OBJECTIVES: This study examined the relationship between job stress and the common carotid intima-media thickness as an indicator of atherosclerosis (cardiovascular disease) among male firefighters in a metropolitan city. METHODS: Between November and December 2011, a total of 838 participants were analyzed using a questionnaire, which included the participants' general characteristics, job-related factors, health-related behaviors, and job stress. Job stress was measured using the Korean Occupational Stress Scale-Short Form (KOSS-SF). The job stress data was merged with the clinical laboratory data and common carotid intima-media thickness (CIMT) by a medical examination. The relationship between job stress and the CIMT was examined by multiple logistic regression analysis. RESULTS: Multiple logistic regression analyses adjusted for the general and cardiovascular risk factors revealed, the organizational system (adjusted OR 1.381 95% CI=1.005~1.898) to be associated with the right CIMT. Multiple logistic regression analyses adjusted for general and cardiovascular risk factors and job types, the occupational climate (adjusted OR 1.392, 95% CI=1.009~1.922) was also associated with the right CIMT. CONCLUSIONS: The level of job stress, particularly in regard to the organizaional system, shows a correlation with the right CIMT. Therefore, further preventive efforts and studies of firefighters will be needed to reduce job stress and help prevent cardiovascular disease.