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Protective effects of Tanshinone IIA against interleukin-1 beta induced obstruction of energy metabolism of rabbit annulus fibrosus cells in vitro

Yong CHEN ; Shuhua YANG ; Qichuan ZHANG ; Jianguo ZHOU ; Jijun HUANG ; Liming XIONG

Orthopedic Journal of China.2009;17(21):1657-1661.

[Objective]To investigate the protective effect of Tanshinone IIA (TSⅡA) against interleukin-1β (IL-1β) induced obstruction of energy metabolism of rabbit annulus fibrosus cell in vitro.[Methods]Rabbit annulus fibrosus (AF) cells were cultured in 3-dimension alginate beads and randomly divided into 7 groups. Various concentrations of TSⅡA and IL-1β was added to the medium for intervention: no drug was added in group A as normal control, 4 μg/ml TSⅡA in group B, 10 μg/ml IL-1β in group C, and both 10 μg/ml IL-1β and different concentrations of TSⅡA in groups D-G (0.5 μg/ml, 1 μg/ml, 2 μg/ml and 4 μg/ml respectively). After 3 days of incubation, the cells were collected for measuring the activity of Na+-K+-ATPase and succinate dehydrogenase (SDH), MTT assay for cell proliferation, and AnnexinⅤ-PI staining for cell apoptosis.[Results]The activity of Na+-K+-ATPase of group G (10 μg/ml IL-1β+4μg/ml TS IIA; 3.23±0.28 U/mgprot) was increased significantly as compared with group C (10 μg/ml IL-1β; 1.118±0.15 U/mgprot, P＜0.01). The activity of SDH of group G was 12.48±0.97 U/mgprot, which was obviously higher than that of group C (3.03±0.60 U/mgprot, P＜0.01). The absorbance of MTT assay of group G (0.77±0.06) was significantly increased as compared with group C (0.31±0.07,P＜0.01). The absorbance of groups D-G increased as the concentration of TSⅡA increased. The apoptotic cell rate and dead cell rate of group G was 21.08±1.46% and 8.99±0.33%, which were both lower than that of group C (43.11±2.7,P＜0.01 and 11.71±0.32,P＜0.01).[Conclusion]TSⅡA is able to promote cell proliferation and decrease cell apoptosis of AF by alleviating IL-1β induced inhibition on cell energy metabolism.

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The study of multi- functional instrument based on micro- computer for treatment of disabled body

Wen LU ; Fengtan HAN ; Yulai LU

Orthopedic Journal of China.2005;13(15):1187-1188.

Intelligentized muti-functional limb treatment and rehabilitation based on micro-computer is introduced in this paper. It is mainly used for rehabilitation in the disablement of limb. The range speed and training time can be automatically controlled. Training parameter and result can be monitored on computer. The apparatus has the advantages of high reliability, easy operation and compact design. It is a new kind of intelligent limb rehabilitation.

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Surgical treatment of arachnoid cysts in sacral canal:analysis of 23 cases

Huiren TAO ; Xinkui LI ; Mingquan LI ; Quanping WANG

Orthopedic Journal of China.2004;12(13):965-968.

Objective: To study characteristics of diagnosis and treatment of arachnoid cysts in the sacral canal. Method: After laminectomy of the sacral canal, arachnoid cysts were treated in three ways: 13 cases underwent excision of the most of the cyst wall and suture of redundant wall around the intracystic nerve; 8 cases underwent the excision of the most of the cyst wall and plugging the communicating hole with a block of muscle; 2 cases underwent excision of most of the cyst wall and leaving them unsutured. Clinical results were evaluated after 30. 2 months' follow-up. Changes in the imaging materials (X-ray, CT, CTM and MRI) were also evaluated. The clinical behaviors, pathologies and complications post-operatively were analyzed. Result: Long T1 and T2 signals of the cysts could be clearly showed in MRI, and the signal density was the same as that of cerebrospinal fluid. Clinical symptoms were caused by compression of sacral nerve. Generally, there were communicating holes between cysts and thecal sacs. There were no statistical differences between first two methods of treatments. The complications post-operatively included erosion of wound skin and intracranial infection. Conclusion: MRI allows us to better illustrate the arachnoid cyst in sacral canal, and the cyst seems to arise as a result of congenital defect of thecal dura. Excision of the most of the cyst wall and plugging the communicating hole with a block of muscle seems to to a reasonable method to treat the carachnoid cysts in the sacral canal. Do not put the drain tube and forbidding patients to lie supinely are better for reducing the complications.

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Re-application of External Fixators for Complications of Limb Lengthening and Deformity Correction

Orthopedic Journal of China.2002;10(12):1167-1170.

Objective: To treat limb length discrepancy or deformity using external fixation,and Correct potential complications. The authors present their figures for reapplication of external fixator frames in the same bone segment following complications during or after the treatment phase. Methods: Two hundred and sixty-one patients (297 limbs) underwent this type of treatment in our unit between Feb. 1991 and July 1999 with either Orthofix or Ilizarov fixators.228 in children and 69 limb segments in adults. Results: Reapplication of 22 fixators in children (9.65%), and 4 fixators in adults (5.8%) was performed. This gives an overall reapplication rate of 8.75%. The reason for reapplication was fracture and / or deformity of the regenerate (15 segments). Four patients eventually came to amputation. Conclusion: The authors recommended the continue use of this technique for the treatment of severe deformity particularly in congenital disorders.

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Biological Study of Hydroxyapatite Gradient Coatings

Chenguang LUAN ; Qingming YANG

Orthopedic Journal of China.2001;8(4):378-380.

Objective: To estimate the biological characteristics of HA gradient coating in vivo.Method:We inserted coated and uncoated implants in bilateral femur of loading area in dogs.Result:Histological findings demonstrated that HA coated implants bind the host bone tightly and the amount and velocity of the new bone formation are more than the uncoated implants.The mean interface shear strength between HA gradient coated implants were greater than those of uncoated implants (p<0.01).Conclusion:The results of this study confirms that HA gradient coatings can has its practical value in orthopeadics fields.

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The Treatment of Metaphyseal Cancellous Bone Fractures with Fragment Fixation System lmplants(FFS)

Guohui ZHANG ; Jiwei TIAN ; Tingmin NING

Orthopedic Journal of China.2001;8(4):350-351.

Objective: To discuss the clinical effect of the treatment of metaphyseal cancellous bone fracture with fragment fixation system implants(FFS).Methods:Thirty patients treated with FFS were reviewed.Results:The patients were followed up for 7～　24 months (8.7 months in average).The fractures in all cases were healed in 6 months and the function recovered or nearly reeovered. Conclusion:By traction with FFS to treat this kind of fracture,the fractures and joint function recovered.The operation is simple and trauma is little.

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Treatment of Supracondylar Fracture of the Humerus Fixed by Tension Band with Sphenoid－shaped Osteotomy

Ruisen ZHAN ; Huifang YANG ; Song WU

Orthopedic Journal of China.2001;8(4):340-343.

Objective: To report a newly designed method for treating supracondylar fracture of the humerus,and to inquire into the problems of cubitus varus deformity and joint stiff.Methods:Based on a review of anatomy,a new method which called tension band with sphenoid-shaped osteotomy through posterior approach was designed and applied for 46 cases of patients in clinic.The clinical effect was compared with effect of crossing Kirchner's wire.Results:The tension band with sphenoid-shaped osteotomy was a better method and can abide by anatomical and biomechanical principles.After follow-up for 12-36 months,curative effect was estimated as follow:30 cases were excellent,14 cases good and 2 cases poor according to Home's evaluation.Conclusions:It is a better methods in treating supracondylar fracture of the humerus following advantages including simple,reliable fixation and early mobilization etc.

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Study on Accelerating Rat Fracture Healing by Injection of Soluble Multipeptides Abstracted from Bone Tissue

Fobao LI ; Dongliang XU ; Zhonghan YANG

Orthopedic Journal of China.2001;8(4):384-386.

Objective: To study the effects of soluble multi-peptide agent,marked “Gu Kang Tai Ling”,derived from bone tissue on rat bone fracture healing.Methods 80 right tibia defects of rats were sawed.The “Gu Kang Tai Ling”were intramuscularly injected to the rats.The quality of the defect healing was investigated continuously and respectively by the defect bone histomorphometry,biomechanics,X-ray film,and bone mineral density(BMD).Results: Under the treatment of the agent,at early stage trabecular bone volume (TBV)ratio increased 24.7%,and osteoblast surface(OBS)26.7%,at late stage mean trabecular healing surface rate(MTHSR)was increased 38.8%,tibia anti-fracture strength 0.4527～1.4350N，and BMD 7.65% compared with the control group.Conclusion: “Gu Kang Tai Ling”can accelerate rat fracture healing and improve the quality of healing.

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The Biomechanical Study of Tension Band with Cancellous Bone Screw for the Treatment of Patella Fracture

Yucai XIU ; Xianjun REN

Orthopedic Journal of China.2001;8(4):381-383.

Objective: To compare the biomechanical strength of tension band with cancellous bone screws with AO tension band,modified tension band and cancellous screws alone for the treatment of patella fracture.Methods:20 fresh frozen cadaveric knee specimen were divided into four groups randomly.Transverse osteotomies of the patella were performed and the simulated fractures were fixed with four techniques.The biomechanical testing was perfomed by using WD-10E electrical mechanical testing machine.The internal fixation was considered failure when fracture gap exceeding 1mm.Results:All techniques functioned adepuately under 420 N loading of quadriceps tendon.However,biomechanical strength was greatest in tension band with cancellous bone screws (P＜0.05)，lowest in AO tension bands and no stability enough in cancellous bone screw alone.Conclusion:Tension band with cancellous bone screws is the best technique for the treatment of patella fracture.

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Resection Arthroplasty of the Sternoclavicular Joint to Treat Dislocation of the Sternoclavicular Joint

Xiaosheng LIN ; Yuanxi LIU ; Fusheng TAN

Orthopedic Journal of China.2001;8(3):228-229.

To investigate the possibility of resection arthroplasty of the sternoclavicular joint in treatment of dislocation of this joint.Methods:Five patients who had had resection arthroplasty of the sternoclavicular joint and in whom the costoclavicular ligament had to be reconstructed,follow-up averaged 1.8 years.Results:The average duration of follow-up were 1.8 years.All of the patients had an excellent result,no cases had infection、pain and abnormalities.Conclusion:We believe that resection arthroplasty of the sternoclavicular joint and preservation reconstruction of the costoclavicular joint is essential,and it is a satisfactory and safe way for the treatment of dislocation of the sternoclavicular joint.

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