Perineal pagent's disease involving the inguinoscrotal area.
Journal of the Korean Cancer Association.1991;23(2):465-469.
No abstract available.
Journal of the Korean Cancer Association
1966 to Present ISSN: 0496-6872
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A case of congenital mesoblastic nephroma-diagnosed during intrauterine life.
Journal of the Korean Cancer Association.1991;23(2):458-464.
No abstract available.
Journal of the Korean Cancer Association.1991;23(2):451-457.
Intraglomerular malignant lymphomatosis: a report of a case-.
Journal of the Korean Cancer Association.1991;23(2):443-450.
No abstract available.
Journal of the Korean Cancer Association.1991;23(2):436-442.
A computer program for survival analysis.
Journal of the Korean Cancer Association.1991;23(2):429-435.
No abstract available.
Survival Analysis*
Survival Analysis*
Journal of the Korean Cancer Association.1991;23(2):424-428.
No abstract available.
Drug Therapy*
Drug Therapy*
Journal of the Korean Cancer Association.1991;23(2):418-423.
No abstract available.
Drug Therapy, Combination* ; Metoclopramide* ; Ondansetron* ; Prospective Studies* ; Vomiting*
Drug Therapy, Combination* ; Metoclopramide* ; Ondansetron* ; Prospective Studies* ; Vomiting*
A clinical study of breast cancer.
Journal of the Korean Cancer Association.1991;23(2):410-417.
Journal of the Korean Cancer Association.2000;32(3):578-586.
PURPOSE: Because of difficulty of obtaining metaphase cells from tumor specimens, there are only a few cytogenetic studies in nasal NK/T-cell lymphomas, and so far no consistent specific chromosomal abnormalities have been described. In this study, we have used degenerate oligonucleotide primed PCR (DOP-PCR) and comparative genomic hybridization (CGH) to deter mine chromosomal alterations from 6 nasal NK/T-cell lymphoma tissues dissected from formalin- fixed paraffin-embedded slide sections. MATERIALS AND METHODS: For the isolation of tumor DNA, four 7-micrometer-thick tissue sections from each sample were dewaxed and rehydrated, and areas of high tumor cell content (more than 60%) were dissected and pooled into a tube. Normal DNA was prepared from the peripheral blood of a healthy volunteer. Tumor DNA was labeled with biotin-16-dUTP by DOP-PCR and normal DNA was labeled with digoxigenin-dUTP using a nick translation kit. In CGH, equal amounts of differently labeled DNA from the tumors and normal reference DNA were hybridized simul taneously to normal metaphase chromosomes. They were visualized by different fluordegrees Chromes, and the signal intensities were quantitated separately as gray levels for each chromosome. The over- and underrepresented DNA segments were determined by computation of image ratios and average ratio profiles. RESULTS: Our results show that gains of DNA copy number were more prevalence than DNA losses. The most commonly observed gains were mapped to chromosomal regions of 1p32.2 ter,19 and 20 in 4 of 6 cases (67%). The other frequent gains were found on chromosomes 12q in 3 of 6 cases. The most frequent loss was detected on 6q in 4 of 6 cases(67%), and less fre quently observed on 13q21.1 q34 and 13q14 q34. CONCLUSION: These genomic changes found in specific chromosomal regions are likely to harbor genes of importance in nasal NK/T-cell lymphomagenesis, therefore such cytogenetic mapping of genomic imbalance may be of value for further molecular delineation of NK/T-cell lymphoma.
Chromosome Aberrations ; Comparative Genomic Hybridization* ; Cytogenetics ; DNA ; Healthy Volunteers ; Lymphoma* ; Metaphase ; Polymerase Chain Reaction ; Prevalence
Chromosome Aberrations ; Comparative Genomic Hybridization* ; Cytogenetics ; DNA ; Healthy Volunteers ; Lymphoma* ; Metaphase ; Polymerase Chain Reaction ; Prevalence
Country
Republic of Korea
Publisher
Korean CancerAssociation
ElectronicLinks
http://koreamed.org/JournalVolume.php?id=36Editor-in-chief
Abbreviation
Journal of the Korean Cancer Association
Vernacular Journal Title
대한암학회지
ISSN
0496-6872
EISSN
Year Approved
2007
Current Indexing Status
Currently Indexed
Start Year
1966
Description
Discontinued and the name of the journal changed to Cancer Research and Treatment: 2001 (v33 n3) to Present pISSN 1598-2998 eISSN 2005-9256
Current Title
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