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The effects of PHT,CT,Calcium and phospho- rus during the anesthesia and operative stress

Chinese Journal of Anesthesiology.1994;0(01):-.

The changes of parathyroid hormone (PTH),calcitonin(CT)of three different anesthesia methods were observed perioperatively in 38 patients who were divided into two age groups (22 ~ 50 and 51 ~ 60). Postoperative serum Ca, P levels decreased as compared with preoperative values,espe.cially in the old. age groups with no statistic significance. These results indicate that during anesthesia and operative stress the CDS is inhibited and the regulation of the autonomic nervous system is affected, with obscure the relationship between parathyroid hormone, calcitonin and Ca, P with the alteration of Ca,P metabolism. Serum Ca may increase to the baseline by supplement of calcium gluconate during and after operation, but the operation after 4 ~ 5 days, serum Ca may also return to normal without any intervention.

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Hepatic histopathological studies of hepatotoxicity of halothane vs sevoflurane in enzyme- induced hypoxic rats

Weifeng YU ; Weiqiang ZHENG ; Jinguyang WANG

Chinese Journal of Anesthesiology.1994;0(01):-.

Male Sprague~Dawley rats were pretreated with phenobarbital and randomly divided into 6 groups and were exposed to O2,/N2/l. 2 MAC anesthetics for I hr; NC, 21 % O2/79% N2; HC, 14 %O2,/86%N2; NH, 21 %O2/79% N2/l. 2 MAC halothane;HH, 14 %O2/86 %N2/ 1. 2 MAC Halothane; NS, 21 %O2/79%N2/ 1. 2 MAC sevoflurane; HS, 14 %O2/86 %N2/ 1. 2 MAC sevoflurnae. Liver specimens andblood were taken 24 hrs after exposure. Thenecrosls and denaturatlon of hepatocellularwere quantltatlvely estlmated by stereoscopy.Ultrastructural morphology was analysed by computer. The liver ofall rats given halothane (14%O2) had extensive centrilobu- lar necrosls and denaltlration. There were an increase in serum glutamic pyruvic transmi- nase accompnaying the morphologic damage。No marked hepatotoxicity was foundin the rats following sevoflurane expoure compared with controls. Hypoxia was the main cause of swelling of mltochondria. Results suggest that sevoflurane has less hepattc injtry than holotnane.

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The factors of predicting neurologic functions on brian resuscitation using closed-thoracic cardio-pulmonary bypass-An experimental study in rabbits

Daqing MA ; Yuan ZHOU ; Xing XU

Chinese Journal of Anesthesiology.1994;0(01):-.

0. 4, P

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Changes of haemorheology during induction and maintenance of anesthesia

Xianwei ZHANG ; Xiuyun BA ; Shiao JIN

Chinese Journal of Anesthesiology.1994;0(01):-.

Haemorheological changes, including blood viscosity (?b) and plasma viscosity (?p) measured on a cone-plate viscometer, erythrocyte aggregation calculated, erytkrocyte deformability (DI) determined by the nuclear pore microfiltration technique and red blood cell shape using scanning electromicroscopy, were observed in patients during anesthesia There acs a significant reduction in ?b (at shear rates range 7. 68- 307. 20 s-l ), ?p and haemotocrit after induction (preintubation ) and 30 min after enflurane in the presence of iv fentanyl, compared with pre-aneathesia, accompanying remarkable increased DI. No changes of erythrocyte shape, however, was found add, nor was the difference of the index between induction period and maintenance of anesthesia. These findings suggest that general anesthesia leads to haemorheological alterations which may improve the microcirculation of the patients.

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Etfects of ATP on cerebral blood flow velocity and vascular responses during hyperventilation.

Yi ZHANG

Chinese Journal of Anesthesiology.1994;0(04):-.

The effects of ATP on cerebral blood flow velocity and vascular responses to hyperventilation using TCD in the middle cerebral artery were studied in 15 patients. Anesthesia was maintained by infusion of 1% procaine (1ml.kg-1/min) and inhalation of 1% enflurane-40%N2O-O2. Mean blood flow velocity in left middle cerebral artery was measured and cerebral vascular reactivity to hyperventilytion was assessed before and during the administration of ATP.The cerebral reactivity was expressed as the percentage change in mean blood flow velocity per unit change in PETCO2. During the administration of 1%ATP,a 34% reduction in MAP with mean blood flow velocity decreased significantly from 61.5 to 53.1cm/s (P

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Effects of trimetazidine on reperfusion arrhythmias and its mechanism.

Lixian XU ; Yuqing LI

Chinese Journal of Anesthesiology.1994;0(03):-.

The experiment of recirculating blood perfusion device showed that trimetazidine (TMZ ) 30 mol/L could significantly inhibit the arrhythmias induced by ischemia and reperfusion, decrease the content of malondialdehyde and improve superoxide dismutase activity of red blood cell in isolated rabbit hearts. In the experiment with coronary artery occlusion of rats, TMZ 4mg/kg administered intravenously could also inhibit arrhythmias induced by ischemia and reperfusion. The mechanism may be related to the depression of lipid peroxidation reaction.

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Effect of salvia miltiorrkiza and its effective composition on hypoxic pulmonary vaoconstriction in guinea pig.

Lianhua CHEN ; Changsi XIAO ; Qinyan GONG

Chinese Journal of Anesthesiology.1994;0(03):-.

The experiment was designed to investigate the effect of salvia miltiorrhiza (Danshen ) and its effective composition, phenyl lactic acid (Danshensu )on the hypoxic pulmonary vasoconstriction (HPV). Acute hypoxia was induced by replacing mixed gas 95%O2+ 5 %CO2 with 95%N2 + 5 %CO2. Hypoxic pulmonary vasoconstriction was diminished by injectic Danshen, Injectic Danshen compound and Danshensu with concentration dependently. Tile effect of Danshensu was the most,and Injectic Danshen Co was second by comparison. The results suggested that Danshen can antagonist HPV which was mainly produced by Danshensu, one of the effective composition of Danshen,and that more potent inhibitory action on HPV was by Injectio Danshen compound compared with Injectio Danshen,and this may be related to the addition of Dalbergia odorifera , the other composition of Injectic Danshen compound.

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The hemodynamic effects of hypotension induced by PGE_1.

Liang WEN ; Yoqian CHEN ; Min BI

Chinese Journal of Anesthesiology.1994;0(04):-.

The hemodynamic effects of deliberated hypotension induced by PGE1 or SNP on 14 dogs anesthetized by ketamine were studied separately.MAP was decreased by 30%~40% after infusing PGE,or SNP Hemodynamic variables were measured before and 15 min 30 min after hypotension and 15 min after the discontinuation of infusion.The results indicated that SVRI, PVRI, MPAP, LVSWI and RVSWI all decreased significantly during PGE1-or SNP-induced hypotension. CVP decreased and HR increased significantly during SNP-induced hypotension, but with no significant change during PGE1-induced hypotension and with SVI. CI. PCWP remained unchanged in these two groups throughout the experiments.

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Inhibitory effects of salviae miltiorrhizae and SOD on lipid Peroxidation after hemorrhagic shock.

Zhenyuan XIA ; Jinfu YU ; Xinyun SHI

Chinese Journal of Anesthesiology.1994;0(04):-.

Effects of salviae miltiorrhizae (SM) and SOD on serum and tissue (liver, intestine) lipid peroxidation were studied on rabbits in reperfusion after hemor rhage shock.The results showed that both SM and SOD could effectively reduce the serum MDA,while the inhibitory effect of SM on tissue (intestine) lipid Peroxidation was more significant than that of SOD.90 min after shock,18 rabbits were equally divided into 3 groups,one third of shed blood was re-infused and simultaneously teperfused with balanced salt solution (BSS) (group A), SOD in BSS (group B) and SM in BSS (group C). After reperfusion, serum MDA increased significantly in group A, while serum in MDA in group B and C decreased gradually and was significantly lower than that of group A after reperfusion of 3 hr (I3). Intestine MDA in group C was evidently lower than that in group A (P

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The pharmacodynamics of alcuronium and atracurium and their erfects on circulatory function.

Yannan HANG ; Dajin SUN ; Xiangyui WANG

Chinese Journal of Anesthesiology.1994;0(04):-.

The pharmacodynamics and its circulatory effects of alcuronium and atracurium were investigated in cardiac and noncardiac surgical patients.The results demonstrated that:l Compared with atracurium group,the duration of action of alcuronium is longer in cardiac patients than that of non-cardiac patients, but there is no difference in the onset of action between these two groups; 2. Half of the patients which received alcuronium need reversal with neostigminel 3. The effects on the circulation of these two drugs were nor remarkable;Therefore,alcuronium is also suitable for cardiac and non-cardiac surgical patients

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