Journal of Gynecologic Oncology  2010;21(3):199-202

doi:10.3802/jgo.2010.21.3.199

Primary amelanotic melanoma of the cervix: case report with review of literature.

Rajan DUGGAL 1 ; Radhika SRINIVASAN

Affiliations

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Keywords

Aamelanotic melanoma; HMB-45 antibody

Country

Republic of Korea

Language

English

Abstract

Primary malignant melanoma of the uterine cervix is a rare neoplasm with poor prognosis. It may be misdiagnosed especially when amelanotic, in which case immunohistochemistry is useful in reaching the diagnosis. We present one such case of a 65-year-old postmenopausal female patient presenting with bleeding per vaginum. Speculum examination revealed an ulcero-proliferative growth involving the cervix. On histopathological examination it was originally suspected to be a poorly differentiated carcinoma or a non-epithelial malignant tumor, but was subsequently correctly diagnosed by immunohistochemical staining with the HMB-45 antibody and S-100 protein.