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Investigation on the Selection of Essential Drug List in China

China Pharmacy.2005;0(24):-.

OBJECTIVE:To promote essential drug list into practice.METHODS:Relevant problems on the selection of National Essential Drug List were explored and analyzed.RESULTS & CONCLUSION:There are some problems on coordination of safety and effectiveness of drugs,price and the selection of traditional Chinese medicine.The advantage of first choice of essential drugs is not reflected completely.Large or small problems exist in selection process and individual drug verification.There was low credibility of drug evaluation.On the whole,the selection and formulation of essential drug list should be adjusted and improved continuously to guarantee the requirement of public medication.

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Some Problems of Pharmacy Management in Primary Hospital

Wenfang WANG ; Xiufeng WU ; Shurong DU ; Lili YAN

China Pharmacy.2005;0(24):-.

OBJECTIVE:To provide reference for the improvement of pharmacy management in primary hospital.METHODS:Some problems about pharmacy management and its operation process in primary hospital were introduced briefly.Reasons of above problems were investigated and analyzed,and relevant countermeasures were put forward.RESULTS & CONCLUSION:Pharmacy management of primary hospital should be strengthened,standardized and improved.More efforts should be put into the pharmacy work of primary hospital in order to make primary hospital become a great contributor for primary medical care.

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Comparison and Analysis on Foreign and Chinese Instructions of Felodipine

Tianping LI ; Zhiyong ZHANG

China Pharmacy.2005;0(24):-.

OBJECTIVE:To provide reference for the standardization of the instructions of felodipine.METHODS:The instructions of felodipine in China were compared with the national regulation as well as foreign instructions of felodipine.The problems of Chinese instructions of felodipine were analyzed to put forward revision measures.RESULTS & CONCLUSIONS:The problems of Chinese instructions of felodipine are items shortage or missing,lacking of warnings for drug safety.It is suggested that related administration departments and enterprises should revise and improve the instructions of felodipine.

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Study on the Pharmacokinetics and Bioequivalence of Mycophenolate Mofetil Soft Capsules

Jungang DENG ; Lidong DENG

China Pharmacy.2005;0(24):-.

OBJECTIVE:To study the relative bioavailability and pharmacokinetics of Mycophenolate mofetil capsules vs.Mycophenolate mofetil soft capsules in healthy volunteers.METHODS:In double period randomized crossover study,20 healthy volunteers were given a single oral dose of trial capsule and reference capsule 4 pills(0.25 g per pill).The concentration of mycophenolate(MPA) was determined by HPLC.Pharmacokinetic parameters were calculated using DAs 2.0 software and the bioequivalence of 2 formulations were evaluated.RESULTS:Main pharmacokinetic parameters of trial capsule vs.reference capsule were as follows:AUC0→t:(69.95?14.13)?g?h?mL-1 vs.(66.95?19.05)?g?h?mL-1;AUC0→∞:(85.18?20.51)?g?h?mL-1 vs.(77.39?23.78) ?g?h?mL-1;Cmax:(31.26?13.09)?g?mL-1 vs.(31.90?14.45)?g?mL-1;tmax:(0.875?0.358)h vs.(0.775?0.291)h.The relative bioavailability of Mycophenolate mofetil soft capsules in 20 healthy volunteers was(109.6?26.9)%.CONCLUSION:Results of study indicated the 2 formulations are bioequivalent.

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Utilization of Microbioecologics in Outpatient Department of Pediatrics of Our Hospital

Jie LI ; Yanrong WANG

China Pharmacy.2005;0(24):-.

OBJECTIVE:To investigate the utilization of microbioecologics in outpatient department of pediatrics of our hospital.METHODS:Prescriptions were randomly collected from outpatient department of pediatrics of our hospital in Dec.2009 to analyze the utilization of microbioecologics.RESULTS:Of total 8 858 prescriptions,microbioecologics were used in 486 cases,accounting for 5.48%;bifidobacterium combined with lactobacillus,enterococcus and bacillus cereus tablets(live) accounted for 59.26%.Microbioecologics combined with antibiotics accounted for 8.49% but the combination of tow kinds of microbioecologics hadn't been found.CONCLUSIONS:The utilization of microbioecologics is rational in outpatient department of pediatrics of our hospital on the whole.

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The Effect Analysis of the Procurement System in Ningxia Rural Areas

Ying LANG ; Lingui LI

China Pharmacy.2005;0(24):-.

OBJECTIVE:To analyze the results of Procurement System implementation in Ningxia Rural Areas.METHODS:Typical sampling method selected 4 township hospitals of Xiji county and Pengyang county in Ningxia as a sample,through qualitative and quantitative methods to design the questionnaire and interview outline.RESULTS & CONCLUSION:during 06～08 years,the actual bidding variety of rural drugs accounted in Ningxia move gradually decreased the percentage of species;township hospitals in drug revenues decreased year by year the proportion of total income;drugs out of stock is serious;drugs are few,temporarily not bidding drugs are in high price;common drugs bidding directory is small;rural health room staff are paid lowly.Recommendating to establish a sound procurement system to make it better.

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Clinical Efficacy of Edaravone Combined with Xingnaojing in the Treatment of Acute Severe Brain Injury

Weiming WANG ; Yiqin JIN ; Suilin YE ; Jin LIU ; Xuelei ZHANG

China Pharmacy.2005;0(24):-.

OBJECTIVE:To analyze the clinical efficacy of edaravone combined with Xingnaojing in the treatment of acute severe head injury.METHODS:72 patients with acute severe brain injury were collected from Nov.2008 to Nov.2009 and randomly divided into 2 groups.Treatment group were treated with edaravone and Xingnaojing and control group received edaravone alone.14 days after treatment,APACHE-Ⅱ and GCS score were collected.The overall efficacies of 2 groups were evaluated three months after suffering from injury.RESULTS:The GCS score of treatment group was increased while APACHE-Ⅱ score was decreased,there was statistical significance in difference between 2 groups(P

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Cost-effectiveness Analysis of 3 Kinds of Antimicrobial Drugs for Acute Lithiasic Cholecystitis

Yinglu LU ; Lihua SUN

China Pharmacy.2005;0(24):-.

OBJECTIVE:To evaluate economic effectiveness of 3 kinds of antimicrobial drugs for acute lithiasic cholecystitis,and to provide reference for rational use of antimicrobial drugs in biliary disease surgery.METHODS:A multicenter prospective randomized controlled study was conducted in 493 clinical cases of acute lithiasic cholecystitis.Cost-effectiveness analysis of cefoperazone/sulbactam sodium(therapy A n=180),cefuroxime(therapy B n=148) and levofloxacin(therapy C n=165) for acute lithiasic cholecystitis were carried out.RESULTS:Effective rates of three kinds of therapeutic regimens 95.56%,73.65%,84.24%,respectively.CONCLUSION:Incremental cost-effectiveness analysis of three kinds of therapeutic regimens shows therapy A is economical and the best choice for acute lithiasic cholecystitis compared with group B and C.

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Study on Interaction between the Price of 7-Amino-cephalsporanic Acid and the Price of Its Preparation Cefazolin Sodium

Caixin HAN

China Pharmacy.2007;0(25):-.

OBJECTIVE:To probe into the interaction between the price of 7-amino-cephalsoranic acid(7-ACA) and the price of its preparation(cefazolin sodium) and to provide reference for price strategy of pharmaceutical enterprises.METHODS:Correlation analysis,autocorrelation analysis and auto-regressive distributed lag were applied to analyze the samples which were collected from monthly selling price of 7-ACA of China Shijiazhuang Pharmaceutical Group Co.,Ltd.during 24 months.RESULTS:There was positive correlation between the price of 7-ACA and the price of cefazolin sodium with correlation coefficient of 0.682 5.The price of 7-ACA and cefazolin sodium are autocorrelative respectively.The price of 7-ACA was influenced by previous price,besides raw material cost,production cost and selling expenditures.The price of 7-ACA changed 3 months later because of previous price.The price of 7-ACA would change 2 months later as the price of cefazolin sodium changed and it changed 1 month later as previous price changed.When the price of 7-ACA changed,the price of cefazolin sodium price would change one month later.CONCLUSION:Effective price strategy should be decided according to the interaction between the price of crude drug and the price of preparation besides the cost of raw materials,production costs and selling expenditures.

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Effect of Reteplase Combined with Low-molecular Heparin Sodium in the Treatment of Early Acute Cerebral Infarction

Daopei LI ; Baomei LI ; Yunhui CHEN

China Pharmacy.2005;0(24):-.

OBJECTIVE:To observe efficacy and safety of reteplase combined with low-molecular heparin sodium intravenous thrombolysis in the treatment of early cerebral infarction.METHODS:102 cases of early acute cerebral infarction from Jan.2007 to Aug.2009 were received intravenous thrombolytic therapy.52 cases were treated with reteplase combined with low-molecular heparin sodium as observation group and 50 cases were treated with reteplase as control group.The neurological deficit scores(NIHSS) values at 1,7 and 14 d before and after treatment were compared between 2 groups.The complication of 2 groups were evaluated after treatment.RESULTS:The NIHSS score in observation group were decreased significantly as compared with control group,there were significant difference(P0.05).CONCLUSION:Intravenous administration of 10 MU reteplase combined with 5 000 U?12 h-1 low-molecular heparin sodium is superior to reteplase alone in the treatment of acute cerebral infarction.Reteplase combined with low-molecular heparin sodium does not increase the risk of bleeding in key site of patients(including the elderly).

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