Calcium silicate based sealers (CSBS) were introduced under the background of a calcium silicate based hydrophilic cement (mineral trioxide aggregate: MTA), composed by tricalcium and dicalcium silicate. Inspired by the excellent sealing ability and biocompatibility of MTA, the sealers establish a biological point of view on the canal obturation. There is no doubt that premixed calcium silicate based sealers has gained wide acceptance in clinical application, but unstable setting time, slight solubility and retreatability of the CSBS might compromise the usage and value of the new class of endodontics sealers. Further clinical studies are required to improve the properties of the calcium silicate based sealers.