Journal Detail Information

1

Cite

Share

Multiple jaw cysts not associated with basal cell nevus syndrome.

Korean Journal of Oral and Maxillofacial Radiology.2003;33(3):195-198.

We present two cases of multiple jaw cysts not associated with basal cell nevus syndrome. Case 1: a nine year-old boy visited CNU Hospital for orthodontic treatment and his radiographs showed cystic lesions surrounding the crowns of teeth #13 and #17 respectively, which were diagnosed as dentigerous cysts. Subsequently, two more cysts were found on his follow-up radiographs in 12 and 15 months. The two cysts were determined to be odontogenic keratocysts. The boy had no skeletal abnormalities and no skin lesions associated with basal cell nevus syndrome. Case 2: a fifty-eight year old man had three impacted third molars with pericoronal radiolucencies, which were diagnosed as dentigerous cysts. He had no additional abnormalities associated with basal cell nevus syndrome. Multiple jaw cysts can occur at any age, and periodic radiographic surveillance may be needed for any cases of impacted tooth.
Basal Cell Nevus Syndrome* ; Crowns ; Dentigerous Cyst ; Follow-Up Studies ; Humans ; Jaw Cysts* ; Jaw* ; Male ; Molar, Third ; Odontogenic Cysts ; Skin ; Tooth ; Tooth, Impacted

2

Cite

Share

The accuracy of reformatted images using a new virtual 3-dimensional dental implant system.

Jin Seok CHOI ; Eun Kyung KIM ; Won Jeong HAN

Korean Journal of Oral and Maxillofacial Radiology.2003;33(3):187-193.

PURPOSE: To compare the measurements of the mandible and the detectability of the mandibular canal on reformatted images using a newly developed 3-dimensional implant simulation program with traditionally used CT multi-planar reconstruction program and true measurements. MATERIALS AND METHODS: Ten dry dog mandibles were used in this study. Occlusal templates for CT examination were fabricated and marked with gutta percha at ten sites. Axial CT scans were taken and reconstructed using DentaScan (D group) and Vimplant program (V group), and each mandible was sectioned at the previously marked sites (R group). Maximum vertical height (H) and maximum width (W) of the mandible, the distances from buccal border of the mandibular canal to the most buccal aspect of the mandible (X), and the distance from the superior border of the mandibular canal to the alveolar crest (Y) were measured, and the mandibular measurements in each group were compared. Detectability of mandibular canal was evaluated using a 3-point scale in both V and D groups by three oral radiologists and compared. RESULTS: H in the V group was slightly greater than that in the D group, and W and X in the V group was slightly less than those in the D group. H in the V group was less than that in the R group, and W and X in the V group was larger than those in the R group. The detectability of the mandibular canal did not show statistically significant differences between V and D groups. CONCLUSION: The results of the experiment show that the newly developed, inexpensive Vimplant TM simulation program can be used as an alternative to the traditionally used, and more expensive CT multiplanar reconstruction program.
Animals ; Dental Implants* ; Dogs ; Gutta-Percha ; Image Processing, Computer-Assisted ; Mandible ; Tomography, X-Ray Computed

3

Cite

Share

Effects of irradiation on the mRNA expression of the osteocalcin and osteopontin in MC3T3-E1 osteoblastic cell line.

Su Beom CHO ; Ssang Yong HA ; Sang Rae LEE ; Kwang Joon KOH

Korean Journal of Oral and Maxillofacial Radiology.2003;33(3):179-185.

PURPOSE: To investigate the effects of irradiation on the phenotypic expression of the MC3T3-E1 osteoblastic cell line, particularly on the expression of osteocalcin and osteopontin. MATERIALS AND METHODS: Cells were irradiated with a single dose of 0.5, 1, 4, and 8 Gy at a dose rate of 5.38 Gy/min using a cesium 137 irradiator. After the specimens were harvested, RNA was extracted on the 3rd, 7th, 14th, and 21st day after irradiation. The RNA strands were reverse-transcribed and the resulting cDNAs were subjected to amplification by PCR. RESULTS: The irradiated cells demonstrated a dose-dependent increase in osteocalcin and a dose-dependent decrease in osteopontin mRNA expression compared with the non-irradiated control group. The amount of osteocalcin mRNA expression decreased significantly at the 3rd day after irradiation of 0.5, 1, 4, and 8 Gy, and also decreased significantly at the 3rd, 14th, and 21st day after irradiation in the 8 Gy exposed group compared with the control group. The degree of osteopontin mRNA expression increased significantly at the 7th day after irradiation of 0.5, 1, 4, and 8 Gy. CONCLUSION: These results showed that each single dose of 0.5, 1, 4, and 8 Gy influenced the mRNA expression of osteocalcin and osteopontin associated with the calcification stage of osteoblastic cells, suggesting that each single dose affected bone formation at the cell level.
Cell Line* ; Cesium ; DNA, Complementary ; Osteoblasts* ; Osteocalcin* ; Osteogenesis ; Osteopontin* ; Polymerase Chain Reaction ; RNA ; RNA, Messenger*

4

Cite

Share

Reproducibilities of cephalometric measurements of three-dimensional CT images reconstructed in the personal computer.

Kug Jin JEON ; Hyok PARK ; Hee Cheol LEE ; Kee Deog KIM ; Chang Seo PARK

Korean Journal of Oral and Maxillofacial Radiology.2003;33(3):171-178.

PURPOSE: The purpose of this study was to report the reproducibility of intra-observer and inter-observer consistency of cephalometric measurements using three-dimensional (3D) computed tomography (CT), and the degree of difference of the cephalometric measurements. MATERIALS AND METHODS: CT images of 16 adult patients with normal class I occlusion were sent to personal computer and reconstructed into 3D images using V-Works 3.5 TM (Cybermed Inc., Seoul, Korea). With the internal program of V-Works 3.5 TM, 12 landmarks on regular cephalograms were transformed into 21 analytic categories and measured by 2 observers and in addition, one of the observers repeated their measurements. Intra-observer difference was calculated using paired t-test, and inter-observer by two sample test. RESULTS: There were significant differences in the intra-observer measurements (p< 0.05) in four of the categories which included ANS-Me, ANS-PNS, Cdl-Go (Lt), GoL-GoR, but with the exception of Cdl-Go (Lt), ZmL-ZmR, Zyo-Zyo, the average differences were within 2 mm of each other. The inter-observer observations also showed significant differences in the measurements of the ZmL-ZmR and Zyo-Zyo categories (p< 0.05). With the exception of the Cdl-Me (Rt), ZmL-ZmR, Zyo-Zyo categories, the average differences between the two observers were within 2 mm, but the ZmL-ZmR and Zyo-Zyo values differed greatly with values of 8.10 and 19.8 mm respectively. CONCLUSION: In general, 3D CT images showed greater accuracy and reproducibility, with the exception of suture areas such as Zm and Zyo, than regular cephalograms in orthodontic measurements, showing differences of less than 2 mm, therefore 3D CT images can be useful in cephalometric measurements and treatment planning.
Adult ; Cephalometry ; Humans ; Microcomputers* ; Reproducibility of Results ; Seoul ; Sutures ; Tomography, X-Ray Computed

5

Cite

Share

Effect of irradiation on the acinar cells of submandibular gland in streptozotocin-induced diabetic rats.

Seung Hyun LEE ; Eui Hwan HWANG ; Sang Rae LEE

Korean Journal of Oral and Maxillofacial Radiology.2003;33(3):161-169.

PURPOSE: To observe the histologic changes and clusterin expression in the acinar cells of the submandibular gland in streptozotocin-induced diabetic rat following irradiation. MATERIALS AND METHODS: Mature Sprague-Dawley rats were divided into three groups: control, diabetic, and diabetic-irradiated groups. Diabetes mellitus was induced in the Sprague-Dawley rats by injecting streptozotocin, while the control rats were injected with citrate buffer only. After 5 days, rats in diabetic-irradiated group were irradiated with single absorbed dose of 10 Gy to the head and neck region. The rats were killed at 1, 3, 7, 14, 21, and 28 days after irradiation. The specimen including the submandibular gland were sectioned and observed using histologic and immunohistochemical methods. RESULTS: Morphologic change of acinar cells was remarkable in the diabetic group, but was not observed in the diabetic-irradiated group. Necrotic tissues were observed in the diabetic-irradiated group. Coloring of toluidine blue stain was most increased at 14 days in the diabetic group, however there were no significant change throughout the period of the experiment in the diabetic-irradiated group. Expression of clusterin was most significant at 14 days in the diabetic group, but gradually decreased with time after 7 days in the diabetic-irradiated group. Degeneration of clusterin was observed in the diabetic-irradiated group. CONCLUSION: This experiment suggests that the acinar cells of submandibular gland in rats are physiologically apoptosed by the induction of diabetes, but that the apoptosis is inhibited and the acinar cells necrotized after irradiation.
Acinar Cells* ; Animals ; Apoptosis ; Citric Acid ; Clusterin ; Cranial Irradiation ; Diabetes Mellitus ; Head ; Neck ; Rats* ; Rats, Sprague-Dawley ; Salivary Glands ; Streptozocin ; Submandibular Gland* ; Tolonium Chloride

6

Cite

Share

The elimination of the linear artifacts by the metal restorations in the three dimensional computed tomographic images using the personal computer and software.

Hyok PARK ; Hee Cheol LEE ; Kee Deog KIM ; Chang Seo PARK

Korean Journal of Oral and Maxillofacial Radiology.2003;33(3):151-159.

PURPOSE: The purpose of this study is to evaluate the effectiveness and usefulness of newly developed personal computer-based software to eliminate the linear artifacts by the metal restorations. MATERIALS AND METHODS: A 3D CT image was conventionally reconstructed using ADVANTAGE WINDOWS 2.0 3D Analysis software (GE Medical System, Milwaukee, USA) and eliminated the linear artifacts manually. Next, a 3D CT image was reconstructed using V-works 4.0 TM (Cybermed Inc., Seoul, Korea) and the linear artifacts eliminated manually in the axial images by a skillful operator using a personal computer. A 3D CT image was reconstructed using V-works 4.0 TM (Cybermed Inc., Seoul, Korea) and the linear artifacts were removed using a simplified algorithm program to eliminate the linear artifacts automatically in the axial images using a personal computer, abbreviating the manual editing procedure. Finally, the automatically edited reconstructed 3D images were compared to the manually edited images. RESULTS AND CONCLUSION: We effectively eliminated the linear artifacts automatically by this algorithm, not by the manual editing procedures, in some degree. But programs based on more complicated and accurate algorithms may lead to a nearly flawless elimination of these linear artifacts automatically.
Artifacts* ; Humans ; Imaging, Three-Dimensional ; Microcomputers* ; Seoul ; Tomography, X-Ray Computed

7

Cite

Share

Effect of irradiation on cell cycle, cell death and expression of its related proteins in normal human oral keratinocytes.

Mi Ae KANG ; Min Suk HEO ; Sam Sun LEE ; Sung Ook OH ; Sul Mi LEE ; In Seong JEON ; Soon Chul CHOI ; Tae Won PARK

Korean Journal of Oral and Maxillofacial Radiology.2003;33(3):143-149.

PURPOSE: To investigate the radiosensitivity of the normal human oral keratinocytes (NHOK), and the effect of irradiation on cell cycle and protein expression. MATERIALS AND METHODS: To evaluate the radiosensitivity of NHOK, the number of colonies and cells were counted after irradiation and the SF2 (survival fraction at 2 Gy) value, and the cell survival curve fitted on a linear-quadratic model were obtained. LDH analysis was carried out to evaluate the necrosis of NHOK at 1, 2, 3, and 4 days after 2, 10, and 20 Gy irradiation. Cell cycle arrest and the induction of apoptosis were analyzed using flow cytometry at 1, 2, 3, and 4 days after 2, 10, and 20 Gy irradiation. Finally, proteins related cell cycle arrest and apoptosis were analysed by Western blot. RESULTS: The number of survived cell was significantly decreased in a dose-dependent manner. The cell survival curve showed SF2, alpha, and beta values to be 0.568, 0.209, and 0.020 respectively. At 20 Gy irradiated cells showed higher optical density than the control group. After irradiation, apoptosis was not observed but G2 arrest was observed in the NHOK cells. 1 day after 10 Gy irradiation, the expression of p53 remained unchanged, the p21 (WAF1/Cip1) increased and the mdm2 decreased. The expression of bax, bcl-2, cyclin B1, and cyclin D remained unchanged. CONCLUSION: These results indicate that NHOK responds to irradiation by G2 arrest, which is possibly mediated by the expression of p21 WAF1/Cip1, and that cell necrosis occurs by high dose irradiation.
Apoptosis ; Blotting, Western ; Cell Cycle Checkpoints ; Cell Cycle* ; Cell Death* ; Cell Survival ; Cyclin B1 ; Cyclin D ; Flow Cytometry ; Humans* ; Keratinocytes* ; Necrosis ; Radiation Tolerance ; Radiation, Ionizing

8

Cite

Share

An assessment of maxillary sinus and alveolar bone in cross-sectional linear tomogram of panorama.

Jae Duk KIM

Korean Journal of Oral and Maxillofacial Radiology.2003;33(3):137-141.

PURPOSE: To evaluate the precision of measurements taken of dental implants in bucco-lingually sectioned views of the maxilla by linear tomograms of the panorama and to assess the visibility of the inferior wall of the maxillary sinus. MATERIALS AND METHODS: Eighty sites prepared with implants of gutta percha cone in the sockets of the upper premolars and molars of 10 dry skulls were radiographically examined using linear tomograms of panorama, and scanned coronally and axially by computed tomography. The differences in mm between the measurements in bucco-lingually sectioned images of maxillary alveolar bone and the true length and width of the implanted gutta percha cones were compared as mean values (mean) and standard deviations (SD) for each radiographic technique. Linear tomography of panorama was compared with computed tomography for visualization of the relationship between the inferior wall of maxillary sinus and the end of each implant. RESULTS: The deviations between the actual implant length and the measured values taken from the linear tomograms (0.44 +/-0.39 mm) was significantly less than the measured values from the multiplanar reconstructed images of the axially scanned computed tomogram (1.21+/-0.90 mm). There was statistically significant difference (p< 0.05) between two techniques in the differences between the measurements and true implant length. The relationship of the inferior border of maxillary sinus with end of implant was worse identified with the linear tomogram of panorama (68%) than the multiplanar reconstructed image of axially scanned computed tomogram (99%). CONCLUSION: We could not find any differences in the accuracy of length measurement between the linear tomogram of panorama and computed tomogram, but computed tomogram allowed for a better visualization of the inferior wall of the maxillary sinus than the linear tomogram.
Bicuspid ; Dental Implants ; Gutta-Percha ; Maxilla ; Maxillary Sinus* ; Molar ; Radiography, Panoramic ; Skull ; Tomography, X-Ray

9

Cite

Share

The correlationship between mandibular radiomorphometric indices in panorama and bone mineral density in Cu-equivalent image of intraoral film.

Jae Duk KIM

Korean Journal of Oral and Maxillofacial Radiology.2003;33(3):131-135.

PURPOSE: To determine whether the mandibular radiomorphometric indices in panoramic radiography are correlated with the bone mineral density of Cu-equivalent images in intraoral film. MATERIALS AND METHODS: The bone mineral density (BMD) of the mandibular premolar area was measured in the Cu-equivalent image of intraoral film. The Panoramic Mandibular Index (PMI) and Mandibular Cortical Width (MCW) were measured in panoramic radiographs of six dry mandibles, and the Pearson correlation between PMI, MCW, and BMD were tested. RESULTS: There were no significant correlations between PMI and BMD (r = 0.280), nor between MCW and BMD (r = 0.237). CONCLUSION: The results show that PMI and MCW were poor diagnostic indicators of mandibular BMD in the six dry mandibles used in this study. The correlationship between the mandibular radiomorphometric indices (PMI and MCW) and mandibular BMD needs to be researched further using large in vivo patient samples.
Bicuspid ; Bone Density* ; Humans ; Mandible ; Radiography, Panoramic

10

Cite

Share

Effect of irradiation on the healing of extraction sockets in diabetic rats.

Il Joong KIM ; Eui Hwan HWANG ; Sang Rae LEE

Korean Journal of Oral and Maxillofacial Radiology.2003;33(1):5-14.

PURPOSE: To observe the histologic pattern of healing in molar tooth extraction sockets of streptozotocin-induced diabetic rats following irradiation. MATERIALS AND METHODS: Mature Sprague-Dawley rats were divided into three groups: control, diabetic, and diabetic-irradiated groups. Diabetes mellitus was induced by injecting streptozotocin. Control rats were injected with a citrate buffer only. After 5 days, the right maxillary first molar was extracted under general anesthesia from each of the rats. After the extraction, rats in the diabetic-irradiated group were irradiated with a single absorbed dose of 10 Gy to the head and neck region. The rats were killed at 1, 3, 7, 14, 21, and 28 days after treatment. Tissue sections were stained with hematoxylineosin and Masson's trichrome. RESULTS: In the diabetic and diabetic-irradiated groups, the early healing process of the socket extraction was similar to the control group, but bone formation was delayed at 7 days after the treatment. In the diabetic-irradiated group, alveolar bone surrounding the extraction socket showed signs of necrosis at 3 days after treatment, and hemorrhage was observed in connective tissue within the extraction socket at 14 days after treatment. CONCLUSION: This experiment revealed that the healing process of the extraction socket was severely delayed and retarded by irradiation in the diabetic state.
Anesthesia, General ; Animals ; Citric Acid ; Connective Tissue ; Cranial Irradiation ; Diabetes Mellitus ; Head ; Hemorrhage ; Molar ; Neck ; Necrosis ; Osteogenesis ; Rats* ; Rats, Sprague-Dawley ; Streptozocin ; Tooth Extraction ; Wound Healing

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share