Journal Detail Information

1

Cite

Share

Embolization of Inferior Epigastric Artery for Treatment of Rectus Sheath Hematoma Caused by Insulin Injection During Anticoagulation and Antiplatelet Therapy.

Yon Woong PARK ; Min Keun KIM ; Jeong Won PARK ; Chan Wook LEE ; Seung Pyo HONG ; Young Soo LEE ; Jae Kean RYU ; Ji Yong CHOI ; Kee Sik KIM ; Jin Bae LEE

Journal of the Korean Geriatrics Society.2014;18(4):256-259. doi:10.4235/jkgs.2014.18.4.256

Rectus sheath hematoma, caused by rupture of epigastric vessel or muscle tear, is most frequently encountered in association with anticoagulation therapy, trauma, operation, and hematologic disorder. It rarely occurs spontaneously. Rectus sheath hematoma related to subcutaneous injection of insulin is very rare. We report a case of percutaneous catheterbased coil embolization for treatment of rectus sheath hematoma caused by subcutaneous injection of insulin on abdomen during anticoagulation and antiplatelet therapy in an 83-year-old thin woman with diabetes.
Abdomen ; Aged, 80 and over ; Embolization, Therapeutic ; Epigastric Arteries* ; Female ; Hematoma* ; Humans ; Injections, Subcutaneous ; Insulin* ; Rectus Abdominis ; Rupture

2

Cite

Share

Simultaneous Development of ST-Segment Elevation Myocardial Infarction and Pulmonary Embolism in an Healthy Elderly Woman.

Seung Hwan LEE ; Hyun Seok KIM ; Dong Seok LEE ; Hong Min PARK ; Tae Keun LEE ; Yong Kyu LEE

Journal of the Korean Geriatrics Society.2014;18(4):251-255. doi:10.4235/jkgs.2014.18.4.251

A 73-year-old woman who presented with chest discomfort visited the emergency room. The 12-lead electrocardiography showed ST-segment elevation in II, III, and lead augmented vector foot. Emergent coronary angiography revealed a thrombus in the distal right coronary artery. Percutaneous coronary angioplasty with a stent was performed. After the procedure, persistent dyspnea occurred. Her chest computed tomography (CT) showed occlusion of the bilateral pulmonary artery. We could not find a source for the embolization or a hypercoagulable state. We started a course of dual antiplatelets with oral anticoagulants. Pulmonary embolism was resolved at follow-up chest CT scan. Aspirin, clopidogrel and warfarin were given for 6 months. The patient is doing well now 1 year after the episode.
Aged* ; Angioplasty ; Anticoagulants ; Aspirin ; Coronary Angiography ; Coronary Vessels ; Dyspnea ; Electrocardiography ; Emergency Service, Hospital ; Female ; Fibrinolytic Agents ; Follow-Up Studies ; Foot ; Humans ; Myocardial Infarction* ; Percutaneous Coronary Intervention ; Pulmonary Artery ; Pulmonary Embolism* ; Stents ; Thorax ; Thrombosis ; Tomography, X-Ray Computed ; Warfarin

3

Cite

Share

A Case of Colonic Metastasis from Borderline Ovarian Cancer.

Min Jung KIM ; Hyuk Soo EUN ; Hye Jin KIM ; Kyu Seop KIM ; Seul Young KIM ; Hee Seok MOON ; Hyun Yong JEONG

Journal of the Korean Geriatrics Society.2011;15(3):181-184. doi:10.4235/jkgs.2011.15.3.181

This report describes the case of a patient who had previously undergone surgery for resection of bilateral ovarian tumors and after 5 years presented with colonic metastasis. A 70-year-old woman visited the hospital for a clinical survey due to severe anemia. In 2007, the patient was diagnosed with cancer (papillary serous adenocarcinoma) in both ovaries. The patient had undergone total abdominal hysterectomy with bilateral salpingo-oophorectomy followed by postoperative adjuvant chemotherapy. After treatment, the patient was stable during follow-up. After 5 years, she underwent incidental colonoscopic examination because of severe anemia. The colonoscopic findings revealed an elevated irregular lesion in the descending colon. Colonic metastasis from the papillary serous adenocarcinoma of the ovary was confirmed by immunohistochemical staining during the pathological diagnosis.
Adenocarcinoma ; Aged ; Anemia ; Chemotherapy, Adjuvant ; Colon ; Colon, Descending ; Female ; Follow-Up Studies ; Humans ; Hysterectomy ; Neoplasm Metastasis ; Ovarian Neoplasms ; Ovary

4

Cite

Share

Clinical Characteristics and Outcomes of Geriatric Patients in Upper Gastrointestinal Bleeding.

Ki Sang LEE ; Soong LEE ; Seung Chul PACK ; Hyeon Min LEE ; Jae Kyu LIM ; David HWANG ; Seong Il PARK ; Hoon KANG ; Sung Kyu CHOI

Journal of the Korean Geriatrics Society.2011;15(3):170-180. doi:10.4235/jkgs.2011.15.3.170

BACKGROUND: The incidence of upper gastrointestinal bleeding has decreased in the general population but has increased in geriatric patients worldwide. The aim of this study was to evaluate the clinical characteristics and outcomes of geriatric patients (aged 65 or older) with upper gastrointestinal bleeding and to compare them with non-geriatric patients (less than 65 years old). METHODS: We conducted a retrospective study of 288 patients with upper gastrointestinal bleeding from January 2007 to August 2010. We compared the clinical characteristics and outcomes of geriatric patients (n=148, 51.4%) with those of non-geriatric patients (n=140, 48.6%). RESULTS: Cardiovascular disease, hypertension, and cerebrovascular accidents were more prevalent in the geriatric group, compared with those in the non-geriatric group (p<0.05). Vital signs were more unstable in the geriatric group than those in the non-geriatric group (p<0.05). The geriatric group had taken more ulcerogenic drugs than those in the non-geriatric group (p<0.05). The most common cause of upper gastrointestinal bleeding was peptic ulcer (72.3%) in the geriatric group, whereas it was variceal bleeding (41.4%) in the non-geriatric group. Treatment methods, transfusion volume, operation rate, and mortality were not different between the two groups. The length of hospital stay and length of intensive care unit (ICU) stay were significantly longer in geriatric patients than those in the non-geriatric group (p<0.05). CONCLUSION: Geriatric patients with upper gastrointestinal bleeding had longer ICU and hospital stays than those of non-geriatric patients. Important emerging etiologies such as ulcerogenic drugs and associated chronic illness should be monitored and treated early in these patients.
Cardiovascular Diseases ; Chronic Disease ; Geriatrics ; Hemorrhage ; Humans ; Hypertension ; Incidence ; Intensive Care Units ; Length of Stay ; Peptic Ulcer ; Retrospective Studies ; Stroke ; Vital Signs

5

Cite

Share

Alcohol Drinking Related Health Characteristics in Men of National Merit More than 60 Years Old.

Su Hong KIM ; Sang Hee KIM

Journal of the Korean Geriatrics Society.2011;15(3):162-169. doi:10.4235/jkgs.2011.15.3.162

BACKGROUND: The purpose of this study was to investigate alcohol drinking related health characteristics for improvement of life stability and well-being in war veterans. METHODS: The research design was a descriptive survey design with a convenience sample. Data collection was performed using self-report questionnaires and included 163 veterans who were >60 years old and who visited a cardiovascular medicine out-patient department. The process of a change in drinking consciousness was investigated together with healthy action changes, including drinking temptation and deciding to drink alcohol. RESULTS: Failing at work was the greatest drinking temptation. The subjects knew that if they drank continuously, they would become addicted to alcohol. Most subjects experienced mental stress and difficulty living. CONCLUSION: These findings indicate that access to an evidence-based treatment program and systems of care should be provided for veterans who drink alcohol and have other health conditions and illnesses.
Aged ; Alcohol Drinking ; Consciousness ; Data Collection ; Drinking ; Humans ; Male ; Outpatients ; Surveys and Questionnaires ; Research Design ; Veterans

6

Cite

Share

Gene Expression Analysis of the Human Astrocytoma Cell after Abeta25-35 Stimulation Followed by Ibuprofen Administration.

Youngsook CHOI ; Jungwoo EUN ; Sukwoo NAM ; Sangho KIM

Journal of the Korean Geriatrics Society.2011;15(3):144-161. doi:10.4235/jkgs.2011.15.3.144

BACKGROUND: The molecular events leading to the development of sporadic late-onset Alzheimer's disease (AD) have not been defined. A number of mechanism for the protective effects of non-steroidal anti-inflammatory drugs (NSAIDs) in AD have been proposed. We investigated the ibuprofen effect of global gene expression on the amyloid-beta25-35 (Abeta25-35)-stimulated human astrocytoma cell. METHODS: U373MG, a human astrocytoma cell line, was incubated with 25 microM of aggregated Abeta25-35 or aggregated Abeta25-35 plus 100 microM ibuprofen at 37degrees C for 24 hours. Cells treated with ibuprofen alone were used as the negative control. Differential gene expression analysis was carried out with the Illumina human whole genome microarray. Real-time reverse transcriptase polymerase chain reaction (RT-PCR) was also done to validate the gene expression changes. After Welch's t-test, the significant subset of outlier genes were identified by an expression change cut-off 1.5 fold, p<0.05. Kyoto Encyclopedia of Genes and Genomes database was used for cellular signaling pathway analysis. RESULTS: A total of 371 differentially expressed genes were identified from 16,692 detectable signals in Abeta25-35 peptide stimulated U373MG cells- 182 up-regulated genes with 21 biological pathways including biosynthesis of steroid, peroxisome proliferator-activated receptor signaling pathway and focal adhesion and 189 down-regulated genes with 14 biological pathways including transforming growth factor-beta signaling pathway, axon guidance and mitogen activated protein kinase signaling pathway. Ibuprofen suppressed the up-regulated expression of immunity/inflammation (especially, SERPINE1), signal pathway, metabolism and cancer-related genes. The expression of microarray data was confirmed by real-time RT-PCR. CONCLUSION: Aggregated Abeta25-35 induces expression of widespread transcriptional alterations, namely 21 functional groups 182 up-regulated genes and 14 functional groups 189 down-regulated genes in U373MG cells. Ibuprofen, a commonly used NSAID, suppressed Abeta25-35-induced increase of global changes in transcription of sets of genes especially immunity/inflammation, signal pathway, metabolism and cancer-related genes.
Alzheimer Disease ; Amyloid beta-Peptides ; Anti-Inflammatory Agents, Non-Steroidal ; Astrocytoma ; Axons ; Cell Line ; Focal Adhesions ; Gene Expression ; Genome ; Humans ; Ibuprofen ; Oligonucleotide Array Sequence Analysis ; Peptide Fragments ; Peroxisomes ; Protein Kinases ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction

7

Cite

Share

Different Performances on a Confrontational Naming Test in Patients with Alzheimer's Disease and Mild Cognitive Impairment.

Kyung Ae PARK ; Ji Won CHOI ; Jin Min JEON ; Kwang Soo KIM ; Kyung Won PARK

Journal of the Korean Geriatrics Society.2011;15(3):135-143. doi:10.4235/jkgs.2011.15.3.135

BACKGROUND: We analyzed the performance on a naming test and the correlations between the scores on the naming test and neuropsychological test scores in patients with mild cognitive impairment (MCI) and mild Alzheimer's disease (AD). METHODS: The subjects included 69 patients with MCI and 33 patients with mild AD. We performed general cognitive functions, the Korean version of the Boston Naming Test (K-BNT), the digit span test, the Rey figure copy test (RCFT), the Seoul Verbal Learning Test (SVLT), and frontal function tests. The detailed items of the K-BNT were analyzed for the two subject groups, and the correlations between the K-BNT scores and those of the neuropsychological tests were examined. RESULTS: Significant differences were observed on the item for the number of correct answers after two syllables on the K-BNT task in patients with AD and MCI (p<0.05). A qualitative analysis of the incorrect K-BNT responses showed that both the AD and MCI groups made semantic errors more than visuoperceptual and phonemic errors. Significant correlations were found among the Mini-Mental State Examination, the Global Deterioration Scale, clinical dementia rating, digit span, SVLT delayed recall, RCFT and RCFT delayed recall, and the Stroop test color reading items (p<0.01). CONCLUSION: Our result suggests that semantic errors gradually increase with the progress of cognitive disability in the state preceding AD among patients with MCI.
Alzheimer Disease ; Boston ; Coat Protein Complex I ; Dementia ; Humans ; Mild Cognitive Impairment ; Neuropsychological Tests ; Semantics ; Stroop Test ; Verbal Learning

8

Cite

Share

Factors Associated with a Decline in Activities of Daily Living in Patients with Dementia at Geriatric Hospitals: A 6 Month Prospective Study.

Hyuk GA ; Chang Won WON ; Roo Ji LEE ; Il Woo HAN ; In Soon KWON ; Byung Joo PARK

Journal of the Korean Geriatrics Society.2011;15(3):128-134. doi:10.4235/jkgs.2011.15.3.128

BACKGROUND: Decreased activities of daily living (ADL) in elderly people are related to decreased quality of life and death and are a clinically important issue. However, few studies have investigated the various characteristics and risk factors for a decline in ADL among elderly in-patients in geriatric hospitals in Korea. METHODS: In total, 163 elderly in-patients with dementia in three geriatric hospitals located in Incheon, Gwangju and Yongin, Korea were surveyed prospectively for associated factors of a decline in ADL after 6 months. RESULTS: On average, the subjects were 79.4+/-7.6 years old, and 67.5% were female. Approximately 63% had Alzheimer type dementia, 36.8% only attended primary school, 73.0% were widowed, and 38.7% had been admitted to hospitals for less than 1 year. The Korean version of the Mini Mental State Examination (K-MMSE) score was 14.1+/-6.5, and the clinical dementia rating was 1.9+/-0.9. In total, 8.6% were bed-ridden and 59.5% and 64.6% had never experienced fecal and urinary incontinence, respectively. Total ADL scores declined after 6 months follow-up, and significantly associated factors were low K-MMSE score, fecal incontinence, and co-existence of fecal and urinary incontinence. CONCLUSION: Low K-MMSE scores, fecal incontinence, and the co-existence of fecal and urinary incontinence were associated with ADL declines in elderly in-patients with dementia in long-term care hospitals located in three cities in Korea.
Activities of Daily Living ; Aged ; Alzheimer Disease ; Dementia ; Fecal Incontinence ; Female ; Follow-Up Studies ; Humans ; Korea ; Long-Term Care ; Prospective Studies ; Quality of Life ; Risk Factors ; Urinary Incontinence ; Widowhood

9

Cite

Share

Are Vascular Aging and Atherosclerosis Synonymous?.

Hyung Joon YOO

Journal of the Korean Geriatrics Society.2011;15(3):123-127. doi:10.4235/jkgs.2011.15.3.123

The development of plaques along the inner layer of arterial walls is known as atherosclerosis. Atherosclerotic plaques can become hardened by calcium deposition and fibrous tissue of the arterial wall may proliferate leading to arteriosclerosis. In a typical textbook, arteriosclerosis only has three categories-atherosclerosis, Monckeberg medial calcific sclerosis, and arteriolosclerosis, leaving out vascular aging when in fact, aging is the strongest risk factor for atherosclerosis. Thus, vascular aging is often confused with atherosclerosis. Up to now, there has been no appropriate pathological term for vascular aging. And arteriosclerosis is different from vascular aging, as atherosclerosis includes some components of pathologic aging. But in actuality, physiological aging and pathological aging can not be clearly distinguished. Therefore, in terms of aging, arteriosclerosis is included in vascular aging. More research is required to define vascular aging.
Aging ; Arteriolosclerosis ; Arteriosclerosis ; Atherosclerosis ; Calcium ; Monckeberg Medial Calcific Sclerosis ; Plaque, Atherosclerotic ; Risk Factors

10

Cite

Share

A Case of Global Aphasia Without Other Focal Neurologic Lateralizing Signs.

In Uk SONG ; Du Shin JEONG ; Kwang Ik YANG ; Tae Kyeong LEE ; Hyung Kook PARK ; Moo Young AHN

Journal of the Korean Geriatrics Society.2001;5(3):265-269.

Global aphasia without other focal neurologic lateralizing signs (GWLS) is an uncommon stroke syndrome. The pathogenesis of GWLS has been thought as the result of multiple cardioembolism. However, a few cases of GWLS with a single lesion have been reported. We report an unusual case of GWLS with a single left superior temporal infarction. A 73-year-old right handed man was admitted with receptive and expressive language impairment without other focal neurologic lateralizing signs. The patient's global aphasia symptom has being 4 weeks after symptom onset. Brain CT showed only one lesion of left superior temporal lobe. Our case notes that the multiple lesions of the speech area are not only necessary to produce GWLS, and it is not necessarily imply a double lesion or an embolic causes.
Aged ; Aphasia* ; Brain ; Hand ; Humans ; Infarction ; Stroke ; Temporal Lobe

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share