Journal of Korean Society of Pediatric Endocrinology  2011;16(3):189-192

doi:10.6065/jkspe.2011.16.3.189

Pamidronate Treatment in 9-Year-Old Boy Diagnosed with Gorham Disease.

Ju Young YOON 1 ; Ji Eun LEE ; Seung Wan PARK ; Min Jae KANG ; Young Ah LEE ; Sei Won YANG ; Kyung Duk PARK ; Choong Ho SHIN

Affiliations

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Keywords

Osteolysis, essential; Pamidronate; Child

Country

Republic of Korea

Language

Korean

Abstract

Gorham disease is a rare disorder characterized by proliferation of vascular channels resulting in destruction and resorption of osseous matrix. There is no standard treatment defined for this disease, and variable therapies such as medical, surgical, and radiation therapy have been used. Antiresorptive medication, such as bisphosphonate, is used in Gorham disease because they suppress the course of osteolysis and angiogenisis. We report a 9-year-old boy with Gorham disease, who was presented with recurrent hemothorax and treated by pamidronate. After treatment, he showed no recurrence of hemothorax for more than 2 years.