The Korean Journal of Gastroenterology.2011;58(3):166-167. doi:10.4166/kjg.2011.58.3.166
No abstract available.
The Korean Journal of Gastroenterology
2002 (v1, n1) to Present ISSN: 1671-8925
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The Korean Journal of Gastroenterology.2011;58(3):162-165. doi:10.4166/kjg.2011.58.3.162
No abstract available.
Antineoplastic Agents/administration & dosage ; Antiviral Agents/therapeutic use ; Atrophy/pathology ; Carcinoma, Hepatocellular/pathology/radiography/*therapy ; *Chemoembolization, Therapeutic ; Hepatectomy ; *Hepatic Veins ; Hepatitis B, Chronic/complications/diagnosis/drug therapy ; Humans ; Liver Neoplasms/pathology/radiography/*therapy ; Male ; Middle Aged ; *Portal Vein ; Tomography, X-Ray Computed
Antineoplastic Agents/administration & dosage ; Antiviral Agents/therapeutic use ; Atrophy/pathology ; Carcinoma, Hepatocellular/pathology/radiography/*therapy ; *Chemoembolization, Therapeutic ; Hepatectomy ; *Hepatic Veins ; Hepatitis B, Chronic/complications/diagnosis/drug therapy ; Humans ; Liver Neoplasms/pathology/radiography/*therapy ; Male ; Middle Aged ; *Portal Vein ; Tomography, X-Ray Computed
Involvement of Splenic Hemangioma and Rectal Varices in a Patient with Klippel - Trenaunay Syndrome.
The Korean Journal of Gastroenterology.2011;58(3):157-161. doi:10.4166/kjg.2011.58.3.157
Klippel - Trenaunay syndrome (KTS) is characterized by a cutaneous vascular nevus of the involved extremity, bone and soft tissue hypertrophy of the extremity and venous malformations. We present a case of KTS with splenic hemangiomas and rectal varices. A 29-year-old woman was referred for intermittent hematochezia for several years. She had history with a number of operations for cutaneous and soft tissue hamangiomas since the age of one year old and for increased circumference of her left thigh during the last few months. Abdominal CT revealed multiple hemangiomas in the spleen, fusiform aneurysmal dilatation of the deep veins and soft tissue hemangiomas. There was no evidence of hepatosplenomegaly or liver cirrhosis. Colonoscopy revealed hemangiomatous involvement in the rectum. There were rectal varices without evidence of active bleeding. Upon venography of the left leg, we also found infiltrative dilated superficial veins in the subcutaneous tissue and aneurysmal dilatation of the deep veins. The patient was finally diagnosed with KTS, and treated with oral iron supplementation only, which has been tolerable to date. Intervention or surgery is not required. When gastrointestinal varices or hemangiomatous mucosal changes are detected in a young patient without definite underlying cause, KTS should be considered.
Adult ; Colonoscopy ; Female ; Hemangioma/*complications ; Humans ; Iron, Dietary/therapeutic use ; Klippel-Trenaunay-Weber Syndrome/complications/*diagnosis/drug therapy ; Rectum/blood supply ; Spleen/blood supply ; Tomography, X-Ray Computed ; *Varicose Veins
Adult ; Colonoscopy ; Female ; Hemangioma/*complications ; Humans ; Iron, Dietary/therapeutic use ; Klippel-Trenaunay-Weber Syndrome/complications/*diagnosis/drug therapy ; Rectum/blood supply ; Spleen/blood supply ; Tomography, X-Ray Computed ; *Varicose Veins
A Case of Perforated Xanthogranulomatous Cholecystitis Presenting as Biloma.
The Korean Journal of Gastroenterology.2011;58(3):153-156. doi:10.4166/kjg.2011.58.3.153
Xanthogranulomatous cholecystitis is an unusual inflammatory disease of the gallbladder characterized by severe proliferative fibrosis and the accumulation of lipid-laden macrophages in areas of destructive inflammation. Its macroscopic appearance may occasionally be confused with gallbladder carcinoma. We present a case of perforated xanthogranulomatous cholecystitis presenting as biloma. An 80-year-old woman was referred to our hospital with a 1-week history of abdominal pain and febrile sensation. Abdominal CT showed a biloma in the subhepatic area. The follow-up CT showed that the biloma increased in size. Therefore, ultrasonography-guided aspiration was performed. The aspirated fluid/serum bilirubin ratio was greater than 5, which was strongly suggestive of bile leakage complicated by perforated cholecystitis. She underwent a laparoscopic cholecystectomy with cyst aspiration and adhesiolysis. A histological diagnosis of perforated xanthogranulomatous cholecystitis was made.
Aged, 80 and over ; Bilirubin/blood ; Cholecystectomy ; Cholecystitis/*diagnosis/pathology/ultrasonography ; Drainage ; Female ; Gallbladder Neoplasms/diagnosis ; Granuloma/*diagnosis/pathology/ultrasonography ; Humans ; Tomography, X-Ray Computed ; Xanthomatosis/*diagnosis/pathology/ultrasonography
Aged, 80 and over ; Bilirubin/blood ; Cholecystectomy ; Cholecystitis/*diagnosis/pathology/ultrasonography ; Drainage ; Female ; Gallbladder Neoplasms/diagnosis ; Granuloma/*diagnosis/pathology/ultrasonography ; Humans ; Tomography, X-Ray Computed ; Xanthomatosis/*diagnosis/pathology/ultrasonography
The Korean Journal of Gastroenterology.2011;58(3):149-152. doi:10.4166/kjg.2011.58.3.149
Transarterial chemoembolization (TACE) is recommended as one of the first line therapy for unresectable hepatocellular carcinoma (HCC). Rupture of HCC following TACE is a rare and potentially fatal complication. We report a case of hepaticoduodenal fistula with ruptured HCC and liver abscess complicated by TACE. A 52-year-old male was treated by TACE three times, followed by radiation therapy and systemic chemotherapy. 30 days after the last TACE, right upper quadrant pain of abdomen was developed. About 1 month later, computed tomography of abdomen showed ruptured HCC with debris containing liver abscess and hepaticoduodenal fistula. Esophagogastroduodenoscopy revealed hepaticoduodenal fistula and hepatic parenchyme covered with exudate. The patient was managed with supportive care, but the hepaticoduodenal fistula persisted.
Carcinoma, Hepatocellular/radiotherapy/*therapy ; Chemoembolization, Therapeutic/*adverse effects ; Endoscopy, Digestive System ; Gastric Fistula/*etiology ; Humans ; Liver Abscess/etiology ; Liver Diseases/*etiology ; Liver Neoplasms/radiotherapy/*therapy ; Male ; Middle Aged ; Rupture, Spontaneous/etiology ; Tomography, X-Ray Computed
Carcinoma, Hepatocellular/radiotherapy/*therapy ; Chemoembolization, Therapeutic/*adverse effects ; Endoscopy, Digestive System ; Gastric Fistula/*etiology ; Humans ; Liver Abscess/etiology ; Liver Diseases/*etiology ; Liver Neoplasms/radiotherapy/*therapy ; Male ; Middle Aged ; Rupture, Spontaneous/etiology ; Tomography, X-Ray Computed
A Case of a Neuroendocrine Carcinoma in the Minor Papilla.
The Korean Journal of Gastroenterology.2011;58(3):144-148. doi:10.4166/kjg.2011.58.3.144
Neuroendocrine tumors are usually found in the ileum, appendix, rectum, colon and stomach. Ampullary neuroendocrine tumor is extremely rare and only a few cases of neuroendocrine carcinoma of the minor papilla have been reported. The preoperative diagnosis is very challenging because either asymptomatic or manifests as nonspecific abdominal pain. The tumor is relatively small and located at the deep mucosa and submucosa. Endoscopy with deep biopsy, endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography are good diagnostic tools. The best therapeutic choice is surgery. We report an unusual case of a 55-year-old woman who underwent endoscopy as part of a regular health checkup and was diagnosed a neuroendocrine carcinoma in the minor papilla, which was successfully resected by pancreaticoduodenectomy.
Carcinoma, Neuroendocrine/*diagnosis/pathology/ultrasonography ; Duodenal Neoplasms/*diagnosis/pathology/ultrasonography ; Duodenoscopy ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Pancreaticoduodenectomy ; Tomography, X-Ray Computed
Carcinoma, Neuroendocrine/*diagnosis/pathology/ultrasonography ; Duodenal Neoplasms/*diagnosis/pathology/ultrasonography ; Duodenoscopy ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Pancreaticoduodenectomy ; Tomography, X-Ray Computed
Clinical Trials with Stem Cells in Digestive Diseases and Future Perspectives.
The Korean Journal of Gastroenterology.2011;58(3):139-143. doi:10.4166/kjg.2011.58.3.139
Many techniques for isolation, expansion and handling of stem cells are being developed rapidly, and preclinical evidence has shown the possibility to use this technology for refractory diseases in the near future. Among refractory digestive diseases, Crohn's disease and liver cirrhosis may be two main diseases where stem cell therapy can be applied for anti-inflammation and regeneration of tissue. Currently, with respect to these two diseases, clinical trials using hematopoietic stem cells and mesenchymal stem cells from bone marrow or adipose tissue have shown some evidence of clinical benefits to immune modulation, suppression of inflammation and regeneration of functional cells. However, for the development of practical stem cell therapy, we need more data on underlying mechanisms, effective subpopulation of stem cells and its sources, and effective parameters for monitoring and estimation. With technical advances, the research on embryonic and induced pluripotent stem cells will also contribute to the new therapeutic strategies for digestive regenerative medicine. In the future, a variety of stem cell therapies may be therapeutic options for refractory digestive diseases, but many technical challenges remain to be solved.
Bone Marrow Cells/cytology ; Clinical Trials as Topic ; Crohn Disease/therapy ; Digestive System Diseases/*therapy ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/cytology ; Humans ; Liver Cirrhosis/therapy ; Mesenchymal Stromal Cells/cytology/transplantation
Bone Marrow Cells/cytology ; Clinical Trials as Topic ; Crohn Disease/therapy ; Digestive System Diseases/*therapy ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/cytology ; Humans ; Liver Cirrhosis/therapy ; Mesenchymal Stromal Cells/cytology/transplantation
Preclinical Experience in Stem Cell Therapy for Digestive Tract Diseases.
The Korean Journal of Gastroenterology.2011;58(3):133-138. doi:10.4166/kjg.2011.58.3.133
Adult stem cells are multipotent and self-renewing cells that contain several functions; i) migration and homing potential: stem cells can migrate to injured and inflamed tissues. ii) differentiation potential: stem cells which migrated to injured tissues can be differentiated into multiple cell types for repairing and regenerating the tissues. iii) immunomodulatory properties: stem cells, especially mesenchymal stem cells can suppress immune system such as inflammation. All those characteristics might be useful for the treatment of the digestive tract diseases which are complex and encompass a broad spectrum of different pathogenesis. Preclinical stem cell therapy showed some promising results, especially in liver failure, pancreatitis, sepsis, and inflammatory bowel disease. If we can understand more about the mechanism of stem cell action, stem cell therapy can become a promising alternative treatment for refractory digestive disease in the near future. In this review, we summarized current preclinical experiences in diseases of the digestive tract using stem cells.
Adult Stem Cells/cytology/*transplantation ; Digestive System Diseases/*therapy ; Drug Evaluation, Preclinical ; Humans
Adult Stem Cells/cytology/*transplantation ; Digestive System Diseases/*therapy ; Drug Evaluation, Preclinical ; Humans
Stem Cell Properties of Therapeutic Potential.
The Korean Journal of Gastroenterology.2011;58(3):125-132. doi:10.4166/kjg.2011.58.3.125
Stem cell research is a innovative technology that focuses on using undifferentiated cells able to self-renew through the asymmetrical or symmetrical divisions. Three types of stem cells have been studied in laboratory including embryonic stem cell, adult stem cells and induced pluripotent stem cells. Embryonic stem cells are pluripotent stem cells derived from the inner cell mass and it can give rise to any fetal or adult cell type. Adult stem cells are multipotent, have the ability to differentiate into a limited number of specialized cell types, and have been obtained from the bone marrow, umbilical cord blood, placenta and adipose tissue. Stem cell therapy is the most promising therapy for several degenerative and devastating diseases including digestive tract disease such as liver failure, inflammatory bowel disease, Celiac sprue, and pancreatitis. Further understanding of biological properties of stem cells will lead to safe and successful stem cell therapies.
Adult Stem Cells/cytology/metabolism/transplantation ; Embryonic Stem Cells/cytology/metabolism/transplantation ; Humans ; Induced Pluripotent Stem Cells/cytology/metabolism/transplantation ; Stem Cells/*cytology/metabolism
Adult Stem Cells/cytology/metabolism/transplantation ; Embryonic Stem Cells/cytology/metabolism/transplantation ; Humans ; Induced Pluripotent Stem Cells/cytology/metabolism/transplantation ; Stem Cells/*cytology/metabolism
The Korean Journal of Gastroenterology.2010;56(3):196-200. doi:10.4166/kjg.2010.56.3.196
Endoscopic submucosal dissection (ESD) is an useful therapeutic technique for large gastrointestinal epithelial tumors that it provides an en bloc resection. Although there is some controversy about the role of ESD for colorectal lesions, for large lesions in the distal rectum, ESD has the advantage of preserving anal function. However, the large amount of insufflating gas used during the procedure can cause severe abdominal pain and discomfort. Moreover, high intra-luminal pressure caused by a by large amount of gas can cause a micro-perforation. There is no consensus as to whether ESD is the optimal treatment for synchronous large colorectal laterally spreading tumors (LSTs) that cannot be removed en-bloc by conventional endoscopic mucosal resection. Here, a case with two neighboring synchronous large LSTs, one located in the rectum and the other in the distal sigmoid colon, were sequentially removed by separate ESD procedures performed on two consecutive days in a patient who could not tolerate a long procedure.
Adenoma, Villous/diagnosis ; Colonoscopy ; Colorectal Neoplasms/*diagnosis/pathology/surgery ; *Dissection ; Humans ; Intestinal Mucosa/pathology/surgery ; Male ; Middle Aged ; Neoplasms, Multiple Primary/*diagnosis/pathology/surgery ; Rectum/pathology
Adenoma, Villous/diagnosis ; Colonoscopy ; Colorectal Neoplasms/*diagnosis/pathology/surgery ; *Dissection ; Humans ; Intestinal Mucosa/pathology/surgery ; Male ; Middle Aged ; Neoplasms, Multiple Primary/*diagnosis/pathology/surgery ; Rectum/pathology
Country
Republic of Korea
Publisher
Korean Society of Gastroenterology
ElectronicLinks
http://www.kjg.or.kr/Editor-in-chief
Abbreviation
Korean J Gastroenterol
Vernacular Journal Title
대한소화기학회지
ISSN
1598-9992
EISSN
2233-6869
Year Approved
2007
Current Indexing Status
Currently Indexed
Start Year
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