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External Beam Radiation Therapy of Aden carcinoma of the Prostate.

Ihn H HAN ; Christos KANELLITSAS ; Janice La ROUERE ; Sakthi P VADIVEL

Journal of the Korean Society for Therapeutic Radiology.1984;2(2):245-252.

The record of radiation therapy cases during a five-ear period at the University of Michigan Hospitals has been analyzed. Of a total of 73 Aden carcinoma of prostate, the majority belonged to Stage B and C which represented 49 and 20 cases, respectively. The mortality rate after irradiation was clearly related to the tumor stage. Local irradiation resulted in 88% of the local control of well-ifferentiated Aden carcinomas. Stage C cases had 50% mortality, whereas that of Stage B patients was 14%. Results of this study are in general agreement with previous data in terms of the local disease control after irradiation and provide a basis for conservative radiotherapy regimen as an approach in the treatment of localized prostatic carcinomas.
Humans ; Michigan ; Mortality ; Prostate* ; Radiotherapy ; Yemen*

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Treatment of Unresectable Non-Small-Cell Lung Cancer with Curative Radiotherapy.

Il han KIM ; Sung Whan HA ; Charn Il PARK ; Young Soo SHIM ; Noe Kyeong KIM ; Keun Youl KIM ; Yong Chol HAN

Journal of the Korean Society for Therapeutic Radiology.1984;2(2):203-212.

From 1979 to 1982, 80 patients with unresectable non-mall-ell lung cancer without metastasis were treated with high-ose radiotherapy to the primary and to regional lymph nodes with or without supraclavicular lymphatic in the Department of Therapeutic radiology, Seoul National University Hospital. Of these, 56 patients (70%) were completely evaluable, and 59 patients (74%) had squamous cell carcinoma, 13% large cell undifferentiated carcinoma and 8% Aden carcinoma. 21 patients (26%) had Stage II and 59 patients (74%) had Stage III. The complete and partial response rate in the high-ose (~ 6,000rad) radiotherapy was 70% with 19% complete response. 69 patients (86%) failed in the treatment, by the failure pattern, 64% had local failure alone, 35% had local failure and distant metastasis and 1% had distant metastasis alone. The failure rate in the thorax was 76% in squamous cell carcinoma, 40% in Aden carcinoma and 20% in large cell undifferentiated carcinoma. Preliminary result shows that actuarial survival at 1, 2 and 3 years were 56%, 26% and 20% in overall patients and 64%, 37% and 21% in Stage II and 54%, 21% and 18% in Stage III, respectively. Overall median survival was 14 months; 17 months in Stage II and 13 months in Stage III. 8 patients (10%) have lived a minimum of 2 years with no evidence of disease. There was no fatal complication confirmed to be induced by radiotherapy, so definitive high-ose radiotherapy was tolerated well without major problems and resulted in good local control and survival.
Carcinoma ; Carcinoma, Squamous Cell ; Humans ; Lung Neoplasms* ; Lung* ; Lymph Nodes ; Neoplasm Metastasis ; Radiation Oncology ; Radiotherapy* ; Seoul ; Thorax ; Yemen

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The result of Radiation Therapy of Supraglottic Laryngeal Cancer for 15 Years.

Seong Yul YOO ; Kyoung Hwan KOH ; Sung Hee SUH ; Jin Yong KIM ; Youn Sang SHIM

Journal of the Korean Society for Therapeutic Radiology.1984;2(2):185-190.

To assess the result of radiation therapy for fifteen years experience, a total of 125 cases of pathologically proven supraglottic laryngeal cancer had been analyzed according to patient survival retrospectively. All the patients had been treated with radiation therapy in curative aim using Co-0 teletherapy machine. The results are as follows; 1. According to AJCC staging, five year survival rate was 58.3% in stage I, 44.4% in II, 31.8% in III and 28.6% in IV. 2. According to T-taging, five year survival rate was 57.1% in stage T1, 40.5% in T2, 34.0% in T3 and 19.0% in T4. 3. According to N staging, five-ear survival rate was 43.5% in negative node group and 26.8% in positive node group. 4. According to the histologic grade, the better in differentiation, the more in number of cases and the better in prognosis. 5. In summary, five year actuarial survival rate was 37.3% and ten-ear survival rate was 34.2%, and ten-ear survivors totaled 16 cases.
Humans ; Laryngeal Neoplasms* ; Prognosis ; Retrospective Studies ; Survival Rate ; Survivors

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Radiotherapy Results of Brain Astrocytomas.

Chang Ok SUH ; Gwi Eon KIM ; Jung Ho SUH

Journal of the Korean Society for Therapeutic Radiology.1984;2(2):177-184.

A retrospective analysis of survival data of 52 cases with brain astrocytomas was presented. All patients received post-perative radiotherapy in the period of 1973~1983 at YUMC, Yonsei Cancer Center. There were 24 patients with Grade II, 12 patients with Grade III and 16 patients with Grade IV astrocytomas. Survival rates were analyzed according to histologic grade of malignancy, age, tumor location. radiation dose and extent of surgical tumor resection. 5 year actuarial survival for patients with Grade II astrocytomas was 32.9% ad Grade III was 42.9%. The 1 year and 2 year survival rate of Grade IV astrocytomas were 46.7% and 0%. Histologic grade of tumor was important prognostic factor in brain astrocytomas. Age and extent of surgical resection were significant prognostic factors in all grades of astrocytomas and tumor location and radiation dose were significant in Grade II astrocytomas.
Astrocytoma* ; Brain* ; Glioblastoma ; Humans ; Radiotherapy* ; Retrospective Studies ; Survival Rate

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Single and Fractionated Irradiation of Mammary Tumor of Rat.

Sung Whan HA ; Seung Jae HUH ; Charn Il PARK

Journal of the Korean Society for Therapeutic Radiology.1984;2(2):173-176.

The therapeutic effect of mammary breast cancer of rat (Sprague Dawley) was estimated by single and 5 fractionated irradiation of Co60 X-ay. Response rates over 50% were 20, 43, 67, 80% respectively by single dose irradiation of 800, 1,200, 1,600, 2,000rad, and 20, 38, 57, 88% by 5 fractionated irradiation of 1,400, 2,100, 2,800, 3,500rad. 50% tumor control dose (TCD50) were 1,282rad, 2 312rad respectively with single and fractionated irradiation
Animals ; Breast Neoplasms ; Rats*

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An Experimental Study on The of Hyperthermia on Radiation Therapy of Mammary Carcinoma of Rat.

Charn Il PARK ; Seung Jae HUH ; Sung Whan HA

Journal of the Korean Society for Therapeutic Radiology.1984;2(2):167-172.

The renewed interest in the use of hyperthermia in cancer therapy is based on radiobiological And clinical evidence indicating that there may be significant thereapeutic advantages with the use of hyperthermia alone or combined with irradiation plus heat. Authors performed the experiment using the chemically induced mammary carcinoma of rats to observe the difference in temperature changes between tumor and normal tissue during heat, and to compare the response of the tumors to radiation alone and to radiation plus hyperthermia. The results were as follows 1. Temperature of tumors was significantly higher than in the normal tissue during heating and the difference was about 1.5degree C. 2. TCD50 in radiation alone and hyperthermia immediately following radiation was 1,282 rad and 795 rad, respectively and TER value was 1.81.
Animals ; Fever* ; Heating ; Hot Temperature ; Rats*

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Analysis of Prognostic Factors in Glioblastoma Multiforme.

Sang Wook LEE ; Gwi Eon KIM ; Chang Ok SUH ; Woo Cheol KIM ; Ki Chang KEUM ; Sei Kyung CHANG

Journal of the Korean Society for Therapeutic Radiology.1996;14(3):181-190.

PURPOSE: To find the more effective treatment methods that improving thesurvival of patients with glioblastoma multiforme(GBM), we analyze the prognostic factors and the outcome of therapy in patients with GBM. METHODS AND MATERIALS: One hundred twenty-one patients with a diagnosis of GBM treated at Severance Hospital between 1973 and 1993 were analyzed for survival with respect to patients characteristics, that is, duration of symptom, age, and Karnofsky performance status, as well as treatment related variables such as extent of surgery and radiotherapy. RESULTS: The median survival time(MST) and 2-year overall survival rate (OSR) of the patients with GBM were 13 months and 20.8%, respectively. Duration of symptom, age, Karnofsky performance status(KPS), radiotherapy, and extent of surgical resection were associated with improved survival in a univariate analysis. Patients whose duration of symptom was longer than 3 months, had the 2-year OSR of 47.2%(p=0.0082), who were younger than age 50, 32.9%(p=0.0003). In patients with a KPS of 80 or higher, the 2 year OSR was 36.9%(p=0.0422). Patients undergoing radiotherapy had the 2-year OSR of 22.9%(p=0.030), and surgical resection of 23.3%(p<0.000). A cox regression model confirmed a significant correlation of duration of symptom, age, radiotherapy,and extent of surgical resection with survival, excluding KPS(p=0.8823). The 2-year OSR were 22.3% and 19.4%, combined with chemotherapy or without, respectively(p=0.06028). The duration of symptom of 3 months or shorter. 50 years of age or older, and undergoing stereotactic biopsy only were considered as risk factors. then patients without any risk factors had the MST of 29 months and 2-year OSR of 53.9% compared to 4 months and 0% for patients who had all 3 risk factors. Most of all treatment failure occurred in the primary tumor site(86.4%) CONCLUSION: The duration of symptom, age, radiotherapy, and extent of surgical resection were a prognostically significant independent variables. To get a better survival, it seems to be reasonable that the study design which improves the local control rates is warranted.
Biopsy ; Diagnosis ; Drug Therapy ; Glioblastoma* ; Humans ; Karnofsky Performance Status ; Radiotherapy ; Risk Factors ; Survival Rate ; Treatment Failure

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Sphenoid Sinus Carcinoma with Intramedullary Spinal Cord Metastasis and Syringomyelia: Report of A Case.

Young Sock KIM ; Yoon Kyeong OH

Journal of the Korean Society for Therapeutic Radiology.1996;14(1):61-68.

PURPOSE: Primary sphenoid carcinoma is rare. It accounts for 0.3% of all primary paranasal sinus malignancies. Because of the rarity of sphenoid carcinoma, large series of patients with outcome and survival statistics are currently unavailable. So we followed up the 1 case of sphenoid sinus carcinoma treated in our hospital and reported the course of the disease. METHODS AND MATERIALS : In a review of case reports and small series of patients, 2-year survival was 7%. Our case is alive at 29 months after diagnosis of sphenoid sinus carcinoma. Intramedullary spinal cord metastasis (ISCM) is an unusual complication of cancer. In our case rapidly progressive paraparesis and urinary retention developed at 25 months after diagnosis of sphenoid sinus carcinoma. MRI of the thoracic spines showed the intramedullary spinal cord tumor mass at T3 and T4 level with accompanying syringomyelia.Here we report a case of ISCM associated with syringomyelia which has developed after primary sphenoid sinus carcinoma with a review of literature about the clinical behavior and treatment of this lesion.
Diagnosis ; Humans ; Magnetic Resonance Imaging ; Neoplasm Metastasis* ; Paraparesis ; Sphenoid Sinus* ; Spinal Cord Neoplasms ; Spinal Cord* ; Spine ; Syringomyelia* ; Urinary Retention

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Postirradiation Changes of White Blood Cellsand Lymphocyte Subpopulations in Cancer Patients.

Woong Ki CHUNG ; Byung Sik NAH ; Taek Keun NAM ; Young Hee NOH ; Sung Ja AHN

Journal of the Korean Society for Therapeutic Radiology.1996;14(1):53-60.

PURPOSE: Radiation-induced alteration in the immune function is well known phenomenon in cancer patients. Our purpose is to evaluate the extent of immune suppression immediately after mediastinal or pelvic irradiation, which include significant volume of active bone marrow in adults. METHODS AND MATERIALS: 48 cancer patients with mediastinal(N=29) and pelvic irradiation(N=19) were the basis of this analysis. Age ranged from 36 to 76 and mean and median value was 57 years, respectively. Sex ratio was 1.3(M:F = 27/21). The immunological parameters were the complete blood cell(CBC) with differenial cell(D/C) count, T cel subset(CD3, CD4, CD8, CD19), NK cell test(CD16,CD56), and serum immunoglobulin (lgG,lgA,lgM) level. RESULTS: The mean value of white blood cell(WBC) was reduced from 7017 to 4470 after irradiation (p=0.0000). In the differential count, the number of lymphocyte, neutrophil, and basophil was markedly reduced with statistical significance(p<0.01) and the number of monocyte was not changed and, on the contrary, that of eosinophil was increased by irradiation.In the lymphocyte subpopulation analysis, the number of all subpopulations, CD3(T cell), CD4(helper T cell), CD8(suppressor T cell), CD16(NK cell), CD19(B cell) was reduced with statistical significance. The mean ratio of CD4 to CD8 in all patients was 1.09 initially and reduced to 0.99 after radiotherapy(p = 0.34), but the proportional percentage of all subpopulations was not changed except CD19(B cell) after irradiation.In the immunoglobulin study, initial values of lg G, lg A, and lg M were relatively above the normal range and the only lg M was statistically significantly reduced after radiotherapy(p=0.02) CONCLUSION: Mediastinal and pelvic irradiation resulted in remarkable suppression of lymphocyte count in contrast to the relatively good preservation of other components of white blood cells. But the further study on the functional changes of lymphocyte after radiotherapy may be necessary to conclude the effects of the radiation on the immunity of the cancer patients.
Adult ; Basophils ; Bone Marrow ; Eosinophils ; Humans ; Immunoglobulins ; Killer Cells, Natural ; Leukocytes ; Lymphocyte Count ; Lymphocyte Subsets* ; Lymphocytes* ; Monocytes ; Neutrophils ; Radiotherapy ; Reference Values ; Sex Ratio

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Late Rectal Complication in Patients Treated with High Dose Rate Brachytherapy for Stage IIB Carcinoma of the Cervix.

Gwi Eon KIM ; Woo Cheol KIM ; Ki Chang KEUM ; Chang Ok SUH ; Eun Ji CHUNG

Journal of the Korean Society for Therapeutic Radiology.1996;14(1):41-52.

PURPOSE: This paper reports a dosimetric study of 88 patients treated with a combination of external radiotherapy and high dose rate ICR for FIGO stage IIB carcinoma of the cervix. The purpose is to investigate the correlation between the radiation doses to the rectum. external radiation dose to the whole pelvis. ICR reference volume. TDF, BED and the incidence of late rectal complications, retrospectively METHODS AND MATERIALS: From November 1989 through December 1992, 88 patients with stage IIB cervical carcinoma received radical radiotherapy at Department or Radiation Oncology in Yonsei University Hospital. Radiotherapy consisted of 44-54 Gy(median 49 Gy) external beam irradiation plus high dose rate intracavitary brachy therapy with 5 Gy per fraction twice a week to a total dose of 30 Gy on point A. The maximum dose to the rectum by contrast(r,R) and reference rectal dose by ICRU 38(dr, DR) were calculated. The ICR reference volume was calculated by Gamma Dot 3.11 HDR planning system, retrospectively. The time-dose factor(TDF) and the biologically effective dose (BED) were calculated. RESULTS: Twenty seven(30.7%) of the 88 patients developed late rectal complications : 12 patients(13.6%) for grade 1, 12 patients(13.6%) for grade 2 and 3 patients(3.4%) for grade 3. We found a significant correlation between the external whole pelvis irradiation dose and grade 2, 3 rectal complicaition. The mean dose to the whole pelvis for the group of patients with grade 2, 3 complication was higher, 4093.3+/-453.1 cGy, than that for the patients without complication 3873.8+/-415.6 (0.05p<0.1). The gradual increase in the frequency of grade 2, 3 rectal compication increased as a function of the dose of external beam therapyto the whole pelvis(midline shielding start dose) and total rectal dose. The mean total rectal dose by rectal barium(R) for the group of patients with grade 2, 3 rectal complication was higher, 7163.0+/-838.5 cGy, than that for the patients without rectal complication, 6772.7+/-884.0(p<0.05). There was no correlation of the rate of grade 2, 3 rectal complication with the ICR rectal doses(r,dr), ICR reference volume, TDF and BED. CONCLUSION: This investigation has revealed a significant correlation between the dose calculated at the rectal dose by ICRU 38(DR) or the most anterior rectal dose by contrast(R), dose to the whole pelvis and the incidence of grade 2,3 late rectal complications in patients with stage IIB cervical cancer undergoing external beam radiotherapy and HDR ICR. Thus there rectal reference points doses and whole pelvis dose appear to be useful prognostic indicators of late rectal complication in high dose rate ICR treatment in cervical carcinoma.
Brachytherapy* ; Cervix Uteri* ; Female ; Humans ; Incidence ; Pelvis ; Radiation Oncology ; Radiotherapy ; Rectum ; Retrospective Studies ; Uterine Cervical Neoplasms

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