Cancer Research on Prevention and Treatment 2021;48(1):49-54

doi:10.3971/j.issn.1000-8578.2021.19.1587

Prognosis Analysis of Non-small Cell Lung Cancer with Diameter over 7.0 cm Based on SEER Database

Tingting FENG 1 ; Zhongzhong CHEN ; Wenjin YAN ; Yuxiu WANG ; Jun ZHANG ; Xingxiang XU ; Yong CHEN ; Junjun YANG ; Lingfeng MIN

Affiliations

+expand

Keywords

Tumor size; NSCLC; Surgery; SEER database; Prognosis

Country

China

Language

Chinese

Abstract

Objective To analyze the mortality risk and evaluate the curative effects of surgery and non-surgery on NSCLC with diameter > 7.0 cm. Methods We collected the data of NSCLC patients with diameter > 7.0 cm from 2010 to 2015 from the SEER database. The 1, 2, 3-year survival rates were analyzed by life table method. Overall survival curve was estimated by Kaplan-Meier method. Univariate and multivariate Cox regression models were used to analyze the independent prognostic factors. Results The 1, 2, 3-year survival rates were 51.8%, 33.0% and 25.0%, respectively. In univariate and multivariate analyses, tumor size, N stage and treatment were the independent prognostic factors (P < 0.001). Conclusion Surgery is benefited for the prognosis of stage N0-N1 NSCLC patients with diameter > 7.0 cm. And for stage N2 NSCLC patients with diameter 7.0-9.0 cm, surgical treatment has advantages in improving the prognosis. Surgical and non-surgical patients with tumor diameter ≥9.0 cm or lymph node N3 stage have no statistically significant differences in prognosis. In addition, palliative treatment does not improve the prognosis of patients.