The Journal of the Korean Society for Therapeutic Radiology and Oncology.2002;20(4):396-404.
The Journal of the Korean Society for Therapeutic Radiology and Oncology
1983 to Present ISSN: 1229-8719
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The Journal of the Korean Society for Therapeutic Radiology and Oncology.2002;20(4):391-395.
PURPOSE: To confirm the accuracy of the radiation dose at the isocenter by the standard linear accelerator-based stereotactic radiosurgery technique which was developed at Seoul National University Hospital. MATERIALS AND METHODS: Radiation dosimetry was undertaken during standard 5-arc radiosurgery using 6 MV X-ray beam from CL2100C linac. The treatment head was attached with circular tertiary collimators of 10 and 20 mm diameter. We measured the absorbed dose at the isocenter of a multi-purpose phantom using two kinds of detector : a 0.125 cc ionization chamber and a silicon diode detector. RESULTS: The dose differences at each arc plane between the planned dose and the measured dose at the isocenter raged from -0.73% to -2.69% with the 0.125 cc ion chamber, and from -1.29% to -2.91% with the diode detector during radiosurgery with the tertiary collimator of 20 mm diameter. Those with the 10-mm tertiary collimator ranged from -2.39% to -4.25% with the diode. CONCLUSION: The dose accuracy at the isocenter was +/-3%. Therefore, further efforts such as modification in processing of the archived image through DICOM3.0 format are required to lessen the dose difference.
Head ; Radiometry ; Radiosurgery* ; Rage ; Seoul* ; Silicon
Head ; Radiometry ; Radiosurgery* ; Rage ; Seoul* ; Silicon
Comparison of Three- and Four-dimensional Robotic Radiotherapy Treatment Plans for Lung Cancers.
The Journal of the Korean Society for Therapeutic Radiology and Oncology.2010;28(4):238-248. doi:10.3857/jkstro.2010.28.4.238
PURPOSE: To compare the dose distributions between three-dimensional (3D) and four-dimensional (4D) radiation treatment plans calculated by Ray-tracing or the Monte Carlo algorithm, and to highlight the difference of dose calculation between two algorithms for lung heterogeneity correction in lung cancers. MATERIALS AND METHODS: Prospectively gated 4D CTs in seven patients were obtained with a Brilliance CT64-Channel scanner along with a respiratory bellows gating device. After 4D treatment planning with the Ray Tracing algorithm in Multiplan 3.5.1, a CyberKnife stereotactic radiotherapy planning system, 3D Ray Tracing, 3D and 4D Monte Carlo dose calculations were performed under the same beam conditions (same number, directions, monitor units of beams). The 3D plan was performed in a primary CT image setting corresponding to middle phase expiration (50%). Relative dose coverage, D95 of gross tumor volume and planning target volume, maximum doses of tumor, and the spinal cord were compared for each plan, taking into consideration the tumor location. RESULTS: According to the Monte Carlo calculations, mean tumor volume coverage of the 4D plans was 4.4% higher than the 3D plans when tumors were located in the lower lobes of the lung, but were 4.6% lower when tumors were located in the upper lobes of the lung. Similarly, the D95 of 4D plans was 4.8% higher than 3D plans when tumors were located in the lower lobes of lung, but was 1.7% lower when tumors were located in the upper lobes of lung. This tendency was also observed at the maximum dose of the spinal cord. Lastly, a 30% reduction in the PTV volume coverage was observed for the Monte Carlo calculation compared with the Ray-tracing calculation. CONCLUSION: 3D and 4D robotic radiotherapy treatment plans for lung cancers were compared according to a dosimetric viewpoint for a tumor and the spinal cord. The difference of tumor dose distributions between 3D and 4D treatment plans was only significant when large tumor movement and deformation was suspected. Therefore, 4D treatment planning is only necessary for large tumor motion and deformation. However, a Monte Carlo calculation is always necessary, independent of tumor motion in the lung.
Four-Dimensional Computed Tomography ; Humans ; Lung ; Lung Neoplasms ; Organothiophosphorus Compounds ; Population Characteristics ; Prospective Studies ; Spinal Cord ; Tumor Burden
Four-Dimensional Computed Tomography ; Humans ; Lung ; Lung Neoplasms ; Organothiophosphorus Compounds ; Population Characteristics ; Prospective Studies ; Spinal Cord ; Tumor Burden
The Journal of the Korean Society for Therapeutic Radiology and Oncology.2010;28(4):231-237. doi:10.3857/jkstro.2010.28.4.231
PURPOSE: We investigated the effect of location changes in the inferior border of the belly board (BB) aperture by adding a bladder compression device (BCD). MATERIALS AND METHODS: We respectively reviewed data from 10 rectal cancer patients with a median age 64 years (range, 45~75) and who underwent computed tomography (CT) simulation with the use of BB to receive pelvic radiotherapy between May and September 2010. A CT simulation was again performed with the addition of BCD since small bowel (SB) within the irradiated volume limited boost irradiation of 5.4 Gy using the cone down technique after 45 Gy. The addition of BCD made the inferior border of BB move from symphysis pubis to the lumbosacral junction (LSJ). RESULTS: Following the addition of BCD, the irradiated volumes of SB and the abdominopelvic cavity (APC) significantly decreased (174.3+/-89.5 mL vs. 373.3+/-145.0 mL, p=0.001, 1282.6+/-218.7 mL vs. 1571.9+/-158 mL, p<0.001, respectively). Bladder volume within the treated volume increased with BCD (222.9+/-117.9 mL vs. 153.7+/-95.5 mL, p<0.001). The ratio of irradiated bladder volume to APC volume with BCD (33.5+/-14.7%) increased considerably compared to patients without a BCD (27.5+/-13.1%) (p<0.001), and the ratio of irradiated SB to APC volume decreased significantly with BCD (13.9+/-7.6% vs. 24.2+/-10.2%, p<0.001). The ratios of the irradiated SB volumeand irradiated bladder volume to APC volume negatively correlated (p=0.001). CONCLUSION: This study demonstrated that the addition of BCD, which made the inferior border of BB move up to the LSJ, increased the ratio of the bladder to APC volume and as a result, decreased the irradiated volume of SB.
Humans ; Rectal Neoplasms ; Urinary Bladder
Humans ; Rectal Neoplasms ; Urinary Bladder
Evaluation of Scatter Reduction Effect of the Aft-Multiple-Slit (AMS) System Using MC Simulation.
The Journal of the Korean Society for Therapeutic Radiology and Oncology.2010;28(4):224-230. doi:10.3857/jkstro.2010.28.4.224
PURPOSE: We designed the aft-multiple-slit (AMS) system to reduce scatter in cone-beam computed tomography (CBCT). As a preliminary study, we performed a Monte Carlo N-Particle Transport Code (MCNP) simulation to verify the effectiveness of this system. MATERIALS AND METHODS: The MCNPX code was used to build the AMS geometry. An AMS is an equi-angled arc to consider beam divergence. The scatter-reduced projection images were compared with the primary images only and the primary plus scatter radiation images with and without AMS to evaluate the effectiveness of scatter reduction. To obtain the full 2 dimensional (2D) projection image, the whole AMS system was moved to obtain closed septa of the AMS after the first image acquisition. RESULTS: The primary radiation with and without AMS is identical to all the slit widths, but the profiles of the primary plus scattered radiation varied according to the slit widths in the 2D projection image. The average scatter reduction factors were 29%, 15%, 9%, and 8% when the slit widths were 5 mm, 10 mm, 15 mm, and 20 mm, respectively. CONCLUSION: We have evaluated the scatter reduction effect of the AMS in CBCT imaging using the Monte Carlo (MC) simulations. A preliminary study based on the MCNP simulations showed a mount of scatter reduction with the proposed system.
Cone-Beam Computed Tomography
Cone-Beam Computed Tomography
In vivo Radiosensitization Effect of HDAC Inhibitor, SK-7041 on RIF-1 Cell Line.
The Journal of the Korean Society for Therapeutic Radiology and Oncology.2010;28(4):219-223. doi:10.3857/jkstro.2010.28.4.219
PURPOSE: To test the radiosensitizing effect of the newly synthesized novel histone deacetylase inhibitor, SK-7041 in vivo. MATERIALS AND METHODS: The RIF-1 cell line was implanted into the back of a 6-week-old female C3H mouse, intradermally. The mice were grouped into control, drug, radiation (RT), and RT+drug group. SK-7041, 4 mg/kg was administered intraperitoneally for six cycles every 12 hours for mice in the drug and RT+drug group. An identical volume of phosphate buffered saline (PBS) was administered at the same frequency to mice in the control and RT groups. A single 5 Gy fraction was delivered to mice in RT and RT+drug group 6 hours after the fourth delivery. The volume of the implanted tumor was measured every 2~3 days to formulate the growth delay curve. RESULTS: For the control, drug, RT, and RT+drug groups, the average duration for implanted tumor to reach a volume of 1,500 mm3 was 10 days, 10 days, 9 days, and 12 days, respectively. Moreover, the tumor volume on D14 was 276.7 mm3, 279.9 mm3, 292.5 mm3, and 185.5 mm3, respectively (p=0.0004). The difference for the change in slope for the control and drug versus the RT and RT+drug groups were borderline significant (p=0.0650). CONCLUSION: The results of this study indicate that SK-7041 has a radiosensitizing effect for the RIF-I cell line in vivo at a low concentration and this effect may be synergistic. Implementing this result to clinical trial is warranted.
Amides ; Animals ; Biphenyl Compounds ; Cell Line ; Drug and Narcotic Control ; Female ; Histone Deacetylase Inhibitors ; Humans ; Mice ; Mice, Inbred C3H ; Radiation-Sensitizing Agents ; Tumor Burden
Amides ; Animals ; Biphenyl Compounds ; Cell Line ; Drug and Narcotic Control ; Female ; Histone Deacetylase Inhibitors ; Humans ; Mice ; Mice, Inbred C3H ; Radiation-Sensitizing Agents ; Tumor Burden
Catalase Induced by All-Trans Retinoic Acid Is Involved in Antiproliferation of 36B10 Cells.
The Journal of the Korean Society for Therapeutic Radiology and Oncology.2010;28(4):211-218. doi:10.3857/jkstro.2010.28.4.211
PURPOSE: All-trans retinoic acid (ATRA) has antiproliferative effects against brain tumor cells. Recently, ATRA has been reported to induce catalase. We investigated whether catalase induction by ATRA is associated with its antiproliferative effects. MATERIALS AND METHODS: 36B10 cells were exposed to 0~50microM ATRA for 24 or 48 hours and mRNA, protein, and activity of catalase were measured. Reactive oxygen species (ROS) were measured using 2',7'-dichlorofluorescin diacetate. A clonogenic assay was used to confirm the cytotoxic effect. RESULTS: The mRNA, protein, and activity of catalase were found to increase in a concentration- and incubation-time-dependent manner. The increase in catalase activity induced by ATRA was decreased by the addition of 3-amino-1,2,4-triazole (ATZ). ROS was also increased with ATRA and decreased by the addition of ATZ. The decrease in cell survival induced by ATRA was partly rescued by ATZ. CONCLUSION: Catalase induction by ATRA is involved in ROS overproduction and thus inhibits the proliferation of 36B10 cells.
Amitrole ; Brain Neoplasms ; Catalase ; Cell Survival ; Fluoresceins ; Reactive Oxygen Species ; RNA, Messenger ; Tretinoin
Amitrole ; Brain Neoplasms ; Catalase ; Cell Survival ; Fluoresceins ; Reactive Oxygen Species ; RNA, Messenger ; Tretinoin
The Results of Curative Concurrent Chemoradiotherapy for Anal Carcinoma.
The Journal of the Korean Society for Therapeutic Radiology and Oncology.2010;28(4):205-210. doi:10.3857/jkstro.2010.28.4.205
PURPOSE: To evaluate the predictive factors for treatment response and prognostic factors affecting survival outcomes after concurrent chemoradiotherapy (CCRT) for patients with anal squamous cell carcinoma. MATERIALS AND METHODS: Medical records of forty two patients with histologically confirmed analsquamous cell carcinoma, who had complete CCRT between 1993 and 2008, were reviewed retrospectively. Median age was 61.5 years (39~89 years), and median radiotherapy (RT) dose was 50.4 Gy (30.0~64.0 Gy). A total of 36 patients had equal to or less than T2 stage (85.7%). Fourteen patients (33.3%) showed regional nodal metastasis, 36 patients (85.7%) were treated with 5-fluorouracil (5-FU) plus mitomycin, and the remaining patients were treated by 5-FU plus cisplatinum. RESULTS: The median follow-up time was 62 months (2~202 months).The 5-year overall survival, locoregional relapse-free survival, disease-free survival, and colostomy-free survival rates were 86.0%, 71.7%, 71.7%, 78.2%, respectively. Regarding overall survival, the Eastern Cooperative Oncology Group (ECOG) performance status and complete response were found to be significant prognostic factors on univariate analysis. For multivariate analysis, only the ECOG performance status was significant. No significant factor was found for locoregional relapse-free survival or disease-free survival and similarly for treatment response, no significant factor was determined on logistic regression analysis. There were 7 patients who had local or regional recurrences and one patient with distant metastasis. The only evaluable toxicity in all patients was radiation dermatitis of perianal skin (grade 3), which developed in 4 patients (9.5%) and grade 2 in 22 patients (52.4%). CONCLUSION: This study revealed that patients with a performance score of ECOG 0-1 survived significantly longer than those with a poorer score. Finally, there was no significant predicting factors tested for treatment response.
Anus Neoplasms ; Chemoradiotherapy ; Dermatitis ; Disease-Free Survival ; Fluorouracil ; Follow-Up Studies ; Humans ; Logistic Models ; Medical Records ; Mitomycin ; Multivariate Analysis ; Neoplasm Metastasis ; Recurrence ; Retrospective Studies ; Skin ; Survival Rate
Anus Neoplasms ; Chemoradiotherapy ; Dermatitis ; Disease-Free Survival ; Fluorouracil ; Follow-Up Studies ; Humans ; Logistic Models ; Medical Records ; Mitomycin ; Multivariate Analysis ; Neoplasm Metastasis ; Recurrence ; Retrospective Studies ; Skin ; Survival Rate
Long-Term Results of 2-Dimensional Radiation Therapy in Patients with Nasopharyngeal Cancer.
The Journal of the Korean Society for Therapeutic Radiology and Oncology.2010;28(4):193-204. doi:10.3857/jkstro.2010.28.4.193
PURPOSE: To analyze the treatment outcomes, complications, prognostic factors after a long-term follow-up of patients with nasopharyngeal carcinoma treated with radiation therapy (RT) alone or concurrent chemoradiation therapy (CCRT). MATERIALS AND METHODS: Between December 1981 and December 2006, 190 eligible patients with non-metastatic nasopharyngeal carcinoma were treated at our department with a curative intent. Of these patients, 103 were treated with RT alone and 87 patients received CCRT. The median age was 49 years (range, 8~78 years). The distributions of clinical stage according to the AJCC 6th edition included I: 7 (3.6%), IIA: 8 (4.2%), IIB: 33 (17.4%), III: 82 (43.2%), IVA: 31 (16.3%), IVB: 29 (15.3%). The accumulated radiation doses to the primary tumor ranged from 66.6~87.0 Gy (median, 72 Gy). Treatment outcomes and prognostic factors were retrospectively analyzed. Acute and late toxicities were assessed using the RTOG criteria. RESULTS: A total of 96.8% (184/190) of patients completed the planned treatment. With a mean follow-up of 73 months (range, 2~278 months; median, 52 months), 93 (48.9%) patients had relapses that were local 44 (23.2%), nodal 13 (6.8%), or distant 49 (25.8%). The 5- and 10-year overall survival (OS), disease-free survival (DFS), and disease-specific survival (DSS) rates were 55.6% and 44.5%, 54.8% and 51.3%, in addition to 65.3% and 57.4%, respectively. Multivariate analyses revealed that CCRT, age, gender, and stage were significant prognostic factors for OS. The CCRT and gender were independent prognostic factors for both DFS and DSS. There was no grade 4 or 5 acute toxicity, but grade 3 mucositis and hematologic toxicity were present in 42 patients (22.1%) and 18 patients (9.5%), respectively. During follow-up, grade 3 hearing loss in 9 patients and trismus in 6 patients were reported. CONCLUSION: The results of our study were in accordance with findings of previous studies and we confirmed that CCRT, low stage, female gender, and young age were related to improvement in OS. However, there are limitations in the locoregional control that can be achieved by CCRT with 2D conventional radiation therapy. This observation has led to further studies on clarifying the efficacy of concurrent chemotherapy by intensity modulated radiation therapy.
Disease-Free Survival ; Female ; Follow-Up Studies ; Hearing Loss ; Humans ; Mucositis ; Multivariate Analysis ; Nasopharyngeal Neoplasms ; Recurrence ; Retrospective Studies ; Trismus
Disease-Free Survival ; Female ; Follow-Up Studies ; Hearing Loss ; Humans ; Mucositis ; Multivariate Analysis ; Nasopharyngeal Neoplasms ; Recurrence ; Retrospective Studies ; Trismus
The Comparison of DVH between Multiple arc FSRT and Conformal FSRT.
The Journal of the Korean Society for Therapeutic Radiology and Oncology.1999;17(3):261-267.
PURPOSE: .In FSRT (Fractionated stereotactic radiotherapy) planning, we studied the usefulness between multiple arc FSRT and conformal FSRT by comparing tumor shape and DVH(dose volume histogram). MATERIALS AND METHDS: In Chungnam Univ. hospital, we had treated the sixteen patients with FSRT from Aug. 1997 to Dec. 1998. In choosing multiple arc FSRT or conformal FSRT, we had considered multiple arc FSRT if tumor shape was similar to sphere or the value of IF was less than 1.25, conformal FSRT if tumor shape was very irregular or IF was more than 1.3. For evaluation of treatment planning, we had considered the appropriate DVH for tumor volume and for critical organs. RESULT: The errors between reference point and the coordinates point on AP, Lat radiography were less than 1 mm before treatment. We had planned 3~5 arcs for multiple arc FSRT, 5~6pots for conformal FSRT. The mean dose distribution of tumor volume of cumulative DVH between multiple arc FSRT and conformal FSRT was 90.6, 86%, respectively. The dose of critical organs irradiated was less than 5% maximum dose of cumulative DVH. CONCLUSION: We had obtained the similar value between multiple arc FSRT and conformal FSRT, so that we had appropriate treatment planning of FSRT for multiple arc FSRT and conformal FSRT according to tumor shape and size.
Chungcheongnam-do ; Humans ; Radiography ; Tumor Burden
Chungcheongnam-do ; Humans ; Radiography ; Tumor Burden
Country
Republic of Korea
Publisher
The Korean Society for Radiation Oncology
ElectronicLinks
http://koreamed.org/JournalVolume.php?id=17Editor-in-chief
Abbreviation
J Korean Soc Ther Radiol Oncol
Vernacular Journal Title
대한방사선종양학회지
ISSN
1229-8719
EISSN
Year Approved
2007
Current Indexing Status
Currently Indexed
Start Year
1983
Description
Current Title
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