Journal Detail Information

1

Cite

Share

The Inhibitory Effects of Platelet Glycoprotein IIb/IIIa Receptor Blocker-Coated Stent on Neointima Formation and Inflammatory Response in Porcine Coronary Stent Restenosis.

Ok Young PARK ; Myung Ho JEONG ; Jung Ha KIM ; Weon KIM ; Seung Hyun LEE ; Young Joon HONG ; Ju Han KIM ; Woo Suk PARK ; In Soo KIM ; Myung Ja CHOI ; Young Keun AHN ; Jong Tae PARK ; Jeong Gwan CHO ; Dong Lyun CHO ; Jong Chun PARK ; Jung Chaee KANG

Korean Circulation Journal.2003;33(5):439-445. doi:10.4070/kcj.2003.33.5.439

BACKGROUND AND OBJECTIVES: Previously, we reported that Abciximab (ReoPro(r))-coated stent inhibited in-stent neointimal hyperplasia. ReoPro(r) is known to suppress vascular inflammation through CD 11b/18 (macrophage-1 receptor). We observed inhibitory effects of neointima formation and inflammatory reaction after stenting in a porcine model. MATERIALS AND METHODS: The surface of the stent was coated with ReoPro(r) by means of plasma polymerization followed by chemical grafting. Stent overdilation injury was performed with control bare stent (Group I, n=13) and ReoPro(r)-coated stents (Group II, n=13) in 26 porcine coronary arteries. Follow-up coronary angiogram and the histopathologic assessments of stented porcine coronary were performed on day 14 (Group I:n=6, Group II:n=6) and day 28 (Group I:n=7, Group II:n=7) after stenting. RESULTS: Pathologic area stenosis was 19.7+/-5.3% in Group I and 15.9+/-3.3% in Group II at day 14, and 33.6+/-27.7% and 22.6+/-6.6%, respectively, at day 28 (p<0.05 at day 28). The ratio of inflammatory cells out of the number of total cells in the neointima was 21.8+/-6.5% in Group I and 22.5+/-11.6% in Group II at day 14, and 27.3+/-18.3% in Group I and 28.6+/-10.7% in Group II at day 28 post stenting (p=NS). And those of the media were 2.89+/-1.13% in Group I and 1.36+/-1.27% in Group II at day 14, and 6.61+/-5.61% and 6.26+/-4.51% at day 28 (p=NS). Fibrinoid materials associated with inflammatory reaction were observed in both groups at days 14 and 28. CONCLUSION: An inflammatory reaction was not suppressed with the use of ReoPro(r)-coated stenting in a porcine stent restenosis model.
Blood Platelets* ; Constriction, Pathologic ; Coronary Restenosis ; Coronary Vessels ; Follow-Up Studies ; Glycoproteins* ; Hyperplasia ; Inflammation ; Neointima* ; Plasma ; Polymerization ; Polymers ; Stents* ; Transplants

2

Cite

Share

A Case of Isolated Left Main Coronary Ostial Stenosis Due to Acute Angle Take-off with Clockwise Rotation of Coronary Sinus confirmed by MRI Image.

Sang Hoon LEE ; Suk JEON ; Yeon A LEE ; Jae Young JANG ; Hye Sook CHOI ; Heon Sook KIM ; Seung Muk JUNG ; Rack Kyoung CHOI ; Dal Soo LIM ; Suk Keun HONG ; Hweung Kon HWANG ; Tae Hoon KIM ; Yang Min KIM

Korean Circulation Journal.2003;33(5):435-438. doi:10.4070/kcj.2003.33.5.435

Isolated left main coronary ostial stenosis is a very rare condition. In the majority of cases there are coexisting diseases in multiple coronary vessels. Here, a case of isolated left main coronary ostial stenosis due to an acute angle take-off, with clockwise rotation of the coronary sinus, confirmed by cardiac MRI is presented. A 44-year old female patient presented with an exertional and stabbing anterior chest pain. The patient had no premedical history. A coronary angiogram showed an isolated left main coronary ostial stenosis due to an acute take-off of the left main coronary artery. A cardiac MRI showed an acute angle take-off of the left main coronary artery, with clockwise rotation of the coronary sinus. The patient underwent surgical angioplasty of the coronary ostia, with a patch of autologous pericardium. This acute angle take-off may be due to rotation of the coronary sinus.
Adult ; Angioplasty ; Chest Pain ; Constriction, Pathologic* ; Coronary Sinus* ; Coronary Stenosis ; Coronary Vessels ; Female ; Humans ; Magnetic Resonance Imaging* ; Pericardium

3

Cite

Share

A Case of Cardiac Metastasis from Lung Cancer Presented with Persistent ST Segment Elevation Simulating Acute Myocardial Infarction.

Jang Young KIM ; Junghan YOON ; Byung Su YOO ; Seung Hwan LEE ; Soon Hee JUNG ; In Soo HONG ; Kyung Hoon CHOE

Korean Circulation Journal.2003;33(5):431-434. doi:10.4070/kcj.2003.33.5.431

Myocardial involvement by a lung neoplasm rarely appears, on an ECG, mimicking acute myocardial infarction. We experienced a case of metastatic lung cancer, to the cardiac apex, showing persistent ST segment elevation in the precordial leads, which simulated an acute anterior myocardial infarction.
Electrocardiography ; Lung Neoplasms* ; Lung* ; Myocardial Infarction* ; Neoplasm Metastasis*

4

Cite

Share

Effects of Endothelium-derived Relaxing Factors on the Regulation of ATP-sensitive Potassium Channel Activity in Cardiac Myocytes.

Jeong Min JU ; Dong Ho SHIN ; Han Seong JEONG ; Hyung Wook PARK ; Jeong Gwan CHO ; Jae Ha KIM

Korean Circulation Journal.2003;33(5):420-430. doi:10.4070/kcj.2003.33.5.420

BACKGROUND AND OBJECTIVES: Effects of the three major endothelium-derived relaxing factors (EDRFs), namely nitric oxide (NO), prostacyclin (PGI2), and 11, 12-epoxyeicosatrienoic acid (EET) on the ATP-sensitive potassium channel (K ATP channel) activity were examined in isolated cardiac ventricular myocytes. MATERIALS AND METHODS: K ATP channel activities were measured in the enzymatically (collagenase) isolated single mouse ventricular myocytes using excised inside-out, cell-attached, and perforated whole-cell patch clamp techniques. RESULTS: In inside-out patches, NO donors, SNP and spermine NONOate, did not affect the K ATP channel activity. In the presence of both ATP and ADP in the bath solution, the NO donors attenuated the activity of the K ATP channel. In cell-attached patches, the NO donors potentiated pinacidil-induced K ATP channel activity. In perforated whole-cell patch configuration, the NO donors decreased the K ATP current induced by PCO 400, a K ATP channel opener. PGI2 did not affect the K ATP channel activity in excised insideout patch. However, in the pres-ence of ATP in the internal solution, PGI2 increased the channel activity in a dose-dependent manner. In cell-attached patches, PGI2 did not only affect the channel activity itself, but also the dinitrophenol-induced K ATP channel activity. 11, 12-EET had no effect on K ATP channel activities.CONCLUSION: These results indicate that some of the endothelium-derived relaxing factors (nitric oxide and prostacyclin) are involved in the regulation of ATP-sensitive potassium channel activities in mouse ventricular myocytes; and the regulation type was com-plicated, activation or inhibition, depending on the cellular environment.
Adenosine Diphosphate ; Adenosine Triphosphate ; Animals ; Baths ; Endothelium-Dependent Relaxing Factors* ; Epoprostenol ; Humans ; Mice ; Muscle Cells ; Myocytes, Cardiac* ; Nitric Oxide ; Patch-Clamp Techniques ; Potassium Channels* ; Potassium* ; Spermine ; Tissue Donors

5

Cite

Share

Integrins Mediating Adhesion and Proliferation of ADP-stimulated Vascular Smooth Muscle Cells.

Seung Jae JOO ; Tae Joon CHA ; Jae Woo LEE

Korean Circulation Journal.2003;33(5):409-419. doi:10.4070/kcj.2003.33.5.409

BACKGROUND AND OBJECTIVES: Adenosine diphosphate (ADP), which is usually secreted from activated platelets, may activate integrins on vascular smooth muscle cells, resulting in adhesion and proliferation. Integrins, mediating the ADP-stimulated adhesion and proliferation of vascular smooth muscle cells, was investigated in this study. MATERIALS AND METHODS: Prothrombin (PT) and bone sialoprotein (BSP) were used as activation-dependent ligands in an adhesion assay. The adhesion of human aortic smooth muscle cells (HASMC) were measured after ADP stimulation, using ligand-coated 24-well plates. The 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the ADP-stimulated proliferation of the HASMC.RESULTS: ADP activated the HASMC to increase their adhesion to the PT or BSP, and their proliferation in a dose-dependent manner. The adhesion of the ADP-stimulated HASMC to the PT was completely blocked by P5H9, a blocking monoclonal Ab (mAb) to integrin alphavbeta5 (92% inhibition), but was only slightly inhibited by LM609, a blocking mAb to integrin alphavbeta3 (30% inhibition). The adhesion of the ADP-stimulated HASMC to the BSP was partially inhibited by both P5H9 (46% inhibition) and JBS5, a blocking mAb to integrin alpha5beta1 (75% inhibition), but was not affected by c7E3, a blocking mAb to integrin beta3. The ADP-stimulated proliferation of the HASMC was inhibited by both c7E3 and LM609 (98% and 93% inhibition, respectively), but not by either P1F5, a blocking mAb to integrin alphavbeta5 or JBS5. CONCLUSION: These results indicate the different roles of integrins on vascular smooth muscle cells after ADP stimulation; the integrins alphavbeta5 and alpha5beta1 for adhesion, and the integrin alphavbeta3 for proliferation.
Adenosine Diphosphate ; Humans ; Integrin alpha5beta1 ; Integrin alphaVbeta3 ; Integrin beta3 ; Integrin-Binding Sialoprotein ; Integrins* ; Ligands ; Muscle, Smooth, Vascular* ; Myocytes, Smooth Muscle ; Negotiating* ; Prothrombin

6

Cite

Share

Correlation between Intima-Media Thickness in Carotid Artery and the Extent of Coronary Atherosclerosis.

Ki Rack PARK ; Ki Young KIM ; Sang Mi YOON ; Jang Ho BAE ; In Whan SEONG

Korean Circulation Journal.2003;33(5):401-408. doi:10.4070/kcj.2003.33.5.401

BACKGROUND AND OBJECTIVES: We performed this study to elucidate whether there were significant correlations 1) between intima-media thickness (IMT) of carotid artery and the extent of coronary atherosclerosis and 2) between carotid IMT and risk factors of atherosclerosis in patients with coronary atherosclerosis. SUBJECTS AND METHODS: All study subjects (n=326, 200 males, 59+/-10 years) had chest pain and underwent coronary angiography. IMT was measured in the far wall of the internal and common carotid arteries and the carotid bulb using high-resolution ultrasound with a 3-11 MHz linear probe. We also evaluated the presence of plaque in the carotid artery. The extent of coronary atherosclerosis was divided into 4 groups (0, 1, 2, and 3) according to the number of coronary arteries narrowed more than 50% of the diameter. RESULTS: In patients with one or more diseased coronary vessels, IMT of the common carotid artery was thicker (0.81+/-0.15 mm vs. 0.91+/-0.28 mm, p<0.05) and plaques were more frequently found (16% vs. 40%, p<0.05). There was also a significant correlation between the extent of coronary artery atherosclerosis and IMT of the common carotid artery (r=0.217, p<0.001) and the internal carotid artery (r=0.177, p<0.01). Multiple regression analysis revealed hypertension and smoking, among the atherosclerosis risk factors, as independent factors in the IMT of the common carotid artery and carotid bulb. CONCLUSION: We concluded that there was a significant correlation between the extent of coronary artery disease and IMT of the carotid artery;and that hypertension and smoking, of all atherosclerosis risk factors, were independent factors in the IMT of the carotid artery.
Atherosclerosis ; Carotid Arteries* ; Carotid Artery, Common ; Carotid Artery, Internal ; Chest Pain ; Coronary Angiography ; Coronary Artery Disease* ; Coronary Vessels ; Humans ; Hypertension ; Male ; Risk Factors ; Smoke ; Smoking ; Ultrasonography

7

Cite

Share

Difference of Systemic Vascular Compliance According to the Severity of Coronary Artery Disease in Ischemic Heart Disease.

Chang Kyun LEE ; Eun Sun JIN ; Byung Ho LEE ; Heung Sun KANG ; Chung Whee CHOUE ; Jung Sang SONG ; Jong Hoa BAE

Korean Circulation Journal.2003;33(5):393-400. doi:10.4070/kcj.2003.33.5.393

BACKGROUND AND OBJECTIVES: It is contradictory that arterial stiffness, especially in a systemic vascular tree, is related to coronary artery disease. This study was performed to establish the relationship between systemic vascular compliance and the severity of coronary artery disease. SUBJECTS AND METHODS: The study population was comprised of 53 chronic stable angina patients and 45 normal healthy controls. Coronary angiography was used to determine the involved vessels. The systemic vascular compliance and other hemodynamic variables were measured by a non-invasive pulse dynamic waveform analysis. RESULTS: In the patient group, 15 (24.5%) had one-vessel disease, 15 (24.5%) a two-vessel disease and the remaining 23 (43%) had a three-vessel disease. In the patients with a three-vessel disease, the systemic vascular compliance was significantly lower than those of the other two groups (p<0.05). The systemic vascular compliance of the patients with multi-vessel diseases (including two-vessel and three-vessel) was also significantly lower than that of the controls or patients with a one-vessel disease (p<0.05). The systemic vascular compliance was found to have a significant negative association with the severity of coronary artery disease (Spearman's rho=-0.296, p<0.05). CONCLUSION: This study has shown that arterial stiffness (or systemic vascular compliance) is significantly associated with the severity coronary artery disease, and the serial non-invasive measurement of the systemic vascular compliance may be useful in the early detection of severe coronary artery disease.
Angina, Stable ; Compliance* ; Coronary Angiography ; Coronary Artery Disease* ; Coronary Vessels* ; Hemodynamics ; Humans ; Myocardial Ischemia* ; Vascular Stiffness

8

Cite

Share

The Clinical Significance of Elevated Troponin in Patients with Acute Coronary Syndrome with Normal Electrocardiogram.

Sang Yeob LIM ; Myung Ho JEONG ; Eun Hee BAE ; Doo Sun SHIM ; Sang Hyun LEE ; Weon KIM ; Ju Han KIM ; Ok Young PARK ; Woo Suk PARK ; Young Keun AHN ; Jeong Gwan CHO ; Jong Chun PARK ; Soon Pal SUH ; Byoung Hee AHN ; Sang Hyung KIM ; Jung Chaee KANG

Korean Circulation Journal.2003;33(5):385-392. doi:10.4070/kcj.2003.33.5.385

BACKGROUND AND OBJECTIVES: The level of cardiac specific troponin (cTn) may be important in patients with acute coronary syndrome (ACS), but with normal electrocardiography (ECG). SUBJECTS AND METHODS: Three hundred and nineteen patients (61+/-11 years, M:F=212:107), with ACS and normal ECG, who underwent a diagnostic coronary angiogram (CAG), between July 2000 and June 2001, were analyzed according to their cTn level. The clinical characteristics, initial CAG findings and major adverse cardiac events (MACE), during a one-year clinical follow-up, were compared between positive and negative cTn groups. RESULTS: Of the enrolled patients, 191 had a negative cTn (group A, 61+/-10 years, M:F=131:60), and 128 a positive cTn (group B, 60+/-11 years, M:F=81:47), and 176 (55.2%) were shown to have significant coronary artery stenosis on CAG. There were no significant differences in risk factors between the two groups. The mean left ventricular ejection fraction was 64+/-9%, and was lower in group B than in group A (59+/-10% vs. 67+/-7%, p<0.05). cTn positivity was associated with the percentage of significant coronary artery stenosis present (88% vs. 32%, p<0.05), a smaller minimal luminal diameter (1.09+/-0.44 mm vs. 2.68+/-0.33 mm, p<0.05) and a larger diameter of stenosis (68+/-6% vs. 44+/-6%, p<0.05). A multi-vessel lesion was more common in group B than in group A (58.3% vs. 30.3%, p<0.05). During the one-year follow-up period, 36 patients developed MACE, resulting in 3 deaths, 7 acute myocardial infarctions and 34 patients with restenosis. MACE was observed in 9 patients of group A and in 27 of group B (4.7% vs. 21.1%, p<0.05). CONCLUSION: The troponin levels are valuable for the early diagnosis, and prediction of the long-term prognosis, in patients with ACS and a normal ECG.
Acute Coronary Syndrome* ; Angina, Unstable ; Constriction, Pathologic ; Coronary Disease ; Coronary Stenosis ; Early Diagnosis ; Electrocardiography* ; Follow-Up Studies ; Humans ; Myocardial Infarction ; Phenobarbital ; Prognosis ; Risk Factors ; Stroke Volume ; Troponin*

9

Cite

Share

The Effect of Ischemic Preconditioning on Long-term Prognosis in Acute Myocardial Infarction.

Cheol Hong KIM ; Kyu Hyung RYU ; Jin Won JO ; Ji Hyun HONG ; Seong Woo HAN ; Sang Jin HAN ; Yung LEE

Korean Circulation Journal.2003;33(5):374-384. doi:10.4070/kcj.2003.33.5.374

BACKGROUND AND OBJECTIVES: The brief repetitive periods of ischemia and reperfusion before a myocardial infarction appears to precondition the heart, making it more resistant to subsequent longer periods of ischemia. This phenomenon is known as ischemic preconditioning (IP). We studied the long-term effects of IP in patients with acute myocardial infarction. SUBJECTS AND METHODS: Between January 1991 and August 1993, we examined, prospectively, 113 consecutive patients who had an acute myocardial infarction and arrived to the hospital within 6 hours after the onset of chest pain. IP was defined as prodromal angina within 24 hours before the myocardial infarction. Patients were divided 2 groups:Non-IP group and IP group. Clinical characteristics, laboratory findings, coronary angiographic findings, cardiac events, and mortality at admission and during follow-up were compared between these two groups. RESULTS: The IP group had 64 patients while the Non-IP group had 49. In terms of risk factors for ischemic heart disease, hypertension was more common in the IP group (p<0.05). Peak serum creatine kinase level of the IP group was 1,387.0+/-1,255.0 IU/L and that of the Non-IP group was 2,372.7+/-2,420.5 IU/L (p<0.05). The time interval between the onset of infarction and peak creatine kinase level was shorter in the IP group than in the Non-IP group (10.6+/-4.8 hours vs. 7.1+/-4.6 hours;p<0.05). For cardiac events during the follow-up period, there were more incidences of congestive heart failure and reinfarction in the IP group than in the Non-IP group (p<0.05). Mortality rate did not differ between the two groups. Univariate analysis identified five factors predictive of 3-year mortality: age, sex, coronary angiogram frequency, hypertension, and smoking. However, none of these factors were independently associated with death in the multivariate analysis. CONCLUSION: Close monitoring for cardiac events may be necessary for patients who have had IP before myocardial infarction as they had a higher incidence for congestive heart failure and reinfarction during the follow-up.
Angina Pectoris ; Chest Pain ; Creatine Kinase ; Follow-Up Studies ; Heart ; Heart Failure ; Humans ; Hypertension ; Incidence ; Infarction ; Ischemia ; Ischemic Preconditioning* ; Mortality ; Multivariate Analysis ; Myocardial Infarction* ; Myocardial Ischemia ; Prognosis* ; Prospective Studies ; Reperfusion ; Risk Factors ; Smoke ; Smoking

10

Cite

Share

A Comparison of Tenecteplase(TNK-tPA) and Alteplase(rt-PA) in Korean Patients with Acute Myocardial Infarction(A Randomized, Multi-Centered Coronary Angiographic Trial).

Myung Ho JEONG ; Weon KIM ; Jung Chaee KANG ; Seong Wook HAN ; Seung Ho HUR ; Kwon Bae KIM ; Kwang Soo CHA ; Moo Hyun KIM ; Heung Sun KANG ; Jong Hwa BAE ; In Ho CHAE ; Byung Hee OH ; Myeong Ki HONG ; Seong Wook PARK ; Seung Jung PARK ; So Yeon CHOI ; Seung Jae TAHK ; Dong Hoon CHOI ; Yang Soo JANG ; Seung Yun CHO ; Byung Su YOO ; Jung Han YOON ; Kyung Hoon CHOE

Korean Circulation Journal.2003;33(5):362-373. doi:10.4070/kcj.2003.33.5.362

BACKGROUND AND OBJECTIVES: This is a comparative, randomized, multi-centered, angiographic trial for the comparison of TNK-tPA with rt-PA, in Korean patients with an acute myocardial infarction (AMI). SUBJECTS AND METHODS: Fifty four patients that were eligible for thrombolysis, diagnosed with an AMI, were randomized into two groups:TNK-tPA (single bolus injection, 25-50 mg weight adjusted;n=25) or rt-PA (accelerated intravenous infusion, up to 100 mg;n=29) at the emergency room. The primary endpoint was the percentage of patients with a TIMI (Thrombolysis In Myocardial Infarction) III flow 90 min following the administration of the study drug. The secondary endpoints were an infarct-related artery patency at 90 min, the percentage of patients with ST segment resolution at 60 and 180 min, and at 30 days mortality. RESULTS: The baseline demographic data, including age, sex and body weight, and a medical history of prior myocardial infarction and risk factors were no different between the TNK-tPA and rt-PA groups. The pain-to-needle and door-to-needle times were also no different. The ST segment resolution was no different between the two groups. A TIMI grade 3, on a coronary angiogram, 90 min following the drug administration, was observed in 19 (76.0%) of the TNK-tPA and 17 (58.6%) of the rt-PA (p=0.24) patients. However, a TIMI grade more than 2 was higher in the TNK-tPA (100%;25/25) than in rt-PA group (72.4%;21/29)(p=0.0052). The in-hospital adverse events, and clinical outcomes at 30 days, were no different between the two groups. CONCLUSION: TNK-tPA is more convenient, and may be a preferred thrombolytic agent, for the revascularization of an AMI.
Arteries ; Body Weight ; Coronary Disease ; Emergency Service, Hospital ; Humans ; Infusions, Intravenous ; Mortality ; Myocardial Infarction ; Myocardial Revascularization ; Risk Factors ; Thrombolytic Therapy

DISPLAY OPTIONS

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share

Cite

Share