Positive mental health and well-being constitute individuals' functionality and adaptability toward a healthier life. The threats of biological disasters, from large-scale outbreaks to pandemics, take a toll on many impacts. While focusing on the epidemiologic features of novel infectious diseases, mental health impacts are neglected, particularly the adverse psychological effects of isolation. Research studies have found that isolation triggers or exacerbates mental conditions, particularly post-traumatic disorder, depression, and anxiety. These mental conditions evolve from the acute stage and threaten psychological well-being and economic productivity. As part of the largest global health workforce worldwide, nurses take leadership in advocating recommended policy changes to inform mental health-related decision-making.