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Effect of Ibudilast on the quality of life of patients with steroid resistant allergic rhinitis:a randomized,double blind,controlled study

Hong LUO ; Xiaoling LIU ; Zezhang TAO ; Nengbing YAN ; Guangzhen PAN ; Yan JIANG ; Ye YU ; Jiangping LI

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(11):-.

OBJECTIVE To assess the effect of Ibudilast on the quality of life (QOL) of patients with steroid resistant allergic rhinitis.METHODS A randomized,double-blind,placebo-controlled study was carried out with Ibudilast in 66 patients with the steroid resistant allergic rhinitis.QOL was measured with Short-Form Health Survey (SF-36) questionnaire (Chinese version).Ibudilast (10rag twice daily,34 patients),placebo (32 patients) was given for 3 weeks. The SF-36 questionnaire was administered at the start of treatment and after 3 weeks of treatment.Sings and Symptom-medication scores were measured daily during the study.RESULTS There were no significant differences between the Ibudilast and placebo group in terms of sings and symptoms or QOL scores before study.After 3 weeks of treatment,symptoms scores were significantly decreased and QOL scores significantly improved in the Ibudilast group compared with those in placebo group (both P

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Surgical approaches for maxillary sinus cyst

Jianying HAO ; Hong KONG ; Dongdong ZHU ; Cuida MENG

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(01):-.

OBJECTIVE To investigate the surgical approaches for maxillary sinus cyst. METHODS A total of 32 patients with maxillary sinus cyst underwent operation for removal the cysts. Among them, 8 patients with maxillary sinus cyst and sinusitis were operated on through Messerklinger approach, 19 patients with maxillary cyst received modified Caldwell-Luc operation under nasal endoscope and 5 patients received endoscopic removal of maxillary cyst through the maxillary sinus antrostomy at the inferior nasal meatus. RESULTS All the patients were followed up for 6 months to one year. There was no recurrence found in patients received modified Caldwell-Luc operation. There were 2 patients recurred in 8 patients who were operated on through Messerklinger approach and one patient had closure of the maxillary sinus ostium and adhesion of nasal cavity. One patient recurred and 2 lost follow up in 5 patients who received endoscopic removal of maxillary cyst through the maxillary sinus antrostomy at the inferior nasal meatus. CONCLUSION The optimal surgical method for maxillary cyst is modified Caldwell-Luc operation under nasal endoscope. Messerklinger technique may suitable for patients with complicated sinusitis.

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Diagnosis and treatment of Castleman disease in the neck

Shan SHAO ; Jing TAN ; Xianfa XU

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(01):-.

OBJECTIVE To investigate the clinical manifestation,diagnosis and treatment of Castleman disease(CD)in the neck. METHODS The data of 2 patients with pathological proved CD in the neck,who were seen in our hospital,were reviewed retrospectively in order to analyze their clinical manifestations,clinical and histological types, imaging characteristics and treatment. RESULTS The age of onset were 24 and 29 years respectively. Both of them only presented as a solitary,painless neck mass and met the criteria of localized CD, and also had histological evidence of the hyaline vascular variant. Complete surgical resection was the first treatment.Both of them were alive without evidence of recurrence for one year and half a year respectively. CONCLUSION CD in the neck often presents as localized lesion,which often presents as a progressive, painless, slowly growing lymph node enlargement that is generally asymptomatic. The locations most commonly are the cervical lymph nodes. CD in the neck is almost always the hyaline-vascular variant and complete surgical excision of the tumor is the best treatment.

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Correlation between spontaneous otoacoustic emissions and transient evoked otoacoustic emissions in neonate

Baoyu SHI ; Jinfeng LIU ; Ningyu WANG ; Fei XIA ; Hui WANG ; Xun WANG ; Jingjing YUAN ; Xin FU

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(01):-.

OBJECTIVE The aim of this study is to investigate the correlation between the spontaneous otoacoustic emission(SOAE)and transient evoked otoacoustic emission(TEOAE)in neonate. METHODS The subjects were 224 ears of 112 newborns(59 females, 53 males). The age of subjects ranged from 2 to 4 days (mean?SD: 2.68?0.74 day years). SOAE and TEOAE were measured with ILO96. RESULTS The correlation between SOAE number and TEOAE level were found (r=0.43, P

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Expression and their significance of c-Met and TIMP-2 in laryngeal squamous cell carcinoma

Juan ZHENG ; Wanrong LI

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(02):-.

OBJECTIVE To study the expression of c-Met,TIMP-2 in laryngeal squamous cell carcinoma and to explore the function and relationship of c-Met,TIMP-2 in the invasion and metastasis of laryngeal squamous cell carcinoma. METHODS Immunohistochemical method(SP) was used to detect the expression of c-Met,TIMP-2 in 41 laryngeal squamous cell carcinoma specimens and 15 specimens adjacent to the tumors.RESULTS The positive rate of c-Met and TIMP-2 in laryngeal squamous cell carcinoma specimens was 56.1% (23/41)and 63.4%(26/41)respectively.The positive rate of c-Met in tissues adjacent to tumors was 13.3%(2/15).No positive expression of TIMP-2 was found in tissues adjacent to tumors.CONCLUSION The expression of c-Met showed a positive correlation with histological differentiation and cervical lymph node metastasis and TIMP-2 showed a positive correlation with cervical lymph node metastasis in laryngeal squamous cell carcinoma.There was no significant relation between the expression of c-Met and TIMP-2 in laryngeal squamous cell carcinoma.

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Nasal sinus mucoceles after hypophysectomy

Li MENG

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(02):-.

OBJECTIVE To explore the causes, predilection sites and treatment of nasal sinus mucoceles after hypophysectomy.METHODS The clinical data of 7 cases with nasal sinus mucoceles after hypophysectomy diagnosed and treated in our Department from Jan.1998 to Aug.2007 were retrospectively studied.RESULTS The mucoceles were located at ethmoid sinus in 2 cases,frontal sinus in 2 cases,frontal and ethmoid sinuses in 3 cases.All of the 7 cases underwent mucocelectomy under nasal endoscope or a combined endoscopic intranasal and extra-nasal approach.No recurrence was found after follow up for 1 to 3 years.CONCLUSION The causes of nasal sinus mucoceles after hypophysectomy are the change of the anatomic structure of nasal cavity after surgery.The stenosis,adhesion of middle nasal meatus or obstruction of the sinus ostium are found in all the patients.Intranasal endoscopic surgery or combined with extra-nasal approach is the first choice for nasal sinus mucoceles.

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Clinical analyses of spontaneous cerebrospinal fluid rhinorrhea

Zhibin ZHAO ; Zhonglin MOU ; Zheng FU ; Yenong TAN

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(02):-.

OBJECTIVE To investigate the best approach of diagnosis and treatment of spontaneous cerebrospinal fluid rhinorrhea.METHODS The clinical data of 13 cases with spontaneous cerebrospinal fluid rhinorrhea performed in our hospital from 1998 to 2007 were analyzed retrospectively.RESULTS The diagnosis of spontaneous cerebrospinal fluid rhinorrhea was established for these 13 cases on a set of diagnostic program,including qualitative determination of sugar in the nasal leakage,nasal endoscopy, CT and MRI scan.All the patients were failed with conservative treatment.All of the 13 patients were cured by surgical repairing under nasal endoscope for follow up of 6 months to 6 years.CONCLUSION The diagnosis program for spontaneous cerebrospinal fluid rhinorrhea includes qualitative determination of sugar in the nasal leakage,nasal endoscopy,CT and MRI scan.Transnasal endoscopic management is the best method for repairing spontaneous cerebrospinal fluid rhinorrhea.

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Preoperative locating diagnosis and transnasal endoscopic surgery for cerebrospinal fluid rhinorrhea in sella turcica region

Chengjun LI ; Pinan LIU ; Shengtian WU ; Zhi LI

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(02):-.

OBJECTIVE To discuss the preoperative locating diagnosis and transnasal endoscopic surgery for cerebrospinal fluid rhinorrhea in sella turcica region.METHODS All of the 22 patients with cerebrospinal fluid rhinorrhea had been located the position of leakage by means of high resolution computed tomography(HRCT),magnetic resonance imaging(MRI)and/or computed tomography cisternography(CTC)techniques,and then the skull base defects were repaired with fascia via transnasal endoscopic surgery.All the patients were followed up for 6 to 51 months.RESULTS Nineteen cases were successfully repaired by operation once and another patient was cured through reoperation.Two cases refused reoperation after failure of the operation and lost follow-up.No complications such as intra-cranial infection and hemorrhage were found during the perioperative period and follow-up.The main failure causes of operation were the necrosis of the repairing fascia,missing the real leakage,and the recurrence of malignant tumor.CONCLUSION It is a key step to locate leakage accurately before operation by means of CT and MRI.Transnasal endoscopic technique is the optimal choice for management of cerebrospinal fluid rhinorrhea in sella turcica region.

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Biopsy for middle skull base neoplasms under nasal endoscope

Fuqiang NI ; Hongyan LI ; Haijin YI ; Pinan LIU

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(02):-.

OBJECTIVE To investigate the significance,indication,operation experience and complication of biopsy for middle skull base neoplasms under nasal endoscope.METHODS A total of 48 patients with middle skull base neoplasms underwent biopsy under nasal endoscope with local or general anesthesia.RESULTS Biopsy was successfully done in 95.8%patients.Two patients failed to the procedure because of bleeding.Forty two patients were diagnosed pathologically through the biopsy at the first time,and 4 patients were diagnosed through the biopsy at the second time.The positive rates of the biopsy near and in the lesions were 82.6%and 97.8%respectively. The positive rates were significantly different between those two different biopsy sites(P=0.02).Blood loss was less than 50ml in 85.4%patients.Only one patient had the complication of leakage of cerebrospinal fluid.CONCLUSION Biopsy of middle skull base neoplasms under nasal endoscope can identify the pathological nature of the lesions with minimal invasion and less complication,and it is a reliable method.The pathological positive rate is relative to the sites of the biopsy.Serial biopsies can increase the positive rate.

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Endoscopic surgery in nasal-skull base tumor

Changling SUN ; Chang SHU ; Jianchao CHEN ; Xiao YIN

Chinese Archives of Otolaryngology-Head and Neck Surgery.2006;0(02):-.

OBJECTIVE To investigate the efficacy and feasibility of endoscopic surgery to manage the tumors involving naso-ethmoidal complex and anterior skull base.METHODS 19 cases of tumors involving nasal cavity,ethmoid sinus and anterior skull base were summarized retrospectively, including 3 cases of ethmoidal squamous carcinoma, 3 cases of esthesioneuroblastoma,3 cases of melanoma,1 case of plasmocytoma,2 cases of ethmoidal adenocarcinoma,4 cases of adenoid cystic carcinoma,2 cases of meningioma.RESULTS Tumors were totally removed in 18 cases and subtotally removed in 1 case,all the cases were followed up for 1 to 3 years.Of the 3 cases of melanoma,1 case died of brain metastases 1 year after surgery,1 case recurred 8 months after surgery,1 case of adenoid cystic carcinoma recurred 17 months after surgery.No recurrence were found in the rest 16 cases during 1-3 years of following-up.CONCLUSION Endoscopic surgery is a effective method for malignant tumors localized in nasal cavity and ethmoid sinus and benign anterior skull base tumors involving nasal cavity and sinuses.Indication must be carefully selected for malignant tumors and postoperative radiotherapy should be advised.

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