Korean Circulation Journal  1990;20(4):815-818

doi:10.4070/kcj.1990.20.4.815

Clinical Effects of Isosorbide 5-Mononitrate(Elantan(R)) on Angina Pectoris.

Jung Yoo LEE ; Dong Il LEE ; Ji Ae SHIN ; Kwang Su CHA ; Min Ki LEE ; Jae yung HU ; Yung Woo SHIN ; Yeong Kee SHIN

Keywords

Isosorbide 5-mononitrate; Angina pectoris

Country

Republic of Korea

Language

Korean

Abstract

An open trial was carried out to investigate the efficacy and tolerance of isosorbide 5-mononitrate(Elantan(R)) in 30 patients diagnosed as angina pectoris at Pusan national university hospital. Drugs were given 20mg two times daily for 2 to 3 weeks and the results were assessed in terms of effects on anginal pain and untoward side effects experienced during administration of medication. Treament resulted in an overall improvement in 25 patients(83.4%), complete abolition of anginal attacks in 17 patients(56.7%) and reduction in frequency of attacks in 8 patients(26.7%). So called "Nitrated headache" was observed in 5 patients(16.6%) but improved with proceeding of administration in 3 patients. This trial indicates that isosorbide 5-mononitrate should be efficacious as well as tolerated in patients with coronary heart disease.