Korean Journal of Obstetrics and Gynecology  2001;44(4):804-807

Normal pregnancy recovered from ovarian failure after multiagent chemotherapy for ovarian carcinoma with positive second-look operation.

Mi Kyung KOO 1 ; Sam Hyun CHO ; Su Hyun JO ; Seung Ryong KIM ; Hyung MOON ; Yoon Yoong HWANG

Affiliations

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Keywords

Ovarian failure; pregnancy; chemotherapy; ovarian cancer

Country

Republic of Korea

Language

Korean

Abstract

We report a successful pregnancy in a woman who at the age of 31years received chemotherapy for mucinous cystadenocarcinoma of the right ovary. She was treated with multiple chemotherapy including cis-platinum, cyclophosphamide, adriamycin, and oral melphalan. She had microscopic residual cancer at the opposite ovary at second-look laparotomy. She developed secondary amenorrhea with symptoms of menopause after commencing treatment which persisted on its completion. Biochemical investigations were consistent with ovarian failure, which was assumed to be chemotherapy-induced. She was given hormonal replacement therapy with a conjugated equine estrogen/medroxyprogesterone acetate combination, resulting in regular withdrawal bleeding. The patient conceived 5 years after completing chemotherapy and gave birth a normal infant at term.