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The Basic Properties and Spectral History of Distortion - product Otoacoustic Emissions in Young Subjects With Normal Hearing

Huabin LI ; Naichuan ZHONG

Journal of Audiology and Speech Pathology.1997;0(04):-.

To study the basic properties of DPOAE including the Spectral History of DPOAE in subjects with normal hearing, Thresholds of octave pure tone from 0.125 to 8 kHz and Tympanometry in 226 Hz were measured to exclude the abnormal function of middle ear in 38 ears of 19 young subjects, then the spectrum of DPOAE、DP - Gram、I/O function curve、Latency and Spectral History of DPOAE were recorded. DPOAE can be detected in all subjects, the amplitude of DPOAE has great intersubjectal variety, the largest two values are 9.11 dB SPL at 1. 5 kHz and 7.72 dB SPL at 6 kHz, DP - Gram has two peaks. The amplitude increased with the increasement of primary tone level, The latency shortened with the increasement of primary frequency. The Spectral History in most of them is flat, the coefficiency of variance is 2. 53?1. 89% , the abnormal rate is 18.5% implying the Spectral History maybe have role in predicating subclinic cochlear lesion.

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The Sythesized Examination of Acoustic Multilateral Analysis and EGG Curve for Voice Disaeses

Ke LEI ; Xu YANG

Journal of Audiology and Speech Pathology.1997;0(04):-.

In order to understand the vibration regularity and morphologic alteration of vocal folds objectively and directly without invading and disturbing the normal pronunciation, the voice acoustic multilateral analysis was conducted and electroglottograph was defecated for 59 cases of normal voice and 102 cases (136 times) of pathological voice by Dr. Speech software through computer' s multimedia technique. The results showed that except F0 there was no sexual difference in the parameters such as jitter, shimmer, NNE and SDF0; there was obvious difference in the parameters between normal and pathological voice. There was a falling tendency for the parameters between preoperation and postoperation. The Egg curve's variation can well reflect the morphologic alteration of vocal folds in voice diseases, and the abnormal ratio is 83.7 % and obvious lower in postoperation reexamined cases.

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Diagnostic Value of Main Frequency of Transient Evoked Otoacoustic Emissions in Meniere's Disease

Wei QUO ; Suzhen ZHANG ; Xingqi LI

Journal of Audiology and Speech Pathology.1997;0(04):-.

The purpose of this study was to assess the diagnostic value of main frequency of transient evoked otoacoustic emissions for Meniere's disease. The click- evoked transient otoacoustic emissions(TEOAE) in normal subjects and in patients with Meniere' s disease were examined using ILO 88 otodynamic analyzer system to observe the main frequency distrbution. The main frequeencies ranged from 1.2 to 1.6 kHz in normal ears, and from 0.8 to 1. 1 kHz in Meniere' s ears. The main frequency range of normal ears was obviously higher than that in Meniere's ears. After application of glycerol, the main frequencies in some Meniere's ears were shifted from relative low frequency range to relative high frequency range. TEOAE appeared in some Meniere's ears in which TEOAEs could not be evoked before application of glycerol. The results suggest that the TEOAE can be used in the diagnosis of Meniere's disease.

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Gentamicin and Its Metabolite Effect [Ca~(2+)]i in Isolated Outer Hair Cells

Xianming CHEN ; Jinling WANG ; Ling QU

Journal of Audiology and Speech Pathology.1998;0(02):-.

Objective To investigate the relationship between [Ca2 +]i and gentamicin ototoxicity. Methods Isolated outer hair cells were loaded with [Ca2 +]i - sensitive fluorescence dye Fluo- 3, and confocal laser microscopy was used to determine [Ca2 +]i when K +- Hanks、gentamicin or its metabolite were added. Results Gentamicin decreased [Ca2 +]i in short time, and inhibited inward calcium current induced by K + . On the contrary, metabolized gentamicin increased [Ca2 + ] i for a long period. It did not effect calcium current induced by K + . Conclusion Metabolized gentamicin increased [Ca2 + ]i, which may result in its ototoxicity.

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Acoustic Evaluation of Three Vocal Fold Diseases in Pre - and Post - Laryngeal Microsurgery

Chunsheng WEI ; Wei WANG

Journal of Audiology and Speech Pathology.1998;0(03):-.

Objective To evaluate acoustic effects of laryngeal microsurgery on vocal polyp, vocal cyst and vocal leuko- plakia. Methods 300 cases in vocal fold diseases were measured acoustically pre - and post - microsurgery. Results After openation, jitter, shimmer and NNE decreased statistically in vocal polyp and vocal cyst patients, and did not improve in vocal leukoplakia patients. Whether or not the surgery was done, F0 of all patients did not change Conclusion Laryngeal microsurgery had definite effect on clearing benign focus. After surgery, vocal functioin improved in vocal polyp and cyst patients, and in vocal leukoplakia, there was no improvement in such a short time as one week.

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Clinical Observation of Tympanic Administration through Eustachian Tube in Treating Middle Ear Adhesion

Kai CHEN

Journal of Audiology and Speech Pathology.1998;0(03):-.

30 dB and little was 23、14、8、18 ears, respectively. The effective rate was 71.4%. No adverse reaction was seen. Conclusion the technique was non - traumatic, economical, practical and effective.

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Effect of Otologic Drill Noise on Inner Ear Functions of the Guinea Pig

Shiping BAO ; Jizhou GUO

Journal of Audiology and Speech Pathology.1998;0(03):-.

0.05). Conclusion The noise induced by otologic drill did not show the effect that could damage the inner ears and led to the deterioration of the inner ear function.

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The Expression of Hyaluronan Synthase mRNA in the Endolymphatic Sac Cells and Renal Tubules

Zhonglin MOU ; Zhaohua LIU ; Jian CHEN

Journal of Audiology and Speech Pathology.1998;0(03):-.

Objective To study the difference between the mRNA expressions of hyaluronan synthase in the epithelial cells of endolymphatic sac and renal tubules with the oligonucleotide probe. Methods The oligonucleotide probe of hyaluronan synthase was designed and synthesized, the mRNA expressions of hyaluronan synthase in the epithelial cells of endolymphatic sac and renal tubules were detected with hybridization in situ. Results mRNA of hyaluronan synthases were strongly expressed in some epithelial cells of endolymphatic sac and renal tubules. Conclusion It is confirmed that a dual regulatory system for hyaluronan /hyaluronidase exists in the epithelial cells of endolymphatic sac and renal tubules at the level of molecular biology.

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Analysis of Clinical Findings and Audioloical Result of Auditory Neuropathy

Fude LI ; Jiaping CHEN ; Ruimin LIANG

Journal of Audiology and Speech Pathology.1998;0(03):-.

Objective To study the clinical findings and audiological characteristics of auditory neuropathy. Methods Clinical findings, pure tone threshold, acoustic impedance audiometry, speech audiometry, auditory brainstem response (ABR) and distortion product otoacoustic emission( DPOAE) were analyzed in 23 cases of auditory neuropathy. Results The patients were predominantly youngster, female more than male. Pure tone audiometry revealed mainly binaural symmetric upward - sloping audiogram with mild and moderate hearing loss at low frequencies. Speech discrimination score was obviously reduced, which was disproportionately to the pure tone threshold. Ipsilateral and contralateral stapedial reflex were absent. ABR was severely abnor- mal. DPOAIE was normal or nearly normal. Conclusion Clinical findings and systemic audiometry revealed the main characteristics of auditory neuropathy, which could be used not only for the understanding, but also for the diagnosis of this disease.

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Characteristics of Hearing Loss Caused by Local Microcirculatory Disorders in the Cochlea Apical Part of Guinea Pigs

Xueyuan ZHANG ; Jibao WANG

Journal of Audiology and Speech Pathology.1998;0(03):-.

Objective To study the characteristics of hearing loss caused by local microcirculatory disorders in the cochlea apical part of guinea pigs. Methods The local microcirculatory disorders in the cochlea apical part of guinea pigs were caused by photochemical reaction. Morphological changes were observed by light microscope. The CAP - N1 amplitude, CAP - N1 latency, CAP - N1 threshold shift and CM amplitude which were evoked by short tone burst were recorded by Madsen 2250. Re- sults Histopathological changes showed that microthrombosis in the capillaries of stria vascularies and spiral ligment were located in the apical and third turn of cochlea. The CAP - N1 amplitude, CAP - N1 latency, CAP-N1 threshold shift and CM amplitude showed that the hearing loss was remarkable in the low - range frequencies. Conclusion When the local microcirculatory disor- ders in the cochlear apical part took place, the hearing loss was more marked in the low - range frequencies.

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