A Case of Absence of One Tube and a Corresponding Ovary.
Korean Journal of Obstetrics and Gynecology.1997;40(5):1074-1076.
Korean Journal of Obstetrics and Gynecology
1958 to Present ISSN: 0494-4755
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Korean Journal of Obstetrics and Gynecology.1997;40(5):1069-1073.
Congenital adrenal hyperplasia, which is caused by the disorder of the enzyme for synthesizingadrenal hormones, results in hypertropy of the clitoris due to overporduction of adrenalandrogen. Diagnosis of the congenital adrenal hyperplasia can be obtained by the study ofsteroid levels in blood and urine. The blood levels of ACTH, testosterone and 17-hydroxyprogesteronewere increased and the concentration of 17-ketosteroid were decreased after the dexamethasonesuppression test. The internal genital organ was normal appearance on the pelvic CTscan. Clitoromegaly due to congenital adrenal byperplasia was corrected previously by the variousoperational procedures in which the clitoris was removed entirely for only physial appearance.However the sensitive function of the clitoris after the operative correction throughpuberty is to be preserved by the method "clitoroplasty" for preserving neurovascular supply tothe clitoris. The writer experienced a case of a 5-year-old girl with congenital adrenalhyperplasia and tried this clitoroplasty for surgical treatment of clitoromegly for preservation ofpostoperative sensitivity of the clitoris.
Adrenal Hyperplasia, Congenital* ; Adrenocorticotropic Hormone ; Child, Preschool ; Clitoris* ; Diagnosis ; Female ; Genitalia ; Humans ; Testosterone
Adrenal Hyperplasia, Congenital* ; Adrenocorticotropic Hormone ; Child, Preschool ; Clitoris* ; Diagnosis ; Female ; Genitalia ; Humans ; Testosterone
Korean Journal of Obstetrics and Gynecology.1997;40(5):1049-1056.
To determine the distinction of primary ovarian carcinoma from metastatic ovariancarcinoma, the author studied total 40 cases of malignant tumors(13 primary ovarian carcinomas:7 serous, 4 mucinous, and 2 endometrioid, 7 metastatic ovarian adenocarcinomas,10 gastric adenocarcinomas and 10 colonic adenocarcinomas) using primary antibody to CEA,CK7, CK20 and CK18. The results were summerised as follows: The expression of CK7was demonstrated in all(7) serous and 3 out of 4 mucinous adenocarcinoma, and 1 out of10 each gastric and colonic adenocarcinoma. The CK20 positivity was seen in 4 out of 10cases of colonic adenocarcinoma and 3 out of 7 cases of metastatic adenocarcinoma. Allprimary ovarian carcinoma and gastric adenocarcinoma were negative for CK20 except forfocal positivity in only 1 ovarian mucinous adenocarcinoma. All types of serous andendometrioid adenocarcinoma were negative for CEA. But, the vast majority of mucinousadenocarcinoma, metastatic adenocarcinoma, gastric and colonic adenocarcinoma were positivefor CEA. The CK18 may not be helpful to differentiate the primay or metastatic carcinomabecause all cases examined were positive for CK18 except for 1 ovarian mucinous carcinoma.Immunostainning for CK7 may be helpful on differential diagnosis of primary andmetastatic ovarian carcinoma, especially mucinous adenocarcinoma and metastatic gastric andcolonic adenocarcinoma. The CK20 may be a useful marker for differential diagosis inprimary and metastatic ovarian carcinomas. The CEA may be of value on differential diagnosisof mucinous and nonmucinous(serous and endomerioid) ovarian carcinomas, and metastaticcolonic adenocarcinoma and endometrioid carcinoma.In conclusion, immunohistochemical study for CEA, CK7, and CK20 may be helpful indifferential diagnosis between primary and metastatic ovarian carcinoma.
Adenocarcinoma ; Adenocarcinoma, Mucinous ; Colon ; Diagnosis ; Diagnosis, Differential* ; Female ; Immunohistochemistry ; Mucins ; Neoplasm Metastasis ; Ovary
Adenocarcinoma ; Adenocarcinoma, Mucinous ; Colon ; Diagnosis ; Diagnosis, Differential* ; Female ; Immunohistochemistry ; Mucins ; Neoplasm Metastasis ; Ovary
Korean Journal of Obstetrics and Gynecology.1997;40(5):1037-1043.
The addition of a monthly course of progesterone decrease the incidence of endometrialhyperplasia and endometrial carcinoma. The progesterones used in hormonal replacementtherapy(HRT) differ markedly in their progesteronic, androgenic and even estrogenicactivities. These characteristics may influence both symptomatic and metabolic side effects.The purpose of this study was to examine effect of bone and lipid metabolism inpostmenopausal women treated with conjugated equine estrogens plus dydrogesterone.A total 131 postmenopausal women(surgical menopause=95, natural menopause=36)and not-treated postmenopausal women(control=22) were invited to participate in thisstudy. Patients were divided into groups which had received conjugated equine estrogen(CEE)0.625 mg/day 21-day-cycle each month(n=20), CEE 0.625 mg/day plus Dydrogesterone 10mg/day 10-day-cycle each month(n=111), and no treatment control group(n=20).Serum lipid and lipoprotein(Triglyceride, Total cholesterol, High density lipoprotein, Lowdensity lipoprotein) and serum osteocalcin, urinary Deoxypyridinoline were examined in allpatients.There were no significant differences in bone and lipid metabolism between CEE andCEE plus Dydrogesterone groups.In conclusion, Dydrogesterone may be used safely in postmenopausal women withoutMetabolic side effect.
Cholesterol ; Dydrogesterone* ; Endometrial Neoplasms ; Estrogens, Conjugated (USP)* ; Female ; Hormone Replacement Therapy ; Humans ; Incidence ; Lipid Metabolism ; Lipoproteins ; Metabolism* ; Osteocalcin ; Progesterone
Cholesterol ; Dydrogesterone* ; Endometrial Neoplasms ; Estrogens, Conjugated (USP)* ; Female ; Hormone Replacement Therapy ; Humans ; Incidence ; Lipid Metabolism ; Lipoproteins ; Metabolism* ; Osteocalcin ; Progesterone
Diagnosis of DMD/BMD by Multiplex PCR and Southern Blot Analysis.
Korean Journal of Obstetrics and Gynecology.1997;40(5):1030-1036.
Duchene and Becker muscular dystrophy(DMD/BMD) results from mutations in thedystrophin gene, and enormous genetic locus that spans more than two million base paris ofDNA on the human X chromosome. Some 60% of DMD patients exhibit deletions, which canbe found by cDNA hybridization or, were recently, by polymerase chain reaction analysis.We have used the multiplex PCR to identify deletion mutations in the human dystrophingene. By simultaneously amplifying genomic regions flanking 17 sepastrate exons inmutational hot spots, we were able to detect 16 exons in one family. The DNA encoding eachof the 17 exons in the dystrophin gene is copied a million fold to make it visible in anagarose gel. To be certain that the missing band is not artifact of the amplificationprocedure, the DNA from the blood sample was analyzed by Southern hybridization.
Artifacts ; Blotting, Southern* ; Chromosomes, Human, X ; Diagnosis* ; DNA ; DNA, Complementary ; Dystrophin ; Exons ; Genetic Loci ; Humans ; Multiplex Polymerase Chain Reaction* ; Muscular Dystrophy, Duchenne ; Polymerase Chain Reaction ; Sequence Deletion
Artifacts ; Blotting, Southern* ; Chromosomes, Human, X ; Diagnosis* ; DNA ; DNA, Complementary ; Dystrophin ; Exons ; Genetic Loci ; Humans ; Multiplex Polymerase Chain Reaction* ; Muscular Dystrophy, Duchenne ; Polymerase Chain Reaction ; Sequence Deletion
A Study of the Relationship of Preeclampsia with Total Plasma Fibronectin.
Korean Journal of Obstetrics and Gynecology.1997;40(5):1024-1029.
Of 119 full-term pregnant subjects studied from October, 1995 to March, 1996, 79 hadpreeclampsia(severe; 43, mild; 36) and 40 were normotensive controls. The plasma fibronectinlevels of each subject were assayed by turbidometric immunoassy(Boehringer Mannheim).The objective of this study was to evaluate the relationship of plasma fibronectin withpreeclampsia as a marker for vascular injury.The results were as follows:1. There were significant differences of plasma fibronectin values among the normotensivepregnancy, mild preeclampsia and severe preeclampsia. Within each group of patients,plasm a fibronectin values were 101.7 +/- 59.4 ng/ml and 249.7 +/- 96.3 ng/ml and 329.2 +/- 169.5 ng/ml, respectively (p < 0.001).2. Plasma fibronectin values had positive correlations with severity of preeclampsia,proteinuria, diastlic blood pressure and systolic blood pressure, but negative correlationswith birth weight and platelet count(p < 0.001).3. When the severity of proteinuria on preeclampsia were +1, +2, and +3 or more,plasma fibr onectin values revealed 246.0 +/- 93.3 ng/ml, 342.3 +/- 185.1 ng/ml and 345.0 +/- 168.1ng/ml, respectively and there were significant differences among three groups.4. To verify the variables correlated with plasma fibronectin by using mutiple regressionanalysis, the only variable which was selected significantly was the severity of preeclampsia(r(2) : 0.529).5. With receiver operating characteristic(ROC) curve analysis of the relationship betweenplasma fibronectin values and preeclampsia, if cut off value was selected at the levelof 175ng/ml or more, the sensitivity for diagnosis of preeclampsia was 87.3%, specificity90.0%, positive predictive value 94.5%, and negative predictive value 78.3%, respectively.
Birth Weight ; Blood Platelets ; Blood Pressure ; Diagnosis ; Fibronectins* ; Plasma* ; Pre-Eclampsia* ; Proteinuria
Birth Weight ; Blood Platelets ; Blood Pressure ; Diagnosis ; Fibronectins* ; Plasma* ; Pre-Eclampsia* ; Proteinuria
Korean Journal of Obstetrics and Gynecology.1997;40(5):1019-1023.
The isolation of fetal cells from maternal circulation has the potential to allow relativelyself prenatal diagosis for all pregnant women. The present technology, however, has notreached the accuracy required for clinical diagnosis because of maternal cell contaminationSo we published a new method for enrichment of nRBC in a fetal cell isolation(1996).In this study, attempted to FISH analysis of nRBC which was isolated by our ownmethods. We evaluated the efficiency of FISH.As the results, we have successfully used FISH on enriched nRBC.We were able to identified 2 abnormal fetus which were confirmed by conventionalcytogenentic study as Down syndrome(Fig.1) and Klinefeltre syndrome(Fig.2). And thesensitivity and specificity for FISH was 86%(49/57) and 92.3%(36/39), respectively.According to our results, fetal cell analysis by FISH can be reliable used for prenatalaneuploidy diagnosis. However, the problems of enrichment of the fetal cell and FISH probeor condition should be over come before analyze.
Aneuploidy ; Diagnosis ; Erythroblasts* ; Female ; Fetus ; Fluorescence* ; Humans ; Pregnant Women ; Sensitivity and Specificity
Aneuploidy ; Diagnosis ; Erythroblasts* ; Female ; Fetus ; Fluorescence* ; Humans ; Pregnant Women ; Sensitivity and Specificity
Measurements of Fetal Nuchal Skinfold Thickness in Normal Fetuses during Second Trimester.
Korean Journal of Obstetrics and Gynecology.1997;40(5):1013-1018.
OBFECTIVE: A nuchal skinfold thickness measurement of >or=6mm is widely used as anonivasive tool in screening fetuses with Down syndrome. The aim of this study is to obtainnormative data on the nuchal skinfold thickness in chromosomally normal fetuses duringsecond trimester. METHOD: Fetal nuchal skinfold thickness was measured in the suboccipitobregmaticplan as part of second trimester ultrasonography. Three hundred thirtyfive fetuses,confirmed to be without chromosomal abnormality through evaluation by amniocentesisand/or postnatal examination, were included. RESULT: The mean of measurements increased from 2.74mm to 5.30mm between 15Weeks and 26 weeks of gestation. The measurements of fetal nuchal kinfold thicknesscorrelated linearly with gestational age(y=-1.755+0.29, r(2)=0.406, p=0.0001). Fetal genderhad no influence on this measurement. In contrast to the fact that three of 271 fetuses at or=21 weeks showed nuchal thickness measurement of >or=6mm. CONCLUSION: During second trimester, measurements of fetal nuchal skinfold thicknessincreases as a function of gestational age in normal fetuses. There were no influence offetal gender and no ethnic difference from other countries in this measurement at 15~20weeks of gestation. However, measurements of fetal nuchal skinfold thickness >or=6mm asa screening tool for Down syndrome seems to be confined to fetuses at 15~20 weeks` gestation.
Chromosome Aberrations ; Down Syndrome ; Female ; Fetus* ; Gestational Age ; Humans ; Mass Screening ; Pregnancy ; Pregnancy Trimester, Second* ; Skinfold Thickness* ; Ultrasonography
Chromosome Aberrations ; Down Syndrome ; Female ; Fetus* ; Gestational Age ; Humans ; Mass Screening ; Pregnancy ; Pregnancy Trimester, Second* ; Skinfold Thickness* ; Ultrasonography
Korean Journal of Obstetrics and Gynecology.1997;40(5):1002-1012.
In performing in vitro fertilization and embryo transfer(IVF-ET) program, we haveIdentified multifollicular ovarian pattern which can be distinguished from polycystic ovaries(PCO) by transvaginal ultrasonograpy. Mutifollicular ovaries(MFO) are normal in size ofslightly enlarged, and filled with six or more cysts 4~10 mm in diameter: in contrast toPCO, ovarian stroma is not increased. Women with MFO have the characteristic clinical andEndocrine features which are distinct from those associated with PCO.The objective of this retrospective clinical study was to evaluate the outcomes ofcontrolled ovarian yperstimulation(COH) in infertile patients with MFO, and to compare thepregnancy outcomes in MFO patients with those of PCO or tubal factor only patients. IVF-ET was performed using COH with midluteal GnRH agonist suppression and gonadotropinsin 61 MFO patients(68 cycles), 9 PCO patients(11 cycles), and 188 patients(296 cycles) withtubal factor infertility at Seoul National University Hospital from January, 1995 to August,1996.There were no statistically significant differences in the age of patients, the durationof infertility, and the cancellation rate of COH among three groups. Although patients withMFO of PCO needed less amount of gonadotropins, they showed higher peak serum E2Level and more oocytes were retrieved compared with tubal factor patients(p < 0.05). However,no significant differences existed in the fertilization rate, the number of embroys transferred,and the cumulative embryo score(CES) among three groups. The clinical pregnancy rate(PR) per ET and the implantation rate per embroy were 33.3%(22/66) and 10.1%(36/358),respectively, in MFO, 40.0%(4/10) and 9.4%(5/53) in PCO, and 28.7%(83/289) and 7.6%(108/1,403) in tubal factor patients, and they showed no significant differences. In addition,the ectopic PR, the abortion rate, and the multiple PR were not different among three groups.The occurrence rate of ovarian hyperstimulation syndrome(OHSS) was higher in MFO(10.3%) and PCO(18.2%) compared with tubal factor patients(2.7%,p < 0.05).These data suggest that althought patients with MFO or PCO have the different clinicaland endocrine features, the outcomes of IVF-ET using midluteal GnRH agonist andgonadotropins are similar each other. However, as patients with MFO parttern in transvaginalultrasonography have a higher incidence of OHSS than tubal factor patients, morecareful monitoring of COH for IVF-ET is required.
Abortion, Induced ; Embryo Transfer* ; Embryonic Structures* ; Female ; Fertilization ; Fertilization in Vitro* ; Gonadotropin-Releasing Hormone ; Gonadotropins ; Humans ; Incidence ; Infertility ; Oocytes ; Pregnancy ; Retrospective Studies ; Seoul ; Ultrasonography*
Abortion, Induced ; Embryo Transfer* ; Embryonic Structures* ; Female ; Fertilization ; Fertilization in Vitro* ; Gonadotropin-Releasing Hormone ; Gonadotropins ; Humans ; Incidence ; Infertility ; Oocytes ; Pregnancy ; Retrospective Studies ; Seoul ; Ultrasonography*
Is Doppler Velocimetry Useful for the Prediction of Uteroplacental Insufficiency?.
Korean Journal of Obstetrics and Gynecology.1997;40(5):995-1001.
This study was designed to investigate a possible role for Doppler velocimetry as apredictor of uteroplacental insufficiency with fetal heart rate(FHR) tracing. From January1994 to through May 1996, we studied 419 high risk pregnant women who underwent Dopplervelocimetry within 1 week of intrapartum cardiotocogram or contraction stress test(CST) after 30 gestational weeks. The presence of a diastolic notch in uterine artery,elevated systolic/diastolic(S/D) ratios in umbilical artery(more than 3.0), or in uterine artery(more than 2.6) were considered abnormal. All of the 419 subjects were performed intrapartumcardiotocogram or CST within 1 week after Doppler veocimetry. Seventeen caseswere associated with persistent late deceleration or positive CST. The sensitivity, specificity,positive predictive value, negative predictive value, and relative risk of umbilical arteryS/D ratio for predicting abnormal FHR tracing were 23.5%(4/17), 89.3%(359/402), 8.5%(4/47), 96.5%(359/372), and 0.97. those of uterine artery S/D ratio and diastolic notch were29.4%(5/17), 92.5%(372/402), 14.3%(5/35), 96.9%(372/384), 1.35 and 35.3%(6/17), 90.3%(363/402), 13.3%(6/45), 97.6%(363/374), 3.88 respectively. The presence of uterine arterydiastolic notch in Doppler velocimetry seems to be a better predictor for abnormal FHRtracing after 30 weeks gestation than are S/D ratios in umbilical or uterine arteries.In conclusion, we can suggest that the presence of diastolic notch in uterine arteryDoppler velocimetry might be useful to predict the uteroplacental insufficiency after 30gestational weeks.
Cardiotocography ; Deceleration ; Female ; Fetal Heart ; Humans ; Pregnancy ; Pregnant Women ; Rheology* ; Uterine Artery
Cardiotocography ; Deceleration ; Female ; Fetal Heart ; Humans ; Pregnancy ; Pregnant Women ; Rheology* ; Uterine Artery
Country
Republic of Korea
Publisher
Korean Society of Obstetrics and Gynecology
ElectronicLinks
http://ogscience.org/Editor-in-chief
Abbreviation
Korean J Obstet Gynecol
Vernacular Journal Title
대한산부인과학회잡지
ISSN
0494-4755
EISSN
Year Approved
2007
Current Indexing Status
Currently Indexed
Start Year
1958
Description
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