Korean Journal of Neuromuscular Disorders 2020;12(2):36-38

doi:10.46518/kjnmd.2020.12.2.36

A Guillain-Barré Syndrome with Anti-GQ1b and Anti-GT1a Antibodies Positivity Manifesting with Acute Bulbar Palsy and Subsequent Delayed Ophthalmoplegia

Seonmin YOON 1 ; Jong Seo BAE ; Byeol-A YOON ; Jong Kuk KIM ; Yerim KIM ; Sang-Hwa LEE

Affiliations

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Country

Republic of Korea

Language

Korean

Abstract

In Guillain-Barré syndrome (GBS) and its variant, anti-GQ1b antibody has a pathogenic role for ophthalmoplegia. In addition, anti-GT1a antibody is related with lower cranial nerve involvement. This report describes a 60-year-old male patient with GBS manifesting with initially isolated dysphagia and subsequently developed ophthalmoplegia. Both immunoglobulin G type anti-GQ1b and anti-GT1a antibodies were detected in the patient’s serum. A mechanism regarding subsequent involvement of respective cranial nerves remains to be elucidated.