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Dong Chul SHIN ; Moo Sung MOON ; Seung Kang CHOI ; Jin Moo LEE

Korean Journal of Urology.1979;20(3):325-328.

A 71 years old housewife with epidermoid carcinoma of cervix was diagnosed as crossed renal ectopia (probably with fusion) incidentally by intravenous pyelography during baseline study of cervical carcinoma.
Aged ; Carcinoma, Squamous Cell ; Cervix Uteri ; Female ; Humans ; Urography

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A Case of Prenephrectomy Renal Artery Embolization for Renal Cell Carcinoma..

Jae Man SONG ; Hak Young LEE ; Moo Sung MOON ; Jin Moo LEE

Korean Journal of Urology.1979;20(3):320-324.

Prenephrectomy therapeutic renal artery embolization by injecting gelfoam into therenal artery was done in a 47 year-old female patient with hypernephroma. This technique facilitated nephrectomy and decreased blood loss. A post-infarction syndrome characterized by flank pain, fever and nausea also occurred in this patient. We report our experience herein with review of literature.
Arteries ; Carcinoma, Renal Cell* ; Female ; Fever ; Flank Pain ; Gelatin Sponge, Absorbable ; Humans ; Middle Aged ; Nausea ; Nephrectomy ; Renal Artery*

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Erratum: Correction of Title. Correlation Between Lower Urinary Tract Symptoms and Premature Ejaculation in Korean Men Older Than 40 Years Old.

Jae Doo UM ; Dong Il KANG ; Jang Ho YOON ; Kweon Sik MIN

Korean Journal of Urology.2014;55(6):434-434. doi:10.4111/kju.2014.55.6.434

In this paper, the title was described incorrectly.

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Urothelial Tumors of the Urinary Bladder in Two Adolescent Patients: Emphasis on Follow-up Methods.

Sungchan PARK ; Kun Suk KIM ; Suk Ju CHO ; Dong Gi LEE ; Byoung Chang JEONG ; Kwan Hyun PARK ; Minki BAEK

Korean Journal of Urology.2014;55(6):430-433. doi:10.4111/kju.2014.55.6.430

Here we describe two cases of papillary urothelial neoplasm of low malignant potential in adolescent boys. One case was a 16-year-old boy with a polypoid mass beside the right ureteral orifice and the other case was a 13-year-old boy with a papillary mass beside the left ureteral orifice. The initial presentation was hematuria in both cases and the bladder mass was detected by ultrasonography. Complete resection of the bladder tumor was performed by using an 11-Fr pediatric resectoscope. Follow-up has been performed with urine analysis, urine cytology, and bladder ultrasonography or cystoscopy every 3 months with no evidence of recurrence.
Adolescent* ; Cystoscopy ; Follow-Up Studies* ; Hematuria ; Humans ; Male ; Recurrence ; Ultrasonography ; Ureter ; Urinary Bladder Neoplasms ; Urinary Bladder*

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Glued Angiocatheter: A Rare Complication of Intrarenal Pseudoaneurysm Glue Angioembolization.

Varun SHARMA ; Santosh KUMAR ; S K SINGH ; A K MANDAL

Korean Journal of Urology.2014;55(6):426-429. doi:10.4111/kju.2014.55.6.426

Endovascular management of intraparenchymal renal artery pseudoaneurysms is a reasonable and effective therapeutic technique. Endovascular management preserves the maximum amount of renal tissue and reduces the potential risk of nephrectomy. We present the case of an angiocatheter that became stuck in the renal artery following the injection of cyanoacrylate glue for angioembolization of an intrarenal pseudoaneurysm.
Adhesives* ; Aneurysm, False* ; Cyanoacrylates ; Embolization, Therapeutic ; Nephrectomy ; Nephrostomy, Percutaneous ; Renal Artery

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Beta-Defensin 124 Is Required for Efficient Innate Immune Responses in Prostate Epithelial RWPE-1 Cells.

Kyeoung Hwa KIM ; Jaehyouk LEE ; Jun Hyun HAN ; Soon Chul MYUNG

Korean Journal of Urology.2014;55(6):417-425. doi:10.4111/kju.2014.55.6.417

PURPOSE: The present study aimed to determine the role played by beta-defensin 124 (DEFB124) in the innate immunity of prostate epithelial RWPE-1 cells during bacterial infection. MATERIALS AND METHODS: The expression of DEFB124 was examined by quantitative real-time polymerase chain reaction (PCR), Western blotting, and immunocytochemistry. Enzyme-linked immunosorbent assays and quantitative real-time PCR were performed to determine the production of cytokines and chemokines. Western blotting and chromatin immunoprecipitation studies were performed to assess the interaction between DEFB124 and nuclear factor-kappa B (NF-kappaB) in peptidoglycan (PGN)-stimulated RWPE-1 cells. By chemotaxis assay, we assessed the effect of DEFB124 on the migration of monocytes. RESULTS: Exposure to PGN induced DEFB124 upregulation and NF-kappaB activation through IkappaBalpha phosphorylation and IkappaBalpha degradation. Bay11-7082, an NF-kappaB inhibitor, blocked PGN-induced DEFB124 production. Also, NF-kappaB was shown to be a direct regulator and to directly bind to the -3.14 kb site of the DEFB124 promoter in PGN-treated human prostate epithelial RWPE-1 cells. When DEFB124 was overexpressed in RWPE-1 cells, interestingly, the production of cytokines (interleukin [IL] 6 and IL-12) and chemokines (CCL5, CCL22, and CXCL8) was significantly increased. These DEFB124-upregulated RWPE-1 cells markedly induced chemotactic activity for THP-1 monocytes. CONCLUSIONS: Taken together, these results provide strong evidence for the first time that increased DEFB124 expression via NF-kappaB activation in PGN-exposed RWPE-1 cells enhances the production of cytokines and chemokines, which may contribute to an efficient innate immune defense.
Bacterial Infections ; Blotting, Western ; Chemokines ; Chemotaxis ; Chromatin Immunoprecipitation ; Cytokines ; Defensins ; Enzyme-Linked Immunosorbent Assay ; Humans ; Immunity, Innate* ; Immunohistochemistry ; Monocytes ; NF-kappa B ; Peptidoglycan ; Phosphorylation ; Prostate* ; Real-Time Polymerase Chain Reaction ; Up-Regulation

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Effect of Potassium Magnesium Citrate and Vitamin B-6 Prophylaxis for Recurrent and Multiple Calcium Oxalate and Phosphate Urolithiasis.

S V Krishna REDDY ; Ahammad Basha SHAIK ; Suneel BOKKISAM

Korean Journal of Urology.2014;55(6):411-416. doi:10.4111/kju.2014.55.6.411

PURPOSE: To study the effects of long-term treatment with potassium magnesium citrate and vitamin B-6 prophylaxis (Urikind-KM6; 1,100-mg potassium citrate, 375-mg magnesium citrate, and 20-mg pyridoxine hydrochloride/5 mL) every 8 hours over 3 years. MATERIALS AND METHODS: A total of 247 patients with recurrent idiopathic hypocitraturia with or without hyperuricosuria and randomized controls were studied prospectively for 3 years. The total patients were divided into three groups. Control group 1 consisted of 61 patients (24.7%) who had moderate to severe hypocitraturia with or without hyperuricosuria and were recurrent stone formers but discontinued prophylaxis because of drug intolerance within 1 month of therapy. Control group 2 constituted 53 patients (21.5%) who were first-time stone formers and who had mild hypocitraturia with or without hyperuricosuria and were not put on prophylactic therapy and were followed for 3.16+/-0.08 years. Control group 3 constituted 133 patients (54.8%) who were recurrent stone formers who had moderate to severe hypocitraturia with or without hyperuricosuria and were put on prophylaxis therapy and were followed for 3.16+/-0.08 years. All patients were followed up at 6-month intervals. RESULTS: Potassium magnesium citrate prophylaxis produced a sustained increase in 24-hour urinary citrate excretion from initially low values (221.79+/-13.39 mg/dL) to within normal to high limits (604.04+/-5.00 mg/dL) at the 6-month follow-up. Urinary pH rose significantly from 5.62+/-0.2 to 6.87+/-0.01 and was maintained at 6.87+/-0.01. The stone recurrence rate declined from 3.23+/-1.04 per patient per year to 0.35+/-0.47 per patient per year. CONCLUSIONS: Potassium magnesium citrate prophylaxis was effective in reducing the recurrence of calcium oxalate and phosphate urolithiasis.
Calcium Oxalate* ; Citric Acid* ; Follow-Up Studies ; Humans ; Hydrogen-Ion Concentration ; Magnesium* ; Potassium Citrate ; Potassium* ; Prospective Studies ; Pyridoxine ; Recurrence ; Urolithiasis* ; Vitamins*

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A Population-Based Study of Factors Associated With Nocturia in Reproductive-Aged Turkish Women.

Hasmet SARICI ; Onur TELLI ; Berat Cem OZGUR ; Omer Gokhan DOLUOGLU ; Muzaffer EROGLU ; Selen BOZKURT

Korean Journal of Urology.2014;55(6):405-410. doi:10.4111/kju.2014.55.6.405

PURPOSE: This study aimed to investigate the prevalence of nocturia according to the International Continence Society (ICS) definition in Turkish women and to determine the associated risk factors and the correlation of other voiding symptoms with nocturia. MATERIALS AND METHODS: A prospective epidemiological study was carried out by use of self-reported questionnaires in 4,250 reproductive-aged women from January 2013 to May 2013. The International Consultation on Incontinence Questionnaire-Short Form and a questionnaire developed by the researchers according to the ICS were administered to define nocturia and other lower urinary tract symptoms. Other physical, reproductive, and health characteristics were also recorded concurrently. RESULTS: Overall, 1,636 women were included in the final analyses. The women had an average age of 34.4+/-5.26 years. The overall prevalence of nocturia was 34.7% (567 of 1,636 women). Women with nocturia were older (p<0.001), had a higher body mass index (p=0.026), and had more children (p<0.001). Nocturia occurred more frequently in women with a history of nocturnal enuresis (p<0.001). Three or more pregnancies, 3 or more deliveries, and age >40 years were significant risk factors for nocturia. We also found that other lower urinary tract symptoms correlated significantly (p<0.001) with nocturia. CONCLUSIONS: Although the prevalence of nocturia is higher with increasing age, younger adults are also affected. Nocturia may cause sleep disorders, mood disturbances, reduced quality of life, and distractibility. Thus, even if one void nightly causes a patient to experience bother, nocturia should be queried about and should be treated if necessary according to the cause of the disease.
Adult ; Body Mass Index ; Child ; Epidemiologic Studies ; Female ; Humans ; Lower Urinary Tract Symptoms ; Nocturia* ; Nocturnal Enuresis ; Pregnancy ; Prevalence ; Prospective Studies ; Quality of Life ; Questionnaires ; Risk Factors ; Sleep Disorders

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The Changes of Voiding Pattern After Midurethral Sling Between Pure Stress Urinary Incontinence and Stress Urinary Incontinence With Overactive Bladder Group.

Sun Wook KIM ; Woo Hyun KIM ; Byung Il YOON ; Yong Hyun CHO ; Dong Wan SOHN

Korean Journal of Urology.2014;55(6):400-404. doi:10.4111/kju.2014.55.6.400

PURPOSE: The purpose of this study is to compare changes in voiding pattern after midurethral sling surgery (MUS) between the stress urinary incontinence (SUI) group and the overactive bladder (OAB)+SUI group. MATERIALS AND METHODS: From January 2008 to February 2011, a retrospective survey was conducted of 225 female patients who had been diagnosed with SUI and undergone MUS. The subjects were divided into the SUI group and the OAB+SUI group. Changes in the overactive bladder symptom score (OABSS) and American Urological Association-Symptom Index (AUA-SI) before and three months after the MUS were compared. RESULTS: Of the 225 patients, 165 patients (73.3%) were classified as SUI group, and 60 patients (26.7%) were classified as OAB+SUI group. The mean age of the subjects was 54.7 years (range, 31-80 years), and the mean age of patients was 53.9 years (range, 34-80 years), and 56.8 years (range, 31-78 years) in the SUI group and OAB+SUI group. In SUI group, voiding symptom and storage symptom among the AUA-SI were significantly increased (p<0.05). OABSS were slight increased, but was statistically insignificant (p=0.847). In OAB+SUI group, voiding symptom score and OABSS showed a significant increase (p<0.05), but storage symptom score showed an insignificant increase (p=0.790). CONCLUSIONS: OAB may occur in approximately 18% of SUI patients who undergo MUS surgery, and voiding dysfunctions with deteriorated voiding symptom and storage symptom may also occur. The deteriorated OAB was shown in 45% of SUI patients with OAB after the surgery.
Animals ; Female ; Humans ; Mice ; Retrospective Studies ; Suburethral Slings* ; Urinary Bladder, Overactive* ; Urinary Incontinence* ; Urinary Incontinence, Urge

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Does the Time From Biopsy to Radical Prostatectomy Affect Gleason Score Upgrading in Patients With Clinical T1c Prostate Cancer?.

Muzaffer EROGLU ; Omer Gokhan DOLUOGLU ; Hasmet SARICI ; Onur TELLI ; Berat Cem OZGUR ; Selen BOZKURT

Korean Journal of Urology.2014;55(6):395-399. doi:10.4111/kju.2014.55.6.395

PURPOSE: It is debated whether treatment delay worsens oncologic results in localized prostate cancer (PCa). Few studies have focused on the role of a delay between the time of biopsy and the time of surgery. Thus, we aimed to investigate the effect of the time period between biopsy and surgery on Gleason score upgrading (GSU). MATERIALS AND METHODS: A total of 290 patients who underwent radical retropubic prostatectomy in Ankara Training and Research Hospital were included in the study. The biopsy Gleason score, age, total prostate-specific antigen (PSA) value, prostate volumes, and PSA density (PSAD) were analyzed in all patients. The patients were divided into two groups: patients with GSU (group 1) and patients without GSU (group 2). Variables having a p-value of < or =0.05 in the univariate analysis were selected and then evaluated by use of multivariate logistic regression models. Results were considered significant at p<0.05. RESULTS: GSU occurred in 121 of 290 patients (41.7%). The mean age of the patients was 66.0+/-7.2 years in group 1 and 65.05+/-5.60 years in group 2 (p=0.18). The mean PSA values of groups 1 and 2 were 8.6+/-4.1 and 8.8+/-4.3 ng/dL, respectively. The mean prostate volumes of groups 1 and 2 were 43.8+/-14.1 and 59.5+/-29.8 mL, respectively. The PSAD of group 1 was significantly higher than that of group 2 (0.20 vs. 0.17, p=0.003). The mean time to surgery was shorter in group 2 (group 1, 52.2+/-22.6 days; group 2, 45.3+/-15.5 days; p=0.004). According to the logistic regression, time from biopsy to surgery is important in the prediction of GSU. CONCLUSIONS: We suggest that the time period between biopsy and surgery is a significant factor that affects GSU in patients with clinically localized PCa.
Biopsy* ; Humans ; Logistic Models ; Neoplasm Grading* ; Passive Cutaneous Anaphylaxis ; Prostate ; Prostate-Specific Antigen ; Prostatectomy* ; Prostatic Neoplasms*

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