Journal of Korean Orthopaedic Research Society  2015;18(1):9-17

Surface Characteristics and Biocompatibility of Micro Arc Oxidized Titanium Alloy.

Young Wook LIM 1 ; Eun Sang LEE ; Yong Sik KIM ; Kwang Yun SONG ; Soon Yong KWON

Affiliations

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Keywords

Micro Arc Oxidized (MAO); Biocompatibility; Titanium Alloy

Country

Republic of Korea

Language

Korean

Abstract

PURPOSE: The aim of this research was to characterize micro arc oxidized titanium (MAO-Ti), accompanied by biocompatibility test in vivo as well as in vitro in comparison to the different types of surface modification; machined, blasted and plasma spray. MATERIALS AND METHODS: XRD and SEM investigations were performed in order to assess the structure and morphology. Biologic and morphologic responses to the osteoblast cell lines (Saos-2) were then examined, using Promeg(R) proliferation assay, alkalinephosphatase activity, alphavbeta3 integrin expression and cytoskeleton staining (Rhodamine-Phallodine). The analysis of gene expression for osteocalcin and collagen I was done through RT-PCR. RESULTS: MAO-Ti showed more activity on osteointegration and cell differentiation compared to other types of surface modification. CONCLUSION: In summary, MAO-Ti appears to exhibit more favorable biocompatibility than the compared groups in vitro and in vivo as well.