Korean Journal of Psychopharmacology  2002;13(3):141-147

Tailored Pharmacotherapy of Psychotropic Drugs.

In Won CHUNG 1 ; Kyu Young LEE

Affiliations

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Keywords

Tailored pharmacotherapy; Psychotropic drugs; Pharmacogenetics; Pharmacogenomics

Country

Republic of Korea

Language

Korean

Abstract

The pharmacotherapeutic responses such as clinical efficacy and adverse events exhibit wide variabilities in individuals and even in different races and populations. The human genetic diversity has been known as the one of the main factors in the variations of drug responses expressed in the area of pharmacokinetics and pharmacodynamics. Polygenetic implications have been suggested in the pathophysiology of psychiatric disorders. The risks in psychiatric disorders could be explored by combining the polymorphisms of multiple candidate genes. This suggests that drug therapy should be tailored to the genetic make-up of the individual. The emerging field of pharmacogenomics could be a landmark for the development of more effective clinical efficacy and less adverse events by individually tailored drugs.