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Primary Observation of Bone Metabolism Abnormality in Child Patients with Taking Antiepileptic Drugs

lianxiu, ZENG ; lusheng, ZHOU ; mingci, ZHENG

Journal of Applied Clinical Pediatrics.1992;0(05):-.

Objective: To Search for the influence of Antiepileptic drugs on bone metabolism in children, Design Case-Control research Patients and Other Participants 20 Child patients with taking antiepileptic drugs for a long time(AEDs group), the longest thae of taking medicine is 6 years and the shortest is 0.5 year. There are15 epileptic patients without taking antiepileptic rugs in the no n-AEDs group and 30 health childrenin control group. Measurement Methods Alkaline phosphatase(AKP) and tarstrate-resistant acid phosphatase (TR-ACP) were determined by improved Kind-King method and Bessey-Lowry method respectively. Ca-lcium (Ca) and ph?sph?rus (P) in the blood were determined by 400E type auto-biochemistry analyzer. Results The AKP activities of ADEs. non-ADEs and control group are 190?47、144?38、143?40IU/L respectively, There are significant difference between ADEs. non-ADEs group, and ADEs, con-trol group (P20CIU/L, 2 patients with hypoealcemiaand 2 patients with hypophosphorum. TR-ACP activities. Ca and P levels are not significant diffe-reuce among the group?. Conclusions Taking antiepileptic drugs bas influeare ou bone metabolism in children.

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The Research of Serum IgG Subgroup in Clild Patients with Juvenile Rheumatoid Arthridylitis

feng, XIONG ; leili, DENG ; lijia, WANG ; xiqiang, YANG

Journal of Applied Clinical Pediatrics.1992;0(05):-.

0.5).IgG、IgA and IgM of controlgroup and observation group in 10～13 years old are similar to that in 5～9 years old group. The IgG_1of control group and observation group in 5～9 years old are 5.501?0.976 and 9.715?3.746g/L respe-etively (t=5.046, P0.05),IgG_3 are0.517?0.167 and 0.828?0.578g/L respectively (t=2.132, P0.05).The IgG_2 Levels of observation groupis higher than that of control group in 10～13 years old(P

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The Changes of T Cells Subpopulations and Immunoglobulin and Their Relationship in Children Patients with Simple Nephrotic Syndrome.

qiu-ye, ZHANG ; zeng-yi, DONG ; mei-yu, YANG ; shu-lan, DONG ; xiu-ting, YANG

Journal of Applied Clinical Pediatrics.1992;0(06):-.

Objective To search for the changes of T cells subpopulations and immunoglobulin and their relation-ship in children patients with simple nephrotic syndrome. Design Case-control research. Patients aud Participants 39 patients with simple nephrotic syndrome were divided into two groups:the incipient group and relapse group (6 cases were determined at the incipient and relapse time) .Thereare 28 patients in incipient group, 19 males and 9 females, at the age of 2 to 10 years old. There are20 patients in relapse group, 12 males and 8 females, at the age of 3 to 13 years old. There are 35health children in control group, 21 males and 14 females, 2～13 years old. Interventions T cells subpopulations were determined by indirect immunofluorescence of OKT linesmonoclonal antibodies. The serum IgG was determined by routine simple agar immunodiffusion tests. Results and Conclusions The CD_3~+ and CD_4~+ cells are of no change in the children patients withsimple nephrotic syndrome, and the CD_8~+ and CD_(10)~+ cells are obviously increased, the Values of CD_4~+/CD_8~+ are obviously lower than those in the control qroup, there are no difference between the incipientand relapse groups. The levels of serum IgG were decreased in the 85.3% children patients, IgM were inc-reased in 29.4% of that. The values of CD_4~+/CD_8~+ have positive correlation and negative correlationwith the levels of serum IgG and IgM respectively.

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A Synchronus Study on the Iron Status of Mothers and Babies

ruwen, WANG ; xueyu, ZHANG ; zuzhao, ZHOU ; liyang, LI ; shifen, HAO ; yajun, XIE

Journal of Applied Clinical Pediatrics.1986;0(02):-.

From August, 1984 to February, 1985, We kept a synchronous observation of 92mothers and their babies on the relationship of iron status between them. The 92 pregnantwomen, of whom the gestational periods were not longer than 36 weeks, were divided rando-mly into wo groups: a medication group and a control group. For all, Hb, Hct, FEPand SF were tested. In the 4th week after labor, Hb, Hct and SF of the mothers ofthe medication group were higher than that of the control group (P

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Astragali and acanthopanax root for idiopathic nephrotic syndrome hypoadrenocorticism in children:the protection and clinical significance

he-qun, ZOU ; yun-qin, WANG

Journal of Applied Clinical Pediatrics.1986;0(02):-.

Objective To search for a way of treating chi1dren's idtopathic nephrotic syndrome (INS) hypoadrenocorticismand its significance. Meethods Thirty-nine patients (31 males and 8 females) with INS were randomly divided into twogroups: 21 patients in tera-peutic group (treated by prednisone, astragali and acanthopanax root) and 18patients in control group (Simply treated by prednisone). 1ml blood was respectively drawn from all thepatients at 8 o'clock (one time before treatment and one time after treatment), the serum cortisol wasdetermined by radioimmunoassay (RIA). Results In control group, the levels of serum cortisol still remained lower than the normal value aftertreatment and the levels after large dosages prednisone treatment were markedly lower than that beforetrea-tment. The values of serum cortisol returned to be normal after treatment in therapeutic group. Conclusion Astragali and acanthopanax root can restore the hypoadrenocorticism in children with INS.

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The clinical analysis on 41 cases of scleredema neonatorum combined with pneumorrhagia

juan, LI ; kelun, WEI

Journal of Applied Clinical Pediatrics.1993;0(03):-.

0.05), FⅧ, c: 28.9?8.7 vs 43.9?11.4 per cent (P

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An analysis of Clinic, CT and MRI in 150 child patients with cerebral palsy

shumin, DU ; xin-sheng, ZHANG

Journal of Applied Clinical Pediatrics.1993;0(Z1):-.

Objective To search for the CT and MRI morphological changes in the child patients with cerebral palsy. Method The CT scranning and MRI were carried out in 150 child patients with cerebral palsy, andthe results were analysed. Results In 150 cases, 97 cases (54.6 per cent) have abnormal findings of CT scranning. Diffuse ence-phalatrophy (42 cases), encephalomalacia focus (24 cases) porencephaly (9 cases), and localized ence-phalatrophy (7 cases) ect are the common CT morphological changes in the patients with cerebral palsy.In the 53 patients with normal findings of CT scranning, MRI was carried out for 30 cases and 25 cases(83.3 per cent) were abnormal. The delayed myelinogeny of white matter of brain is the main MRI mor-phalogical abnormality. Conclusion CT scranning and MRI have important value on the etiological diagnosis for child patientswith cerebral palsy. The combination of them can improve the diagnostic accordance rate.

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The observation on the relationship between iron deficiency and altitude hypoxia

zhen-ting, QIN ; li-yang, SHEN ; hong-cai, MIAO ; ji-chuan, LIU ; li-ming, LIN ; er-dao, GE ; Gage DUSEK ; ci, WEI ; guang-fu, YUAN

Journal of Applied Clinical Pediatrics.1986;0(01):-.

Background Since the measurement method establishment of serum ferritin abroad in early period of theseventies, the iron deficiency had been divided into two types: the non-anemia and anemia types. In orderto go step further studies, we must ertablish the bemoglobin targets of the two types. Methods One hurdred and fifty-two children in experimontal group, from 6 to 7 years old, and allcome from Qinghai province. There are 29 children in Xining city, 24 in Guide, 26 in Gongbe, 40 in Gui-nan and 33 in Maduo countics. There are 36 health children aged from 6 to 7 years old in the controlgroup, and all comes from Beijing. The Hb, RBC, HCT, HCTW and FEP wcre determined. Results The three targets correlating with Hb (Hb, MCH and MCHC); correlating with RBC (RBC,HCT and MCV); the two targets correlating with RBC_weight (HCTW and CMCW) and correlating withFEP of RBC(FEP and MCEP) have very significant difference between experimental group and control group. Conclusion The determination values of the 10 targets are not same in children in different districts,and the values of all the target: are increased on different degree along with the increase in altitude of ele-vation. There is very important significance on the studies of iron deficiency and altitude hypoxia to establish the normal values of the 10 targets.

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Relationship between Helicobacter Pylori and Pathological Lesiens in 458 Bioptic Specimens from gastric Mucosa in children

hong-feng, TANG ; hua-ying, YE

Journal of Applied Clinical Pediatrics.1986;0(02):-.

Objectives To search for the relationship between HP and lesions of gastric mucosa of children.Methods Four hundred and fifty-eight bioptic specimens-from eastrie mueosa in children were strained with hematoxylin-eosin(HE)and Warthin-Starry for light microscopic study.Results HP was detected in 152 specimens. HP deteetable rate-in specimens with normal mucosa was 1. 1%, in compari-on with 42.3% in those with chronic superficial gastritis and 14. 3% in those with chronic atrophic gastrins .Specimens with chronic active gastritls, mostry manitesting local active lesions,had HP detectable rate of as high as 80.2%、69. 7% of the specimene with HP were found to have obvious lymph follicles reaction within lamina propria in their gastric mucosa.Conclusions There is a close relationship between HP infection and Pediatric chronic gastritis(especially chronic active gastritis). Histopathologically, HP-associated gastritis is characterized by chronic and local active inflamations, and tbe formation of lymph follicles within lamina propria.

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Effects of InterleukIn2, 6 (IL-2,6) on Immune Function in Children With Bronchopneumonia

dong-bo, JIANG ; ji-gao, SHEN

Journal of Applied Clinical Pediatrics.1986;0(02):-.

Objective IL-2,6 production by PBMNC (peripheral blood mononucleat cells) were ineaeured with an attempt to illustrate the immune function of children with bronchopneumonia.Methods The biological activities of IL-2,6 were measured by CTLL and CESS cell lines respectively In addition, mitogen-stimulated blastogenic transformation (MSBT) was also measured. The results were analysed statistically. Patients or Other Farticipants T enty-eight cases of children with bronshopneumonia, male, 16,female: 12. Age: 8 months to 7 years, average 3. 9 years. 15 normol controls, male: 8, female 7.Age: 2 to 6 years, average 3 .5 years.Interventions 5～6ml of venous blood was obtaincd, followed PBMNC were centrifugalized by. FicollHypaque. Wash three:times with RPMI-1640 medium. Resuspend cell at 5 ?106/ml. Add 1% PHA and culture for 48h. Horvest supernatant and store at - 20℃.Measurement and Main Rcsults The levels of IL-2 in children with bronchopneumonia and normal children were (CPM) 9 538 + 3 363, 16 152 ? 3 411 (t test, P

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