Analysis on the status of hepatitis B vaccine rate in floating among one-year old children.
Chinese Journal of Epidemiology.2007;28(4):415-416.
Chinese Journal of Epidemiology
2002 (v1, n1) to Present ISSN: 1671-8925
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Chinese Journal of Epidemiology.2007;28(4):413-414.
Progress on the study of disease burden and economic impact of next influenza pandemic.
Chinese Journal of Epidemiology.2007;28(4):405-407.
Research advancement of human Streptococcus suis epidemiology.
Chinese Journal of Epidemiology.2007;28(4):402-404.
An applied multilevel model used in the study on behavior of smoking.
Chinese Journal of Epidemiology.2007;28(4):398-401.
OBJECTIVETo introduce the nature and its application of a multilevel model.
METHODSData was analyzed from a baseline survey of smoking behavior among middle school students sponsored by a WHO smoking controll project. Multilevel analysis was used on available data and to compare the results from logistic regression.
RESULTSThe outcomes of null multilevel model approved that there was hierarchical structure on data. The influencing factors of middle school students smoking appeared to be gender, age, attitude, environment and public education at schools. When the variable of public education by classes was not included, the standard errors by multilevel analysis became smaller than the corresponding standard errors through logistic regression method.
CONCLUSIONMultilevel model seemed a good method for analyzing data with hierarchical or cluster structure, it could be applied in stratified or cluster sampling of epidemiological or community-based investigation.
Humans ; Models, Theoretical ; Smoking ; Students
Chinese Journal of Epidemiology.2007;28(4):394-397.
OBJECTIVETo study the relation between single nucleotide polymorphism(SNP) at the 91T-->A(Phe31Ile) position of the STK15 gene and the susceptibility of esophageal squamous cell carcinoma (ESCC) in She county--a ESCC high incidence region in North China.
METHODSPolymerase-chain reaction(PCR)-restriction fragment length polymorphism (RFLP) analysis was used to detect the genotypes of STKl5 Phe31Ile(91T-->A) SNP, and the samples came from 296 ESCC patients and 302 healthy controls.
RESULTSThe risk of ESCC significantly increased in the group which had been smoking or having a family history of upper gastrointestinal cancer (UGIC) (the OR = 1.68 and 1.77, 95% CI: 1.34-2.10 and 1.44-2.19, respectively). Rates of the three genotypes (Phe/Phe, Phe/Ile, Ile/Ile) of the STK15 Phe31Ile (91T-->A) SNPs in ESCC patients were 11.5%, 34.8% and 53.7%, respectively, and were not significantly different from that in the healthy group (11.9%, 36.8% and 51.3%) (chi2 = 0.35, P = 0.84). When compared to Phe/Phe genotype, Phe/Ile and Ile/Ile of STK15 91T-->A(Phe31Ile)did not show effect on the risk of ESCC according to the odds ratio results which were 0.98 (95% CI: 0.57-1.69) and 1.09 (0.65-1.82) respectively. STK15 91T-->A (Phe31Ile) SNP also did not significantly influence on the development of ESCC even the samples were stratified by sex, smoking status and family history of upper gastrointestinal cancer.
CONCLUSIONThe STK15 Phe31Ile(91T-->A) polymorphisms seemed irrelevant with the risk of ESCC in She county.
Aurora Kinase A ; Aurora Kinases ; Carcinoma, Squamous Cell ; genetics ; Case-Control Studies ; Esophageal Neoplasms ; genetics ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Protein-Serine-Threonine Kinases ; genetics
Chinese Journal of Epidemiology.2007;28(4):390-393.
OBJECTIVEThe purpose of this study was to describe survival status and risk factors of mortality on inpatients with ischemic stroke.
METHODS617 patients with continuous ischemic stroke cases were collected from January 2002 to June 2005 retrospectively in the Department of Neurology, Xijing Hospital, Fourth Military Medical University. In order to perceive relevant information on survival and the cause of death. All patients were followed through phone calls or mailing. The follow-up program was completed in January 2006. Kaplan-Meier methods were used for survival description. Monovariant and multivariant Cox's proportional hazard regression model were used to analyze prognostic factors on mortality.
RESULTSThe longest time in the follow-up program was 47 months with 59 dropped-out cases, making the dropout rate as 9.5%. Of these patients, 80 cases died during the period of study(60 for ischemic stroke,3 for cerebral hemorrhage, 10 for cardiac disease, 7 for other cause). The median survival time was 42. 16 months. The survival rates of one-year, two-year and three-year period were 91.9%, 89.4% and 85.3%, respectively. Monovariant and multivariant Cox's proportional hazard regression model showed that the risk factors associated with mortality were old age (RR = 1.043, 95% CI: 1.013-1.074), lower Glasgow scores (RR = 0.855, 95% CI: 0.742-0.985) ,poor conscious levels(RR = 4.085, 95% CI: 2.128-7.844) and having complication (RR = 1.765, 95% CI: 1.108-2.812).
CONCLUSIONThe results of this study suggested that the risk factors were old age, lower Glasgow scores, poor conscious levels and having complication on mortality of ischemic stroke.
Aged ; Brain Ischemia ; mortality ; China ; epidemiology ; Humans ; Retrospective Studies ; Risk Factors ; Stroke ; mortality ; Survival Rate
Chinese Journal of Epidemiology.2007;28(4):385-389.
OBJECTIVETo elucidate the evolution pattern of human influenza virus A H3 subtype by detecting positive selected codons in hemagglutinin gene.
METHODSAll H3 sequences in NCBI GenBank and influenza sequence database were downloaded and two step cluster method was applied to divide sequences into six groups, which were corresponding to different period by turns. Fixed Effect Model was applied to detect positive selected codons in each group, and two step cluster method was then used again to summarize variation patterns of selective pressure among sites.
RESULTSPositive selected codons were different in groups corresponding different periods. 50 amino acid codons had been identified as positive selected sites in at least one time span. Among them, 42 codons belonged to one of the five known antigen-combinng regions. A larger amount of sites as well as relatively higher selection pressure were identified in antibody combining regions A and B. Results showed that the 50 sites could be divided into seven different patterns. While other six patterns corresponding to positive selected codons at only one time span, the sites of the seventh pattern were under positive selection in several periods.
CONCLUSIONPositive selection codons in evolution of H3A1 strains were alternated in different time period whereas antibody combining regions A and B played more important roles in the evolution process. Other 8 identified codons out of the antibody combining regions might belong to unknown antigen regions.
Amino Acid Sequence ; Codon ; Hemagglutinins ; genetics ; Humans ; Influenza A Virus, H3N2 Subtype ; genetics ; Influenza, Human ; genetics ; Selection, Genetic
Study on the carbapenemase genotype and molecular epidemiology of Acinetobacter baumannii.
Chinese Journal of Epidemiology.2007;28(4):381-384.
OBJECTIVETo investigate antibiotic resistance, clonal relatedness and carbapenemase genotype among carbapenem-resistant Acinetobacter baumannii collected from 3 comprehensive hospitals in Ningbo city, Zhejiang province.
METHODS28 strains of carbapenem resistant Acinetobacter baumannii were collected from Ningbo Li Hui-li Hospital, Ningbo Li Hui-li Hospital, Ningbo First Hospital, and N ingbo Second Hospital. The minimum inhibitory concentrations (MIC) of these strains were examined by agar dilution and E-test method. Homology of these isolates was analyzed by pulse-field gel electrophoresis (PFGE) and Genotype of carbapenemases were analyzed by PCR and verified by DNA sequencing.
RESULTS28 strains of Acinetobacter baumanii were highly resistant to all of the antibiotics except polymyxin E. They were classified into 4 clones based on PFGE pattern. Clone A and B had been spreading widely. All of the 28 strains produced carbapenemases which were confirmed as OXA-23 by PCR and sequencing. Metallo-beta-lactamase was not detected in any of the isolates.
CONCLUSIONAll of t hecarbapenem-resistant Acinetobacter baumannii collected from Ningbo were producing OXA-23 carbapenemase, suggesting that the transmission of clones had occurred in the 3 hospitals.
Acinetobacter Infections ; drug therapy ; epidemiology ; Acinetobacter baumannii ; drug effects ; genetics ; metabolism ; Bacterial Proteins ; genetics ; China ; Drug Resistance, Microbial ; Genotype ; Hospitals ; Humans ; Molecular Epidemiology ; Polymerase Chain Reaction ; beta-Lactamases ; genetics
Multi-PCR identification and virulence genes detection of Campylobacter jejuni isolated from China.
Chinese Journal of Epidemiology.2007;28(4):377-380.
OBJECTIVEThis study was to simultaneously identify Campylobacter jejuni and Campylobacter coli isolates in China by Multi-PCR assay and to study the prevalence of six virulence and toxin genes on them.
METHODSA multi-PCR method with three sets of primers specifically designed for application of a 16S rRNA as a universal control, mapA, ceuE based on the specific sequence of C. jejuni and C. coli, was applied to detect 65 Campylobacter isolates from China. Another two separately PCR Primers were directed towards the hippuricase gene (hipO) characteristic of C.jejuni and glyA gene characteristic of C. coli were performed for further confirmation. The presence of the cadF, virB11, flaA, cdtA, cdtB, cdtC genes among these 65 strains were investigated by PCR.
RESULTSFrom multi-PCR detection, 42 isolates belonged to C. jejuni, other 23 isolates belong to C. coli. Data showing the identification were 100% in concordance with the separated PCR for hipO and glyA amplification. The efficiency (100%) of identification by these three primers multi-PCR method was higher than the biochemical test (83.1%). The cadF and flaA genes were detected from 100% (65/65) of the isolates and the PCR product of each gene were identical with each isolate. Only 10.8% (7/65) of the isolates were positive for virB11. The cdtA gene was found in 92% (60/65) of the isolates. 97.6% (41/42) of C. jejuni had cdtB gene, whereas no PCR product with this primers for all the C. coli isolates. cdtC was presented in all the isolates but the lengths of PCR products were different. For C. jejuni, it was 555 bp, for C. coli, it was about 465 bp.
CONCLUSIONThis three primers simultaneous multi-PCR method seemed to be useful for the identification of C. jejuni and C. coli isolates from China since cadF and flaA genes were widely spread in Campylobacter isolates in this country. The present report on virB11 was similar to previous reports from other countries, but the distribution of cdt gene cluster in Campylobacter species isolated from China might be different.
Campylobacter coli ; genetics ; isolation & purification ; pathogenicity ; Campylobacter jejuni ; genetics ; isolation & purification ; pathogenicity ; China ; DNA Primers ; Genes, Bacterial ; Polymerase Chain Reaction ; Virulence ; genetics
Country
China
Publisher
中华医学会
ElectronicLinks
http://chinaepi.icdc.cnEditor-in-chief
lxbonly@public3.bta.net.cn
Abbreviation
Chinese Journal of Epidemiology
Vernacular Journal Title
中华流行病学杂志
ISSN
0254-6450
EISSN
Year Approved
2007
Current Indexing Status
Currently Indexed
Start Year
1981
Description
历史沿革【现用刊名：中华流行病学杂志;创刊时间：1981】，该刊被以下数据库收录【CA 化学文摘(美)(2009);CBST 科学技术文献速报(日)(2009);中国科学引文数据库(CSCD—2008)】，核心期刊【中文核心期刊(2008);中文核心期刊(2004);中文核心期刊(2000);中文核心期刊(1996);中文核心期刊(1992)】。
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