PURPOSE: The purpose of this study was to identify the influence of the ego-resilience and social support on the depression among hospital nurses. METHODS: The subjects of this study were 369 nurses in a hospital. We used the self-reported questionnaire to assess the level of ego-resilience, social support and depression of hospital nurses. The data were analyzed using descriptive statistics, frequency, t-test, ANOVA and logistic regression. RESULTS: The mean scores of ego-resilience, social support and depression were 42.6, 28.3 and 14.1, respectively. When scores of ego-resilience and social support were high, the level of mild and major depression of subjects decreased. The influencing factors of depression level were the department of work, ego-resilience and social support. CONCLUSION: The findings suggest that developing programs to improve ego-resilience and social support might be useful. Further study is required to justify the scale on ego-resilience and social support.