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Korean Journal of Anesthesiology

1968  to  Present  ISSN: 0302-5780

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The Clinical Evaluation to Recovery Time of Blood Glucose Level after Anesthesia and Operation .

Chun Sub RHIM ; Seung Wan BAIK ; Sang Young LEE

Korean Journal of Anesthesiology.1988;21(1):192-197. doi:10.4097/kjae.1988.21.1.192

The recovery time of the blood glucose level after anesthetic and surgical stress in 30 surgical pediatric patients with A.S,A. physical status class 1 or 2 was evaluated Although they had fasted from 4 to ll hours, none of the patients exhibited hypoglycemia, dehydration or hypotension; This showed that the duration of fasting, age, body weight, and sex did not influence hypoglycemia, dehydration. and hypotension. All patients were anesthetized with Halothane(0.5~1.5 Vol. %)-N2O(1.5L/min) under endotracheal intubation. Just after surgical stimulus, the blood glucose concentration increased about 27mg%, and then returned to pre-operative values within 30 minutes. The author concluded that the hormonal effects arising from the strong stimuli disappeared within 30 minutes. Also, the increase in blood glucoee concentration during intraabdominal surgery was more notable than in surgery to the skin, head or neck. Changes in blood glucose concentration in the recovery room are poasibly related to postoperative pain control.
Anesthesia* ; Blood Glucose* ; Body Weight ; Dehydration ; Fasting ; Head ; Humans ; Hypoglycemia ; Hypotension ; Intubation, Intratracheal ; Neck ; Pain, Postoperative ; Recovery Room ; Skin

Anesthesia* ; Blood Glucose* ; Body Weight ; Dehydration ; Fasting ; Head ; Humans ; Hypoglycemia ; Hypotension ; Intubation, Intratracheal ; Neck ; Pain, Postoperative ; Recovery Room ; Skin

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A Clinical Study of Geriatric Anesthesia .

Hyo Seop CHOI ; Ki Nam LEE ; Jun Il MOON ; Chong Hyun LEE

Korean Journal of Anesthesiology.1988;21(1):180-191. doi:10.4097/kjae.1988.21.1.180

Due to improvements in medical care, the socioeconomic level and public health, life expectancy has dramatically increased. Thus, advances in the development of life-support systems and the control of infection have resulted in many surgical and anesthetic procedures being performed on extremely elderly patients. In contrast to younger patients, elderly patients may manifest more than one pathologic process associated with progressive degenerative changes in various organs of the aged, especially in the heart, brain, and kidney. Since both progressive degenerative change occurring in the elderly population and the cumulative incidence of disease in that population result in death intraoperatively or during the immediate postoperative period, the anesthesiologist must be particularly alert to the possibility of anesthetic risks in the elderly. The elderly patient is more likely to have hypertension, congestive heart failure, cardiac dysrhythmias, chronic pulmonary disease, and diabetes. Preoperative evaluation and treatment of those conditions must be extensively reviewed prior to the induction of anesthesia. To evaluate geriatric anesthetic experiences, 539 cases of patients aged over 60 years of 4,266 anesthetic cases admitted to P.M.C. from January to December, 1986 were analyzed according to age, sex, physical status, anesthetic technique an6 agents, surgical department, preoperative chest X-ray findings, preoperative E.C.G findings, and postoperative complications. The results are as follows. 1) Of 4,266 anesthetic patients 539(12.6%) were over 60 3ears of age and 322(59.7%) were males and 217(40.3%) females. 2) In the classification of physical status, the most common evidence was class 2 in 303 cases. Emergency surgery comprised 27.1%. 3) The anesthesia technique employed was usually general anesthesia and this suggested that balanced anesthesia used with narcotics offers several advantages to geriatric patients. 4) In the surgical department, 310 cases(57.5%) were for general surgery, 75 cases(13,9%), orthopedic surgery; 57 cases(10.6%), urology; and 49 cases(9.1%), neurosurgery, respectively. Cancer was present in 198 cases(36.7%), 5) Preoperative chest X-ray findings: The most common finding was pulmonary tuberculosis in 44 cases(8.2%). Pneumonia, pulmonary emphysema, and so forth were also observed. 6) Preoperative E.C.G findings: The most common findings was myocardial ischemia in 48 cases(8.9%). Also myocardial infarction observed in 8 cases(1.5%) 7) Postoperative complications were as follows: The most common incidence was wourid infection in 29 cases(5.4%) followed by pneumonia. There were a number of miscellaneous complications. but postoperatively, they did not present any significant problems. 8) The overall mortality rate was 3.5%(19 cases). The difference in the mortality rate related to age was not statistically significant(p>0.1), but the mortality rate related to physical status was statistically significant(p<0.001). 9) Optimizing a patient's preoperative condition by the anesthesiologist, consultants, and other physicians was assumed to reduce perioperative morbidity and mortality.
Aged ; Anesthesia* ; Anesthesia, General ; Arrhythmias, Cardiac ; Balanced Anesthesia ; Brain ; Classification ; Consultants ; Emergencies ; Female ; Heart ; Heart Failure ; Humans ; Hypertension ; Incidence ; Kidney ; Life Expectancy ; Lung Diseases ; Male ; Mortality ; Myocardial Infarction ; Myocardial Ischemia ; Narcotics ; Neurosurgery ; Orthopedics ; Pneumonia ; Postoperative Complications ; Postoperative Period ; Public Health ; Pulmonary Emphysema ; Thorax ; Tuberculosis, Pulmonary ; Urology

Aged ; Anesthesia* ; Anesthesia, General ; Arrhythmias, Cardiac ; Balanced Anesthesia ; Brain ; Classification ; Consultants ; Emergencies ; Female ; Heart ; Heart Failure ; Humans ; Hypertension ; Incidence ; Kidney ; Life Expectancy ; Lung Diseases ; Male ; Mortality ; Myocardial Infarction ; Myocardial Ischemia ; Narcotics ; Neurosurgery ; Orthopedics ; Pneumonia ; Postoperative Complications ; Postoperative Period ; Public Health ; Pulmonary Emphysema ; Thorax ; Tuberculosis, Pulmonary ; Urology

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Comparison of Temperatures at Various Sites during Open Heart Surgery Anesthesia .

Sang Do LEE ; Kyung Sik KIM ; Woon Yi BAEK ; Jung Kil HONG ; Jin Woong PARK ; Byung Kwon KIM

Korean Journal of Anesthesiology.1988;21(1):172-179. doi:10.4097/kjae.1988.21.1.172

Because wide swings in temperature can occur during cardiac anesthesia all patients undergoing cardiac anesthesia should have their temperatures monitered. This is especially true in situations where deliberate hypothermia during cardiopulmonary surgery is an area of controversy. This study of 20 cases of open heart surgery was undertaken to compare the changes in tympanic membrane, nasopharyngeal, rectal and great toe temperatures and of to evaluate their correlation during the induction, cardiopulmonary bypass, rewarming and post-cardiopulmonary bypass periods. The temperature at each site was monitored every 10 minutes for 60 minutes of each period. The results were as follows, During the induction period, the temperature of the tympanic membrane, nasopharynx and rectum decreased significantly(p<0.05~p<0.01), but the temperatures of the great toe temperatures increased for 20 minutes and then slowly decreased during the next 30 to 60 minutes. During the cardiopulmonary bypass period, the sympanic membrane temperatures which were best correlated with the nasopharyngeal temperatures(p<0.05~p<0.01), decreased faster than the rectal, nasopharyngeal and great toe temperatures. During the rewarming period, the tympanic membrane temperatures increased most quickly and were significantly correlated with the nasopharyngeal temperatures(p<0.05) only at 0 and 10 minutes. During the post-cardiopulmonary bypass period, the tympanic membrane and nasopharyngeal temperatures decreased slowly and were significantly correlated with each other(p<0.01), but the rectal and the great toe temperatures increased slowly.
Anesthesia* ; Cardiopulmonary Bypass ; Heart* ; Humans ; Hypothermia ; Membranes ; Nasopharynx ; Rectum ; Rewarming ; Thoracic Surgery* ; Toes ; Tympanic Membrane

Anesthesia* ; Cardiopulmonary Bypass ; Heart* ; Humans ; Hypothermia ; Membranes ; Nasopharynx ; Rectum ; Rewarming ; Thoracic Surgery* ; Toes ; Tympanic Membrane

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A Clinical Study on the Temperature Correction of Blood Gas Values during Hypothermia in Patients Undergoing Open Heart Surgery .

Keum Yi KANG ; Suk Hwan LIM ; Young Jin HAN

Korean Journal of Anesthesiology.1988;21(1):164-171. doi:10.4097/kjae.1988.21.1.164

Blood gas values corrected for temperature were compared to uncorrected values in 35 cases of open heart surgery and the following results were obtained. 1) The corrected pH values were higher than the uncorrected values, and a 1 degrees C decrease in the rectal temperatures resulted in an increase pH values by 0.013(Y=-0.013x + 0.504, p<0.01). 2) The corrected values for PCO2 were lower han the uncorrected values, and a 1 degrees C decrease in the rectal temperature resulted in a decrease in corrected PCO2 values by 1.256mmHg(Y=-1.256x + 49.267, p<0.01). 3) The corrected values for PO2 were slightly lower than the uncorrected values, and the differences between temperature corrected and uncorrected PO2 values had statistically significant, but clinically no significant correlation (Y=-3.236x + 133.075, p<0.01). 4) The differences between temperature corrected and uncorrected base excess values had no satistical correlation. 5) If the uncorrected pH values were maintained around 7.4 at any temperature then the corrected pH values at each temperature were very close to the theoretically ideal values (Y=-0.014x).
Heart* ; Humans ; Hydrogen-Ion Concentration ; Hypothermia* ; Thoracic Surgery*

Heart* ; Humans ; Hydrogen-Ion Concentration ; Hypothermia* ; Thoracic Surgery*

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Changes in SGOT and CK - MB Levels during for Open Heart Surgery Anesthesia .

Jong Sung LEE ; Woon Yi BAEK ; Jung Kil HONG ; Jin Woong PARK ; Byung Kwon KIM

Korean Journal of Anesthesiology.1988;21(1):157-163. doi:10.4097/kjae.1988.21.1.157

The purpose of this study were to investigate the changes in serum SGOT, CK and CK-MB levels and the significance of these changes during general anesthesia for open heart surgery. Fourteen patients, who had open heart surgery at Kyungpook National University hospital, were chosen at random their serum SGOT, CK and CK-MB levels were recorded before anesthesia(control group), pre cardiopulmonary bypass, during cardiopulmonary bypass and in the recovery room. The results were as follows: The serum SGOT levels were 21.83+/-4.91 IU/L, 27.20+/-11.83, 34.81+/-16.60 and 72.58+/-37.77, respectively. They very significantly increased (p<0.01) during cardiopulmonary bypass and recovery room compared with pre anesthesia. The serum CK levels were 58.07+/-6.31 IU/L, 91.79+/-44.58, 141.93+/-66.55 and 347.43+/-84.61 respectively. They significantly increased (p<0.05) at pre cardiopulmonary bypass, very significantly increased(p<0.01) during cardiopulmonary hypass and recovery room compared with the preanesthesia. The serum CK-MB levels were 0.00 U/L, 4.54+/-11.80, 14.66+/-17.61 and 80.07+/-34.72 respectively. They very significantly increased(p<0.01) during the cariopulmonary bypass and recovery room.
Anesthesia* ; Anesthesia, General ; Aspartate Aminotransferases* ; Cardiopulmonary Bypass ; Gyeongsangbuk-do ; Heart* ; Humans ; Recovery Room ; Thoracic Surgery*

Anesthesia* ; Anesthesia, General ; Aspartate Aminotransferases* ; Cardiopulmonary Bypass ; Gyeongsangbuk-do ; Heart* ; Humans ; Recovery Room ; Thoracic Surgery*

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The Effect of Extracorporeal Circulation on Serum Angiotensin Converting Enzyme ( SACE ) Levels .

Keon Sik KIM ; Moo Su CHOI ; Dong Soo KIM ; Kwang II SHIN

Korean Journal of Anesthesiology.1988;21(1):151-156. doi:10.4097/kjae.1988.21.1.151

It is well known that the pulmonary capillary endothelium is rich in angiotensin converting enzyme(ACE), which is released in the event of smoking, acute lung injury, or some lung diseases such as Gauchers disease and hypertension. Serum ACE levels may be clinically useful because they are reflections of pulmonary circulation. In order to evaluate the effect of extracorporeal circulation and pulmonary perfusion on serum ACE levels, we measured serum ACE level during prebypass, total bypass(5', 30', 60') and pulmonary perfusion (30', 60', 24 hrs.) in 10 open-heart patients. The results were as follows: 1) The SACE level before the begining of extracorporeal circulation was 10.03+/-1.66u/ml and decreased significantly to 2.79+/-0.63u/ml(p<0.005) 5min. after extracorporeal circulation was initiated. 2) The decreased SACE level seen during extracorporeal circulation returned to a nearly normal (9.33+/-1.8u/ml) 24hrs. after pulmonary perfusion. 3) There were no significant correlations between the SACE level and the variation of age during extracorporeal circulation and pulmonary perfusion. The above results suggest that SACE levels are proportional to the amount of pulmonary blood flow.
Acute Lung Injury ; Angiotensins* ; Cardiopulmonary Bypass ; Endothelium, Vascular ; Extracorporeal Circulation* ; Gaucher Disease ; Humans ; Hypertension ; Lung Diseases ; Peptidyl-Dipeptidase A* ; Perfusion ; Pulmonary Circulation ; Smoke ; Smoking

Acute Lung Injury ; Angiotensins* ; Cardiopulmonary Bypass ; Endothelium, Vascular ; Extracorporeal Circulation* ; Gaucher Disease ; Humans ; Hypertension ; Lung Diseases ; Peptidyl-Dipeptidase A* ; Perfusion ; Pulmonary Circulation ; Smoke ; Smoking

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Metabolic Changes after Hypothermic Cardiopulmonary Bypass Surgery .

Jang Ho SUNG ; Inn Se KIM ; Sang Young LEE

Korean Journal of Anesthesiology.1988;21(1):143-150. doi:10.4097/kjae.1988.21.1.143

Temperature changes after cardiopulmonary bypass surgery(CPB) markedly affect postoperative ventilation. Despite core rewarming after CPB, on admission to the intensive care unit the rectal temperature is about 34~35 degrees C over the next 12 hours, the temperature rises to 38~39 degrees C. Unless minute ventilation is increased hypercarbia occurs presumably because dead space and/or CO2 production are increased. This prospective review was designed to confirm these clinical impressions and to provide direction for future studies. Temperature changes, PaCO2, pH, sodium and potassium values of 42 patients who had undergone cardiac valvular replacement surgery with hypothemic cardiopulmonary bypass were observed during surgery and during the first 12 postoperative hours in the intensive care unit. The results are as follows: 1.The mean nasopharyngeal temperature was 26.3 degrees C, 34.4 degrees C, 34.9 degrees C, and 36.4 degrees C during bypass, rewarming, admission to the intensive care unit, and after 4 hours, respectively. The temperature curve was sigmoid rather than linear. 2. During rewarming, the most common abnormality of PaCO2 on anesthetic mechanical ventilation was acute respiratory acidosis(PaCO2 45mmHg, pH 7.35) which occurred in 48% of the patients. After bypass and in the intensive care unit, respiratory alkalosis occurred in 36% and 45% of the patients, respectively. 3. The serum sodium values decreased in 19% of the patients during bypass but not significantly. 4. The serum potassium value increased in 21% of the patients during bypass surgery, but not significantly, and after surgery it returned to normal limits. This suggests that ventilatory management in the early postoperative period after hypothermic cardiopulmonary bypass surgery should be carefully monitered and adjusted as necessary to the increased metabolic rate during rapid rewarming.
Alkalosis, Respiratory ; Cardiopulmonary Bypass* ; Colon, Sigmoid ; Humans ; Hydrogen-Ion Concentration ; Hypothermia ; Intensive Care Units ; Postoperative Period ; Potassium ; Prospective Studies ; Respiration, Artificial ; Rewarming ; Sodium ; Ventilation

Alkalosis, Respiratory ; Cardiopulmonary Bypass* ; Colon, Sigmoid ; Humans ; Hydrogen-Ion Concentration ; Hypothermia ; Intensive Care Units ; Postoperative Period ; Potassium ; Prospective Studies ; Respiration, Artificial ; Rewarming ; Sodium ; Ventilation

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An Evaluation of the Pediatric Operating Rooms and Pediatric Surgical Patients in Children's Hospital Seoul National University .

Seong Deok KIM ; Yong Chul KIM ; Young Kyun CHUNG

Korean Journal of Anesthesiology.1988;21(1):136-142. doi:10.4097/kjae.1988.21.1.136

A retrospective analysis was performed on 3,285 pediatric surgical patients in 8 operating rooms, at Children's Hospital, Seoul National University from February 1, 1986 to December 31, 1986. The results can be summarized as follows: 1) Departmental distribution of patients; Pediatric surgery 29%, thoracic surgery 20%, plastic surgery and ENT 10%, respectively. 2) Age distribution; Younger than 1yr 17%, preschool (2~5yr) 43%, 6~10 yr 26%, older than 10 yr 14%. 3) Male to female ration; 62%:38%. 4) Elective and emergency surgeries comprised 91.3% and 8.7%, respectively. Emergency pediatric surgery was the highest in number (15.5% of all pediatric surgeries). The average number of daily elective surgeries was 19.2. 5) Pediatric operating room utilization rates; neurosurgery 78.4%, urology 77.8%, thoracic surgery 72.4%, etc. 6) Primary anesthetics; General inhalation anesthesia was administered to 97.4% of all pediatric surgical patients.
Age Distribution ; Anesthesia, Inhalation ; Anesthetics ; Emergencies ; Female ; Humans ; Male ; Neurosurgery ; Operating Rooms* ; Retrospective Studies ; Seoul* ; Surgery, Plastic ; Thoracic Surgery ; Urology

Age Distribution ; Anesthesia, Inhalation ; Anesthetics ; Emergencies ; Female ; Humans ; Male ; Neurosurgery ; Operating Rooms* ; Retrospective Studies ; Seoul* ; Surgery, Plastic ; Thoracic Surgery ; Urology

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The Effect of Naloxone on the Reversal of Hypovolemic Shock in Rats .

Guie Yong LEE ; Choon Hi LEE

Korean Journal of Anesthesiology.1988;21(1):123-135. doi:10.4097/kjae.1988.21.1.123

The effects of morphine in bringing sleep and an end to pain have been known from the beginning of recorded history. But the existence of endogenous opiates(endorphin) has been demonstrated only in the last decade. Endorphin bind to opiate receptors and exhibit potent opiate-like activity. In the corticotroph cells of the anterior lobe of pitultary, ACTH and beta-endorphin are synthesized simultaneously. There is a hypothalamic releasing factor which causes the secretion both beta-endorphin and ACTH, but ACTH and beta-endorphine are also released simultaneously by stress. Endorphins adversely affect the circulatory status and these effects are reversed by the intravenous injection of the narcotic antagonist, naloxone. The author studied Dirksen's hypothesis that endorphins may be involved in the pathophysiology of hemorrhagic shock. In this experiment, the author divided in the pathophysiology of hemorrhagic shock. In this experiment, the author divided laboratory animals into 3 groups and administered normal saline, salicylate or hyprocortisone, respectively. l. normal saline pretreated group. ll. salicylate pretreated group. lll. hydrocortisone pretreated group. Each group was then divided into 4 subgroups and treated as follows: 1) hypovolemic shock + normal saline. 2) hypovolemic shock + naloxone. 3) hypovolemic shock + hydrocortisone. 4) hypovolemic shock + PGE1. The following results were obtained: 1) MAP was significantly increased after naloxone and PGE1 adminitration in the normal saline pretreated group. 2) MAP was not changed in the salicylate pretreated group. 3) MAP was significantly increased after naloxone and PGE1 administration in the hydrocortisone pretreated group. 4) Pulse pressure was significantly increased after anloxone, hydrocortisone and PGE1 administration in the normal saline and hydrocortisone pretreated groups. From the above experiment, it may be inferred that endorphins and prostaglandin may play a role in the pathophysiology of hypovolemic shock.
Adrenocorticotropic Hormone ; Alprostadil ; Animals ; Animals, Laboratory ; beta-Endorphin ; Blood Pressure ; Corticotrophs ; Endorphins ; Hydrocortisone ; Hypovolemia* ; Injections, Intravenous ; Morphine ; Naloxone* ; Pituitary Hormone-Releasing Hormones ; Rats* ; Receptors, Opioid ; Shock* ; Shock, Hemorrhagic

Adrenocorticotropic Hormone ; Alprostadil ; Animals ; Animals, Laboratory ; beta-Endorphin ; Blood Pressure ; Corticotrophs ; Endorphins ; Hydrocortisone ; Hypovolemia* ; Injections, Intravenous ; Morphine ; Naloxone* ; Pituitary Hormone-Releasing Hormones ; Rats* ; Receptors, Opioid ; Shock* ; Shock, Hemorrhagic

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The Effects of Hyperventilation on Acid - Base Changes in Arterial Blood and the Cerebrospinal Fluid during Anesthesia .

Chang Han RYOU ; Meen Gu KIM ; Moo Il KWON ; Kwang II SHIN

Korean Journal of Anesthesiology.1988;21(1):117-122. doi:10.4097/kjae.1988.21.1.117

The use of controlled hyperventilation during neurosurgical procedures prevents the deleterious effects of hypercarbia on the cerebral blood flow and intracranial pressure. hyperventilation with hypocarbia produces cerebral vasoconstriction, reduced cerebral blood flow and a reduction in brain size in the majority of patients with increased intracranial pressure. But since excessive cerebral vasoconstriction might induce cerebral ischemia, there has been much discussion concerning the optimal level of hypocarbia. Several studies have shown biochemical evidence of a change in cerebral glucose utilization to anaerobic metabolism during hypocarbia. In our investigation, the effect of hyperventilation on 10 neurosurgical patients was evaluated by blood gas analysis and the estimation of lackate and pyruvate in arterial blood and the cerebrospinal fluid. The results were as follows: 1) PaCO2 decreased from a prearesthetic value of 38+/-2.2 mmHg to 22+/-2.1mmHg 1 hour postinduction and 24+/-2.2mmHg at 2 hours due to hyperventilation. pH was 7.58+/-0.047 1 hour postinduction and 7.56+/-0.018 at 2 hours. PaO2 was 251+/-33.0mmHg 1 hour postinduction 1 hour and 215+/-20.9mmHg at 2 hours under a 50% inspired oxygen concentration(FiO2=0.5). 2) The arterial blood lactate value increased statistically significantly from a preanesthetic value of 9.3+/-1.5mg% to 11.8+/-1.47mg% 1 hour postinduction(p<0.01) to 12.5+/-1.53mg% at 2 hours(p<0.005). However all values were within the normal range(4.7+/-15.1mg%), and the lacte/pyruvate ratio did not change. 3) In the cerebrospinal fluid, pH was 7.45+/-0.057, PCO2 was 34+/-3.5mmHg and PO2 was 91+/-6.7mmHg following hyperventilation for 1 hour. The lactate value of the cerebrospinal fluid was 19.2+/-3.14mg%(normal range: 11.0~27.0mg%) and the lactate/pyruvate ration was 14.5+/-2.39. 4) No evidence of an excessive increase in CSF lactate was seen in any case. The above findings suggest that maintenance of an adequate oxygen concentration and a carbon dioxide value over 20mmHg would prevent cerebral ischemia following hypocarbia due to hyperventilation.
Anesthesia* ; Blood Gas Analysis ; Brain ; Brain Ischemia ; Carbon Dioxide ; Cerebrospinal Fluid* ; Glucose ; Humans ; Hydrogen-Ion Concentration ; Hyperventilation* ; Intracranial Pressure ; Lactic Acid ; Metabolism ; Neurosurgical Procedures ; Oxygen ; Pyruvic Acid ; Vasoconstriction

Anesthesia* ; Blood Gas Analysis ; Brain ; Brain Ischemia ; Carbon Dioxide ; Cerebrospinal Fluid* ; Glucose ; Humans ; Hydrogen-Ion Concentration ; Hyperventilation* ; Intracranial Pressure ; Lactic Acid ; Metabolism ; Neurosurgical Procedures ; Oxygen ; Pyruvic Acid ; Vasoconstriction

Country

Republic of Korea

Publisher

Korean Society of Anesthesiologists

ElectronicLinks

http://ekja.org

Editor-in-chief

E-mail

Abbreviation

Korean J Anesthesiol

Vernacular Journal Title

대한마취과학회지

ISSN

0302-5780

EISSN

Year Approved

2007

Current Indexing Status

Currently Indexed

Start Year

1968

Description

Current Title

Korean Journal of Anesthesiology

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