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Effect of Intralesional Interleukin-2 on Murine Bladder Tumor.

Hyeon Hoe KIM ; Eun Sik LEE ; Sang Jin YOON ; Moon Ki JO ; Chongwook LEE

Korean Journal of Urology.1996;37(12):1327-1332.

PURPOSE: We tried to evaluate the anticancer effect of intralesional interleukin-2 on murine bladder tumor. MATERIALS AND METHODS: In vitro direct anticancer effect of interleukin-2 upon MBT-2 cells was examined using MTT colorimetric assay in various concentration of human recombinant interleukin-2. Also in vivo study was carried out measuring the tumor implantation rates and growth of the implanted tumors on C3H/He mice receiving six consecutive injections of various concentrations of interleukin-2. RESULTS: No definite direct anticancer effect was found on in vitro study. Also, the tumor implantation rate and growth of the implanted tumors were similar whether interleukin-2's were injected or not. CONCLUSION: Intralesional injection of interleukin-2 does not seem to be effective upon murine bladder tumor.
Animals ; Humans ; Injections, Intralesional ; Interleukin-2* ; Mice ; Urinary Bladder Neoplasms* ; Urinary Bladder*

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Detection of Cellular Proliferation during Compensatory Renal Growth in Neonatal Rats Using Flow Cytometry and Activity of Nitric Oxide Synthase.

Koon Ho RHA ; Sang Won HAN ; Seung Kang CHOI

Korean Journal of Urology.1996;37(12):1319-1326.

Renal compensatory growth, after the loss of functioning parenchyme due to nephrectomy or hydronephrosis, is an important clinical phenomenon which often eventually results in glomerulosclerosis and renal failure. Thus numerous efforts have been made to elucidate the mechanism of compensatory growth and to discover the methods which can impede the compensatory process. Compensatory renal growth in mature animals is mainly by cellular hypertrophy, the increase in cellular component without increase in number of cells. But small portion of growth is composed of hyperplasia, the increase in total number of cells. To evaluate hyperplasia and hypertrophy, flowcytometry is employed. The DNA ploidy pattern of each kidney cell is analyzed, and the proportion of synthetic and replicating cells is calculated. For evaluation of hypertrophy, the presumed causative metabolite, nitric oxide, is indirectly titrated by measuring the activity of its key enzyme, nitric oxide synthase. The results of the experiment are as follows. 1. The increase in fraction of synthetic and replicating cells in flow cytometry is a definite evidence of cellular hyperplasia, thus hyperplasia is involved in neonatal compensatory renal growth. 2. Cellular hyperplasia is profound after 48 to 72 hours of injury 3. A statistically significant difference was noted at 12 hours after nephrectomy between control and experimental groups in G, + M phase (mitotic phase). 4. Nitric oxide is an important messenger of early (within 48 hours) renal compensatory growth in neonatal rats. 5. In view of the adult model experiment of nitric oxide synthase, where nitric oxide is confirmed to be involved in renal compensatory hypertrophy, nitric oxide is also related to the renal hypertrophy in neonatal periods. In conclusion, the compensatory renal growth in neonatal period is due to both hyperplasia and hypertrophy. Nitric oxide is a key signaling messenger of early compensatory renal growth, it can be stated that if the process of hypertrophy could be selectively blocked, prevention of renal failure as a consequence of glomerulosclerosis can be a reality.
Adult ; Animals ; Cell Division ; Cell Proliferation* ; DNA ; Flow Cytometry* ; Humans ; Hydronephrosis ; Hyperplasia ; Hypertrophy ; Kidney ; Nephrectomy ; Nitric Oxide Synthase* ; Nitric Oxide* ; Ploidies ; Rats* ; Renal Insufficiency

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Adenomatoid Tumor of Epididymis.

Myung Kook SHIN ; Dong Sun KIM ; Duck Ki YOON ; Sung Kun KOH

Korean Journal of Urology.1986;27(3):500-502.

Adenomatoid tumor is extremely rare benign neoplasm occurring in the genital tract. They are mesothelial origin tumors and frequently found in the testis, epididymis, tunica vaginalis, or spermatic cord in male. But most adenomatoid tumors are found near or in epididymis. While in female they are usually located in the fallopian tube, uterus, and ovary. Adenomatoid tumors are usually small, firm or solid, and asymptomatic, these are clinically found or routine physical examination. They are usually less than 2cm in diameter, but may measure up to 5cm, Histologically the tumor consists of tubules and gland like spaces lined with cuboidal or flattened in a fibrous stroma. The tumor was first described and adenomyoma by Sakaguchi in 1915. Since that time there have been numerous case reports of similar tumors. But the term, adenomatoid tumor, introduced by Golde and Ash in 1945 seems to have been even more widely used. Recently we experienced a case of adenomatoid tumor of epididymis, which was found incidentally during physical examination and confirmed by excisional biopsy in a patient who complained lower abdominal pain.
Abdominal Pain ; Adenomatoid Tumor* ; Adenomyoma ; Biopsy ; Epididymis* ; Fallopian Tubes ; Female ; Humans ; Male ; Ovary ; Physical Examination ; Spermatic Cord ; Testis ; Uterus

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Two Cases of Hypospadias Repaired by Using the Bladder Mucosal Graft Technique.

Woo Sik CHUNG ; Sang Won HAN ; Hyung Ki CHOI

Korean Journal of Urology.1986;27(3):495-499.

In the repair of hypospadia, the use of bladder mucosal grafts in cases in which previous adequate foreskin for urethral reconstruction is lacking or in which previous repairs have failed, is feasible. The bladder mucosal graft offers several theoretical advantages. It is of the same histologic character as the normal urethra, is not hair bearing, tends to re-epithelialize exposed surfaces and has great dispensability. We have experienced two cases of the perineal and penoscrotal hypospadias repaired successfully by the bladder mucosal graft technique.
Female ; Foreskin ; Hair ; Hypospadias* ; Male ; Transplants* ; Urethra ; Urinary Bladder*

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Two Cases of Primary Signet-Ring-Cell Adenocarcinoma of the Urinary Bladder.

Jun CHEON ; Myung Kook SHIN ; Jae Heung CHO ; Se Kyong KIM ; Nam Hee WON

Korean Journal of Urology.1986;27(3):489-494.

Primary Signet-ring-cell adenocarcinoma of the urinary bladder is an extremely rare variant that promotes considerable interest, 21 cases reported as of 1981. Morphologically, this tumor is identical to signet-ring-cell carcinomas of the gastrointestinal tract, breast, lung and nasal cavity, and differentiation must be carried out with great care. Characteristically, primary signet-ring-cell adenocarcinoma carries a poor prognosis with early penetration of the mucosa, submucosa, and muscularis. This tumor is sessile, infiltrates early, extends locally to adjacent organs, and metastasized late. Many patients reported died of local extension with ureteral obstruction and uremia rather than wide spread metastasis. We are reporting two cases of primary signet-ring-cell adenocarcinoma of the urinary bladder treated with radical cystectomy and transurethral resection with radiotherapy, which died of local extension with ureteral obstruction and uremia, with pathological findings and review of the literatures.
Adenocarcinoma* ; Breast ; Cystectomy ; Gastrointestinal Tract ; Humans ; Lung ; Mucous Membrane ; Nasal Cavity ; Neoplasm Metastasis ; Prognosis ; Radiotherapy ; Uremia ; Ureteral Obstruction ; Urinary Bladder Neoplasms ; Urinary Bladder*

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A Case of Ileovesical Fistula due to Malignant Lymphoma.

Ho Cheol WOO ; Seong Cheol YANG

Korean Journal of Urology.1986;27(3):485-487.

The recorded cases of ileovesical fistula are surprisingly few. However, when encountered, they present an interesting problem which commands the attention of urologist. Ileovesical fistula due to malignant lymphoma is a rare disease and usually first manifested by a long period of urinary symptom. We report a case of ileovesical fistula due to malignant lymphoma, diffuse, poorly differentiated, lymphocytic type, in sixty-four-year-old male patient with the brief review of literature.
Fistula* ; Humans ; Lymphoma* ; Male ; Rare Diseases

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Aortorenal Bypass with Saphenous Vein in the Patient of Left Renal Arterial Stenosis and Right Renal Hypoplasia.

Bong Suck SHIM ; Young Yo PARK ; Eun Kee KIM ; Bum Koo CHO

Korean Journal of Urology.1986;27(3):478-484.

Renal hypertension is found to be the cause in 5-15% of patients with hypertension, and may be vascular or renal parenchymal in nature. Recent advances in diagnostic technique and vascular reconstructive techniques now enable successful management in many patients with renal hypertension. We observed one case of renovascular hypertension due to right renal hypoplasia and left renal arterial stenosis, in 22 year-old female patient with complaints of headache and dizziness for 10 days. The treatment was done by right nephrectomy and left aortorenal bypass procedure with saphenous vin. Herein we reported a case of renovascular hypertension with a review of the literatures.
Constriction, Pathologic* ; Dizziness ; Female ; Headache ; Humans ; Hypertension ; Hypertension, Renal ; Hypertension, Renovascular ; Nephrectomy ; Saphenous Vein* ; Young Adult

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A Retrospective Study on the Treatment and Complications of Posterior Urethral Injury.

Hong Sup KIM ; Young Tai LEE

Korean Journal of Urology.1986;27(3):473-477.

In order to persue better methods in treating posturethral injury, the authors have observed and compared 49 posterior urethral injury patients hospitalized in the Department of Urology of Yonsei University College of Medicine according to the level of injury and severity, especially posturethral injury treatment and its effectiveness, complications and its management during the period of 10 years; from January 1, 197S to December 31, 1984. As a result, primary realignment has shown more urethral stricture complication than delayed urethroplasty, although on difficulty was encountered in treatment by the advancement in endourologic surgery. Primary realignment in the case of simple posterior urethral injury and delayed urethroplasty in the case of severe combined injury with accompanying disease has presented a good clinical result.
Humans ; Retrospective Studies* ; Urethral Stricture ; Urology

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A Study on Preservation of Normal Ejaculatory Function After Transurethral Resection in Benign Prostatic Hypertrophy.

Young Soo KIM ; Se Kyong KIM

Korean Journal of Urology.1986;27(3):465-471.

It is well known fact that dry ejaculation is commonly found following simple prostatectomy including transurethral resection of hypertrophied prostate. To preserve normal ejaculatory function following transurethral resection in benign prostatic hypertrophy patients, we have modified the technique of transurethral resection to give less injury to the bladder neck, ejaculatory duct, urethral mucosa and branches of nerves by preserving smaller lateral lobe in cases one lateral lobe is much smaller than the other, or preserving lower one third of a lateral lobe in cases of big bilateral lobes, resecting all other lobes(B-type), and this technique was applied in 66 cases. Control group was 24 cases in which all lobes were resected like ordinary transurethral resection technique(A-type). Ninety cases, ranged in age from 42 to 79 years (mean; 68.0 years), were followed by interviewing with the questionaionaires concerning sexual desire, erection, vaginal penetration, orgasm and ejaculation. Loss of ejaculatory function was noted preoperatively in 4 cases of the group A and in 6 cases of the group B. Four out of 60 cases had dry ejaculation in the group in which B-type of transurethral resection of prostate was applied, while 15 out of 20 cases had dry ejaculation or anejaculation in the group A. There were 3 patients who had undergone B-type operation first and one to four years later A-type operation was also performed, and they complained of no ejaculatory disturbance after B-type operation. However, dry ejaculation did occur after A-type operation in all three patients. All 90 cases were able to achieve an erection with sexual desire preoperatively and postoperatively Seven cases of decreased orgasm were noted in the group B, while 8 cases complained of decreased orgasm in the group A. Judging from above results this modified technique of transurethral resection of prostate is a useful method to preserve normal ejaculatory function.
Ejaculation ; Ejaculatory Ducts ; Humans ; Male ; Mucous Membrane ; Neck ; Orgasm ; Prostate ; Prostatectomy ; Prostatic Hyperplasia* ; Transurethral Resection of Prostate ; Urinary Bladder

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A Study on Serum and Urinary Calcium, Inorganic Phosphorus and Serum Parathyroid Hormone Levels in Patients with Renal Stone.

Tae Seok HA ; Dae Soo CHANG

Korean Journal of Urology.1986;27(3):459-464.

A study was performed on contributing factors of stone formation, such as serum and urinary calcium, inorganic phosphorus and serum PTH in 63 patients with renal stone comparing those in 45 controls. The following results were obtained. 1. The mean values of serum calcium levels of patients were significantly higher than those of controls in total male and female. And those of urinary calcium levels of patients were significantly higher than those of controls in total and female but not in male. 2. The mean values of serum and urinary inorganic phosphorus levels did not show significant difference between patients and controls. 3. The mean values of serum parathyroid hormone levels of patients were higher than those of controls, but did not show significant difference between both groups. 4. The incidences of hypercalcemia, hypercalciuria, hyperphosphatemia and elevated serum parathyroid hormone levels of patients were higher then those of controls, but showed significant difference between both groups in hypercalcemia and hypercalciuria.
Calcium* ; Female ; Humans ; Hypercalcemia ; Hypercalciuria ; Hyperphosphatemia ; Incidence ; Male ; Parathyroid Hormone* ; Phosphorus* ; Urinary Calculi

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