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Effect of regulatory T cell in SEB/OVA allergic rhinitis of animal model

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(06):-.

OBJECTIVE To establish mice model of allergic rhinitis(AR) and study the role of Staphylococcal enterotoxin B(SEB)and ovalbumin(OVA)in the model,and investigate the change of regulatory T cell(Treg)in the nasal mucosa of mice.METHODS Forty Balb/c mice were randomized into OVA group(A),SEB group(B),OVA+SEB group(C)and normal solution group(D).AR model was established.The symptom scores and count of Foxp3 positive cells in nasal mucosa were analyzed by factorial design.RESULTS The symptom scores in Group A,B,C,D were 0.90?0.99,0.70?0.82,6.80?1.03,0.60?0.70 respectively.Group C was successfully established as AR model.OVA and SEB had interaction(P

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Expression of the Snail,Slug,and E-cadherin and their clinical significance in nasopharyngeal carcinoma

Dawei MENG ; Jimin BAO ; Jing SUN ; Baoyue LI ; Yunpeng MA ; Zhe LI

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(06):-.

OBJECTIVE To investigate the expression of transcription factors Snail,Slug and cell adhesion molecule E-cadherin in nasopharyngeal carcinoma(NPC)and evaluate their relationship with clinical pathological features and metastases.METHODS Immunohistochemistry and quantitative polymerase chain reaction were carried out to detect the expression of Snail,Slug and E-cadherin in 65 NPC samples and normal nasopharyngeal mucosa(18 cases).The expression of Snail and Ecadherin in distinct differentiation nasopharyngeal carcinoma was analyzed and the relationship of them with clinical pathological features was discussed.RESULTS Real-time PCR analysis and immunohistochemistry showed that Slug was elevated with increasing tumor grade.E-cadherin expression was reduced corresponding with prognostic indices and tumor.Snail showed no obvious change.The relative expression levels of E-cadherin mRNA were significantly different between lymph node metastasis group and nometastasis group(P

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Local anesthesia in endoscopic sinus surgery

Chun HUANG ; Chang SHU ; Yan ZHANG ; Changling SUN ; Jia SHEN

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(06):-.

OBJECTIVE To investigate the feasibility of endoscopic sinus surgery under local anesthesia.METHODS A total of 810 patients underwent endoscopic sinus surgery from January 2000 to December 2007 with complete follow-up data were included in this study.Validity of anesthesia was evaluated using VAS(visual analogous scale).Operation time,bleeding quantity during operation,operation therapeutic efficacy,hospitalization cost and patient's evaluation to the operation were recorded.RESULTS The mean VAS score of local anesthesia was 3.18?0.46.Cases with no pain and mild pain accounted for 78.28%,with moderate pain 16.71%,and with severe pain 5.01%.The average bleeding quantity during operation,operation time,complication incidence,cure rate at 6 months after operation,hospitalization cost,patients' evaluation in local anesthesia were(43.25?27.46)ml,(41.14?9.479) min,1.78%,78%,4000～6000 yuan(RMB),9.28? 2.21 respectively.CONCLUSION For the endoscopic sinus surgery,most cases can be operated under local anesthesia if the indication were selected correctly and the sophisticated skills and advanced instrument were available.

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Electromyographic study of suprahyoid muscles and intrinsic laryngeal muscles in dogs

Ni ZHOU ; Zhiwen XU ; Wensheng WEN

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(07):-.

OBJECTIVE To study the synchronous electromyograhic features of suprahyoid muscles [anterior digastric muscle(AD), posterior digastric muscle(PD),stylohyoid muscle(STH),mylohyoid muscle(MH)and geniohyoid muscle(GH)] and intrinsic laryngeal muscles [lateral cricoarytenoid muscle(LCA)and posterior cricoarytenoid muscle(PCA)]. METHODS Synchronous electromyograhic features of 13 dogs were observed under the circumstances of breath, swallowing and phonation. RESULTS ①AD, PD, STH, MH, GH and PCA discharged during inspiratory phase, while LCA discharged during expiratory phase. ②During swallow, suprahyoid muscles and LCA showed intensive synchronous discharge. The myoelectricity of PCA was suppressed while myopotential can be detected during intermission. ③During phonation, AD, PD, LCA and PCA showed an intensive synchronous discharge, while emergence time of PCA was later. GH and STH showed no myoelectricity activities. CONCLUSION①During phonation and swallowing, MH is synchronized with LCA. It can be chosen as the backup muscle for the reestablishment of glottic adduct function. ②During inspiratory phase, GH is synchronized with PCA. It can be chosen as the backup muscles for the reestablishment of vocal cord abduct function.

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Effect of repeated debridement on the efficacy of endoscopic sinus surgery

Lijie ZHAI ; Lin SHI ; Yong LI

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(07):-.

OBJECTIVE To investigate the effect of repeated debridement on the efficacy of endoscopic sinus surgery(ESS). METHODS A total of 67 patients underwent ESS were divided into intervention group and control group. Debridement was performed at the 1st, 4th, 8th week after operation for the patients in intervention group, while once per week for the patients in control group. The primary outcome measure was visual analogue scale(VAS)and Lund-Kennedy endoscopic score(LKES). RESULTS Comparing the two groups on all domains of digital VAS and LKES at the 4th, 8th week after operation, there were no significant difference between the two groups. CONCLUSION Benefit of frequent debridement during the early postoperative period was no positive correlation with patients recovering after ESS. Therefore, in terms of subjective recovery and health care costs,appropriate extending postoperative management time and decreasing intervention frequency do not decrease the efficacy of endoscopic sinus surgery.

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Latency characteristics of speech evoked auditory brainstem response

Qiuyang FU ; Yong LIANG ; Yuanyuan SU ; Tao WANG

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(07):-.

OBJECTIVE To explore the latency characteristics of speech evoked auditory brainstem response(speech-ABR)from healthy Chinese adults by different stimulation intensities and its significance in neural encoding of speech in the brainstem. METHODS ABRs to speech syllables of 32 subjects were recorded in four stimulus intensities varied from 20 to 80 dB SPL by 20 dB steps, under 11.1/s stimulus rate. A set of featured waves were determined under these intensities, and then the characteristics of their latencies were analyzed. RESULTS A series of featured waves were observed starting from onset response(including V and A waves), transitional C wave, then following frequency-following responses(FFRs), and the offset O wave. As the reduction of stimulus intensity, the latencies of speech-ABR delayed significantly(P

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The observation on risk factors of the sudden sensorineural hearing loss in Qinghai

Ning LING ; Ying YANG ; Shanhong LI

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(07):-.

OBJECTIVE To reduce or avoid the risk factors of idiopathic sudden hearing loss in Qinghai. METHODS The clinical data of 143 sudden hearing loss patients was analyzed in Qinghai by the questionnaire. RESULTS The high incidence of sudden hearing loss happened at 2 to 6 hours after waking up in the morning. And most of the patients occurred at 18～50 years old(accounted 70.63%). 79.65% of the patients were mental laborers, 57.34% were drinkers, and 59.44% were very tired before illness. There were significant differences(P

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Clinical features and treatment of refractory mycotic otitis media

Xiang LIU ; Chongxi CHEN ; Qiong YANG

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(07):-.

OBJECTIVE To study the clinical features and the treatment of refractory mycotic otitis media. METHODS From February 2005 to February 2009, 62 cases diagnosed as refractory mycotic otitis media were randomly divided into two groups. One group was 31 cases treated with local daubing Miconazole Nitrate Cream and another group was 31 cases treated with oral Itraconazole. The clinical features and fungi of distribution were retrospectively analyzed. RESULTSAspergillus was the most common fungi(70.6%). After two weeks treatment, 29 cases were cured in the group of Itraconazole, while 21 cases were cured in the group of Miconazole Nitrate Cream. CONCLUSIONRefractory mycotic otitis media is deep-seated mycotic infection and the primary pathomycete was aspergillus. The curative effect with oral Itraconazole was significantly better than that with local daubing Miconazole Nitrate Cream.

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Expression of human telomerase reverse transcriptase in malignant transformation of sinonasal inverted papilloma

Anliu WANG ; Honggang LIU ; Bo ZHANG ; Lin HOU

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(07):-.

OBJECTIVE To explore the relationship of telomerase and canceration of sinonasal inverted papilloma(IP). METHODS Telomerase activity was measured by hybridization in situ in sinonasal mucosa of 10 cases of chronic in?ammation, 45 cases of sinonasal IP with dysplasia(45 cases were divided into three groups: IP with mild dysplasia, IP with moderate dysplasia and IP with severe dysplasia, 15 cases in each group), and 21 cases of cancerated sinonasal IP. RESULTSThe positive expression rates of telomerase was 0% in sinonasal mucosa with chronic inflammation, 0% in sinonasal IP with mild dysplasia, 13.3% in sinonasal IP with moderate dysplasia, 73.3% in sinonasal IP with severe dysplasia and 80.9% in cancerated sinonasal IP. CONCLUSION Telomeras plays a critical role in malignant transformation of sinonasal IP, and it is a marker of malignant transformation tendency of sinonasal IP.

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Significance of Fas, FasL and FADD expression in squamous cell carcinoma of larynx

Haili SUN ; Hua GUO ; Yuhe LIU ; Ting LI ; Shuifang XIAO

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(07):-.

OBJECTIVE To investigate the expression and significance of Fas, FasL and FADD in laryngeal carcinoma. METHODS Immunohistochemical method was used to examine the expression of Fas, FasL and FADD in laryngeal carcinoma specimen and adjacent normal tissues. RESULTS The positive rates of Fas and FADD in laryngeal carcinoma tissue were significantly lower than that in adjacent normal tissue, while FasL in laryngeal carcinoma tissue was higher than that in adjacent normal tissue(P

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