Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes.
1. Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, 200030, China.
2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
3. Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China.
4. Henan Sesame Research Center, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China.
5. College of Traditional Mongolian Medicine, Inner Mongolia Medical University, Mongolia, 010110, China.
6. State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China.
7. Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, 200040, China.
8. Department of Physiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, USA.
9. Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
10. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. cluo@simm.ac.cn.
11. State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China. byu@sioc.ac.cn.
12. Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, 200030, China. qqtang@shmu.edu.cn.
13. Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, 200030, China. yongjundang@fudan.edu.cn.
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