Korean Journal of Pediatrics  2008;51(2):214-218

doi:10.3345/kjp.2008.51.2.214

Palliative effect of (131)I-MIBG in relapsed neuroblastoma after autologous peripheral blood stem cell transplantation.

Yong Jik LEE 1 ; Jeong Ok HAH

Affiliations

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Keywords

Relapsed neuroblastoma; (131)I-MIBG; Palliative therapy

Country

Republic of Korea

Language

English

Abstract

Neuroblastoma is one of the most common extracranial solid tumor of childhood, and treatment of refractory neuroblastoma remains a significant clinical problem. Iodine-131-metaiodobenzylguanidine ((131)I-MIBG) therapy is an alternative approach to treat stage IV neuroblastoma. We report the palliative effect of (131)I-MIBG in three cases of relapsed neuroblastoma after autologous peripheral blood stem cell transplantation. (131)I-MIBG is an effective and relatively nontoxic palliative therapy resulting in reduction of pain and prolongation of survival.