The purpose of this study was to evaluate the influence of fabrication methods of lithium disilicate reinforced glass-ceramic crown on marginal and internal fit. Lithium disilicate reinforced glass-ceramic crowns were fabricated using ingots for heat press forming and blocks for CAD/CAM milling manufactured by Hass and Ivoclar/Vivadent. Dentiform of maxillary central incisor was prepared with a 6°taper and 1 mm deep chamfer margin and duplicated with silicone. Then the polyurethane resin was poured at silicone mold to produce working model. Marginal and internal fit were measured by the silicone replica technique. Each silicon replica was cut into labio-lingual and mesio-distal sections and the thickness of the light body silicon was measured. Fourteen reference points were determined and measured using a microscope. As a result of calculating and comparing the average value of 14 points in all groups, the measured value was within 120 µm, the clinically acceptable range suggested by previous literatures. In all groups, the marginal fit was smaller than the internal fit. At the margin area, significant differences were identified only between the ECM group and the EPM group, and there was no statistically significant difference between the remaining groups. At the deep chamfer area, the ECM and ABM group produced by the CAD system had excellent compatibility. In the axial wall and incisal area, ECM was superior to both EPC and EPM. Also, both ABM and APC groups were statistically significantly superior than APM.