Journal Detail Information

1

Cite

Share

Progress of induction chemotherapy on laryngeal cancer

Chinese Archives of Otolaryngology-Head and Neck Surgery.2001;8(2):125-.

Synthetical therapy of laryngeal carcinoma will be a tendency in clinical practice.The induction chemotherapy plays an important role in it.The induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer were applied widely and the significant experiences had also been reported widely. The references of induction chemotherapy of laryngeal cancer were summarized in this paper.

2

Cite

Share

Clinical efficacy of voice training in the perioperative period of vocal cord polyp

Fengqin QU ; Haixia LI ; Meisheng LI ; Shuhua XU ; Yunhua ZHU

Chinese Archives of Otolaryngology-Head and Neck Surgery.2017;24(3):156-158. doi:10.16066/j.1672-7002.2017.03.012

OBJECTIVE To study the clinical efficacy of voice training on voice recovery in patients with vocal cord polyps during perioperative period.METHODS A total of 72 patients with vocal cord polyp were chosen in this study and they were randomly divided into study group and control group. After operation, the control group received routine treatment, and the study group received voice training on the basis of routine treatment. The results of voice acoustic analysis in the two groups were compared at 8 weeks after operation.RESULTS After 8 weeks, the maximum phonation time(MPT), dysphonia severity index (DSI) and the highest frequency(F0-High) of the study group were significantly higher than that of control group (P<0.05). The fundamental frequency perturbation(Jitter) of the study group was markedly lower than that of the control group(P<0.05). There was no statistical difference in the fundamental frequency(F0), the lowest intensity(I-Low) and amplitude perturbation(Shimmer) between the two group (P>0.05).CONCLUSION Voice training in the early postoperative period of vocal cord polyps was helpful to the recovery of the voice.

3

Cite

Share

Effects of salicylate on dopamine levels in rat nucleus accumbens

Weini HU ; Junxiu LIU ; Lanqun MAO ; Furong MA

Chinese Archives of Otolaryngology-Head and Neck Surgery.2017;24(3):153-155. doi:10.16066/j.1672-7002.2017.03.011

OBJECTIVE To investigate dopamine level changes in the Nucleus Accumbens (NAc) of the limbic system by salicylate and the role of dopamine in the mechanisms of tinnitus.METHODS We recorded the change of dopamine before and after sodium salicylate injection in rats by microdialysis combined with electrochemical methodologies in the nucleus accumbens (NAc).RESULTS Salicylate produced significant increase in dopamine level in the NAc, to a maximum of (321±97)% of baseline and then remain stable. In contrast, saline only produced slight increase.CONCLUSION The increase of dopamine in the NAc may be related to the generation of tinnitus. The data in vivo provide direct evidence of the important role that the dopaminergic system plays in the generation of tinnitus.

4

Cite

Share

Epidemiological characteristics of inhalational allergen in children with allergic rhinitis in Tianjin

Liang LI ; Yuanyuan LANG ; Jiayi ZHANG ; Bei SHEN

Chinese Archives of Otolaryngology-Head and Neck Surgery.2017;24(3):140-143. doi:10.16066/j.1672-7002.2017.03.008

OBJECTIVE To analyze the results of the inhalational allergen detection in children with allergic rhinitis in Tianjin, and to understand the common allergens and their distribution.METHODS Mediwiss (Screen Allergy) was used to determine the specificity of allergen specific IgE in serum. According to sex, age, season, the distribution of allergens was described.RESULTS The most common inhalant allergens in Tianjin were mixed fungus(52.35%), followed by Dermatophagoides pteronyssinus(35.88%), dog dander(24.31%), cat dander(15.10%). The positive single allergen(59.03%) was most common, followed by positive double allergens(25.88%); The positive rate of the boy with inhalation allergen was higher than that of the girl; The positive rate of the inhalation allergen in the infant stage was significantly lower than that in the preschool, the school age, and the adolescent; In summer, the inhaled allergens positive rate was significantly higher than that in winter and spring, above differences were statistically significant(P<0.05). CONCLUSION Mixed fungus, Dermatophagoides pteronyssinus, dog and cat dander are the most common inhalant allergens in children with AR in Tianjin area. The positive rate of allergens has certain regularity in sex, age and season.

5

Cite

Share

Effect of surgical intervention on the activity of peripheral blood T lymphocyte subsets and NK cell in children with obstructive sleep apnea hypopnea syndrome

Yimin CHEN ; Lili HUANG ; Jiarong WANG ; Liansheng QIU

Chinese Archives of Otolaryngology-Head and Neck Surgery.2017;24(3):124-127. doi:10.16066/j.1672-7002.2017.03.004

OBJECTIVE To explore the condition of the cellular immune function of children with obstructive sleep apnea hypopnea syndrome(OSAHS) and its change after operation METHODS Eighty children diagnosed as OSAHS were included in this study. T lymphocyte subsets and NK cells of the blood were measured before operation and one month after operation respectively. Children without the related disorders or systemic disease were recruited as control group.RESULTS Before operation, CD4+T cell percentage, CD4+/CD8+ ratio and NK cell percentage in OSAHS children were significantly lower than that in the control group[(26.19±3.38)%vs (5.10±4.09)%, (0.90±0.19)%vs (1.61±0.52)%, (11.45±4.35)%vs (13.73±3.78)%,P<0.05], CD8+T cell percentage was significantly higher than that in the control group[(30.02±5.50)%vs (22.31±3.42) %,P<0.05]. The difference, between the two groups, in CD3+T cells was not statistically significant. After operation, the CD4+T cells, CD8+T cells, CD4+/CD8+ ratio, the percentage of NK cells and CD3+T cells showed no significance difference compared with that before operation (P>0.05). CONCLUSION OSAHS may damage the cellular immune function. The operation does not reduce the cellular immune function in the short term.

6

Cite

Share

Bacteriology of adenoids and tonsils in children with sleep-disordered breathing

Zhenyun HUANG ; Dabo LIU ; Huamin ZHONG ; Jianwen ZHONG ; Shuyao QIU ; Shuang FENG ; Xinhua YI

Chinese Archives of Otolaryngology-Head and Neck Surgery.2017;24(3):116-119. doi:10.16066/j.1672-7002.2017.03.002

OBJECTIVE This study was conducted to analyze the underlying bacterial pathogens of the tonsils and adenoids in children with sleep-disordered breathing(SDB).METHODS The core tissue from the tonsils and/or adenoids of 163 SDB children was cultured aerobically. Of the 163 cases, 120 children underwent adenoidectomy and tonsillectomy simultaneously(A+T), 39 children underwent adenoidectomy(A) and 4 tonsillectom(T) only. 124 children who underwent tonsillectomy were subdivided into two groups based on history(with or without a history of recurrent tonsillitis). 71 children with the history were enrolled in the 'recurrent tonsillitis group' and 53 children without the history were enrolled in 'non- recurrent tonsillitis group'.RESULTS Of the total 120 cases who underwent A+T, 114(95.00%) cases had same distribution of bacteria detected in both sides in the same patient. Besides this, 17 cases in whom mixed organisms were identified in both sites shared common pathogen. No significant difference in the detection rates of staphylococcus aureus and haemophilus influenzae were found when we compared seasons(Tonsil:χ2=8.538,P=0.201; Adenoid:χ2=5.427, P=0.490). No significant difference in the type and detection rate of essential bacteria was found when we compared between recurrent tonsillitis group and 'non-recurrent tonsillitis group' (χ2=3.028,P=0.387).CONCLUSION The bacterial isolates from the tonsils and adenoids are virtually identical in type and detection rate in the same SDB patient. The bacterial distribution of the tonsillar and adenoidal core is unaffected by the seasonal variation and history of recurrent tonsillitis.

7

Cite

Share

Vacuum drainage for deep neck infection

Xianfeng WEI ; Peng LIN ; Li LI ; Shengchi ZHANG

Chinese Archives of Otolaryngology-Head and Neck Surgery.2017;24(3):159-161. doi:10.16066/j.1672-7002.2017.03.013

OBJECTIVE To evaluate the effect of vacuum drainage for deep neck infection.METHODS There were 35 patients with deep neck infection in the First Central Hospital of Tianjin from January 2009 to February 2016. These patients were treated by abscess incision and drained with vacuum.RESULTS After treatment, the symptoms of the general fever and pharyngalgia were significantly turned better. The local inflammatory reaction was controlled within one to 3 days and the wounds were most primary healed in 7 days. CONCLUSION The deep neck inflammatory abscess was mostly able to be cured by incision and vacuum drainage of the abscess. The method can significantly reduce the pain of patients and the workload of the physician, and the effect of the method is better than the traditional treatment method.

8

Cite

Share

The effects of rehabilitation on the pre-lingual deaf children with inner malformation after cochlear implantation

Yun LIANG ; Xiulan CHEN

Chinese Archives of Otolaryngology-Head and Neck Surgery.2017;24(3):136-139. doi:10.16066/j.1672-7002.2017.03.007

OBJECTIVE The aim of this study was to evaluate the outcomes of rehabilitation after cochlear implantation in children with malformed inner ear and compare them with a group of congenitally deaf children implantees with a normal inner ear.METHODS 21 children with inner ear malformation were retrospectively studied. The postoperative outcomes of these 21 cases were compared with that of 21 cases with normal inner ear structure. The assessment of all the children included the hearing levels, language ability , categories of auditory performance (CAP) and speech intelligibility rating (SIR) respectively before cochlear implantation, 6 months and 1 year after surgery. The data was analyzed using SPSS 17.0. RESULTS The results of rehabilitation in 9 children with Large Vestibular Aqueduct Syndrome and 6 cases with Mondini abnormality had no significant difference comparing with the control cases. The outcomes of 1case with severe Mondini abnormality and 5 cases with common cavity indicated significant worse than the control cases. CONCLUSION The effect of rehabilitation had no difference between the children with large vestibular aqueduct syndrome and the cases with normal inner structure after cochlear implantation, but was poorer in children with severe Mondini abnormality and common cavity. It was necessary to evaluate the degree of malformation of inner ear structure before cochlear implantation. The hearing abilities have improved quickly 6 months after cochlear implantation. The language abilities will need at least one year to get improved while the SIR need even more time. The development of language functions requires individualized rehabilitation guidance and integrated education.

9

Cite

Share

Consistency of tumor sizes measured by sonographic and pathological examination in papillary thyroid carcinoma

Ying WANG ; Jinwang DING ; Zhijiang HAN ; Zhikai LEI ; You PENG ; Wo ZHANG ; Gang PAN ; Wei WANG ; Dingcun LUO ; Jun LOU

Chinese Archives of Otolaryngology-Head and Neck Surgery.2017;24(3):149-152. doi:10.16066/j.1672-7002.2017.03.010

OBJECTIVE The aim of the study was to evaluated the difference and consistency in tumor size measured by sonographic and pathological examination in papillary thyroid carcinoma(PTC).METHODS A total of 114 patients with PTC, including 122 malignant nodules, was collected from Hangzhou First People's Hospital between Jun 2012 and Jun 2014. The tumor sizes were measured by preoperative sonographic and postoperative pathologic evaluation. Pearson correlation analysis, paired t-test, and Bland-Altman plot were used to evaluate the correlation and consistency in tumor size measured by the two methods.RESULTS Pearson correlation analysis showed that the largest tumor size measured by sonography were positively correlated with pathologic size (r=0.957, P=0.000). Paired t-test showed that there were statistically difference between sonographic size and pathological size (8.24±5.06) mmvs (7.79±4.75) mm,P=0.001. The absolute difference value of the largest tumor size measured by the two methods was from zero to 6.5 mm, with the average of (1.03±1.14) mm. Bland-Altman analysis showed that the limits of agreement (LoA) of difference was from -2.41 mm to 3.33 mm, with the 95% confidence interval from -2.87 mm to 3.78 mm.Within the limit of the consistency, the maximum moduli was 2.9 mm.CONCLUSION There is a significant discrepancy between the preoperative sonographic and the pathologic size of the papillary thyroid carcinoma, which should be taken into account in clinical practice.

10

Cite

Share

Pathogenesis of particulate matters and IL-4 DNA methylation in CD4+T cells in children with AR

Youjin LI ; Niu LI ; Zhe MU ; Beiying MA ; Jie CHEN ; Fan JIANG

Chinese Archives of Otolaryngology-Head and Neck Surgery.2017;24(3):144-148. doi:10.16066/j.1672-7002.2017.03.009

OBJECTIVE To investigate the possible effects of meteorological and environmental factors on IL-4 gene specific DNA methylation levels in CD4+T cells of children with AR.METHODS Thirty five pediatric AR patients(6-12 years) followed up for one year from the Department of Otolaryngology, Shanghai Children Medical Center from Jan, 1, 2012 to Dec. 31, 2012 were included in this study. Data on daily particulate matter of diameter smaller than 10 micrometer(PM10) and particulate matter of diameter smaller than 2.5 micrometer(PM2.5) was available as average values derived from the data of 6 state-controlled monitoring stations distributed across Pudong District, Shanghai. We quantified IL-4(interleukin-4) gene specific DNA methylation levels in CD4+T cells from 35 patients with AR and 30 healthy controls. mRNA levels of IL-4 gene were measured by real-time reverse transcriptase-PCR. Methods of personal exposure assessment of PM2.5 and PM10 were measured.RESULTS Compared with controls, IL-4 promoter region was hypomethylated in AR CD4+T cells(P=0.038). Of all observed CpG sites in IL-4 promoter region, there was significant differences in CpG-48, CpG+54(P=0.041, 0.032). IL-4 mRNA expression was significantly increased in CD4+T cells(P=0.039). The level of IL-4 mRNA expression was negatively correlated to the mean level of methylation in IL-4 promoter region. After adjusting, level of PM10 exposure was negatively correlated with level of methylation in IL-4 promoter region(r2=0.419,β=-0.470,SD=0.781,P=0.045). CONCLUSION Level of methylation in IL-4 promoter region may be affected by PM10 exposure.

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share