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Chinese Journal of Postgraduates of Medicine

2002 (v1, n1) to Present ISSN: 1671-8925

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Antiosteoporotic efficacy of orally alendronate in men with prostate cancer receiving combined androgen blockade

Haibo SHEN ; Zhe ZHANG ; Zhengqin GU ; Liang ZHANG ; Jian KANG ; Jun QI

Chinese Journal of Postgraduates of Medicine.2010;33(27):8-10,63. doi:10.3760/cma.j.issn.1673-4904.2010.27.004

Objective To study osteoporosis in patients receiving androgen deprivation therapy (ADT) with prostate cancer, and determine whether once-weekly oral alendronate can prevent bone loss in men receiving ADT. Methods One hundred and twelve men with nonmetastatic prostate cancer receiving ADT were divided into two groups from April 2007 to April 2008, 56 cases in each group. Group A took alendronate (70 rng once-weekly orally) and calcium supplement, group B received calcium supplement only. Bone mineral density (BMD) were measured both before and 6 months, 12 months after treatment for both groups. Results There were no statistically differences in age, persistence time of castration, prostate specific antigen level and adverse effect between two groups(P> 0.05). At baseline, 39.3%(44/112) of men had osteoporosis and 51.8%(58/112) had low bone mass. After 12 months treatment, in group A, BMD increased 3.7% (95% CI 2.80% to 4.60% ,P<0.01 ) at the spine,0.7%(95% CI 0.10% to 1.40% ,P=0.031)at the total hip and 1.6% (95% CI0.40% to 2.80%,P =0.008) at the femoral neck. In group B decreased 1.4% (95% CI-2.70% to -0.03%, P = 0.045 ) at the spine, 0.7% (95% CI - 1.50% to -0.01%,P = 0.052) at the total hip and 0.7% (95% CI -1.50% to 0.10%, P = 0.081 ) at the femoral neck. The estimated changes in BMD were significantly different between two groups (P < 0.01 ). Conclusions It suggests that ADT induce bone loss which should be treated in early stage. Bone loss that occurred with ADT is prevented and improved with once-weekly oral alendronate.

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Expression of WDHD1 protein in esophageal squamous cell carcinoma and its relationship with clinical significance

Yixiong PANG ; Lei HU ; Weijiang HUANG ; Wei ZHENG ; Zhimin LIAO ; Ping LI

Chinese Journal of Postgraduates of Medicine.2014;37(5):50-51,56. doi:10.3760/cma.j.issn.1673-4904.2014.05.017

Objective To investigate the clinical significance of WDHD1 protein expression in esophageal squamous cell carcinoma.Methods The expression of WDHD1 protein in esophageal squamous cell carcinoma,adenocarcinoma of esophagus and normal esophagus tissues by immunohistochemical MaxVision was detected.Results The expression of WDHD1 protein in the tissues of esophageal squamous cell carcinoma was significantly higher than that in the normal esophagus tissues and adenocarcinoma of esophagus (15.68 ± 3.01 vs.3.89 ± 2.98 and 4.66 ± 2.46)(P < 0.05),there was no significant between normal esophagus tissues and adenocarcinoma of esophagus (P > 0.05).The expression of WDHD 1 protein in the tissues of esophageal squamous cell carcinoma,high-middle differentiation tissues was higher than poorly differentiation,TNM stage Ⅲ + Ⅳ stage was higher than Ⅰ + Ⅱ stage,depth of invasion T3 + T4 was higher than T1 + T2,with lymph node metastasis tissue was higher than without,differences was statistically significant (P <0.05).Conclusions The higher expression of WDHD1 protein is the marker of high invasive and low histological grade of esophageal squamous cell carcinoma,and WDHD1 in esophageal squamous cell carcinomas may play an important role in development.

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The research of relation between non-alcoholic fatty liver disease and total cholesterol,triglyceride,low density lipoprotein-cholesterol in blood

Jianrong LING

Chinese Journal of Postgraduates of Medicine.2014;37(4):40-41,75. doi:10.3760/cma.j.issn.1673-4904.2014.04.012

Objective To investigate the relation between non-alcoholic fatty liver disease (NAFLD) and total cholesterol (TC),triglyceride (TG),low density lipoprotein-cholesterol (LDL-C) in blood,and provide reference for clinical diagnosis and treatment.Methods Eighty cases of normal young men without NAFLD were as control group,80 cases of NAFLD without type 2 diabetes mellitus were as group A,and 80 cases of NAFLD combined with type 2 diabetes mellitus were as group B.Then the blood lipid was analyzed and compared among the 3 groups.Results The TC,TG and LDL-C levels in control group were (4.09 ± 1.01),(1.94 ±2.14) and (2.47 ±0.93) mmol/L respectively,in group A were (5.16 ±2.13),(3.01 ± 1.56) and (3.15 ± 1.12) mmol/L respectively,and in group B were (6.21 ± 1.17),(4.35 ± 1.20)and (3.21 ± 0.15) mmol/L respectively,there were statistical differences among the 3 groups (P < 0.05).The TC,TG and LDL-C levels in group A and group B were significantly higher than those in control group,in group B were significantly higher than those in group A,and there were statistical differences (P < 0.05).Conclusions NAFLD and blood lipids is closely related,and it affects normal operation function of part lipid metabolism.Patients with type 2 diabetes mellitus are significantly abnormal in lipid metabolism.

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The expression level of interleukin-22 in peripheral blood of patients with ankylosing spondylitis and its clinical significance

Jie MIAO ; Pei GAN

Chinese Journal of Postgraduates of Medicine.2013;36(35):33-34,38. doi:10.3760/cma.j.issn.1673-4904.2013.35.011

Objective To study the expression level of interleukin (IL)-22 in the peripheral blood of patients with ankylosing spondylitis and its clinical significance.Methods The mRNA level of IL-22 in the peripheral blood was measured by real-time quantitative polymerase chain reaction,and the plasma level of IL-22 was measured by enzyme linked immunosorbent assay in 30 patients with ankylosing spondylitis and 30 normal controls.Results The mRNA level of IL-22 in the peripheral blood and the plasma level of IL-22 in patients with ankylosing spondylitis were statistically higher than those in normal controls [1.82 ± 0.79 vs.1.31 ± 0.63 and (47.08 ± 17.25) ng/L vs.(30.47 ± 11.24) ng/L,P < 0.05].Conclusion The level of IL-22 in the peripheral blood of patients with ankylosing spondylitis increases,and IL-22 may participate in the occurrence of ankylosing spondylitis.

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Comparison of sevoflurane-remifentanil and propofol-remifentanil anesthesia in elderly patients undergoing radical gastrectomy for cancer

Dezhuang CUI ; Guixiang WANG ; Hanhua LIU ; Liang FANG

Chinese Journal of Postgraduates of Medicine.2010;33(9):8-10,32. doi:10.3760/cma.j.issn.1673-4904.2010.09.004

Objective To compare the efficacy of sevoflurane-remifentanil and propofol-remifentanil anesthesia in elderly patients undergoing radical gastrectomy for cancer.Methods Sixty ASA Ⅱ - Ⅲ patients aged 65-80 years old with gastric cancer were divided into sevoflurane group(group S) and propofol group (group P), 30 cases in each group.Perioperative hemodynamic variables, bispectral index( BIS ) values and the time of recovery from anesthesia, extubation and awake were recorded as well.Results Compared with those before anesthesia,diastolic blood pressure(DBP),mean arterial pressure(MAP), heart rate(HR) and BItS were signifieanfly decreased (P < 0.05 or < 0.01 ).SBP was higher at cutting skin in group S than that in group P (P < 0.05 ).The depths of anesthesia in both groups were maintained well with BIS in 45-60 and vital signs were stable during operation.The time of recovery from anesthesia, extubafion and awake were shorter in group S [(4.1±2.2),(5.4±2.1),(7.3±2.1)min]thanthoseingroupP [(7.5±3.2),(8.6± 4.2), ( 11.2 ± 4.1 ) min]( P < 0.05 or < 0.01 ).Conclusions Either sevoflurane-remifentanil and propofol-remifentanil anesthesia can be used safely in elderly patients undergoing radical gastrectomy for cancer.Sevotlurane-remifentanil combined with anesthesia provides better hemodynamic stability and faster recovery than propofol-remifentanil combined with anesthesia in elderly patients.

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The study on wrong diagnosis in the patients with epidemic hemorrhage fever in the early stage

Wenjun GAO ; Aiping NIU ; Guangwen ZHANG

Chinese Journal of Postgraduates of Medicine.2006;0(01):-.

Objective To study wrong diagnosis in the patients with epidemic hemorrhage fever in the early stage. Method To analyze the data such as the time of making wrong diagnosis,the wrong diagnosis,the department of treatment and the hospital of treatment before the diagnosis was made and the relationship between the clinical type and making wrong diagnosis. Results Making wrong diagnosis in the patients with epidemic hemorrhage fever was common (88.97%),and it was more happened in the early stage,in the non-typical and mild patients and in the lower grade hospitals.The wrong diagnosis rate (28.95%,11/38)was lower in the Infectious disease department than in the other department (93.65%),P

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Link of type 2 diabetes with insulin resistance and cytokines

Yong ZHOU ; Jian ZHU ; Yi WANG

Chinese Journal of Postgraduates of Medicine.2006;0(01):-.

Objective To study on the changes of the IL-6、IL-8、TNF-? in the type 2 diabetes with insulin resistance and the relation of plasma glucose or insulin resistance and cytokines. Methods (1) To assay the serum level of cytokines in 90 cases with type 2 diabetes mellitus (T2DM) and 30 normal controls. (2)To measure the level of fasting plasma glucose (FPG),hemoglohin A_1c (HBA_1c),fasting insulin(FINS),fasting C-peptide (FCP).(3) To analysis the relation of the level of FPG,HBA_1c,FINS,FCP and cytokines. Results (1) The serum levels of cytokines in T2DM group were significantly increase than in control groups,IL-6 and TNF-? in T2DM group with insulin resistance were significantly increase than in T2DM group without insulin resistance (2) There was significantly positively correlated between insulin resistance and the increasing of cytokine levels. Conclusion There is an excess activation of cytokines in T2DM,which is significantly correlated with insulin resistance. Cytokines play the important role in the occurrence and development of T2DM and insulin resistance.

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Implication of impulse oscillometry in the measurement of bronchial hyperresponsiveness

Hongyu WANG ; Jiaying AN ; Dingfen LUO ; Jinping ZHENG

Chinese Journal of Postgraduates of Medicine.2006;0(01):-.

0.05) in the negative group. However, there was a significant increase in each parameter except Rc in the positive group (P

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Characteristic of sleep electroencephalograph in patients with depressions plus psychogenic anxiety

Peng ZHAO ; Xinbao ZHANG ; Gang HOU ; Dongshan YU

Chinese Journal of Postgraduates of Medicine.2006;0(01):-.

Objective To describe characteristic of sleep electroencephalograph (EEG) in depressions with psychogenic anxiety. Methods It was estimated for sleep EEG in 7 depressive patients with psychogenic anxiety,11 depressive patients with non-psychogenic anxiety and 10 normal controls. Results (1)Time from awake to getting up was significantly longer in non-psychogenic anxiety group than the normal subjects [(12.0?8.4)min vs(3.1?2.8)min,P0.05]. Conclusion (1)Time from awake to getting up is longer in non-psychogenic anxiety group than the normal subjects.(2)The tension of REM is higher in non-psychogenic anxiety group than the normal subjects.(3)It has tendency to be lower for tension of Rapid Eye Move in psychogenic anxiety group than the normal subjects.

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Changes of plasma metalloproteinase-2 and metalloproteinase-9 in patients with intracerebral hemorrhage

Ming YU ; Xiaogang LI

Chinese Journal of Postgraduates of Medicine.2006;0(01):-.

Objective To investigate the changes and the significance of the contents in matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in plasm of patients with intracerebral hemorrhage (ICH). Methods The contents of MMP-2 and MMP-9 in plasm of 50 patients with ICH and 50 healthy people (control group) were measured respectively through ELISA methods. Results Compared with the control group,the increase of the contents of MMP-2 and MMP-9 had obvious statistic significance in plasm of patients with ICH (P0.05),but they had obvious statistic significance in the comparison among other time groups (P

Country

China

Publisher

中华医学会

ElectronicLinks

http://www.zgysjxzz.com

Editor-in-chief

E-mail

yishi@zgysjxzz.com

Abbreviation

Chinese Journal of Postgraduates of Medicine

Vernacular Journal Title

中国医师进修杂志

ISSN

1673-4904

EISSN

Year Approved

2007

Current Indexing Status

Currently Indexed

Start Year

1978

Description

历史沿革【现用刊名:中国医师进修杂志;曾用刊名:医师进修杂志;创刊时间:1978】,核心期刊【中文核心期刊(2000);中文核心期刊(1996);中文核心期刊(1992)】,期刊荣誉【Caj-cd规范获奖期刊】。

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