Translational and Clinical Pharmacology  2017;25(3):114-116

doi:10.12793/tcp.2017.25.3.114

Inhibition of indoxyl sulfate-induced intrarenal renin-angiotensin system activation: targeting the aryl hydrocarbon receptor.

Muhammad Firman AKBAR 1

Affiliations

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Keywords

Chronic Kidney Disease; Indoxyl Sulfate; Aryl Hydrocarbon Receptor; Renin-Angiotensin System

Country

Republic of Korea

Language

English

Abstract

Indoxyl sulfate, a protein-bound uremic toxin, leads to CKD (chronic kidney disease) progression and its complications through the activation of AhR (aryl hydrocarbon receptor) and RAS (renin-angiotensin system). Inhibition of these pathways may slow the development of CKD and CKD-associated complications.