out of 20 cases examined by CT showed paraspinal abscess and 5 cases showed high density intraosseous sequestrum;among 17 by MRI examination,3 showed significant paraspinal abscess and 11 showed small abscess. Conclusions The diagnosis for spinal tuberculosis often remains elusive because of the indolent nature in the elderly patients. It is hard to differentiate it from other lesions such as vertebral metastasis. The following manifestations are helpful for spinal tuberculosis diagnosis: the location of vertebral body destruction adjacent to the end plate,involvement of the adjacent intervertebral disk or verbebral body resulting from penetration through the disk itself or spread of infection beneath the anterior longitudinal or posterior longitudinal ligament.

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Poor prognosis associated with vascular endothelial growth factor(VEGF) and platelet drived endothelial cell growth factor(PD-ECGF) expression in aged patients with gastric carcinoma

Fuxin LUAN ; Mengwei WANG ; Guo YU ; Yali LV ; Mei ZHONG

Chinese Journal of Geriatrics.2003;0(09):-.

Objective To investigate the expression of vascular endothelial growth factor (VEGF) and platelet drived endothelial cell growth factor (PD-ECGF) and their influence on the clinicopathological characteristics and the prognosis in aged patients with gastric carcinoma. Methods The expression of VEGF and PD-ECGF were examined with immnunohistochemical technique through preoperative biopsied specimens in 92 cases. Results The expression of VEGF and PD-ECGF were significantly higher in gastric carinoma than in chronic atrophic gastritis. VEGF and PD-ECGF levels in advanced carcinoma were higher compared with early carcinoma( P

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The clinical study of myasthenia gravis in 232 elderly patients

Shunlun WAN ; Hongyan WANG ; Zhiqiang CONG

Chinese Journal of Geriatrics.2003;0(09):-.

Objective To investigate the clinical features of myasthenia gravis (MG) in elderly people. Methods Elderly patients among all MG patients observed from February 1977 to February 2003 were respectively reviewed. Results Of 3010 MG patients,232(7.7%) were identified with the onset of the disease after or at the age of 60,and males were more than females with the ratio of 1.3∶1. The first and most commonly seen symptom in the elderly people after MG onset were ocular manifestation,occurring in 79.3%. Bulbar symptoms(12.9%) such as dysarthria and swallowing difficulties were the following symptoms. The systemic form (62.9%) were significantly more than ocular form (37.1%). There were less MG patients with autoimmunity diseases such as thyroid diseases associated with MG than that with the other senile diseases,and the myasthenia crisis were even less in the elderly patients with MG. However,it was found that more MG patients with thymoma than with other thymus abnormality. Conclusions The elderly MG patients had its distinctive clinical features. It is beneficial for diagnosing and treating the MG patients in the elderly people by understanding these clinical features.

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Experiment study on anti-nonenzyme glycosylation effect of Grape Seed Proanthocyanidin Extract in Diabetic Rats

Yan ZHOU ; Yabing MA ; Haiqing GAO ; Mei CHENG ; Beian YOU

Chinese Journal of Geriatrics.2001;0(01):-.

0.05) during the experiment. The TC of middle dose GSPE group was marked ly different compared with that of normal group(P

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