Association of HLA-DRB1 alleles with polymyositis/dermatomyositis in northern Chinese Hans.
Chinese Medical Sciences Journal.2002;17(3):198-198.
Chinese Medical Sciences Journal
1986 to Present ISSN: 1001-9294
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Wound infection after scoliosis surgery: an analysis of 15 cases.
Chinese Medical Sciences Journal.2002;17(3):193-198.
OBJECTIVETo discuss the causes and treatments of wound infections after scoliosis surgery.
METHODSNine hundred and twenty-four caes of scoliosis were reviewed, and the clinical data of 15 cases of postoperative infection were analysed retrospectively.
RESULTSAll 15 cases underwent spinal posterior fusion with autologous bone graft using instrumentations. Seven were diagnosed as early infection, and 8 were delayed infection. Radical debridement was performed in all 15 cases. The duration of antibiotics administration was 10 to 34 days with continuous closed irrigation for 2 to approximately 4 weeks and primary closure for the wounds. All patients were followed up for an average of 3.5 years (2 to 7.5 years) with good outcomes and no recurrence.
CONCLUSIONWound infection following surgical correction of scoliosis primarily results from intraoperative seeding, although host-related and operation-related factors may contribute to its development. Once the infections are diagnosed, good results can be achieved by prompt surgical debridement, irrigation and reasonably administered antibiotics. Removal of hardware may be necessary in deep infections.
Adolescent ; Adult ; Anti-Bacterial Agents ; therapeutic use ; Child ; Debridement ; Female ; Follow-Up Studies ; Humans ; Male ; Retrospective Studies ; Scoliosis ; surgery ; Spinal Fusion ; adverse effects ; Staphylococcal Infections ; therapy ; Surgical Wound Infection ; therapy
Chinese Medical Sciences Journal.2002;17(3):189-192.
OBJECTIVEThe characteristics of lip-mouth region including the soft and hard tissues in smiling position with frontal fixed position photographic computer-aided analysis were studied.
METHODSThe subjects were 80 persons (40 male and 40 females, age range: 17 to approximately 25 years) with acceptable faces and individual normal occlusions. The subjects were asked to take maximum smiling position to accept photographic measurement with computer-aided analysis.
RESULTSThe maximum smile line could be divided into 3 categories: low smile line (16.25%), average smile line (68.75%), and high smile line (15%).
CONCLUSIONThe method adopting maximum smiling position to study the lip-month region is reproducible and comparable. This study would be helpful to provide a quantitative reference for clinical investigation, diagnosis, treatment and efficacy appraisal.
Adolescent ; Adult ; Anthropometry ; Dental Occlusion ; Female ; Humans ; Lip ; anatomy & histology ; Male ; Mouth ; anatomy & histology ; Smiling ; Tooth ; anatomy & histology
Surgical treatment of metastatic spinal tumor.
Chinese Medical Sciences Journal.2002;17(3):183-188.
OBJECTIVESTo evaluate the effect of surgical treatment on metastatic spinal tumor.
METHODSThe results of surgical intervention for metastatic spinal tumor of 31 consecutive patients since October 1985 were reviewed.
RESULTSThe average survival time was 17.6 months (range from 3 months to 9 years), and 4 patients are still alive with an average survival time of 24.6 months (range, 14 to approximately 84 months). No postoperative complication was noted. The preoperative symptoms were partially relieved and neurological functions were improved after surgery.
CONCLUSIONSurgical treatment for metastatic spinal tumor could improve the life quality, but should be adopted cautiously. The surgical procedures such as decompression and internal fixation should be involved only when neurological deficits occurred. The surgery with postoperative complementary therapy may not only improve the life quality, but also extend the patients' life span.
Adult ; Aged ; Breast Neoplasms ; pathology ; Decompression, Surgical ; Female ; Humans ; Internal Fixators ; Lung Neoplasms ; pathology ; Male ; Middle Aged ; Prostatic Neoplasms ; pathology ; Quality of Life ; Spinal Neoplasms ; secondary ; surgery ; Thoracic Vertebrae ; surgery
Surgical management of Ehlers-Danlos syndrome: first report of a pedigree in China.
Chinese Medical Sciences Journal.2002;17(3):178-182.
OBJECTIVETo describe a case of Ehlers-Danlos syndrome type IV and its pedigree in China.
METHODSClinical materials of a case of Ehlers-Danlos syndrome type IV and a pedigree of 6 members within 4 generations were analyzed. Dilated internal jugular vein in the proband was removed by operation. The diagnosis, surgical treatment, and postoperative complications were retrospectively reviewed.
RESULTSVessels of the proband in the pedigree were crisp and easily lacinated during the procedure of removing his internal jugular vein. Repeating postoperative hematomas were found though complete stanching was achieved during the operation. The patient was successfully recovered by promptly debridgement and needle sucking. The other 5 members of the pedigree all had the triads of Ehlers-Danlos syndrome.
CONCLUSIONSThough it was of extremely low morbidity rate, the high mortality rate and complication of Ehlers-Danlos syndrome deserve great attention during surgical management, especially in patients with Ehlers-Danlos syndrome type IV. Surgeons should be aware of the ponderance of its complications and combined diseases to avoid fatal intraoperative vascular lascination and incontrollable hemorrhage.
China ; Ehlers-Danlos Syndrome ; genetics ; surgery ; Humans ; Jugular Veins ; surgery ; Male ; Middle Aged ; Pedigree
Diagnosis and surgical management for retrosternal thyroid mass.
Chinese Medical Sciences Journal.2002;17(3):173-177.
OBJECTIVETo understand the clinical manifestations, diagnostic methods, surgical management and prognosis of retrosternal thyroid masses in various pathological types.
METHODSSixty-four cases of retrosternal thyroid masses with surgical intervention were analyzed retrospectively.
RESULTSTrachea-compressed symptoms (65%) and shadows beside the trachea at thoracic inlet (94%) were the most common clinical findings, chest X-ray (70%) and CT scan (96%) had higher diagnostic rate. No death occurred during operation or hospitalization among these patients. Total complications occurred in 15.7% cases (11/70) (including 3 preoperative cases with hoarseness) and postoperative pathological results were mainly multinodular goiter (54.7%), thyroid adenoma (21.9%) and thyroid carcinoma (15.6%) (including local carcinomatous change).
CONCLUSIONSDiagnosis of retrosternal thyroid mass can be correctly made by chest X-ray and CT scan. Most operations on retrosternal thyroid masses can be performed safely through cervical incision with minimal morbidity and low recurrence rate. Retrosternal thyroid carcinoma was potentially invasive and could hardly be resected completely, hence with poor prognosis.
Adenoma ; diagnosis ; surgery ; Adult ; Aged ; Carcinoma ; diagnosis ; surgery ; Female ; Goiter, Nodular ; diagnosis ; surgery ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Thoracotomy ; Thyroid Gland ; diagnostic imaging ; surgery ; Thyroid Neoplasms ; diagnosis ; surgery ; Thyroidectomy ; Tomography, X-Ray Computed
Chinese Medical Sciences Journal.2002;17(3):168-172.
OBJECTIVEThe efficacies of the selective 5-hydroxytryptamine3 (5-HT3) antagonists--ramosetron (0.3 mg) and granisetron (3 mg) in treating acute chemotherapy-induced digestive system dysunction were compared.
METHODSA total of 111 patients were enrolled in a single-blind, randomised crossover study; with data from 98 were used to assess efficacy and data from 110 to assess the safety profile. Ramosetron or granisetron was given intraveneously 15 min befire chemotherpy.
RESULTSThe ability of ramosetron to prevent emesis, nausea and anorexia was similar to granisetron during the first 6 h following the administration of chemotherapy, ciplatin or doxorubicin. However, during the first 24 h after chemotherapy, significant differences between ramosetron and granisetron appeared: emetic episode (P = 0.068), nausea (P = 0.006), and anorexia (P = 0.048) remained lower in ramosetron-treated patients. The safety profile of ramosetron was similar to that of granisetron and adverse events in both groups were generally mild and transient.
CONCLUSIONRamosetron is more potent and longer-lasting than granisetron in preventing chemotherapy-induced digestive disturbances.
Adolescent ; Adult ; Aged ; Anorexia ; chemically induced ; drug therapy ; Antiemetics ; therapeutic use ; Antineoplastic Agents ; adverse effects ; Benzimidazoles ; therapeutic use ; Cisplatin ; adverse effects ; Cross-Over Studies ; Doxorubicin ; adverse effects ; Female ; Granisetron ; therapeutic use ; Humans ; Lung Neoplasms ; drug therapy ; Male ; Middle Aged ; Nausea ; chemically induced ; prevention & control ; Serotonin Antagonists ; therapeutic use ; Single-Blind Method ; Vomiting, Anticipatory ; etiology ; prevention & control
Sonographic patterns and differential diagnosis of cystic renal carcinomas.
Chinese Medical Sciences Journal.2002;17(3):164-167.
OBJECTIVETo study the sonographic features and patterns of cystic renal carcinomas.
METHODSThirteen cases of cystic renal carcinoma confirmed by operation and pathology were examined by ultrasonography, and the cystic walls, septa and solid mural nodules were studied.
RESULTSSolid mural nodules of some cases and irregular thickening of the cystic walls and septa were characteristic findings for the ultrasonic diagnosis of cystic renal carcinomas. According to their pathologic mechanisms and sonographic features, cystic renal carcinomas were classified into 3 patterns: unilocular cystic mass, multiloculated cystic mass and cystic-solid mass.
CONCLUSIONSTypical cystic renal carcinomas can be well diagnosed, while atypical cases may be misdiagnosed as benign renal cysts by ultrasonography. Color Doppler ultrasonography and needle aspiration guided by ultrasonography are helpful in the diagnosis of these atypical cases.
Adult ; Aged ; Biopsy, Needle ; Carcinoma, Renal Cell ; diagnostic imaging ; Diagnosis, Differential ; Female ; Humans ; Kidney Diseases, Cystic ; diagnostic imaging ; Kidney Neoplasms ; diagnostic imaging ; Male ; Middle Aged ; Ultrasonography, Doppler, Color
Chinese Medical Sciences Journal.2002;17(3):160-163.
OBJECTIVETo study the value of serum insulin-like growth factor binding protein-3 (IGFBP-3) levels in differential diagnosis of growth hormone deficiency (GHD).
METHODSTo measure serum IGFBP-3 levels by RIA in normal children and adolescents, GHD children and short-stature children without GHD.
RESULTSSerum level of IGFBP-3 in 129 children with untreated GHD and with no pubertal development was 1.6 +/- 0.9 mg/L, which was less than that in normal group of the same age, but overlapped with the normal children in Tanner stage I. After six-month treatment with recombinant human growth hormone (rhGH), serum level of IGFBP-3 in 59 GHD significantly increased from 1.3 +/- 0.7 mg/L to 2.7 +/- 0.9 mg/L, accompanied by an increase of body heights, growth velocities and serum level of IGF-1. Serum level of IGFBP-3 in 55 short-stature children without GHD was 3.3 +/- 2.2 mg/L, which was not significantly different from that in normal group.
CONCLUSIONSerum IGFBP-3 level can reflect the status of GH secretion in children with GHD and is a useful marker for differential diagnosis of GHD.
Adolescent ; Biomarkers ; blood ; Body Height ; drug effects ; Child ; Diagnosis, Differential ; Female ; Human Growth Hormone ; deficiency ; therapeutic use ; Humans ; Insulin-Like Growth Factor Binding Protein 3 ; blood ; Insulin-Like Growth Factor I ; metabolism ; Male ; Recombinant Proteins ; therapeutic use
Expression of rhBMP-7 gene in transduced bone marrow derived stromal cells.
Chinese Medical Sciences Journal.2002;17(3):157-159.
OBJECTIVETo explore the possibility of expression of exogenous gene in transduced bone marrow derived stromal cells (BMSCs).
METHODSThe marker gene, pbLacZ, was transferred into cultured BMSCs and the expression of transduced gene by X-gal staining was examined. Then plasmid pcDNA3-rhBMP7 was delivered to cultured BMSCs. Through immunohistochemical staining and RT-PCR assay, the expression of rhBMP7 gene was detected.
RESULTSThe exogenous gene could be expressed efficiently in transduced BMSCs.
CONCLUSIONThe present study provided a theoretical basis to gene therapy on the problems of bone and cartilage tissue.
Animals ; Bone Marrow Cells ; cytology ; metabolism ; Bone Morphogenetic Protein 7 ; Bone Morphogenetic Proteins ; biosynthesis ; genetics ; Cells, Cultured ; Genetic Vectors ; genetics ; Rabbits ; Recombinant Proteins ; biosynthesis ; Stromal Cells ; cytology ; metabolism ; Tibia ; cytology ; Transfection ; Transforming Growth Factor beta
Country
China
Publisher
中国医学科学院
ElectronicLinks
http://cmsj.cams.cnEditor-in-chief
actacams@263.net.cn
Abbreviation
Chinese Medical Sciences Journal
Vernacular Journal Title
中国医学科学杂志(英文版)
ISSN
1001-9294
EISSN
Year Approved
2008
Current Indexing Status
Currently Indexed
Start Year
1986
Description
历史沿革【现用刊名：Chinese Medical Sciences Journal;曾用刊名：中国医学科学杂志(英文版);协和医科大学学报(英文版);PROCEDINGS CAMS AND PUMC;创刊时间：1986】，该刊被以下数据库收录【CA 化学文摘(美)(2009);CBST 科学技术文献速报(日)(2009)】。
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