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Ectopic Meningioma of the Ethmoid Sinus: Report of a Case and Review of Literature.

Woo Jung KIM ; Sang Hoon SHIN ; Jae Yong LEE ; Heung Man LEE ; Sang Hag LEE

Journal of Rhinology.1997;4(2):158-160.

Extracranial meningioma arises from ectopic arachinoidal cells and common sites of these tumors are orbit, scalp, upper respiratory tract, and parotid region. Extracranial meningioma of paranasal sinus is rare. This tumor shows various histological findings and is diagnosed by combination of CT, MRI, angiography, and pathological findings. Treatment of choice is surgical excision. Recently, we experienced a case of meningioma involving ethmoid sinus which was completely excised by endoscopic sinus surgery. So, we report our experience of ectopic meningioma of ethmoid sinus with a brief review of the literature.
Angiography ; Ethmoid Sinus* ; Magnetic Resonance Imaging ; Meningioma* ; Orbit ; Parotid Region ; Respiratory System ; Scalp

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Mucoepidermoid Carcinoma of the Ethmoid Sinus: Report of a Case with Bizarre Manifestations.

Jae Yong LEE ; Woo Jung KIM ; Young Ho KIM ; Sang Hoon SHIN ; Heung Man LEE ; Sang Hag LEE

Journal of Rhinology.1997;4(2):154-157.

Mucoepidermoid carcinoma is a common malignant tumor of the major salivary glands but it rarely arises in the nasal cavity and paranasal sinuses. Like other paranasal sinus carcinomas, mucoepidermoid carcinoma of the ethmoid sinus may first be noticed by the extension of tumor mass to adjacent structures such as nasal cavity, orbit, other paranasal sinuses, and anterior skull base. We recently encountered a patient with complaints of right conjunctival edema and drowsy mentality who was initially treated under the impression of the maxillary, ethmoid and sphenoid sinusitis with cavernous sinus thrombosis. The patient underwent sinus surgery for control of ethmoid and sphenoid infection that was refractory to antibiotic treatment. During the operation, there was only inflammatory mucosal thickening without any specific mass lesion. But, the final diagnosis was mucoepidermoid carcinoma of intermediate grade.
Carcinoma, Mucoepidermoid* ; Cavernous Sinus Thrombosis ; Diagnosis ; Edema ; Ethmoid Sinus* ; Humans ; Nasal Cavity ; Orbit ; Paranasal Sinuses ; Salivary Glands ; Skull Base ; Sphenoid Sinus ; Sphenoid Sinusitis

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A Case of Neurilemmoma Arising from Nasal Septum: Transnasal Endoscopic Exicision.

Yong Jin PARK ; Sung Won KIM ; Yong Sok PARK ; He Ro YOON

Journal of Rhinology.1997;4(2):150-153.

Neurilemmoma is characteristically an encapsulated benign tumor originating from the neural sheath of peripheral, autonomic, and cranial nerves. Whereas between 25% and 45% of all such lesions occur in the region of the head and neck, only 4% of them are found in the nose and paranasal sinuses. Recently, we experienced a case of isolated neuilemmoma of the nasal septum in a 33-year-old female patient who complained of nasal obstruction and postnasal drip over 1 year. The tumor mass was successfully removed by transnasal endoscopic excision under general anesthesia. The patient had an uneventful course with no signs of recurrence. We present our review of the clinicopathologic features, radiologic findings and the value of endoscopy in treatment of this tumor.
Adult ; Anesthesia, General ; Cranial Nerves ; Endoscopy ; Female ; Head ; Humans ; Nasal Obstruction ; Nasal Septum* ; Neck ; Neurilemmoma* ; Nose ; Paranasal Sinuses ; Recurrence

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Expression of the Secretory IgA in the Olfactory Mucosa of Developing Mice.

Kyung Su KIM ; Sung Shik KIM ; Joo Heon YOON ; Jeung Gweon LEE

Journal of Rhinology.1997;4(2):145-149.

Although secretory immunoglobulin A (sIgA) is a very important substance in the defence mechanism of respiratory and nasal mucosa, research on its expression in the olfactory mucosa and differences according to development is limited. Therefore, we planned to uncover the sites of sIgA expression in the olfactory mucosa as well as changes in its expression depending on the developmental progress of mice. Our results showed the expression of sIgA in the mucus layer, the Bowman's gland, some of the blood cells and secretory ducts of the olfactory mucosa, and these findings were relatively consistent from gestational day 15 through to the adult stage. The different findings between the gestational day 15 specimens and others include a positive reaction in the Bowman's gland for gestational day 15 specimens. Therefore, we would like to predict with caution that the Immunologic regulation of mice should be completed at least after the 15th gestational day.
Adult ; Animals ; Blood Cells ; Humans ; Immunoglobulin A, Secretory* ; Mice* ; Mucus ; Nasal Mucosa ; Olfactory Mucosa*

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Ciliary Activity of Upper Airway Epithelial Cells of Rats with Experimentally Induced Allergic Rhinitis.

Chul Hee LEE ; Ja Bock YUN ; Kang Soo LEE ; Chae Seo RHEE ; Yang Gi MIN

Journal of Rhinology.1997;4(2):139-144.

OBJECTIVES: The aim of this study was to investigate whether the ciliary activity of respiratory epithelium is affected in allergic rhinitis. METHODS: Twenty Wistar rats were divided into an unsensitized control group and sensitized allergic group. The sensitized group was immunized intraperitoneally with ovalbumin, followed by intranasal administration of ovalbumin. Allergy was determined by an increase in nasal symptoms, the number of tissue eosinophils and a positive result to a passive cutaneous anaphylaxis (PCA) test. Nasal, nasopharyneal, tracheal, and bronchial epithelial cells were obtained from both the control and allergic groups. Ciliary beat frequency (CBF) was measured using a video-computerized analysis technique in vitro. We compared the CBF of two groups in each site. We also evaluated the findings of the nasal mucosa of both groups with an scanning electron microscope. RESULTS: In vitro CBF measurement demonstrated that the CBF of the control and allergic groups did not differ significantly (p>0.05). CONCLUSION: CBF is not affected by respiratory allergy.
Administration, Intranasal ; Animals ; Eosinophils ; Epithelial Cells* ; Hypersensitivity ; Nasal Mucosa ; Ovalbumin ; Passive Cutaneous Anaphylaxis ; Rats* ; Rats, Wistar ; Respiratory Mucosa ; Rhinitis*

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Local Production of IgE in Nasal Polyp.

Chung Hyun CHO ; Tae Young JANG ; Young Seok YUN ; Dong Hak JUNG

Journal of Rhinology.1997;4(2):126-128.

Among the several possible etiologic factors for the development of nasal polyp, localized nasal allergy had been insisted to be one of the major factors. This study aims to explore the existence of local production of IgE within nasal polyp, which can be the indirect evidence of localized nasal allergy. Fifty-two patients, who underwent nasal polypectomies between April 1993 and December 1995, were selected. The levels of total IgE and specific IgE of serum and polyp fluids were assessed. By using Donovan's equation, the percentage of local production of IgE in nasal polyp were calculated. Local production of total IgE was demonstrated in 18 cases of 28 polyp patient group (64.3%). Local production of specific IgE for Dermatophagoides pteronyssinus and Dermatophagoides farinae were demonstrated in 6 cases of 24 polyp patient group (25%). These results suggest the existence of local production of IgE in nasal polyp.
Dermatophagoides farinae ; Dermatophagoides pteronyssinus ; Humans ; Hypersensitivity ; Immunoglobulin E* ; Nasal Polyps* ; Polyps

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Regional Differences in Proliferative Activity of Nasal Epithelium in Rat.

Sang Hag LEE ; Jae Yong LEE ; Heung Man LEE

Journal of Rhinology.1997;4(2):120-125.

We investigated the active proliferation sites of epithelial cells in normal nasal mucosa by immunohistochemical staining of proliferating cell nuclear antigen (PCNA), the marker of S phase of cell cycle and active cell proliferation. The whole nasal mucosa of the ten normal Sprague-Dawley rats were processed for PCNA immunolabeling. In respiratory portion, distinctly positive reaction was seen mainly in the anterior aspect, that is, the nuclei of squamous and non-ciliated cuboidal/transitional epithelium. These types of epithelial cells are transformed to pseudostratified ciliated epithelium in the posterior direction where positive reaction became scanty. In olfactory epithelium, the nuclei immunoreactive for PCNA were distinct in some area, but absent in other adjacent areas, lacking of region-specific immunolabeling that was observed in respiratory mucosa. These results suggest that anterior portion of nasal cavity is the main proliferation zone of normal nasal respiratory epithelium as well as the main site of protective function. In contrast, the neurogenesis of the olfactory nerve cells is not site-specific, indicating that any region covered by olfactory mucosa may be the main proliferation zone.
Animals ; Cell Cycle ; Cell Proliferation ; Epithelial Cells ; Epithelium ; Nasal Cavity ; Nasal Mucosa* ; Neurogenesis ; Olfactory Mucosa ; Olfactory Nerve ; Proliferating Cell Nuclear Antigen ; Rats* ; Rats, Sprague-Dawley ; Respiratory Mucosa ; S Phase

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Acoustic Rhinometry in Nasal Provocation Test.

Tae Young JANG ; Yeong Seok YUN ; Dong Hak JUNG ; Byung Hun KIM ; Young Jin KIM ; Weon Suk CHOI

Journal of Rhinology.1997;4(2):116-119.

A nasal provocation test is the most reliable diagnostic test to confirm allergen in allergic rhinitis. However, there are neither specific objective methods nor a standardized method and interpretation. In 20 normal subjects and 86 allergic rhinitis patients, we applied acoustic rhinometry as a new objective method to assess changes in nasal patency induced by nasal allergen challenge, a procedure which is used for confirming allergic rhinitis. The result shows that a minimal cross-sectional area (MCA) and volume from the nose tip on back to 7 cm (nasal cavity volume) after allergen challenge were significantly decreased in allergic rhinitis patients in comparison with the control subjects. We conclude that acoustic rhinometry can provide a sensitive index for evaluating the results of a nasal provocation test.
Acoustics* ; Diagnostic Tests, Routine ; Humans ; Nasal Provocation Tests* ; Nose ; Rhinitis ; Rhinometry, Acoustic*

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Expression of Transforming Growth Factor-beta(TGF-beta) Family in Nasal Polyps and Postoperative Polypoid Mucosa after Functional Endoscopic Sinus Surgery.

Yeong Seok YUN ; Jong Chul CHOI ; Tae Young JANG ; Dong Hak JUNG

Journal of Rhinology.1997;4(2):111-115.

Transforming growth factor (TGF)-beta1, beta2, and beta3 are multifunctional proteins which play an important role in chronic inflammatory process, angiogenesis, and epithelial differentiation. In nasal polyps and postoperative polypoid mucosa after functional endoscopic sinus surgery (FESS), changes of expression of TGF-beta family were assessed to identify its role in formation of nasal polyps and mucosal healing after FESS. Nasal polyps and polypoid mucosa were obtained during FESS and in outpatient clinic after the surgery, respectively. Immunohistochemical staining was performed. TGF-beta family was highly expressed in the epithelium, subepithelial glands, neutrophils and eosinophils of nasal polyps. On the other hand, expression of TGF-beta family decreased in the epithelium and subepithelial gland of polypoid mucosa according to a postoperative period after FESS. These results suggest that TGF-beta family may play an important role in formation of nasal polyps and it decreases in process of mucosal healing after FESS.
Ambulatory Care Facilities ; Eosinophils ; Epithelium ; Hand ; Humans ; Mucous Membrane* ; Nasal Polyps* ; Neutrophils ; Postoperative Period ; Transforming Growth Factor beta ; Transforming Growth Factors

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Toxicity of Polylactic Acid Polymer in the Treatment of Paranasal Sinusitis.

Yang Gi MIN ; Young Ki KIM ; Sea Young JEON ; Ki Sang RHA ; Seo Young JEONG

Journal of Rhinology.1997;4(2):104-110.

The authors, after inducing acute sinusitis in rabbits, compared cases where we opened the natural ostium and a general dose of administered antibiotics and cases where we opened the natural ostium and locally administered dose of antibiotics using polymer, and found that the application of local antibiotics using polymer is the superior of the two in treating sinusitis. To be able to develop a treatment for sinusitis using antibiotics incorporating polymer, we first need to examine the toxicity of polymer. The purpose of this study was to examine the toxicity of polymer through a general toxicity test as well as a special toxicity test in experiments using animals. As a result of this study, we discovered that poly-L-lactic acid (PLA) polymer works as an intraperitoneal foreign body and causes adhesion of viscera, but nethier acute nor subacute toxicity of PLA polymer was detected, and no negative effect on reproductive function was observed. It was also observed to induce neither immune reaction such as hypersensitivity nor local toxicity to the maxillary sinus mucosa of rabbit. We conclude that the results of this study can provide basic information for developing antibiotics-incorporating PLA polymer for the treatment of sinusitis and for clinical experiments involving such antibiotics.
Animals ; Anti-Bacterial Agents ; Foreign Bodies ; Hypersensitivity ; Maxillary Sinus ; Mucous Membrane ; Polymers* ; Rabbits ; Sinusitis* ; Toxicity Tests ; Viscera

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