Journal Detail Information

1

Cite

Share

R1467H Variants of Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) are Associated with Type 2 Diabetes Mellitus in Koreans.

Qing Song JIN ; So Hun KIM ; Shan Ji PIAO ; Hyun Ae LIM ; Seung Youn LEE ; Seong Bin HONG ; Yong Seong KIM ; Hun Jae LEE ; Moonsuk NAM

Korean Diabetes Journal.2010;34(6):368-373. doi:10.4093/kdj.2010.34.6.368

BACKGROUND: The human Rho guanine nucleotide exchange factor 11 (ARHGEF11) functions as an activator of Rho GTPases and is thought to influence insulin signaling. The R1467H variant of ARHGEF11 has been reported to be associated with susceptibility to type 2 diabetes mellitus (T2DM) in Western populations. METHODS: We investigated the effects of the R1467H variant on susceptibility to T2DM as well as related traits in a Korean population. We genotyped the R1467H (rs945508) of ARHGEF11 in 689 unrelated T2DM patients and 249 non-diabetic individuals and compared the clinical and biochemical characteristics according to different alleles. RESULTS: The H allele was significantly more frequent in T2DM cases than in controls (P = 0.037, 17.1% and 13.1%; respectively). H homozygocity was associated with a higher risk of T2DM compared to those with R/R or R/H genotype (odds ratio, 5.24; 95% confidence interval, 1.06 to 25.83; P = 0.042). The fasting plasma glucose, HbA1c, fasting insulin, HOMA2-IR and HOMA2-%beta levels did not differ significantly between different genotypes. CONCLUSION: Our study replicated associations of the ARHGEF11 polymorphism with increased risk of T2DM in a Korean population and thus supports previous data implicating a potential role of ARHGEF11 in the etiology of T2DM. Further studies revealing the underlying mechanism for this association are needed.
Alleles ; Diabetes Mellitus, Type 2 ; Fasting ; Genotype ; Glucose ; Guanine ; Guanine Nucleotide Exchange Factors ; Humans ; Insulin ; Plasma ; Polymorphism, Single Nucleotide ; rho GTP-Binding Proteins

2

Cite

Share

A Retrospective Study on the Efficacy of a Ten-Milligram Dosage of Atorvastatin for Treatment of Hypercholesterolemia in Type 2 Diabetes Mellitus Patients.

Dong Kyun KIM ; Sa Rah LEE ; Min Sik KIM ; Suk Hyang BAE ; Jin Yeon HWANG ; Jung Min KIM ; Sung Hwan SUH ; Hye Jeong LEE ; Mi Kyoung PARK ; Duk Kyu KIM

Korean Diabetes Journal.2010;34(6):359-367. doi:10.4093/kdj.2010.34.6.359

BACKGROUND: There have been few clinical studies on 10 mg atorvastatin as a starting dosage for treatment of hypercholesterolemia in type 2 diabetes mellitus (T2DM) patients. This retrospective study aims to evaluate the efficacy of 10 mg dosage of atorvastatin in clinical setting. METHODS: One hundred five enrolled patients with high levels of low density lipoprotein cholesterol (LDL-C, > 100 mg/dL) took 10 mg atorvastatin. After 6 months, they were divided into 'Responder group' (LDL-C < 100 mg/dL) and 'Non-responder group' (LDL-C > or = 100 mg/dL), and the response rate was calculated. Thereafter, we subdivided the 'Responder group' into Maintenance (10 mg), Reduced dosage (5 mg), and Discontinuance group (0 mg). The 'Non-Responder group' was subdivided into Maintenance (10 mg) and Double dosage group (20 mg). After consecutive 6 months, the response rates of each 10 mg Maintenance groups were compared to those of the other groups, respectively. RESULTS: Following the first 6 months, the response rate of 10 mg fixed dosage was 74.3%. In the 'Responder group', response rates of 10 mg, 5 mg and Discontinuance groups following 6 months were 52.6%, 53.1%, and 12.5%, respectively. In the 'Non-responder group', response rates of 10 mg and 20 mg groups were 28.6% and 50.0%. Baseline LDL-C levels and body mass index (BMI) of 'Responder group' were significantly lower than those of 'Non-responder group' (P = 0.004, respectively). CONCLUSION: Hypercholesterolemia treatment with 10 mg, fixed dosage of atorvastatin was effective in three quarters of the subjects during the first 6-month treatment; however, a significant number of patients with high LDL-C levels and/or BMI require higher starting and maintenance dosage.
Body Mass Index ; Cholesterol ; Cholesterol, LDL ; Diabetes Mellitus, Type 2 ; Heptanoic Acids ; Humans ; Hypercholesterolemia ; Lipoproteins ; Pyrroles ; Retrospective Studies ; Atorvastatin Calcium

3

Cite

Share

The Correlation and Accuracy of Glucose Levels between Interstitial Fluid and Venous Plasma by Continuous Glucose Monitoring System.

Young Ha BAEK ; Heung Yong JIN ; Kyung Ae LEE ; Seon Mee KANG ; Woong Ji KIM ; Min Gul KIM ; Ji Hyun PARK ; Soo Wan CHAE ; Hong Sun BAEK ; Tae Sun PARK

Korean Diabetes Journal.2010;34(6):350-358. doi:10.4093/kdj.2010.34.6.350

BACKGROUND: Clinical experience with the continuous glucose monitoring systems (CGMS) is limited in Korea. The objective of this study is to evaluate the accuracy of the CGMS and the correlation between interstitial fluid and venous plasma glucose level in Korean healthy male subjects. METHODS: Thirty-two subjects were served with glucose solution contained same amount of test food's carbohydrate and test foods after separate overnight fasts. CGMS was performed over 3 days during hopitalization for each subjects. Venous plasma glucose measurements were carried out during 4 hours (0, 0.25, 0.5, 0.75, 1, 2, 4 hours) just before and after glucose solution and test food load. The performance of the CGMS was evaluated by comparing its readings to those obtained at the same time by the hexokinase method using the auto biochemistry machine (Hitachi 7600-110). Also, correlations between glucose recorded with CGMS and venous plasma glucose value were examined. RESULTS: CGMS slightly underestimated the glucose value as compared with the venous plasma glucose level (16.3 +/- 22.2 mg/dL). Correlation between CGMS and venous plasma glucose values throughout sensor lifetime is 0.73 (regression analysis: slope = 1.08, intercept = 8.38 mg/dL). Sensor sensitivity can deteriorate over time, with correlations between venous blood glucose and CGMS values dropping from 0.77 during 1st day to 0.65 during 2nd and 3rd day. CONCLUSION: The accuracy of data provided by CGMS may be less than expected. CGMS sensor sensitivity is decreased with the passage of time. But, from this study, CGMS can be used for glucose variability tendency monitoring conveniently to the Korean.
Biochemistry ; Blood Glucose ; Extracellular Fluid ; Glucose ; Hexokinase ; Humans ; Korea ; Male ; Plasma ; Reading

4

Cite

Share

The Small Rice Bowl-Based Meal Plan was Effective at Reducing Dietary Energy Intake, Body Weight, and Blood Glucose Levels in Korean Women with Type 2 Diabetes Mellitus.

Hee Jung AHN ; Kyung Ah HAN ; Hwi Ryun KWON ; Kyung Wan MIN

Korean Diabetes Journal.2010;34(6):340-349. doi:10.4093/kdj.2010.34.6.340

BACKGROUND: The typical Korean diet includes rice, which is usually served in a rice bowl. We investigated the effects of a meal plan using rice bowls of varying sizes on dietary energy intake (EI), body weight (BW), and blood glucose levels. METHODS: Forty-two obese women with type 2 diabetes mellitus were randomly assigned to use either a 200 mL small rice bowl (SB), a 380 mL regular rice bowl (RB), or to a control group (C). Both intervention groups were asked to reduce their EI by 500 kcal/day for 12 weeks and simple instructions for using the assigned bowl were provided. Dietary EI and proportion of macronutrients (PMN) were estimated from 3-day dietary records. RESULTS: Reduction of EI was more prominent in the SB group compared to the RB and C group, although EI decreased significantly from baseline in all groups. Carbohydrate and fat intakes of the SB group were decreased greater than those of the RB and C group. However, changes in PMN were not significant across the 3 groups. Reduction of BW and HbA1c levels in the SB group was more prominent compared to the C group. Although, BW and HbA1c were decreased significantly from baseline in both bowl groups. There was no statistical difference between the two groups. CONCLUSION: The small rice bowl-based meal plan was effective at reducing EI, BW, and blood glucose levels, and the observed reductions in EI, carbohydrate, and fat intake were greater than those of the regular rice bowl-based meal plan.
Blood Glucose ; Body Weight ; Diabetes Mellitus, Type 2 ; Diet, Diabetic ; Diet ; Energy Intake ; Female ; Humans ; Meals ; Obesity ; Weight Loss

5

Cite

Share

Correlations of Glucose Levels in Interstitial Fluid Estimated by Continuous Glucose Monitoring Systems and Venous Plasma.

Byung Joon KIM

Korean Diabetes Journal.2010;34(6):338-339. doi:10.4093/kdj.2010.34.6.338

No abstract available.
Extracellular Fluid ; Glucose ; Plasma

6

Cite

Share

Triple Combination Therapy Using Metformin, Thiazolidinedione, and a GLP-1 Analog or DPP-IV Inhibitor in Patients with Type 2 Diabetes Mellitus.

Sun Woo KIM

Korean Diabetes Journal.2010;34(6):331-337. doi:10.4093/kdj.2010.34.6.331

Although there is no HbA1c threshold for cardiovascular risk, the American Diabetic Association-recommended goal of HbA1c < 7.0% appears to be unacceptably high. To achieve an optimal HbA1c level goal of 6.0% or less, a high dosage of sulfonylureas and insulin would be required; the trade-off would be the common adverse effects of hypoglycemia and weight gain. In contrast, hypoglycemia is uncommon with insulin sensitizers and GLP-1 analogs, allowing the physician to titrate these drugs to maximum dosage to reduce HbA1c levels below 6.0% and they have been shown to preserve beta-cell function. Lastly, weight gain is common with sulfonylurea and insulin therapy, whereas GLP-1 analogs induce weight loss and offset the weight gain associated with TZDs. A treatment paradigm shift is recommended in which combination therapy is initiated with diet/exercise, metformin (which has antiatherogenic effects and improves hepatic insulin sensitivity), a TZD (which improves insulin sensitivity and preserves beta-cell function with proven durability), and a GLP-1 analog (which improves beta, alpha-cell function and promotes weight loss) or a dipeptidyl peptidase IV inhibitor in patients with type 2 diabetes mellitus.
Diabetes Mellitus ; Diabetes Mellitus, Type 2 ; Dipeptidyl Peptidase 4 ; Glucagon-Like Peptide 1 ; Humans ; Hypoglycemia ; Insulin ; Insulin Resistance ; Metformin ; Thiazolidinediones ; Weight Gain ; Weight Loss

7

Cite

Share

Response: Bone Mineral Density in Prediabetic Men (Korean Diabetes J 2010;34:294-302).

Ju Hee LEE ; Hyun Jin KIM ; Bon Jeong KU

Korean Diabetes Journal.2010;34(6):386-387. doi:10.4093/kdj.2010.34.6.386

No abstract available.
Bone Density ; Humans ; Male

8

Cite

Share

Letter: Bone Mineral Density in Prediabetic Men (Korean Diabetes J 2010;34:294-302).

Chul Hee KIM

Korean Diabetes Journal.2010;34(6):384-385. doi:10.4093/kdj.2010.34.6.384

No abstract available.
Bone Density ; Humans ; Male

9

Cite

Share

The Usefulness of an Accelerometer for Monitoring Total Energy Expenditure and Its Clinical Application for Predicting Body Weight Changes in Type 2 Diabetic Korean Women.

Ji Yeon JUNG ; Kyung Ah HAN ; Hwi Ryun KWON ; Hee Jung AHN ; Jae Hyuk LEE ; Kang Seo PARK ; Kyung Wan MIN

Korean Diabetes Journal.2010;34(6):374-383. doi:10.4093/kdj.2010.34.6.374

BACKGROUND: The purpose of this study was to evaluate the usefulness of an accelerometer in predicting body weight (BW) change during a lifestyle intervention and to find out whether exercise or overall physical activity is associated with change in insulin sensitivity and body composition. METHODS: A total of 49 overweight (body mass index [BMI] > or = 23 kg/m2) women with diabetes were enrolled and performed lifestyle intervention while monitoring BW, total energy expenditure (TEE) and physical activity energy expenditure (PAEE) using an accelerometer, and energy intake (EI) using a three-day dietary record at baseline and every 2 weeks for 12 weeks. We assessed body composition using bioimpedance analysis and compared the actual BW change to the predicted BW change, which was calculated from the energy deficit (ED) between EI and TEE (ED = EI-TEE). RESULTS: Mean age was 57.2 years, duration of diabetes was 8.0 years, and BMI was 27.8 kg/m2. There was no significant difference between EI and TEE at baseline. For 12 weeks, the ED was 474.0 kcal.day-1, which was significantly correlated with BW change (-3.1 kg) (r = 0.725, P < 0.001). However, the actual BW change was 50% lower than the predicted BW change. Both TEE and PAEE correlated with change in KITT (r = 0.334, P = 0.019; r = 0.358, P = 0.012, respectively), BMI (r = -0.395, P = 0.005; r = -0.347, P = 0.015, respectively), and fat mass (r = -0.383, P = 0.007; r = -0.395, P = 0.005, respectively), but only TEE correlated with fat free mass change (r = -0.314, P = 0.030). CONCLUSION: The accelerometer appears to be a useful tool for measuring TEE under free-living conditions for both short- and long-term periods.
Body Composition ; Body Weight ; Body Weight Changes ; Diet Records ; Energy Intake ; Energy Metabolism ; Female ; Humans ; Insulin Resistance ; Life Style ; Motor Activity ; Overweight

10

Cite

Share

Effects of Comprehensive Support on Glycemic Control Using Community Networks in Low- Income Elderly Patients with Diabetes.

Nam Hoon KIM ; Yun Jeong LEE ; Hye Ok KIM ; Cho Rong OH ; Ju Ri PARK ; Soo Yoen PARK ; Hee Young KIM ; Ji A SEO ; Nan Hee KIM ; Kyung Mook CHOI ; Sei Hyun BAIK ; Dong Seop CHOI ; Sin Gon KIM

Korean Diabetes Journal.2008;32(5):453-461. doi:10.4093/kdj.2008.32.5.453

BACKGROUND: Diabetes is common among elderly, and low-income is associated with poor adherence to treatment and increased mortality. We evaluated whether comprehensive support using community networks improves glycemic control among low-income elderly patients with diabetes. METHODS: A total of 49 low-income elderly patients with type 2 diabetes, mean age 73 years, were enrolled. For 1 year, study subjects underwent various lifestyle modification programs provided by community networks. The biochemical data including glycemic markers and anthropometric data were obtained at the baseline and at the end of the study. Also, the patients were asked to complete a questionnaire about their quality of life, self-confidence and self-care behavior. RESULTS: After lifestyle modification program, overall changes of fasting plasma glucose, HbA1c, blood pressure, body weight, and other biochemical markers were not significantly different. In a subgroup analysis of 21 patients with poorly controlled diabetes (fasting glucose > 140 mg/dL or HbA1c > 7.5%), fasting plasma glucose was significantly reduced (P = 0.030). Among patients with baseline HbA1c level > or = 8%, HbA1c levels after intervention decreased from 9.33 +/- 1.07% to 8.27 +/- 1.15% (P = 0.092). The results of the questionnaires revealed significant increases in the scores of quality of life, self-confidence and self-care behavior (P < 0.05). CONCLUSION: Among low-income, elderly patients with type 2 diabetes, lifestyle modification through community networks showed no significant changes in glycemic control markers. More intensive and precise interventions using community networks are needed for the glycemic control of low-income, elderly patients with type 2 diabetes.
Aged ; Biomarkers ; Blood Pressure ; Body Weight ; Community Networks ; Fasting ; Glucose ; Humans ; Life Style ; Plasma ; Quality of Life ; Self Care ; Surveys and Questionnaires

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share