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Gene Expression in Gastric Adenocarcinomas.

Jong Hoon LEE ; Seok Ryeol CHOI ; Sang Young HAN ; Tae Ho HWANG ; Min Chan KIM ; Ghap Joong JUNG ; Mee Sook ROH ; Jin Sook JEONG

Journal of the Korean Gastric Cancer Association.2002;2(4):213-220. doi:10.5230/jkgca.2002.2.4.213

PURPOSE: The cDNA microarray provides a powerful alternative with an unprecedented view in monitoring gene- expression levels and leads to discoveries of regulatory pathways involved in complicated biological processes. Our aim is to explore the different gene-expression patterns in gastric adenocarcinomas. MATENRIALS AND METHODS: By using a cDNA microarray representing 4,600 cDNA clusters, we studied the expression profiling in 10 paired gastric adenocarcinoma samples and in adjacent noncancerous gastric tissues from the same patients. Alterations in the gene-expression levels were confirmed by Vsing Northern blots and reverse-transcription PCR (RT-PCR) in all of 4 randomly selected genes. RESULTS: Genes those were expressed differently in cancer ous and noncancerous tissues were identified. 44 (of which 26 were known) and 92 (of which 43 were known) genes or cDNA were up- and down-regulated, respectively, in more than 80% of the gastric adenocarcinoma samples. In cancer ous tissues, genes related to gene/protein expression, cell- cycle regulation, and metabolism were mostly up-regulated whereas genes related to the oncogene/tumor suppressor gene, cell structure/motility, and immunology were mostly down-regulated. The semi-quantitative RT-PCR results for the four genes we tested were consistent with the array findings. CONCLUSION: These results provide not only a new molecular basis for understanding the biological properties of gastric adenocarcinomas but also a useful resource for future development of therapeutic targets and diagnostic markers for gastric adenocarcinomas.
Adenocarcinoma* ; Allergy and Immunology ; Biological Processes ; Blotting, Northern ; DNA, Complementary ; Gene Expression* ; Genes, Suppressor ; Humans ; Metabolism ; Neoplasms ; Oligonucleotide Array Sequence Analysis ; Polymerase Chain Reaction ; Stomach Neoplasms

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Effect of Oral Intake on Nutritional Status after Gastric Resection.

Kyu Eun LEE ; Hyuk Joon LEE ; Ji Young KIM ; Yoon Ho KIM ; Kuhn Uk LEE ; Kuk Jin CHOE ; Han Kwang YANG

Journal of the Korean Gastric Cancer Association.2002;2(4):205-212. doi:10.5230/jkgca.2002.2.4.205

PURPOSE: Malnutrition is a common postoperative complication that occurs after gastric resection. Several causes for malnutrition have been proposed, which include malabsorption and poor oral calorie intake. We performed this study to evaluate whether nutritional counseling would increase oral calorie intake and improve nutritional status in patients who had undergone gastrectomy. MATENRIALS AND METHODS: Twenty-two patients were randomly selected as the study group from among patients who had undergone gastrectomy for early gastric cancer and gastric polyp between October 1999 and December 2000. Body weight, hemoglobin, serum albumin, and serum transferrin were checked before and after the gastrectomy. Oral calorie intake was evaluated by using a 3-day oral-intake diary, and one nutritionist performed outpatient-based nutritional counseling. Eighteen patients who had undergone gastrectomy for the same disease during the same period were selected as the control group. RESULTS: During an average interval of 14.8 months, the study patients received nutritional counseling an average of 3.4 times at an average interval of 4.4 months. The study group took a mean of 2055.6+/-418.1 Cal per day and the control group 1792.1+/-421.9 Cal (P=0.05). Sixty-eight percent (15 patients) of the study group patients reached the daily-required calorie intake. Postoperative bodyweights were 64.0+/-9.9 kg for the study group and 64.3+/-10.8 kg for the control group (P>0.05). No statistically significant differences were observed among the other. Sixty-five percent of the patients (26 patients) had a weight loss of less than 10% of the preoperative body weight, and 35% had more than a 10% weight loss, but there was no statistical difference between the calorie intakes of these patients. CONCLUSION: Nutritional counselling increased the oral calorie intake, but nutritional status was not improved. These results suggest that nutritional derangement after gastrectomy cannot be corrected by adequate oral intake itself.
Body Weight ; Counseling ; Gastrectomy ; Humans ; Malnutrition ; Nutritional Status* ; Nutritionists ; Polyps ; Postoperative Complications ; Serum Albumin ; Stomach Neoplasms ; Transferrin ; Weight Loss

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Characteristics of Gastric Carcinomas in Two Extreme Age Groups.

Ho Young CHUNG ; Wansik YU

Journal of the Korean Gastric Cancer Association.2002;2(4):200-204. doi:10.5230/jkgca.2002.2.4.200

PURPOSE: The aim of this study was to compare the clinicopathological characteristics and postoperative prognosis of two age groups with gastric cancer in order to establish the proper treatment strategy in these groups of patients. MATENRIALS AND METHODS: Among patients with gastric cancer who underwent a gastrectomy between 1990 and 1996 at the Department of Surgery, Kyungpook National University, the clinicopathological characteristics, including the postoperative survival, of patients younger than 40-years old were compared with those of patients over 69-years old. RESULTS: During that period 1,125 gastric cancer patients underwent a gastrectomy. Among them, 111 patients (9.9%) were less than 40-years old, and 96 patients (8.5%) were over 69-years old. In the young group, 79 patients (71.2%) had a poorly differentiated adenocarcinoma, and 59 patients from the elderly group (61.5%) had a well- or moderately differentiated adenocarcinoma (P<0.05). Curative surgery was performed for 88 (79.3%) patients in the young group and 78 (81.3%) patients in the elderly group. This difference was not statistically significant. There was no statistically significant difference in the 5-year survival rates between the young and the elderly (66.3% vs. 47.2%) groups, but the 5-year survival rate of the young group was significantly higher than that of the elderly group after a curative resection (83.2% vs. 53.3%; P<0.05). Also the 5-year survival rate of the elderly group was significantly higher than that of the young group after a non-curative resection (20.4% vs. 4.6%; P<0.05). CONCLUSION: For young patients, more efforts are needed to detect gastric cancer in its early stages so that a curative surgery can be performed. However, for the elderly, surgical treatment is recommended at any stage because of the relatively high survival rate, even after non-curative surgery.
Adenocarcinoma ; Adult ; Aged ; Gastrectomy ; Gyeongsangbuk-do ; Humans ; Prognosis ; Stomach Neoplasms ; Survival Rate

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Expression of Vascular Endothelial Growth Factor Correlated with Recurrence in Gastric Carcinomas.

Gi Young SUNG ; Young PARK ; Do Sang LEE ; Wook KIM ; Jong Min BAEK ; Dong Jun SHIN ; Jong Man WON ; Jai Hak LEE

Journal of the Korean Gastric Cancer Association.2002;2(4):195-199. doi:10.5230/jkgca.2002.2.4.195

PURPOSE: Angiogenesis is essential for tumor growth and metastasis and depends on the production of angiogenic factors that are secreted by tumor cells. Vascular endothelial growth factor (VEGF) is the most significant angiogenic factor and a selective mitogen for endothelial cells. VEGF, also known as the vascular permeability factor, acts on endothelial cells to increase microvascular permeability and directly stimulate the growth of new blood vessels. Several studies have reported that the expression of VEGF is correlated with hematogenous recurrence via angiogenesis in gastric carcinomas. This research evaluated the relationship between the expression of VEGF and hepatic and peritoneal recurrence in gastric carcinomas. MATENRIALS AND METHODS: Thirty specimens resected from patients with primary gastric carcinomas who had undergone curative resections were divided into three group: Group I, early gastric carcinomas without recurrence; Group II, advanced gastric carcinomas with hepatic recurrence; and Group III, advanced gastric carcinomas with peritoneal recurrence. The expression of VEGF and the density of the microvessel count were examined using immunohistochemistry. RESULTS: 1) The expression of VEGF in Group II and Group III (63.2+/-24.3%) was stronger than that in Group I(7+/-4.2%). The expression of VEGF in Group II (76.5+/-13.2%) was stronger than that of the Group III (50+/-14.2%) (P<0.05). 2) The microvessel count in Group II (49.9+/-14.5) was more than that in Group I (8.6+/-2.6) and Group III (29.1+/-18.1) (P<0.05). 3) The microvessel count was increased significantly with increasing the expression of VEGF. CONCLUSION: The expression of VEGF is associated with advanced stomach cancer and hepatic recurrence has a higher expression of VEGF than peritoneal recurrence with neovascularization. Thus the expression of VEGF can be considered to be a useful indicator of recurrence in gastric carcinoma and especially in hepatic recurrence.
Angiogenesis Inducing Agents ; Blood Vessels ; Capillary Permeability ; Endothelial Cells ; Humans ; Immunohistochemistry ; Microvessels ; Neoplasm Metastasis ; Recurrence* ; Stomach Neoplasms ; Vascular Endothelial Growth Factor A*

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Tumor Markers in Gastric Cancer.

Sung Joon KWON

Journal of the Korean Gastric Cancer Association.2002;2(4):191-194. doi:10.5230/jkgca.2002.2.4.191

No abstract available.
Stomach Neoplasms* ; Biomarkers, Tumor*

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Role of PET Scan in Gastric Cancer as a Diagnostic Tool.

Gi Jeong CHEON ; Byung Il KIM ; Sang Moo LIM

Journal of the Korean Gastric Cancer Association.2002;2(4):184-190. doi:10.5230/jkgca.2002.2.4.184

Clinical application of positron emission tomography (PET) is rapidly increasing for the detection and staging of cancer at whole-body studies performed with the glucose analogue tracer 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG). Although FDG PET cannot match the anatomic resolution of conventional imaging techniques in gastrointestinal and abdominal organs, it is particularly useful for identification and characterization of whole body at the same time. FDG PET can show foci of metastatic disease that may not be apparent at conventional anatomic imaging and can aid in the characterization of indeterminate soft-tissue masses. Most gastrointestinal cancer need to surgical management. FDG PET can improve the selection of patients for surgical treatment and thereby reduce the morbidity and mortality associated with inappropriate surgery. FDG PET is also useful for the early detection of recurrence and the monitoring of therapeutic effect. The gastrointestinal cancers, such as gastroesophageal cancer, colorectal cancer, liver cancer and pancreatic cancer, are common malignancies in Korea. PET is one of the most promising and useful methodology for the management of gastric cancer as well as other gastrointestinal cancers.
Colorectal Neoplasms ; Gastrointestinal Neoplasms ; Glucose ; Humans ; Korea ; Liver Neoplasms ; Mortality ; Pancreatic Neoplasms ; Positron-Emission Tomography* ; Recurrence ; Stomach Neoplasms*

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Role of MRI in Gastric Cancer as a Diagnostic Tool.

Jae Mun LEE

Journal of the Korean Gastric Cancer Association.2002;2(4):180-183. doi:10.5230/jkgca.2002.2.4.180

No abstract available.
Magnetic Resonance Imaging* ; Stomach Neoplasms*

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Role of CT Scan in Gastric Cancer as a Diagnostic Tool.

Jun Sik CHO

Journal of the Korean Gastric Cancer Association.2002;2(4):175-179. doi:10.5230/jkgca.2002.2.4.175

No abstract available.
Stomach Neoplasms* ; Tomography, X-Ray Computed*

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Virtual Gastroscopy.

Se Hyung KIM

Journal of the Korean Gastric Cancer Association.2002;2(4):171-174. doi:10.5230/jkgca.2002.2.4.171

No abstract available.
Gastroscopy*

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A Case of Gastric Schwannoma.

Jae Hyuck CHOI ; Weon Young CHANG ; Jin Suk HUH ; Jae Hyung NOH ; Tae Sung SOHN ; Sung Ho CHOI ; Sung KIM ; Yong Il KIM

Journal of the Korean Gastric Cancer Association.2002;2(2):101-104. doi:10.5230/jkgca.2002.2.2.101

Schwannoma of the stomach is a rare controversial neoplasm which requires extensive studies to clarify its nature as a stromal tumor or leiomyoma. We describe the pathologic, immunohistochemical, and ultrastructural characteristics of schwannoma of the stomach in a 33-year-old woman. The tumor was a well-circumscribed submucosal mass located in the posterior wall of the midbody of the stomach. Microscopically, the cells were made up of fasciculating bundles of spindle cells featured with peripheral lymphoid cell cuffing. The tumor cells revealed a diffuse, strong immunoreactivity to S-100 protein and vimentin, but were negative to desmin and smooth muscle actin. They also had a focal positive reaction to glial fibrillary acidic protein. Ultrastructurally, many tumor cells showed a number of thin, elongated and interdigitating dendritic-cell-like processes, distinctly uniformed basal laminae, frequent cellular attachments, and microfilaments. These findings support the schwannian nature of the tumor.
Actin Cytoskeleton ; Actins ; Adult ; Basement Membrane ; Desmin ; Female ; Glial Fibrillary Acidic Protein ; Humans ; Leiomyoma ; Lymphocytes ; Muscle, Smooth ; Neurilemmoma* ; S100 Proteins ; Stomach ; Vimentin

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